DK1284268T3 - Fremstilling af en polymorf form af et thiazolidindionderivat - Google Patents

Fremstilling af en polymorf form af et thiazolidindionderivat

Info

Publication number: DK1284268T3
Authority: DK; Denmark
Prior art keywords: preparation; polymorphic form; thiazolidinedione derivative; thiazolidinedione; derivative
Prior art date: 1999-04-23

Application number

DK02080320T

Other languages

English (en)

Inventor

Paul David James Blackler

Robert Gordon Giles

Michael John Sasse

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-23

Filing date

2000-04-19

Publication date

2008-04-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26315460&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1284268(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-04-23 Priority claimed from GBGB9909472.4A external-priority patent/GB9909472D0/en

1999-05-25 Priority claimed from GBGB9912197.2A external-priority patent/GB9912197D0/en

2000-04-19 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2008-04-28 Application granted granted Critical

2008-04-28 Publication of DK1284268T3 publication Critical patent/DK1284268T3/da

Links

150000001467 thiazolidinediones Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

DK02080320T 1999-04-23 2000-04-19 Fremstilling af en polymorf form af et thiazolidindionderivat DK1284268T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9909472.4A GB9909472D0 (en)	1999-04-23	1999-04-23	Novel compounds
GBGB9912197.2A GB9912197D0 (en)	1999-05-25	1999-05-25	Novel pharmaceutical
PCT/GB2000/001514 WO2000064892A2 (en)	1999-04-23	2000-04-19	Thiazolidinedione derivative and its use as antidiabetic

Publications (1)

Publication Number	Publication Date
DK1284268T3 true DK1284268T3 (da)	2008-04-28

Family

ID=26315460

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02080320T DK1284268T3 (da)	1999-04-23	2000-04-19	Fremstilling af en polymorf form af et thiazolidindionderivat
DK00920889T DK1173434T3 (da)	1999-04-23	2000-04-19	Thiazolidindionderivat og dets anvendelse som antidiabetisk middel

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK00920889T DK1173434T3 (da)	1999-04-23	2000-04-19	Thiazolidindionderivat og dets anvendelse som antidiabetisk middel

Country Status (40)

Country	Link
US (2)	US6815457B1 (da)
EP (3)	EP1284268B1 (da)
JP (1)	JP2002543075A (da)
KR (1)	KR100744359B1 (da)
CN (1)	CN1208335C (da)
AP (1)	AP1495A (da)
AR (2)	AR023568A1 (da)
AT (2)	ATE382046T1 (da)
AU (1)	AU765498B2 (da)
BG (1)	BG65427B1 (da)
BR (1)	BR0009934A (da)
CA (1)	CA2370258A1 (da)
CO (1)	CO5170424A1 (da)
CY (1)	CY1107238T1 (da)
CZ (1)	CZ20013799A3 (da)
DE (2)	DE60004658T2 (da)
DK (2)	DK1284268T3 (da)
DZ (1)	DZ3155A1 (da)
EA (1)	EA004534B1 (da)
ES (2)	ES2298327T3 (da)
HK (1)	HK1045154B (da)
HR (1)	HRP20010773B1 (da)
HU (1)	HUP0200929A3 (da)
IL (1)	IL146110A0 (da)
MA (1)	MA26785A1 (da)
MX (1)	MXPA01010820A (da)
MY (1)	MY128007A (da)
NO (1)	NO320589B1 (da)
NZ (1)	NZ515163A (da)
OA (1)	OA11871A (da)
PE (1)	PE20010040A1 (da)
PL (1)	PL351686A1 (da)
PT (2)	PT1284268E (da)
RS (1)	RS50114B (da)
SK (1)	SK286423B6 (da)
TR (1)	TR200103061T2 (da)
TW (1)	TW591027B (da)
UA (1)	UA67843C2 (da)
UY (1)	UY26120A1 (da)
WO (1)	WO2000064892A2 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020137940A1 (en) *	1997-12-16	2002-09-26	Smithkline Beecham P.L.C.	5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
US6664278B2 (en)	1997-12-16	2003-12-16	Smithkline Beecham P.L.C.	Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9726568D0 (en)	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
US20040248945A1 (en)	1999-04-23	2004-12-09	Smithkline Beecham P.L.C.	Thiazolidinedione derivative and its use as antidiabetic
AU765498B2 (en)	1999-04-23	2003-09-18	Smithkline Beecham Plc	Novel pharmaceutical
PL351684A1 (en) *	1999-04-23	2003-06-02	Smithkline Beecham Plc	Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt
GB0006133D0 (en)	2000-03-14	2000-05-03	Smithkline Beecham Plc	Novel pharmaceutical
US7241895B2 (en) *	2000-09-26	2007-07-10	Dr. Reddy's Laboratories Limited	Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation
MXPA03002580A (es) *	2000-09-26	2003-10-15	Cord Janet I	Nuevas formas polimorficas de maleato de 5-(4-(2-(n-metil-n-(2-piridil) amino)etoxi)bencil) tiazolidin-2, 4-diona y proceso para su preparacion.
AU2002352391A1 (en) *	2001-12-13	2003-06-23	Smithkline Beecham Plc	A 5(-4-(2-(n-methyl-n-(2-pyridil)amino)ethoxy)benzyl)thiazolidine-2,4-dione (i) 10-camphorsulphonic acid salt and use against diabetes mellitus
GB0130511D0 (en) *	2001-12-20	2002-02-06	Smithkline Beecham Plc	Novel pharmaceutical
WO2003053962A1 (en) *	2001-12-20	2003-07-03	Smithkline Beecham Plc	5- (4- (2- (n-methyl-n- (2-pyridyl) amino) ethoxy) benzyl) thiazolidine-2, 4-dione malic acid salt and use against diabetes mellitus
GB0307259D0 (en) *	2003-03-28	2003-05-07	Glaxo Group Ltd	Process
EP1468997A3 (en) *	2003-04-18	2004-11-03	CHEMI S.p.A.	Polymorphous forms of rosiglitazone maleate
GB2405403A (en) *	2003-08-29	2005-03-02	Cipla Ltd	Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
WO2005073227A2 (en) *	2004-01-28	2005-08-11	Usv Limited	A process for the preparation of 5-[4-[2-[n-methyl-n-(2-pyridyl) amino] ethoxy] phenyl methyl] thiazolidine-2, 4-dione maleate
ITMI20041537A1 (it) *	2004-07-28	2004-10-28	Chemi Spa	Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) *	2005-05-24	2007-09-26	Zentiva, A. S.	Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
US7435741B2 (en) *	2006-05-09	2008-10-14	Teva Pharmaceutical Industries, Ltd.	2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
US20090076093A1 (en) *	2007-09-14	2009-03-19	Protia, Llc	Deuterium-enriched rosiglitazone
EP2184055A1 (en)	2008-11-07	2010-05-12	LEK Pharmaceuticals d.d.	Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE186724T1 (de)	1987-09-04	1999-12-15	Beecham Group Plc	Substituierte thiazolidindionderivate
US6288095B1 (en)	1987-09-04	2001-09-11	Beecham Group P.L.C.	Compounds
GB9124513D0 (en)	1991-11-19	1992-01-08	Smithkline Beecham Plc	Novel process
GB9218830D0 (en)	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds
US5741803A (en)	1992-09-05	1998-04-21	Smithkline Beecham Plc	Substituted thiazolidinedionle derivatives
US5478852C1 (en) *	1993-09-15	2001-03-13	Sankyo Co	Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
DE4404198A1 (de)	1994-02-10	1995-08-17	Henkel Kgaa	2-Fluor-6-nitroaniline
US20010044458A1 (en) *	1994-02-10	2001-11-22	Smithkline Beechamp P.L.C.	Use of insulin sensitisers for treating renal diseases
JPH09512249A (ja)	1994-02-10	1997-12-09	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	腎臓疾患を治療するためのインスリンセンシタイザーの使用
TW438587B (en) *	1995-06-20	2001-06-07	Takeda Chemical Industries Ltd	A pharmaceutical composition for prophylaxis and treatment of diabetes
US6153632A (en) *	1997-02-24	2000-11-28	Rieveley; Robert B.	Method and composition for the treatment of diabetes
GB9711683D0 (en)	1997-06-05	1997-08-06	Smithkline Beecham Plc	Composition
GB9712866D0 (en)	1997-06-18	1997-08-20	Smithkline Beecham Plc	Novel method of treatment
EP1787646A3 (en)	1997-06-18	2007-10-03	Smithkline Beecham Plc	Novel method of treatment
US20020004515A1 (en) *	1997-06-18	2002-01-10	Smith Stephen Alistair	Treatment of diabetes with thiazolidinedione and metformin
DE69837089T2 (de)	1997-06-18	2007-06-21	Smithkline Beecham P.L.C., Brentford	Behandlung der diabetes mit thiazolidindion und sulfonylharnstoff
US20010049380A1 (en) *	1997-06-18	2001-12-06	Smith Stephen Alistair	Treatment of diabetes with thiazolidinedione and sulphonylurea
EP0975343A1 (en)	1997-06-18	2000-02-02	Smithkline Beecham Plc	Treatment of diabetes with thiazolidinedione and alpha-glucosidase inhibitor
US20020028768A1 (en) *	1997-06-18	2002-03-07	Smithkline Beecham P.L.C.	Treatment of diabetes with rosiglitazone and insulin
US20020016287A1 (en) *	1997-07-18	2002-02-07	Smithkline Beecham P.L.C.	Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide
US20020045649A1 (en) *	1997-07-18	2002-04-18	Smithkline Beecham P.L.C.	Treatment of diabetes with thiazolidinedione and sulphonylurea
US20020137940A1 (en)	1997-12-16	2002-09-26	Smithkline Beecham P.L.C.	5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726563D0 (en)	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
GB9726568D0 (en) *	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
GB9726566D0 (en) *	1997-12-16	1998-02-11	Smithkline Beecham Plc	Novel pharmaceutical
AU765498B2 (en)	1999-04-23	2003-09-18	Smithkline Beecham Plc	Novel pharmaceutical
HK1045152A1 (zh)	1999-04-23	2002-11-15	Smithkline Beecham Plc	噻唑烷二酮衍生物及其用作抗糖尿病藥的應用
PL351684A1 (en)	1999-04-23	2003-06-02	Smithkline Beecham Plc	Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt
MXPA03002580A (es)	2000-09-26	2003-10-15	Cord Janet I	Nuevas formas polimorficas de maleato de 5-(4-(2-(n-metil-n-(2-piridil) amino)etoxi)bencil) tiazolidin-2, 4-diona y proceso para su preparacion.

2000
- 2000-04-19 AU AU41306/00A patent/AU765498B2/en not_active Ceased
- 2000-04-19 HK HK02104882.1A patent/HK1045154B/en not_active IP Right Cessation
- 2000-04-19 TR TR2001/03061T patent/TR200103061T2/xx unknown
- 2000-04-19 CA CA002370258A patent/CA2370258A1/en not_active Abandoned
- 2000-04-19 ES ES02080320T patent/ES2298327T3/es not_active Expired - Lifetime
- 2000-04-19 DE DE60004658T patent/DE60004658T2/de not_active Expired - Fee Related
- 2000-04-19 SK SK1491-2001A patent/SK286423B6/sk not_active IP Right Cessation
- 2000-04-19 UA UA2001117938A patent/UA67843C2/uk unknown
- 2000-04-19 NZ NZ515163A patent/NZ515163A/xx unknown
- 2000-04-19 EA EA200101119A patent/EA004534B1/ru not_active IP Right Cessation
- 2000-04-19 MX MXPA01010820A patent/MXPA01010820A/es unknown
- 2000-04-19 AT AT02080320T patent/ATE382046T1/de not_active IP Right Cessation
- 2000-04-19 DK DK02080320T patent/DK1284268T3/da active
- 2000-04-19 KR KR1020017013557A patent/KR100744359B1/ko not_active Expired - Fee Related
- 2000-04-19 DK DK00920889T patent/DK1173434T3/da active
- 2000-04-19 ES ES00920889T patent/ES2204557T3/es not_active Expired - Lifetime
- 2000-04-19 AP APAP/P/2001/002333A patent/AP1495A/en active
- 2000-04-19 CO CO00028932A patent/CO5170424A1/es not_active Application Discontinuation
- 2000-04-19 DE DE60037602T patent/DE60037602T2/de not_active Expired - Fee Related
- 2000-04-19 BR BR0009934-1A patent/BR0009934A/pt not_active Application Discontinuation
- 2000-04-19 EP EP02080320A patent/EP1284268B1/en not_active Expired - Lifetime
- 2000-04-19 CZ CZ20013799A patent/CZ20013799A3/cs unknown
- 2000-04-19 OA OA1200100275A patent/OA11871A/en unknown
- 2000-04-19 HR HR20010773A patent/HRP20010773B1/xx not_active IP Right Cessation
- 2000-04-19 EP EP07150378A patent/EP1903043A1/en not_active Withdrawn
- 2000-04-19 US US10/030,323 patent/US6815457B1/en not_active Expired - Fee Related
- 2000-04-19 PT PT02080320T patent/PT1284268E/pt unknown
- 2000-04-19 PT PT00920889T patent/PT1173434E/pt unknown
- 2000-04-19 WO PCT/GB2000/001514 patent/WO2000064892A2/en not_active Ceased
- 2000-04-19 JP JP2000614244A patent/JP2002543075A/ja active Pending
- 2000-04-19 DZ DZ003155A patent/DZ3155A1/xx active
- 2000-04-19 AR ARP000101870A patent/AR023568A1/es unknown
- 2000-04-19 PE PE2000000364A patent/PE20010040A1/es not_active Application Discontinuation
- 2000-04-19 RS YUP-752/01A patent/RS50114B/sr unknown
- 2000-04-19 CN CNB008090572A patent/CN1208335C/zh not_active Expired - Fee Related
- 2000-04-19 AT AT00920889T patent/ATE247653T1/de not_active IP Right Cessation
- 2000-04-19 HU HU0200929A patent/HUP0200929A3/hu not_active IP Right Cessation
- 2000-04-19 IL IL14611000A patent/IL146110A0/xx unknown
- 2000-04-19 EP EP00920889A patent/EP1173434B1/en not_active Expired - Lifetime
- 2000-04-19 PL PL00351686A patent/PL351686A1/xx not_active Application Discontinuation
- 2000-04-19 AR ARP000101865A patent/AR023564A1/es unknown
- 2000-04-21 MY MYPI20001707A patent/MY128007A/en unknown
- 2000-04-24 TW TW089107633A patent/TW591027B/zh not_active IP Right Cessation
- 2000-04-24 UY UY26120A patent/UY26120A1/es not_active Application Discontinuation
2001
- 2001-10-22 NO NO20015149A patent/NO320589B1/no unknown
- 2001-10-22 MA MA26377A patent/MA26785A1/fr unknown
- 2001-11-20 BG BG106119A patent/BG65427B1/bg unknown
2003
- 2003-11-07 US US10/703,887 patent/US20040092555A1/en not_active Abandoned
2008
- 2008-03-12 CY CY20081100277T patent/CY1107238T1/el unknown

Also Published As

Publication number	Publication date
AU765498B2 (en)	2003-09-18
UA67843C2 (uk)	2004-07-15
BR0009934A (pt)	2002-06-04
HK1045154B (en)	2004-06-25
KR20020028873A (ko)	2002-04-17
US6815457B1 (en)	2004-11-09
OA11871A (en)	2006-03-27
PT1173434E (pt)	2003-12-31
DE60004658D1 (de)	2003-09-25
CZ20013799A3 (cs)	2002-04-17
HK1055293A1 (en)	2004-01-02
PL351686A1 (en)	2003-06-02
DK1173434T3 (da)	2003-12-08
AR023564A1 (es)	2002-09-04
US20040092555A1 (en)	2004-05-13
DZ3155A1 (fr)	2000-11-02
IL146110A0 (en)	2002-07-25
PE20010040A1 (es)	2001-03-10
CA2370258A1 (en)	2000-11-02
DE60037602T2 (de)	2009-01-08
AU4130600A (en)	2000-11-10
KR100744359B1 (ko)	2007-07-30
AP1495A (en)	2005-11-30
EA004534B1 (ru)	2004-06-24
EP1284268A1 (en)	2003-02-19
NO20015149L (no)	2001-12-17
PT1284268E (pt)	2008-03-10
RS50114B (sr)	2009-03-25
BG65427B1 (bg)	2008-07-31
EP1173434A2 (en)	2002-01-23
NO320589B1 (no)	2005-12-27
ES2204557T3 (es)	2004-05-01
MY128007A (en)	2007-01-31
BG106119A (en)	2002-05-31
MA26785A1 (fr)	2004-12-20
UY26120A1 (es)	2000-12-29
WO2000064892A3 (en)	2001-01-25
ATE382046T1 (de)	2008-01-15
NO20015149D0 (no)	2001-10-22
HRP20010773A2 (en)	2002-10-31
EA200101119A1 (ru)	2002-04-25
ATE247653T1 (de)	2003-09-15
EP1284268B1 (en)	2007-12-26
TR200103061T2 (tr)	2002-05-21
SK286423B6 (sk)	2008-09-05
HUP0200929A2 (en)	2002-08-28
CN1355801A (zh)	2002-06-26
HUP0200929A3 (en)	2004-03-29
CY1107238T1 (el)	2012-11-21
WO2000064892A2 (en)	2000-11-02
JP2002543075A (ja)	2002-12-17
SK14912001A3 (sk)	2002-02-05
CN1208335C (zh)	2005-06-29
EP1173434B1 (en)	2003-08-20
TW591027B (en)	2004-06-11
EP1903043A1 (en)	2008-03-26
AR023568A1 (es)	2002-09-04
HRP20010773B1 (en)	2005-06-30
DE60004658T2 (de)	2004-06-24
YU75201A (sh)	2004-09-03
DE60037602D1 (de)	2008-02-07
MXPA01010820A (es)	2002-06-04
CO5170424A1 (es)	2002-06-27
ES2298327T3 (es)	2008-05-16
HK1045154A1 (en)	2002-11-15
NZ515163A (en)	2004-02-27

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