DK309988D0 - Fremgangsmaade til fremstilling af 4-oxo-3h-phthalazin-1-yl-eddikesyre-forbindelser med benzothiazol- eller andre heterocycliske sidekaeder i 3-stillingen og forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af 4-oxo-3h-phthalazin-1-yl-eddikesyre-forbindelser med benzothiazol- eller andre heterocycliske sidekaeder i 3-stillingen og forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden

Info

Publication number: DK309988D0
Authority: DK; Denmark
Prior art keywords: acetic acid; phthalazin; benzothiazol; oxo; preparing
Prior art date: 1987-06-09

Application number

DK309988A

Other languages

English (en)

Other versions

DK309988A (da

Inventor

Banavara Lakshmana Mylari

William James Zembrowski

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-09

Filing date

1988-06-08

Publication date

1988-06-08

1988-06-08 Application filed by Pfizer filed Critical Pfizer

1988-06-08 Publication of DK309988D0 publication Critical patent/DK309988D0/da

1988-12-10 Publication of DK309988A publication Critical patent/DK309988A/da

Links

IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
ZEDQLIHBPGNGEC-UHFFFAOYSA-N 2-(4-oxo-3h-phthalazin-1-yl)acetic acid Chemical class C1=CC=C2C(CC(=O)O)=NNC(=O)C2=C1 ZEDQLIHBPGNGEC-UHFFFAOYSA-N 0.000 title 1
235000011054 acetic acid Nutrition 0.000 abstract 1
150000001243 acetic acids Chemical class 0.000 abstract 1
125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002168 ethanoic acid esters Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Thiazole And Isothizaole Compounds (AREA)

DK309988A 1987-06-09 1988-06-08 Fremgangsmaade til fremstilling af 4-oxo-3h-phthalazin-1-yl-eddikesyre-forbindelser med benzothiazol- eller andre heterocycliske sidekaeder i 3-stillingen og forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden DK309988A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5989987A	1987-06-09	1987-06-09

Publications (2)

Publication Number	Publication Date
DK309988D0 true DK309988D0 (da)	1988-06-08
DK309988A DK309988A (da)	1988-12-10

Family

ID=22026001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK309988A DK309988A (da)	1987-06-09	1988-06-08	Fremgangsmaade til fremstilling af 4-oxo-3h-phthalazin-1-yl-eddikesyre-forbindelser med benzothiazol- eller andre heterocycliske sidekaeder i 3-stillingen og forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden

Country Status (26)

Country	Link
EP (1)	EP0295051B1 (da)
JP (1)	JPH0676391B2 (da)
KR (1)	KR900004698B1 (da)
CN (1)	CN1024347C (da)
AT (1)	ATE90347T1 (da)
AU (1)	AU593742B2 (da)
CA (1)	CA1321791C (da)
CS (1)	CS274628B2 (da)
DD (3)	DD280323A5 (da)
DE (1)	DE3881583T2 (da)
DK (1)	DK309988A (da)
EG (1)	EG18613A (da)
ES (1)	ES2040853T3 (da)
FI (1)	FI93835C (da)
HU (1)	HU205108B (da)
IE (1)	IE61499B1 (da)
IL (1)	IL86660A0 (da)
MY (1)	MY103573A (da)
NO (1)	NO176317C (da)
NZ (1)	NZ224937A (da)
PH (1)	PH25928A (da)
PL (1)	PL157690B1 (da)
PT (1)	PT87669B (da)
SU (1)	SU1678208A3 (da)
YU (1)	YU46696B (da)
ZA (1)	ZA884075B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0322153A3 (en) *	1987-12-21	1990-08-16	Pfizer Inc.	Heterocyclic oxophtalazinyl acetic acids
WO1989006651A1 (en) *	1988-01-19	1989-07-27	Pfizer Inc.	1h-indazole-3-acetic acids as aldose reductase inhibitors
US4904782A (en) *	1988-02-29	1990-02-27	Pfizer Inc.	Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
US4954629A (en) *	1989-05-11	1990-09-04	Pfizer Inc.	Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
FR2647676A1 (fr) *	1989-06-05	1990-12-07	Union Pharma Scient Appl	Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
FI922308L (fi) *	1989-12-15	1992-05-21	Pfizer	Substituerade oxoftalazinylaettiks- syror och deras analoger.
US5064830A (en) *	1990-08-02	1991-11-12	Pfizer Inc.	Lowering of blood uric acid levels
WO1992003432A1 (en) *	1990-08-28	1992-03-05	Pfizer Inc.	3-(5-trifluoromethylbenzothiazol-2-ylmethyl)-4-oxo-3h-phythalazin-1-ylacetic acid monohydrate
WO1992017446A2 (en) *	1991-03-28	1992-10-15	Pfizer Inc.	Pyridazinone acetic acids aldose reductase inhibitors
FR2682108B1 (fr) *	1991-10-07	1994-01-07	Lipha	Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant.
DE69405193T2 (de) *	1993-10-06	1998-01-02	Sumika Fine Chemicals Co Ltd	Verfahren zur Herstellung von Alkyl-3-phthalidylidenacetat
US5700819A (en) *	1994-11-29	1997-12-23	Grelan Pharmaceutical Co., Ltd.	2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications
IL124236A (en) *	1997-05-05	2003-01-12	Pfizer	Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
EP0982306A3 (en) *	1998-08-21	2000-07-05	Pfizer Products Inc.	Polymorph of zopolrestat monohydrate
SG82702A1 (en) *	1999-09-28	2001-08-21	Ebauchesfabrik Eta Ag	Timepiece including a movement mounted in a casing ring
CN116970317B (zh) *	2023-03-20	2024-06-25	安徽庆丰涂料科技有限公司	可呼吸的负离子抗菌涂料及其加工工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE47592B1 (en) *	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
JPS5931509B2 (ja) *	1979-06-06	1984-08-02	昭和電工株式会社	３−ヒドロキシ−３−メチルフタリド又はその核置換体の製造法
IL80475A (en) *	1985-11-07	1993-01-31	Pfizer	Heterocyclic-substituted 4-oxo (or thio)-3h- phthalazinyl-acetic acid derivatives and pharmaceutical compositions containing them

1988
- 1988-06-02 JP JP63136601A patent/JPH0676391B2/ja not_active Expired - Lifetime
- 1988-06-06 PH PH37013A patent/PH25928A/en unknown
- 1988-06-06 MY MYPI88000606A patent/MY103573A/en unknown
- 1988-06-07 ES ES198888305180T patent/ES2040853T3/es not_active Expired - Lifetime
- 1988-06-07 CA CA000568775A patent/CA1321791C/en not_active Expired - Fee Related
- 1988-06-07 DD DD88326850A patent/DD280323A5/de not_active IP Right Cessation
- 1988-06-07 CS CS392488A patent/CS274628B2/cs not_active IP Right Cessation
- 1988-06-07 DE DE8888305180T patent/DE3881583T2/de not_active Expired - Fee Related
- 1988-06-07 PL PL1988272899A patent/PL157690B1/pl unknown
- 1988-06-07 EP EP88305180A patent/EP0295051B1/en not_active Expired - Lifetime
- 1988-06-07 DD DD88316492A patent/DD281600A5/de not_active IP Right Cessation
- 1988-06-07 AT AT88305180T patent/ATE90347T1/de not_active IP Right Cessation
- 1988-06-07 DD DD88326849A patent/DD280320A5/de not_active IP Right Cessation
- 1988-06-08 AU AU17491/88A patent/AU593742B2/en not_active Ceased
- 1988-06-08 FI FI882722A patent/FI93835C/fi not_active IP Right Cessation
- 1988-06-08 CN CN88103507A patent/CN1024347C/zh not_active Expired - Fee Related
- 1988-06-08 IL IL86660A patent/IL86660A0/xx not_active IP Right Cessation
- 1988-06-08 YU YU111188A patent/YU46696B/sh unknown
- 1988-06-08 ZA ZA884075A patent/ZA884075B/xx unknown
- 1988-06-08 DK DK309988A patent/DK309988A/da not_active Application Discontinuation
- 1988-06-08 NO NO882516A patent/NO176317C/no not_active IP Right Cessation
- 1988-06-08 NZ NZ224937A patent/NZ224937A/xx unknown
- 1988-06-08 IE IE171688A patent/IE61499B1/en unknown
- 1988-06-08 SU SU884355901A patent/SU1678208A3/ru active
- 1988-06-08 KR KR1019880006855A patent/KR900004698B1/ko not_active Expired
- 1988-06-08 HU HU882971A patent/HU205108B/hu not_active IP Right Cessation
- 1988-06-08 PT PT87669A patent/PT87669B/pt not_active IP Right Cessation
- 1988-06-09 EG EG320/88A patent/EG18613A/xx active

Also Published As

Publication number	Publication date
KR900004698B1 (ko)	1990-07-02
JPH0676391B2 (ja)	1994-09-28
DK309988A (da)	1988-12-10
ZA884075B (en)	1990-02-28
PL272899A1 (en)	1989-07-10
CA1321791C (en)	1993-08-31
SU1678208A3 (ru)	1991-09-15
AU1749188A (en)	1988-12-15
FI882722A0 (fi)	1988-06-08
PL157690B1 (en)	1992-06-30
NZ224937A (en)	1991-01-29
DD280320A5 (de)	1990-07-04
NO176317B (no)	1994-12-05
YU46696B (sh)	1994-04-05
KR890000476A (ko)	1989-03-14
DD281600A5 (de)	1990-08-15
IL86660A0 (en)	1988-11-30
NO882516D0 (no)	1988-06-08
HU205108B (en)	1992-03-30
DD280323A5 (de)	1990-07-04
CN1024347C (zh)	1994-04-27
EG18613A (en)	1993-08-30
EP0295051A3 (en)	1989-03-22
NO882516L (no)	1988-12-12
ATE90347T1 (de)	1993-06-15
IE61499B1 (en)	1994-11-02
JPS643173A (en)	1989-01-06
EP0295051B1 (en)	1993-06-09
CN88103507A (zh)	1988-12-28
DE3881583D1 (de)	1993-07-15
PT87669B (pt)	1992-09-30
NO176317C (no)	1995-03-15
EP0295051A2 (en)	1988-12-14
PT87669A (pt)	1988-07-01
PH25928A (en)	1991-12-19
CS392488A2 (en)	1990-08-14
DE3881583T2 (de)	1993-09-16
IE881716L (en)	1988-12-09
CS274628B2 (en)	1991-09-15
YU111188A (en)	1989-12-31
ES2040853T3 (es)	1993-11-01
MY103573A (en)	1993-08-28
FI93835B (fi)	1995-02-28
FI882722A7 (fi)	1988-12-10
FI93835C (fi)	1995-06-12
AU593742B2 (en)	1990-02-15

Legal Events

Date	Code	Title	Description
2002-01-28	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK309988A (da)	1988-12-10	Fremgangsmaade til fremstilling af 4-oxo-3h-phthalazin-1-yl-eddikesyre-forbindelser med benzothiazol- eller andre heterocycliske sidekaeder i 3-stillingen og forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden
DE69119216D1 (de)	1996-06-05	Enzymatisches Verfahren zur Herstellung von 7-Aminocephalosporinsäure und Derivate
NO902839L (no)	1990-12-28	Fremgangsmaate for rensing av tryptofan.
DK145789D0 (da)	1989-03-22	Fremstilling af 4-halogen-3-oxo-2-alkoxyiminosmoersyreestre
DK0397048T3 (da)	1994-11-21	Fremgangsmåde til fremstilling af 2-mercapto-4-methyl-1,3-thiazol-5-yl-eddikesyre og dens estere
ATE35130T1 (de)	1988-07-15	Verfahren zur herstellung von 4-acyloxy-3-oxobutter-s\|ureestern.
IL98979A0 (en)	1992-07-15	Lowering of blood uric acid levels with a benzothiazolyl derivative
DK93089A (da)	1989-08-30	Fremgangsmaade til fremstilling af phthalazineddikesyreesterederivater og mellemprodukt ved fremsgangsmaaden
ATE97657T1 (de)	1993-12-15	Verfahren zur herstellung von propionsaeurederivaten.
DK521785A (da)	1986-05-14	Fremgangsmaade til fremstilling af halogenerede 3,3-dimethyl-5-hexan-2-oner
ATE41417T1 (de)	1989-04-15	Verfahren zur herstellung von 4-halogen-2hydroxyimino-acetessigsaeureestern.
DK159432C (da)	1991-03-18	Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater
ATE63536T1 (de)	1991-06-15	Verfahren zur herstellung von carbonsaeurechloriden.
ATE80147T1 (de)	1992-09-15	Verfahren zum herstellen und isolieren von estern der (r)-2-hydroxyphenylbuttersaeure.
DK130082A (da)	1982-03-23	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren iinsuliner