DK129180A - Femgangsmaade til fremstilling af pyrazinoylguanidiner - Google Patents

Femgangsmaade til fremstilling af pyrazinoylguanidiner

Info

Publication number: DK129180A
Authority: DK; Denmark
Prior art keywords: pyrazinoylguanidines; preparing; heterocyclic; eukalemic; preparing same
Prior art date: 1979-03-27

Application number

DK129180A

Other languages

English (en)

Inventor

E J Cragoe

O W Woltersdorf

S J D Solms

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-27

Filing date

1980-03-26

Publication date

1980-09-28

1980-03-26 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1980-09-28 Publication of DK129180A publication Critical patent/DK129180A/da

Links

239000003795 chemical substances by application Substances 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
-1 heterocyclic pyrazinoylguanidines Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
WNBSDCKJFDZMHT-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide Chemical class NC(N)=NC(=O)C1=CN=CC=N1 WNBSDCKJFDZMHT-UHFFFAOYSA-N 0.000 abstract 1
230000001452 natriuretic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK129180A 1979-03-27 1980-03-26 Femgangsmaade til fremstilling af pyrazinoylguanidiner DK129180A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/024,293 US4246406A (en)	1979-03-27	1979-03-27	Heterocyclic substituted pyrazinoylguanidines

Publications (1)

Publication Number	Publication Date
DK129180A true DK129180A (da)	1980-09-28

Family

ID=21819847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK129180A DK129180A (da)	1979-03-27	1980-03-26	Femgangsmaade til fremstilling af pyrazinoylguanidiner

Country Status (10)

Country	Link
US (1)	US4246406A (da)
EP (1)	EP0017152B1 (da)
JP (2)	JPS55130965A (da)
AT (1)	ATE2323T1 (da)
AU (1)	AU533298B2 (da)
DE (1)	DE3061733D1 (da)
DK (1)	DK129180A (da)
IE (1)	IE49578B1 (da)
NO (1)	NO152560C (da)
ZA (1)	ZA801770B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4594349A (en) *	1982-01-04	1986-06-10	Beyer Jr Karl H	Hyperuretic agents
US4496573A (en) *	1982-08-24	1985-01-29	William H. Rorer, Inc.	1-Pyridylmethyl-3-acyl guanidines
US4512991A (en) *	1982-12-27	1985-04-23	Merck & Co., Inc.	3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US6858614B2 (en) *	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenolic guanidine sodium channel blockers
US6858615B2 (en) *	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenyl guanidine sodium channel blockers
AU2003295402A1 (en) *	2002-11-06	2004-06-03	Bristol-Myers Squibb Company	Acyl guanidine compounds and use thereof
US6903105B2 (en) *	2003-02-19	2005-06-07	Parion Sciences, Inc.	Sodium channel blockers
AU2004266704B2 (en) *	2003-08-18	2012-02-23	Parion Sciences, Inc.	Capped pyrazinoylguanidine sodium channel blockers
US20090253714A1 (en) *	2003-08-20	2009-10-08	Johnson Michael R	Methods of reducing risk of infection from pathogens
US7745442B2 (en)	2003-08-20	2010-06-29	Parion Sciences, Inc.	Methods of reducing risk of infection from pathogens
US7399766B2 (en) *	2004-08-18	2008-07-15	Parion Sciences, Inc.	Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) *	2005-07-25	2007-01-25	Parion Sciences, Inc.	Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en)	2005-12-22	2006-02-01	Novartis Ag	Organic compounds
CN101687851B (zh)	2007-05-07	2013-02-27	诺瓦提斯公司	有机化合物
CL2008003651A1 (es)	2007-12-10	2009-06-19	Novartis Ag	Compuestos derivados de 3,5-diamino-6-cloropirazinamida sustituida; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de una condición inflamatoria o alergica, en particular una enfermedad inflamatoria u obstructiva de las vias respiratorias.
US20110098311A1 (en)	2009-10-22	2011-04-28	Vertex Pharmaceuticals Incorported	Compositions for treatment of cystic fibrosis and other chronic diseases
AR086745A1 (es)	2011-06-27	2014-01-22	Parion Sciences Inc	3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
SG10201708931XA (en)	2012-12-17	2017-12-28	Parion Sciences Inc	Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
RU2018138195A (ru)	2012-12-17	2018-12-18	Пэрион Сайенсиз, Инк.	Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
US9102633B2 (en)	2013-12-13	2015-08-11	Parion Sciences, Inc.	Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
WO2025133218A1 (en) *	2023-12-21	2025-06-26	Phamri Norden Ab	Pyrazine derivatives for the treatment of skin disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6409714A (da) *	1962-10-30	1965-10-01
BE639386A (da) *	1962-10-30
US3328404A (en) *	1966-08-25	1967-06-27	Merck & Co Inc	Derivatives of pyrazine
US3432502A (en) *	1966-08-25	1969-03-11	Merck & Co Inc	Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
NL6707564A (da) *	1966-08-25	1968-02-26
US4087526A (en) *	1976-07-23	1978-05-02	Merck & Co., Inc.	(3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

1979
- 1979-03-27 US US06/024,293 patent/US4246406A/en not_active Expired - Lifetime
1980
- 1980-03-18 AU AU56536/80A patent/AU533298B2/en not_active Ceased
- 1980-03-25 IE IE608/80A patent/IE49578B1/en unknown
- 1980-03-25 ZA ZA00801770A patent/ZA801770B/xx unknown
- 1980-03-26 EP EP80101589A patent/EP0017152B1/en not_active Expired
- 1980-03-26 AT AT80101589T patent/ATE2323T1/de not_active IP Right Cessation
- 1980-03-26 DE DE8080101589T patent/DE3061733D1/de not_active Expired
- 1980-03-26 DK DK129180A patent/DK129180A/da not_active IP Right Cessation
- 1980-03-26 NO NO800878A patent/NO152560C/no unknown
- 1980-03-27 JP JP8038319A patent/JPS55130965A/ja active Pending
1981
- 1981-03-18 JP JP3804081A patent/JPS56158771A/ja active Pending

Also Published As

Publication number	Publication date
AU533298B2 (en)	1983-11-17
NO152560C (no)	1985-10-16
NO800878L (no)	1980-09-29
IE49578B1 (en)	1985-10-30
NO152560B (no)	1985-07-08
ATE2323T1 (de)	1983-02-15
JPS55130965A (da)	1980-10-11
JPS56158771A (en)	1981-12-07
IE800608L (en)	1980-09-27
EP0017152A1 (en)	1980-10-15
US4246406A (en)	1981-01-20
ZA801770B (en)	1981-11-25
EP0017152B1 (en)	1983-01-26
DE3061733D1 (en)	1983-03-03
AU5653680A (en)	1980-10-02

Legal Events

Date	Code	Title	Description
1985-12-02	AHB	Application shelved due to non-payment
1989-01-16	PBP	Patent lapsed

Publication	Publication Date	Title
DK129180A (da)	1980-09-28	Femgangsmaade til fremstilling af pyrazinoylguanidiner
DK233880A (da)	1980-12-02	Fremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4,-triaziner
NO791553L (no)	1979-11-13	Stroempe.
NL161666C (nl)	1980-03-17	Schoudergewrichtprothese.
NO802619L (no)	1981-03-09	Kolofoniumdispersjoner.
NL185265C (nl)	1990-03-01	Urineerhulpmiddel.
DK147379A (da)	1979-10-12	Fremgangsmaade til fremstilling af histaminantagonister
DK153379A (da)	1979-10-15	Fremgangsmaade til fremstilling af n,n,n!,n!-tetraacetylethylendiamin
IT7924119A0 (it)	1979-07-05	Mandrino espandibile.
DK156635C (da)	1990-02-12	Analogifremgangsmaade til fremstilling af 24,24-difluor-25-hydroxycholecalciferol
IT7919536A0 (it)	1979-01-23	Coloranti eterociclici.
DK412280A (da)	1980-09-30	Fremgangsmaade til komprimering af formsand
FI803127A7 (fi)	1981-04-04	Heterosyklisiä yhdisteitä.
NL178738C (nl)	1986-11-17	Instelschakeling.
DK129280A (da)	1980-09-28	Fremgangsmaade til fremstilling af pyrazincarboxamider
NO803822L (no)	1981-06-19	Ladebord.
NO802453L (no)	1981-02-18	Heterocykliske forbindelser.
FI801242A7 (fi)	1981-01-01	Hylsylukko.
NL7901561A (nl)	1979-08-29	Temperatuur-gestabiliseerde resonator.
DK40479A (da)	1979-08-02	Fremgangsmaade til fremstilling af monorden
NO144471C (no)	1981-09-09	Trinse for skistav.
DK214479A (da)	1979-11-25	Fremgangsmaade til fremstilling af 2,4-diamono-5-(3,5-dialkyl-4-hydroxybenzyl) pyrimidiner
DK93180A (da)	1980-10-09	Fremgangsmaade til fremstilling af trazenforbindelser
IT8023142A0 (it)	1980-06-30	Derivati prostaciclinici.
IT8021230A0 (it)	1980-04-04	Amminoacetonitrili idrossiimmino sostituiti.