DK154211C - Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser - Google Patents

Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser

Info

Publication number: DK154211C
Authority: DK; Denmark
Prior art keywords: vitamin; compounds; preparation; substituted; fluorous
Prior art date: 1978-07-26

Application number

DK127480A

Other languages

English (en)

Other versions

DK154211B (da

DK127480A (da

Inventor

Hector F Deluca

Heinrich K Schnoes

Jr Joseph L Napoli

Bruce L Onisko

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-07-26

Filing date

1980-03-25

Publication date

1989-03-13

1980-03-25 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1980-03-25 Publication of DK127480A publication Critical patent/DK127480A/da

1988-10-24 Publication of DK154211B publication Critical patent/DK154211B/da

1989-03-13 Application granted granted Critical

1989-03-13 Publication of DK154211C publication Critical patent/DK154211C/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
229940088594 vitamin Drugs 0.000 title abstract 3
239000011782 vitamin Substances 0.000 title abstract 3
229930003231 vitamin Natural products 0.000 title abstract 2
235000013343 vitamin Nutrition 0.000 title abstract 2
150000003722 vitamin derivatives Chemical class 0.000 title abstract 2
229930003316 Vitamin D Natural products 0.000 abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
210000000988 bone and bone Anatomy 0.000 abstract 2
235000019166 vitamin D Nutrition 0.000 abstract 2
239000011710 vitamin D Substances 0.000 abstract 2
-1 vitamin D compounds Chemical class 0.000 abstract 2
229940046008 vitamin d Drugs 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
230000002308 calcification Effects 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Nutrition Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK127480A 1978-07-26 1980-03-25 Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser DK154211C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US92827978		1978-07-26
US05/928,279 US4188345A (en)	1978-07-26	1978-07-26	Fluorovitamin D compounds and processes for their preparation
US7900528		1979-07-24
PCT/US1979/000528 WO1980000338A1 (en)	1978-07-26	1979-07-24	Process for preparing side chain fluorinated vitamin d compounds

Publications (3)

Publication Number	Publication Date
DK127480A DK127480A (da)	1980-03-25
DK154211B DK154211B (da)	1988-10-24
DK154211C true DK154211C (da)	1989-03-13

Family

ID=25456012

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK127580A DK156716C (da)	1978-07-26	1980-03-25	Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser eller 1-fluor-5,6-trans vitamin d-forbindelser eller 1-fluor-3,5-cyclovitamin d-forbindelser
DK127480A DK154211C (da)	1978-07-26	1980-03-25	Fremgangsmaade til fremstilling af 25-fluorsubstituerede vitamin d- og 5,6-trans-vitamin d forbindelser

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK127580A DK156716C (da)	1978-07-26	1980-03-25	Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser eller 1-fluor-5,6-trans vitamin d-forbindelser eller 1-fluor-3,5-cyclovitamin d-forbindelser

Country Status (14)

Country	Link
US (1)	US4188345A (da)
JP (2)	JPS6312867B2 (da)
AU (1)	AU521131B2 (da)
BE (1)	BE877918A (da)
CH (2)	CH650237A5 (da)
DK (2)	DK156716C (da)
FR (1)	FR2433514B1 (da)
GB (1)	GB2026494B (da)
IE (1)	IE48463B1 (da)
IL (1)	IL57801A (da)
NL (2)	NL7920016A (da)
NZ (1)	NZ190939A (da)
SE (2)	SE8001747L (da)
WO (2)	WO1980000338A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4196133A (en) *	1979-03-05	1980-04-01	Wisconsin Alumni Research Foundation	24,24-Difluoro-25-hydroxycholecalciferol
US4410515A (en) *	1981-04-01	1983-10-18	Massachusetts General Hospital	Vitamin D glycosides and a method of use
WO1984000107A1 (en) *	1982-06-30	1984-01-19	Massachusetts Gen Hospital	Vitamin d glycosides
US4428946A (en) *	1982-07-26	1984-01-31	Wisconsin Alumni Research Foundation	Method of preventing milk fever in dairy cattle
US4448721A (en) *	1982-09-20	1984-05-15	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 compounds and process for preparing same
GB2145091B (en) *	1983-08-18	1987-08-12	Wisconsin Alumni Res Found	Vitamin d3 derivatives
US4661294A (en) *	1985-03-18	1987-04-28	The General Hospital Corporation	Biologically active 1-thio derivatives of vitamin D
US5401731A (en) *	1989-06-29	1995-03-28	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab)	Vitamin D analogues
TR25295A (tr) *	1992-02-26	1993-01-01	Simfer Dayanikli Tueketim Mamu	Kati yakit yakan sobalar icin yanma havasi ön isitma sistemi
US5384314B1 (en) *	1994-03-11	1997-08-05	Hoffmann La Roche	1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
US5952317A (en) *	1995-09-21	1999-09-14	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
AU717238B2 (en) *	1995-09-21	2000-03-23	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
US5976784A (en) *	1996-09-20	1999-11-02	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
WO1998051678A1 (en) *	1997-05-16	1998-11-19	Women & Infants Hospital	CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
US8404666B2 (en)	2006-04-06	2013-03-26	Wisconsin Alumni Research Foundation	2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
NZ570712A (en) *	2006-04-06	2011-11-25	Wisconsin Alumni Res Found	2-methylene-1alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof
JP2009532458A (ja) *	2006-04-06	2009-09-10	ウイスコンシンアラムニリサーチファンデーション	２−メチレン−１α−ヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用
CA2639585A1 (en) *	2006-04-06	2007-10-06	Wisconsin Alumni Research Foundation	2-methylene-1.alpha., 25-dihydroxy-18, 19, 21-trinorvitamin d3 and uses thereof
AU2007291005A1 (en) *	2006-04-06	2008-03-06	Wisconsin Alumni Research Foundation	19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring
MX2008012912A (es) *	2006-04-06	2008-11-26	Wisconsin Alumni Res Found	Analogos de 2-metilen-1a,25-dihidroxi-19,21-dinorvitamina d3 y sus usos.
NZ570816A (en) *	2006-04-10	2011-07-29	Wisconsin Alumni Res Found	1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
USD583254S1 (en) *	2007-12-18	2008-12-23	New York & Company, Inc.	Pump container
US8814007B2 (en)	2010-12-31	2014-08-26	Medline Industries, Inc.	Dispenser with directional flow controlling flange and corresponding systems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3833622A (en) *	1969-03-17	1974-09-03	Upjohn Co	Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US4069321A (en) *	1975-10-14	1978-01-17	Merck & Co., Inc.	Blocked cholecalciferol and dihydrotachysterol 3 derivatives

1978
- 1978-07-26 US US05/928,279 patent/US4188345A/en not_active Expired - Lifetime
1979
- 1979-07-06 NZ NZ190939A patent/NZ190939A/xx unknown
- 1979-07-13 IL IL57801A patent/IL57801A/xx not_active IP Right Cessation
- 1979-07-24 NL NL7920016A patent/NL7920016A/nl unknown
- 1979-07-24 JP JP54501218A patent/JPS6312867B2/ja not_active Expired
- 1979-07-24 CH CH2497/80A patent/CH650237A5/de not_active IP Right Cessation
- 1979-07-24 JP JP54501224A patent/JPS6312868B2/ja not_active Expired
- 1979-07-24 NL NL7920012A patent/NL7920012A/nl unknown
- 1979-07-24 WO PCT/US1979/000528 patent/WO1980000338A1/en not_active Ceased
- 1979-07-24 CH CH249680A patent/CH641445A5/de not_active IP Right Cessation
- 1979-07-24 WO PCT/US1979/000529 patent/WO1980000339A1/en not_active Ceased
- 1979-07-25 AU AU49206/79A patent/AU521131B2/en not_active Ceased
- 1979-07-26 BE BE0/196477A patent/BE877918A/xx not_active IP Right Cessation
- 1979-07-26 FR FR7919368A patent/FR2433514B1/fr not_active Expired
- 1979-07-26 GB GB7926135A patent/GB2026494B/en not_active Expired
- 1979-08-08 IE IE1496/79A patent/IE48463B1/en not_active IP Right Cessation
1980
- 1980-03-05 SE SE8001747A patent/SE8001747L/xx unknown
- 1980-03-05 SE SE8001746A patent/SE8001746L/xx unknown
- 1980-03-25 DK DK127580A patent/DK156716C/da not_active IP Right Cessation
- 1980-03-25 DK DK127480A patent/DK154211C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB2026494A (en)	1980-02-06
IE791496L (en)	1980-01-26
BE877918A (fr)	1979-11-16
DK154211B (da)	1988-10-24
WO1980000338A1 (en)	1980-03-06
NL7920012A (nl)	1980-05-30
SE8001747L (sv)	1980-03-05
JPS55500430A (da)	1980-07-17
IE48463B1 (en)	1985-01-23
CH641445A5 (de)	1984-02-29
AU4920679A (en)	1980-01-31
AU521131B2 (en)	1982-03-18
DK156716C (da)	1990-02-19
DK127480A (da)	1980-03-25
IL57801A (en)	1984-03-30
DK156716B (da)	1989-09-25
CH650237A5 (de)	1985-07-15
SE8001746L (sv)	1980-03-05
GB2026494B (en)	1982-12-15
US4188345A (en)	1980-02-12
DK127580A (da)	1980-03-25
FR2433514A1 (fr)	1980-03-14
NZ190939A (en)	1982-09-07
JPS55500428A (da)	1980-07-17
NL7920016A (nl)	1980-05-30
JPS6312868B2 (da)	1988-03-23
FR2433514B1 (fr)	1986-05-23
JPS6312867B2 (da)	1988-03-23
IL57801A0 (en)	1979-11-30
WO1980000339A1 (en)	1980-03-06

Legal Events

Date	Code	Title	Description
1994-03-28	PBP	Patent lapsed

Publication	Publication Date	Title
DK127580A (da)	1980-03-25	Fremgangsmaade til fremstilling af 1-fluorerede vitamin d-forbindelser
ES506400A0 (es)	1982-09-01	Procedimiento para la fabricacion de collares para animales caseros,conteniendo ectoparasiticidas
DK106784A (da)	1984-02-27	Biokompatible, antithrombotiske materialer, som er velegnede til rekonstruktionskirurgi
ES520985A0 (es)	1984-01-16	Procedimiento para la preparacion de nuevos 6,11-dihidrodibenzo (b,e)-tiepin-11-n-alcohilnorescopin-eteres cuaternarios.
DK173883D0 (da)	1983-04-20	Substituerede 8-phenylxanthiner
ES503308A0 (es)	1982-11-01	Un procedimiento para la preparacion de nuevos pirazimil-1,2,4 oxadiazol-5-onas.
ES485489A0 (es)	1980-12-16	Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas
PT77898B (en)	1986-04-11	Process for the preparation of substituted 4-amino-methylenochromanes and 4-aminomethylenecromenes acting on the blood circulation and application thereof in the preparation of pharmaceutical compositions acting on the blood circulation
ES2042742T3 (es)	1993-12-16	Procedimiento para preparar furanonas antiinflamatorias.
DK8685A (da)	1985-01-08	Fremgangsmaade til fremstilling af 1alfa,25-hydroxylerede vitamin d2-og beslaegtede forbindelser
IL58299A0 (en)	1979-12-30	Fluorine containing 1,4-derivatives,their production and their medicinal use
ES507807A0 (es)	1982-10-01	Procedimiento para la obtencion de derivados triciclicos de citosina.
IS2902A7 (is)	1984-06-07	Aðferð til framleiðslu á 1,8-dihydroxy-10-acyl-9-anthrones, sérstaklega til meðferðar á psoriasis
SE8404334D0 (sv)	1984-08-30	16-fluoro-16,17-didehydro-prostanoids and process for their preparation
ES538403A0 (es)	1985-11-01	Procedimiento para la obtencion de antipodas opticos del (+7-1,7-difenil-3-metilaza-7-ciano-8-metil-nonano
DE3373978D1 (en)	1987-11-12	Composition for the care or treatment of the human skin
DK96379A (da)	1979-09-10	Fremgangsmaade til fremstilling af disubstituerede 2,3-dihydroimidazo (1,2-c)-pyrimidiner
ES500419A0 (es)	1982-02-01	Aparato y su correspondiente procedimiento,para el trata- miento en humedo de cueros
DK320081A (da)	1982-01-20	Fremgangsmaade til fremstilling af thiazolyl-2-oxamidsyrederivater
IT7826282A0 (it)	1978-07-28	Esuronil esosaminoglicano solfato naturale, procedimento per la sua preparazione e impieghi terapeutici relativi.
IT7920415A0 (it)	1979-02-22	Preparazione di ceruletide. procedimento per la
ES533553A0 (es)	1985-10-16	Un procedimiento para la preparacion de nuevos derivados del terfenilo.
DE2963558D1 (en)	1982-10-14	N-amino-3,4,5-trihydroxypiperidines, methods for their preparation, medicaments containing them, method for the production of the medicaments and animal feedstuff containing said compounds
IT7830959A0 (it)	1978-12-18	Metodo per la cura della psoriasi.
JPS5218058A (en)	1977-02-10	Method of treating thiocyanate-containing reducible drainage