DK130082A - Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren iinsuliner - Google Patents

Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren iinsuliner Download PDF

Info

Publication number: DK130082A
Authority: DK; Denmark
Prior art keywords: amino acid; ins; denotes; insulin; ser
Prior art date: 1980-07-24

Application number

DK130082A

Other languages

English (en)

Other versions

DK148714B (da

DK148714C (da

Inventor

K Breddam

J T Johansen

F Widmer

Original Assignee

Forenede Bryggerier As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-24

Filing date

1982-03-23

Publication date

1982-03-23

1980-07-24 Priority claimed from DK319780A external-priority patent/DK319780A/da

1982-03-23 Application filed by Forenede Bryggerier As filed Critical Forenede Bryggerier As

1982-03-23 Priority to DK130082A priority Critical patent/DK148714C/da

1982-03-23 Publication of DK130082A publication Critical patent/DK130082A/da

1983-07-12 Priority to DK320483A priority patent/DK149616C/da

1985-09-09 Publication of DK148714B publication Critical patent/DK148714B/da

1986-01-27 Application granted granted Critical

1986-01-27 Publication of DK148714C publication Critical patent/DK148714C/da

Links

150000001413 amino acids Chemical class 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title 1
229940024606 amino acid Drugs 0.000 abstract 6
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
-1 N-substituted amino acid amides Chemical class 0.000 abstract 3
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001412 amines Chemical class 0.000 abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
239000004026 insulin derivative Substances 0.000 abstract 2
239000000758 substrate Substances 0.000 abstract 2
102000005367 Carboxypeptidases Human genes 0.000 abstract 1
108010006303 Carboxypeptidases Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
101000993800 Sus scrofa Insulin Proteins 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000006185 dispersion Substances 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
235000019833 protease Nutrition 0.000 abstract 1
229960002898 threonine Drugs 0.000 abstract 1

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Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK130082A 1980-07-24 1982-03-23 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner DK148714C (da)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
DK130082A DK148714C (da)	1980-07-24	1982-03-23	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DK320483A DK149616C (da)	1980-07-24	1983-07-12	Fremgangsmaade til fremstilling af insuliner

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DK319780A DK319780A (da)	1980-07-24	1980-07-24	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DK319780		1980-07-24
PCT/DK1981/000074 WO1982000301A1 (en)	1980-07-24	1981-07-23	Enzymatic replacement of the b-30 amino acid in insulins
DK8100074		1981-07-23
DK130082A DK148714C (da)	1980-07-24	1982-03-23	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DK130082		1982-03-23

Publications (3)

Publication Number	Publication Date
DK130082A true DK130082A (da)	1982-03-23
DK148714B DK148714B (da)	1985-09-09
DK148714C DK148714C (da)	1986-01-27

Family

ID=26065552

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK130082A DK148714C (da)	1980-07-24	1982-03-23	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DK320483A DK149616C (da)	1980-07-24	1983-07-12	Fremgangsmaade til fremstilling af insuliner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK320483A DK149616C (da)	1980-07-24	1983-07-12	Fremgangsmaade til fremstilling af insuliner

Country Status (1)

Country	Link
DK (2)	DK148714C (da)

1982
- 1982-03-23 DK DK130082A patent/DK148714C/da not_active IP Right Cessation
1983
- 1983-07-12 DK DK320483A patent/DK149616C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK149616C (da)	1987-02-02
DK320483D0 (da)	1983-07-12
DK149616B (da)	1986-08-11
DK320483A (da)	1983-07-12
DK148714B (da)	1985-09-09
DK148714C (da)	1986-01-27

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Legal Events

Date	Code	Title	Description
1985-03-04	PBP	Patent lapsed
1991-03-25	PBP	Patent lapsed