ATE2323T1 - Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung. - Google Patents

Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung.

Info

Publication number
ATE2323T1
ATE2323T1 AT80101589T AT80101589T ATE2323T1 AT E2323 T1 ATE2323 T1 AT E2323T1 AT 80101589 T AT80101589 T AT 80101589T AT 80101589 T AT80101589 T AT 80101589T AT E2323 T1 ATE2323 T1 AT E2323T1
Authority
AT
Austria
Prior art keywords
preparation
pharmaceutical composition
pyrazinoylguanidines
composition containing
heterocyclically substituted
Prior art date
Application number
AT80101589T
Other languages
English (en)
Inventor
Edward J. Cragoe Jr.
Otto W. Woltersdorf Jr.
Susan Jane De Solms
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Application granted granted Critical
Publication of ATE2323T1 publication Critical patent/ATE2323T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT80101589T 1979-03-27 1980-03-26 Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung. ATE2323T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/024,293 US4246406A (en) 1979-03-27 1979-03-27 Heterocyclic substituted pyrazinoylguanidines
EP80101589A EP0017152B1 (de) 1979-03-27 1980-03-26 Heterocyclisch substituierte Pyrazinoylguanidine, Verfahren zur Herstellung und eine sie enthaltende pharmazeutische Zusammensetzung

Publications (1)

Publication Number Publication Date
ATE2323T1 true ATE2323T1 (de) 1983-02-15

Family

ID=21819847

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80101589T ATE2323T1 (de) 1979-03-27 1980-03-26 Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung.

Country Status (10)

Country Link
US (1) US4246406A (de)
EP (1) EP0017152B1 (de)
JP (2) JPS55130965A (de)
AT (1) ATE2323T1 (de)
AU (1) AU533298B2 (de)
DE (1) DE3061733D1 (de)
DK (1) DK129180A (de)
IE (1) IE49578B1 (de)
NO (1) NO152560C (de)
ZA (1) ZA801770B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4496573A (en) * 1982-08-24 1985-01-29 William H. Rorer, Inc. 1-Pyridylmethyl-3-acyl guanidines
US4512991A (en) * 1982-12-27 1985-04-23 Merck & Co., Inc. 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
AU2003295402A1 (en) * 2002-11-06 2004-06-03 Bristol-Myers Squibb Company Acyl guanidine compounds and use thereof
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
SI1663235T1 (sl) * 2003-08-18 2013-12-31 Parion Sciences, Inc. Zaščiteni pirazinoilgvanidinski blokatorji natrijevega kanala
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7399766B2 (en) * 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
KR20100005730A (ko) 2007-05-07 2010-01-15 노파르티스 아게 유기 화합물
EA017919B1 (ru) 2007-12-10 2013-04-30 Новартис Аг Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов
EP2813227A1 (de) 2009-10-22 2014-12-17 Vertex Pharmaceuticals Incorporated Zusammensetzungen für die Behandlung von Mukoviszidose und anderen chronischen Erkrankungen
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
PE20151054A1 (es) 2012-12-17 2015-08-07 Parion Sciences Inc Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
WO2025133218A1 (en) * 2023-12-21 2025-06-26 Phamri Norden Ab Pyrazine derivatives for the treatment of skin disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639386A (de) * 1962-10-30
NL6409714A (de) * 1962-10-30 1965-10-01
NL6707564A (de) * 1966-08-25 1968-02-26
US3328404A (en) * 1966-08-25 1967-06-27 Merck & Co Inc Derivatives of pyrazine
US3432502A (en) * 1966-08-25 1969-03-11 Merck & Co Inc Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
US4087526A (en) * 1976-07-23 1978-05-02 Merck & Co., Inc. (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

Also Published As

Publication number Publication date
IE800608L (en) 1980-09-27
EP0017152B1 (de) 1983-01-26
IE49578B1 (en) 1985-10-30
NO800878L (no) 1980-09-29
EP0017152A1 (de) 1980-10-15
JPS55130965A (de) 1980-10-11
AU5653680A (en) 1980-10-02
DE3061733D1 (en) 1983-03-03
DK129180A (da) 1980-09-28
NO152560B (no) 1985-07-08
JPS56158771A (en) 1981-12-07
ZA801770B (en) 1981-11-25
NO152560C (no) 1985-10-16
AU533298B2 (en) 1983-11-17
US4246406A (en) 1981-01-20

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee