DK127580A - Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser - Google Patents

Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser

Info

Publication number: DK127580A
Authority: DK; Denmark
Prior art keywords: compounds; vitamin; preparation; fluored; procedure
Prior art date: 1978-07-26

Application number

DK127580A

Other languages

English (en)

Other versions

DK156716C (da

DK156716B (da

Inventor

H F Deluca

H K Schnoes

J L Napoli

B L Onisko

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-07-26

Filing date

1980-03-25

Publication date

1980-03-25

1980-03-25 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1980-03-25 Publication of DK127580A publication Critical patent/DK127580A/da

1989-09-25 Publication of DK156716B publication Critical patent/DK156716B/da

1990-02-19 Application granted granted Critical

1990-02-19 Publication of DK156716C publication Critical patent/DK156716C/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
229930003231 vitamin Natural products 0.000 title abstract 2
229940088594 vitamin Drugs 0.000 title abstract 2
235000013343 vitamin Nutrition 0.000 title abstract 2
239000011782 vitamin Substances 0.000 title abstract 2
150000003722 vitamin derivatives Chemical class 0.000 title abstract 2
229930003316 Vitamin D Natural products 0.000 abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
210000000988 bone and bone Anatomy 0.000 abstract 2
235000019166 vitamin D Nutrition 0.000 abstract 2
239000011710 vitamin D Substances 0.000 abstract 2
-1 vitamin D compounds Chemical class 0.000 abstract 2
229940046008 vitamin d Drugs 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
230000002308 calcification Effects 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Nutrition Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK127580A 1978-07-26 1980-03-25 Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser eller 1-fluor-5,6-trans vitamin d-forbindelser eller 1-fluor-3,5-cyclovitamin d-forbindelser DK156716C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US05/928,279 US4188345A (en)	1978-07-26	1978-07-26	Fluorovitamin D compounds and processes for their preparation
US92827978		1978-07-26
PCT/US1979/000529 WO1980000339A1 (en)	1978-07-26	1979-07-24	Process for preparing 1-fluorinated vitamin d compounds
US7900529		1979-07-24

Publications (3)

Publication Number	Publication Date
DK127580A true DK127580A (da)	1980-03-25
DK156716B DK156716B (da)	1989-09-25
DK156716C DK156716C (da)	1990-02-19

Family

ID=25456012

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK127580A DK156716C (da)	1978-07-26	1980-03-25	Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser eller 1-fluor-5,6-trans vitamin d-forbindelser eller 1-fluor-3,5-cyclovitamin d-forbindelser
DK127480A DK154211C (da)	1978-07-26	1980-03-25	Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK127480A DK154211C (da)	1978-07-26	1980-03-25	Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser

Country Status (14)

Country	Link
US (1)	US4188345A (da)
JP (2)	JPS6312868B2 (da)
AU (1)	AU521131B2 (da)
BE (1)	BE877918A (da)
CH (2)	CH641445A5 (da)
DK (2)	DK156716C (da)
FR (1)	FR2433514B1 (da)
GB (1)	GB2026494B (da)
IE (1)	IE48463B1 (da)
IL (1)	IL57801A (da)
NL (2)	NL7920016A (da)
NZ (1)	NZ190939A (da)
SE (2)	SE8001747L (da)
WO (2)	WO1980000339A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4196133A (en) *	1979-03-05	1980-04-01	Wisconsin Alumni Research Foundation	24,24-Difluoro-25-hydroxycholecalciferol
US4410515A (en) *	1981-04-01	1983-10-18	Massachusetts General Hospital	Vitamin D glycosides and a method of use
JPS59501264A (ja) *	1982-06-30	1984-07-19	マサチユ−セツツ　ゼネラル　ホスピタル	ビタミンｄグリコシド類
US4428946A (en) *	1982-07-26	1984-01-31	Wisconsin Alumni Research Foundation	Method of preventing milk fever in dairy cattle
US4448721A (en) *	1982-09-20	1984-05-15	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 compounds and process for preparing same
GB2145091B (en) *	1983-08-18	1987-08-12	Wisconsin Alumni Res Found	Vitamin d3 derivatives
US4661294A (en) *	1985-03-18	1987-04-28	The General Hospital Corporation	Biologically active 1-thio derivatives of vitamin D
US5401731A (en) *	1989-06-29	1995-03-28	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab)	Vitamin D analogues
TR25295A (tr) *	1992-02-26	1993-01-01	Simfer Dayanikli Tueketim Mamu	Kati yakit yakan sobalar icin yanma havasi ön isitma sistemi
US5384314B1 (en) *	1994-03-11	1997-08-05	Hoffmann La Roche	1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
CA2229316C (en) *	1995-09-21	2005-04-12	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
US5952317A (en) *	1995-09-21	1999-09-14	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
US5976784A (en) *	1996-09-20	1999-11-02	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
CA2289209C (en)	1997-05-16	2006-07-25	Women & Infants Hospital	Cyclic ether vitamin d3 compounds, 1.alpha. (oh) 3-epi-vitamin d3 compounds and uses thereof
MX2008012672A (es) *	2006-04-06	2008-10-15	Wisconsin Alumni Res Found	Analogos de 2-metilen-1a-hidroxi-18,19,21-trinor vitamina d3 y sus usos.
JP2009533483A (ja) *	2006-04-06	2009-09-17	ウイスコンシンアラムニリサーチファンデーション	２−メチレン−１α，２５−ジヒドロキシ−１８，１９，２１−トリノルビタミンＤ３およびその使用
WO2008026078A2 (en) *	2006-04-06	2008-03-06	Wisconsin Alumni Research Foundation	19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring
MX2008012671A (es)	2006-04-06	2008-10-15	Wisconsin Alumni Res Found	Analogos 1 a,25-dihidroxi- 19, 26,27-trinor vitamina d 2-sustituidos y sus usos.
EP2046737B1 (en) *	2006-04-06	2011-09-07	Wisconsin Alumni Research Foundation	2-methylene-1 alpha,25-dihydroxy-19,21-dinorvitamin d3 analogs and uses thereof
MX2008012673A (es) *	2006-04-06	2008-10-15	Wisconsin Alumni Res Found	Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos.
US7763598B2 (en) *	2006-04-10	2010-07-27	Wisconsin Alumni Research Foundation	1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
USD583254S1 (en) *	2007-12-18	2008-12-23	New York & Company, Inc.	Pump container
US8814007B2 (en)	2010-12-31	2014-08-26	Medline Industries, Inc.	Dispenser with directional flow controlling flange and corresponding systems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3833622A (en) *	1969-03-17	1974-09-03	Upjohn Co	Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US4069321A (en) *	1975-10-14	1978-01-17	Merck & Co., Inc.	Blocked cholecalciferol and dihydrotachysterol 3 derivatives

1978
- 1978-07-26 US US05/928,279 patent/US4188345A/en not_active Expired - Lifetime
1979
- 1979-07-06 NZ NZ190939A patent/NZ190939A/xx unknown
- 1979-07-13 IL IL57801A patent/IL57801A/xx not_active IP Right Cessation
- 1979-07-24 NL NL7920016A patent/NL7920016A/nl unknown
- 1979-07-24 CH CH249680A patent/CH641445A5/de not_active IP Right Cessation
- 1979-07-24 JP JP54501224A patent/JPS6312868B2/ja not_active Expired
- 1979-07-24 WO PCT/US1979/000529 patent/WO1980000339A1/en not_active Ceased
- 1979-07-24 NL NL7920012A patent/NL7920012A/nl unknown
- 1979-07-24 CH CH2497/80A patent/CH650237A5/de not_active IP Right Cessation
- 1979-07-24 JP JP54501218A patent/JPS6312867B2/ja not_active Expired
- 1979-07-24 WO PCT/US1979/000528 patent/WO1980000338A1/en not_active Ceased
- 1979-07-25 AU AU49206/79A patent/AU521131B2/en not_active Ceased
- 1979-07-26 FR FR7919368A patent/FR2433514B1/fr not_active Expired
- 1979-07-26 GB GB7926135A patent/GB2026494B/en not_active Expired
- 1979-07-26 BE BE0/196477A patent/BE877918A/xx not_active IP Right Cessation
- 1979-08-08 IE IE1496/79A patent/IE48463B1/en not_active IP Right Cessation
1980
- 1980-03-05 SE SE8001747A patent/SE8001747L/xx unknown
- 1980-03-05 SE SE8001746A patent/SE8001746L/xx unknown
- 1980-03-25 DK DK127580A patent/DK156716C/da not_active IP Right Cessation
- 1980-03-25 DK DK127480A patent/DK154211C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB2026494B (en)	1982-12-15
AU521131B2 (en)	1982-03-18
FR2433514A1 (fr)	1980-03-14
SE8001746L (sv)	1980-03-05
JPS55500428A (da)	1980-07-17
NL7920016A (nl)	1980-05-30
BE877918A (fr)	1979-11-16
DK156716C (da)	1990-02-19
IL57801A (en)	1984-03-30
CH650237A5 (de)	1985-07-15
US4188345A (en)	1980-02-12
CH641445A5 (de)	1984-02-29
NZ190939A (en)	1982-09-07
DK127480A (da)	1980-03-25
DK154211C (da)	1989-03-13
SE8001747L (sv)	1980-03-05
AU4920679A (en)	1980-01-31
JPS6312868B2 (da)	1988-03-23
GB2026494A (en)	1980-02-06
JPS6312867B2 (da)	1988-03-23
WO1980000339A1 (en)	1980-03-06
IE791496L (en)	1980-01-26
JPS55500430A (da)	1980-07-17
DK156716B (da)	1989-09-25
NL7920012A (nl)	1980-05-30
WO1980000338A1 (en)	1980-03-06
DK154211B (da)	1988-10-24
FR2433514B1 (fr)	1986-05-23
IL57801A0 (en)	1979-11-30
IE48463B1 (en)	1985-01-23

Legal Events

Date	Code	Title	Description
1994-03-28	PBP	Patent lapsed

Publication	Publication Date	Title
DK127580A (da)	1980-03-25	Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser
ES506400A0 (es)	1982-09-01	Procedimiento para la fabricacion de collares para animales caseros,conteniendo ectoparasiticidas
BR8107071A (pt)	1982-07-20	Valvula cardiaca para protese
MX5222E (es)	1983-04-29	Procedimiento para el tratamiento de lactosuero
DK387281A (da)	1982-03-10	Fremgangsmaade til hydroxylering af aromatiske carbonhudrider
ES522085A0 (es)	1984-12-16	Procedimiento para producir t-p-a humano activador de plasminogeno.
DK164703C (da)	1992-12-21	Analogifremgangsmaade til fremstilling af kvaternaere 6,11-dihydro-dibenzo-oeb,eaa-thiepin-11-n-alkyl-norscopinethere og mellemprodukt til anvendelse ved denne fremgangsmaade
DK95482A (da)	1982-09-06	Fremgangsmaade til fremstilling af aroylimidazoloner
ES507810A0 (es)	1983-10-16	Procedimiento para hidroformilar compuestos olefinicamente insaturados.
FI895447A0 (fi)	1989-11-15	Substituerade adeninderivat anvaendbara som terapeutiska substanser.
ES514940A0 (es)	1983-10-16	Procedimiento para preparar fenoxipiridinas sulfuro-sustituidas teniendo actividad antiviral.
ES2051787T3 (es)	1994-07-01	Un procedimiento para preparar 17beta-(ciclopropiloxi)androst-5-en-3beta-ol y compuestos relacionados.
DK375179A (da)	1980-03-10	N,n-dimethyl-o-pyrazolyl-carbamisyeestere fremgangsmaader til fremstilling deraf og disses anvendelse som skadedyrsbekaempelsesmidler
IS2902A7 (is)	1984-06-07	Aðferð til framleiðslu á 1,8-dihydroxy-10-acyl-9-anthrones, sérstaklega til meðferðar á psoriasis
IT8321550A0 (it)	1983-06-10	Procedimento per la concia delle pelli.
ES538403A0 (es)	1985-11-01	Procedimiento para la obtencion de antipodas opticos del (+7-1,7-difenil-3-metilaza-7-ciano-8-metil-nonano
ES500419A0 (es)	1982-02-01	Aparato y su correspondiente procedimiento,para el trata- miento en humedo de cueros
DK320081A (da)	1982-01-20	Fremgangsmaade til fremstilling af thiazolyl-2-oxamidsyrederivater
IT7826282A0 (it)	1978-07-28	Esuronil esosaminoglicano solfato naturale, procedimento per la sua preparazione e impieghi terapeutici relativi.
ES2018807B3 (es)	1991-05-16	Procedimiento para curtir el cuero
DK306479A (da)	1980-01-22	N-cyclohexyl-n-methoxyacetoacetamid, fremgangsmaade til fremstilling deraf og anvendelse deraf til fremstilling af o-methyl-n-cyclohexyl-2,5-dimethylfuran-3-hydroxamsyre
DK213579A (da)	1979-11-26	Polyhalogenerede hydrocarboner som er velegnede som insekticidmellemprodukter og fremgangsmaader til deres fremstilling
SE7800129L (sv)	1978-07-07	Forfarande for framstellning av sura emnen, serskilt sadana som er lempliga sasom herdning befremjande emnen och/eller garvmedel
JPS5218058A (en)	1977-02-10	Method of treating thiocyanate-containing reducible drainage
ES501180A0 (es)	1982-02-01	Procedimiento de tratamiento de frutas frescas para su pre- paracion ulterior en conserva