DK1289997T3 - Makrolider - Google Patents

Makrolider

Info

Publication number: DK1289997T3
Authority: DK; Denmark
Prior art keywords: macrolides; macrolactam; pimecrolimus; epimerization; concomitant
Prior art date: 2000-05-22

Application number

DK01956441T

Other languages

Danish (da)

English (en)

Inventor

Gerhard Fleissner

Helmut Haecker

Ernst Kuesters

Gerhard Penn

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-22

Filing date

2001-05-21

Publication date

2004-05-10

2001-05-21 Application filed by Novartis Ag filed Critical Novartis Ag

2004-05-10 Application granted granted Critical

2004-05-10 Publication of DK1289997T3 publication Critical patent/DK1289997T3/da

Links

239000003120 macrolide antibiotic agent Substances 0.000 title abstract 2
229940041033 macrolides Drugs 0.000 title abstract 2
206010062016 Immunosuppression Diseases 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000006345 epimerization reaction Methods 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000004968 inflammatory condition Effects 0.000 abstract 1
KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 abstract 1
229960005330 pimecrolimus Drugs 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Neurology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrane Compounds (AREA)

DK01956441T 2000-05-22 2001-05-21 Makrolider DK1289997T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0012383.6A GB0012383D0 (en)	2000-05-22	2000-05-22	Organic compounds

Publications (1)

Publication Number	Publication Date
DK1289997T3 true DK1289997T3 (da)	2004-05-10

Family

ID=9892108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01956441T DK1289997T3 (da)	2000-05-22	2001-05-21	Makrolider

Country Status (14)

Country	Link
US (1)	US6706727B1 (de)
EP (1)	EP1289997B1 (de)
JP (2)	JP4043239B2 (de)
CN (1)	CN1229381C (de)
AT (1)	ATE257481T1 (de)
AU (1)	AU2001278428A1 (de)
CA (1)	CA2405593C (de)
DE (1)	DE60101739T2 (de)
DK (1)	DK1289997T3 (de)
ES (1)	ES2214436T3 (de)
GB (1)	GB0012383D0 (de)
PT (1)	PT1289997E (de)
TR (1)	TR200400723T4 (de)
WO (1)	WO2001090110A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618952D0 (en) *	1996-09-11	1996-10-23	Sandoz Ltd	Process
JP2005512946A (ja) *	2001-05-09	2005-05-12	ノバルティスアクチエンゲゼルシャフト	選択的免疫調節法
GB0200429D0 (en) *	2002-01-09	2002-02-27	Novartis Ag	Organic compounds
WO2004010900A1 (en) *	2002-07-25	2004-02-05	Avantec Vascular Corporation	Devices delivering therapeutic agents and methods regarding the same
US7645876B2 (en) *	2004-12-01	2010-01-12	TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság	Processes for producing crystalline macrolides
WO2005102303A2 (en) *	2004-04-21	2005-11-03	Advanced Ocular Systems Limited	Antiprostaglandins for the treatment of ocular pathologies
WO2006115509A2 (en)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Small molecule immunopotentiators and assays for their detection
GT200500282A (es) *	2004-10-12	2006-05-04		Heteroatomos conteniendo compuestos triciclicos.
CN104250255B (zh) *	2013-06-28	2016-05-25	北京大学	一种柔性内酰胺类大环分子及其制备方法
PL3619215T3 (pl)	2017-05-01	2022-03-21	Meda Pharma Gmbh & Co. Kg	Sposób przekształcania surowej askomycyny w oczyszczony pimecrolimus
EP3741367A1 (de)	2019-05-21	2020-11-25	Premark Pharma GmbH	Behandlung von augenerkrankungen
WO2024209038A1 (en)	2023-04-06	2024-10-10	Premark Pharma Gmbh	Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8430455D0 (en) *	1984-12-03	1985-01-09	Fujisawa Pharmaceutical Co	Fr-900506 substance
DK0427680T3 (da) *	1989-11-09	1995-12-18	Sandoz Ltd	Heteroatom-holdige cykliske forbindelser
DK0851753T3 (da) *	1995-09-19	2004-03-15	Fujisawa Pharmaceutical Co	Aerosolpræparater
DK1056454T3 (da) *	1998-02-23	2003-08-18	Fujisawa Pharmaceutical Co	Anvendelse af makrolidforbindelser til behandling af glaukom

2000
- 2000-05-22 GB GBGB0012383.6A patent/GB0012383D0/en not_active Ceased
2001
- 2001-05-21 CN CNB018098320A patent/CN1229381C/zh not_active Expired - Fee Related
- 2001-05-21 AT AT01956441T patent/ATE257481T1/de active
- 2001-05-21 AU AU2001278428A patent/AU2001278428A1/en not_active Abandoned
- 2001-05-21 DK DK01956441T patent/DK1289997T3/da active
- 2001-05-21 WO PCT/EP2001/005836 patent/WO2001090110A1/en not_active Ceased
- 2001-05-21 PT PT01956441T patent/PT1289997E/pt unknown
- 2001-05-21 DE DE60101739T patent/DE60101739T2/de not_active Expired - Lifetime
- 2001-05-21 EP EP01956441A patent/EP1289997B1/de not_active Expired - Lifetime
- 2001-05-21 US US10/276,622 patent/US6706727B1/en not_active Expired - Fee Related
- 2001-05-21 CA CA002405593A patent/CA2405593C/en not_active Expired - Fee Related
- 2001-05-21 ES ES01956441T patent/ES2214436T3/es not_active Expired - Lifetime
- 2001-05-21 JP JP2001586297A patent/JP4043239B2/ja not_active Expired - Fee Related
- 2001-05-21 TR TR2004/00723T patent/TR200400723T4/xx unknown
2007
- 2007-05-09 JP JP2007124376A patent/JP2007254483A/ja active Pending

Also Published As

Publication number	Publication date
CN1229381C (zh)	2005-11-30
ATE257481T1 (de)	2004-01-15
CA2405593A1 (en)	2001-11-29
HK1054945A1 (en)	2003-12-19
CA2405593C (en)	2009-12-22
ES2214436T3 (es)	2004-09-16
DE60101739D1 (de)	2004-02-12
EP1289997A1 (de)	2003-03-12
JP2007254483A (ja)	2007-10-04
TR200400723T4 (tr)	2004-06-21
JP4043239B2 (ja)	2008-02-06
US6706727B1 (en)	2004-03-16
CN1430620A (zh)	2003-07-16
AU2001278428A1 (en)	2001-12-03
DE60101739T2 (de)	2004-12-09
JP2003534345A (ja)	2003-11-18
GB0012383D0 (en)	2000-07-12
WO2001090110A1 (en)	2001-11-29
PT1289997E (pt)	2004-05-31
EP1289997B1 (de)	2004-01-07

Publication	Publication Date	Title
ID22162A (id)	1999-09-09	Penggunaan turunan-turunan pirazol yang dilebur 1-benzil-3-(hetaril yang disubstitusik)
BR0113643A (pt)	2004-03-02	Compostos de guanidinobenzamidas como agonistas de mc4-r e seus usos
PL1697371T3 (pl)	2007-09-28	Azabicykliczne heterocykle jako modulatory receptora kanabinoidowego
DE60101739D1 (de)	2004-02-12	Makrolide
HN1998000143A (es)	1999-04-09	Tetrahidronaftalenos substituidos y compuestos analogos.
DE60015927D1 (en)	2004-12-23	Phenylharnstoff und phenylthioharnstoffderivate
ATE360630T1 (de)	2007-05-15	Azabicyclische heterocyclen als modulatoren des cannabinoidrezeptors
AU2003301020A1 (en)	2004-07-22	Isoquinolinone derivatives and their use as therapeutic agents
ATE166534T1 (de)	1998-06-15	Germicide wirkstoffkombinationen
FI953748A0 (fi)	1995-08-07	Yhdisteitä, joilla on sekä voimakas kalsium antagonisti- että antioksidanttiaktiivisuus sekä niiden käyttö solua suojaavina aineina
MY137156A (en)	2008-12-31	Dual nk1/nk3 derivatives
UA29406C2 (uk)	2000-11-15	Складні ефіри трициклічних аміноспиртів
PA8432901A1 (es)	2000-05-24	Compuestos de piridilpirrol
DE69713151D1 (de)	2002-07-11	Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
ATE340184T1 (de)	2006-10-15	Makrolidantibiotika
BRPI0017528B8 (pt)	2021-05-25	uso de uma composição contendo sal de cetotifeno
IL110831A0 (en)	1994-11-11	Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
ES2082872T3 (es)	1996-04-01	Composiciones antiglaucoma que contienen 3-arilcarbonil-1-aminoalquil--1h-indol.
NZ503897A (en)	2002-10-25	3,6-hemiketals from the class of 9a-azalides
NZ332321A (en)	2000-04-28	3-Descladinose-2,3-anhydroerythromycin derivatives and medicaments
ES8701193A1 (es)	1986-11-16	Un procedimiento para preparar derivados de acido griseolico
AP9801377A0 (en)	2000-04-29	Tricyclic erythromycin derivatives.
ATE311403T1 (de)	2005-12-15	Derivate des streptogramins, ihre herstellung und sie enthaltende zubereitungen
CO5011051A1 (es)	2001-02-28	Compuesto de carbapenem, uso del mismo y sus compuestos intermedios
UY28535A1 (es)	2005-04-29	Derivados de bencimidazol, composiciones que los contienen, preparacion y usos de los mismos.