DK1292697T3 - Fremgangsmåde til fremstiling af fysiologisk aktivt IL-18-polypeptid - Google Patents

Fremgangsmåde til fremstiling af fysiologisk aktivt IL-18-polypeptid

Info

Publication number
DK1292697T3
DK1292697T3 DK01958830T DK01958830T DK1292697T3 DK 1292697 T3 DK1292697 T3 DK 1292697T3 DK 01958830 T DK01958830 T DK 01958830T DK 01958830 T DK01958830 T DK 01958830T DK 1292697 T3 DK1292697 T3 DK 1292697T3
Authority
DK
Denmark
Prior art keywords
polypeptide
physiologically active
preparing physiologically
preparing
active
Prior art date
Application number
DK01958830T
Other languages
Danish (da)
English (en)
Inventor
Yen Sen Ho
Kyung O Johanson
Robert B Kirkpatrick
Allan R Shatzman
Patrick Mcdevitt
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of DK1292697T3 publication Critical patent/DK1292697T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01958830T 2000-06-15 2001-06-11 Fremgangsmåde til fremstiling af fysiologisk aktivt IL-18-polypeptid DK1292697T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21183200P 2000-06-15 2000-06-15
US22412800P 2000-08-10 2000-08-10
US26492301P 2001-01-20 2001-01-20
PCT/US2001/018804 WO2001098455A2 (en) 2000-06-15 2001-06-11 Method for preparing a physiologically active il-18 polypeptide

Publications (1)

Publication Number Publication Date
DK1292697T3 true DK1292697T3 (da) 2009-11-16

Family

ID=27395664

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01958830T DK1292697T3 (da) 2000-06-15 2001-06-11 Fremgangsmåde til fremstiling af fysiologisk aktivt IL-18-polypeptid

Country Status (24)

Country Link
US (2) US7186528B2 (de)
EP (1) EP1292697B1 (de)
JP (1) JP5121109B2 (de)
KR (1) KR20030022144A (de)
CN (1) CN100390281C (de)
AR (1) AR033979A1 (de)
AT (1) ATE437234T1 (de)
AU (2) AU2001280442B2 (de)
BR (1) BR0111692A (de)
CA (1) CA2412730C (de)
CZ (1) CZ20024085A3 (de)
DE (1) DE60139316D1 (de)
DK (1) DK1292697T3 (de)
ES (1) ES2329875T3 (de)
HU (1) HUP0501002A3 (de)
IL (2) IL153422A0 (de)
MX (1) MXPA02012292A (de)
MY (1) MY136526A (de)
NO (1) NO330682B1 (de)
NZ (1) NZ522845A (de)
PL (2) PL208592B1 (de)
PT (1) PT1292697E (de)
SI (1) SI1292697T1 (de)
WO (1) WO2001098455A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK12942002A3 (sk) * 2000-02-10 2003-05-02 Abbott Laboratories Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
EP1613274B1 (de) 2003-04-15 2010-03-03 GlaxoSmithKline LLC Humane il-18 substitutionsmutanten und deren konjugate
ATE495189T1 (de) 2003-08-15 2011-01-15 Univ Florida Die identifikation von polynukleotiden von porphyromonas gingivalis-virulenz zur diagnose, behandlung und beobachtung von periodontalerkrankungen
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
CA2545024A1 (en) * 2003-11-24 2005-06-02 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
ATE526057T1 (de) * 2004-08-20 2011-10-15 Glaxosmithkline Llc Wundheilung durch verabreichung von menschlichem il-18
US20100061958A1 (en) 2006-09-14 2010-03-11 The Trustees Of The University Of Pennsylvania Modulation of Regulatory T Cells by Human IL-18
AR065803A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Uso de un polipeptido de il- 18 humana y un anticuerpo anti- cd para preparar unmedicamento
US11219672B2 (en) 2014-08-07 2022-01-11 Haruki Okamura Therapeutic agent for cancer which comprises combination of IL-18 and molecule-targeting antibody
JP2019023165A (ja) * 2015-12-11 2019-02-14 国立大学法人京都大学 インターロイキン−１８活性阻害剤
JP7795181B2 (ja) 2017-09-06 2026-01-07 イェール ユニバーシティー インターロイキン－１８バリアントとその利用法
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
AU2023226512A1 (en) 2022-02-23 2024-08-29 Bright Peak Therapeutics Ag Immune antigen specific il-18 immunocytokines and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
US5192324A (en) 1982-02-18 1993-03-09 Howmedica Inc. Bone prosthesis with porous coating
EP0324789B1 (de) * 1986-10-02 2003-08-20 Massachusetts Institute Of Technology Verfahren zur regulierung der metabolischen stabilität von proteinen
US5212058A (en) 1990-05-09 1993-05-18 Massachusetts Institute Of Technology Nucleic acid encoding ubiquitin-specific proteases
ES2071315T3 (es) 1990-05-09 1995-06-16 Massachusetts Inst Technology Proteasa especifica de ubiquitina.
US5914254A (en) * 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
US6110701A (en) 1994-04-08 2000-08-29 Merck Frosst Canada & Co. DNA encoding precursor of interleukin-1β converting enzyme--related cysteine proteinase II (ICErel -II)
US5552536A (en) 1994-04-08 1996-09-03 Merck Frosst Canada, Inc. DNA encoding precursor of interleukin-1 beta converting enzyme - related cysteine proteinase III (ice rel-III)
DE69519454T2 (de) 1994-07-14 2001-05-03 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen
JP2724987B2 (ja) 1994-11-15 1998-03-09 株式会社林原生物化学研究所 インターフェロン−γの産生を誘導するポリペプチド
TW581771B (en) 1994-11-15 2004-04-01 Hayashibara Biochem Lab Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide
US6074050A (en) 1997-12-03 2000-06-13 Hewlett-Packard Company Method and apparatus for venting an ink container
CA2238885A1 (en) 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JPH1080270A (ja) * 1996-07-19 1998-03-31 Hayashibara Biochem Lab Inc ポリペプチドをプロセッシングする酵素
TW515843B (en) * 1996-07-25 2003-01-01 Hayashibara Biochem Lab Process for producing an active polypeptide inducing interferon-γ production
JP4010606B2 (ja) * 1996-07-25 2007-11-21 株式会社林原生物化学研究所 ポリペプチドの製造方法
US6054487A (en) * 1997-03-18 2000-04-25 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
WO1999037793A1 (en) * 1998-01-23 1999-07-29 Novo Nordisk A/S Process for making desired polypeptides in yeast

Also Published As

Publication number Publication date
CZ20024085A3 (cs) 2003-05-14
AU2001280442B2 (en) 2005-10-27
MY136526A (en) 2008-10-31
US7186528B2 (en) 2007-03-06
HUP0501002A3 (en) 2010-01-28
WO2001098455A2 (en) 2001-12-27
NZ522845A (en) 2005-07-29
US7442526B2 (en) 2008-10-28
DE60139316D1 (de) 2009-09-03
EP1292697A2 (de) 2003-03-19
CN1436246A (zh) 2003-08-13
NO20026002L (no) 2003-02-12
KR20030022144A (ko) 2003-03-15
JP2004523204A (ja) 2004-08-05
MXPA02012292A (es) 2003-04-25
HUP0501002A2 (en) 2006-01-30
BR0111692A (pt) 2005-08-30
IL153422A (en) 2011-03-31
ATE437234T1 (de) 2009-08-15
CN100390281C (zh) 2008-05-28
JP5121109B2 (ja) 2013-01-16
US20030143198A1 (en) 2003-07-31
PL366134A1 (en) 2005-01-24
CA2412730A1 (en) 2001-12-27
PT1292697E (pt) 2009-10-28
WO2001098455A3 (en) 2002-08-08
SI1292697T1 (sl) 2009-12-31
HK1055138A1 (en) 2003-12-24
CA2412730C (en) 2011-08-16
US20060177422A1 (en) 2006-08-10
AU8044201A (en) 2002-01-02
EP1292697B1 (de) 2009-07-22
NO20026002D0 (no) 2002-12-13
ES2329875T3 (es) 2009-12-02
AR033979A1 (es) 2004-01-21
IL153422A0 (en) 2003-07-06
NO330682B1 (no) 2011-06-06
EP1292697A4 (de) 2005-08-10
PL208592B1 (pl) 2011-05-31

Similar Documents

Publication Publication Date Title
FI109024B (fi) Menetelmä puhtaan sitalopraamin valmistamiseksi
CY2007029I1 (el) Μεθοδος για την παρασκευη υποκατεστημενων οκτανοϋλ-αμιδιων
FI20011400L (fi) Järjestely radiopuhelinrakenteen integroimiseksi
ATE322251T1 (de) Neurotoxin implantat
FI20011622A7 (fi) Menetelmä sitalopraamin valmistamiseksi
NO20024890L (no) Implantat
NO20025893L (no) Veksthormon sekretagoga
DK1265482T3 (da) Vandige formulationer og fremgangsmåde til fremstilling af samme
ID30091A (id) Metode untuk menyiapkan l-fenilefrina hidroklorida
NO20026002L (no) Fremgangsmåte for fremstilling av et fysiologisk, aktivt IL- 18 polypeptid
DE10196287T1 (de) Bearbeitungsprogramm-Vorbereitungsvorrichtung
FR2806309B1 (fr) Implant
CU23064A3 (es) Conjunto implante dental-transportador
FI20011550L (fi) Polypeptidien immobilisointimenetelmä
FI20011034L (fi) Menetelmä absorboivien aineiden valmistamiseksi
ITMI20021031A0 (it) Procedimento per preparare policarbonato-polioli
IT1319686B1 (it) Procedimento di preparazione di citalopram.
DK1368483T3 (da) Fremgangsmåde til fremstilling af polypeptider
FI20011252L (fi) Rakennusmenetelmä
NO20026215D0 (no) Nytt hormonpreparat
IT1317851B1 (it) Procedimento di preparazione di miscele cementizie.
ITMI20001846A0 (it) Procedimento per ottenere eteri fluorosolfonici
FI991413A7 (fi) Yhteyden pystytysmenetelmä
FI20000199L (fi) Menetelmä bentsyylibentsoaatin valmistamiseksi
NO20001576D0 (no) Forankringsmetode