DK1320526T3 - Farmaceutisk aktive benzsulfonamidderivater som inhibitorer af protein-junkinaser - Google Patents

Farmaceutisk aktive benzsulfonamidderivater som inhibitorer af protein-junkinaser

Info

Publication number
DK1320526T3
DK1320526T3 DK01967623.8T DK01967623T DK1320526T3 DK 1320526 T3 DK1320526 T3 DK 1320526T3 DK 01967623 T DK01967623 T DK 01967623T DK 1320526 T3 DK1320526 T3 DK 1320526T3
Authority
DK
Denmark
Prior art keywords
substituted
benzsulfonamide
formula
derivatives
unsubstituted
Prior art date
Application number
DK01967623.8T
Other languages
English (en)
Inventor
Serge Halazy
Dennis Church
Montserrat Camps
Thomas Rueckle
Marco Biamonte
Stephen Arkinstall
Jean-Pierre Gotteland
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of DK1320526T3 publication Critical patent/DK1320526T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK01967623.8T 2000-09-27 2001-09-27 Farmaceutisk aktive benzsulfonamidderivater som inhibitorer af protein-junkinaser DK1320526T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00810888A EP1193256A1 (en) 2000-09-27 2000-09-27 Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
PCT/IB2001/001773 WO2002026711A1 (en) 2000-09-27 2001-09-27 Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases

Publications (1)

Publication Number Publication Date
DK1320526T3 true DK1320526T3 (da) 2010-10-18

Family

ID=8174938

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01967623.8T DK1320526T3 (da) 2000-09-27 2001-09-27 Farmaceutisk aktive benzsulfonamidderivater som inhibitorer af protein-junkinaser

Country Status (14)

Country Link
US (2) US7417058B2 (da)
EP (2) EP1193256A1 (da)
JP (1) JP4927303B2 (da)
AT (1) ATE478048T1 (da)
AU (2) AU8799201A (da)
CA (1) CA2420568C (da)
CY (1) CY1110904T1 (da)
DE (1) DE60142838D1 (da)
DK (1) DK1320526T3 (da)
ES (1) ES2347136T3 (da)
IL (2) IL154964A0 (da)
PT (1) PT1320526E (da)
SI (1) SI1320526T1 (da)
WO (1) WO2002026711A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1193267A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases
EP1193268A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases
EP1193256A1 (en) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
BR0211401A (pt) * 2001-07-23 2004-08-17 Fos Holding S A Dispositivo para separar a camada de epitélio da superfìcie da córnea de um olho
ES2318041T3 (es) * 2001-07-23 2009-05-01 Laboratoires Serono Sa Derivados de arilsulfonamida como inhibidores de c-jun quinasas (jnk) n-terminales.
WO2003091249A1 (en) 2002-04-25 2003-11-06 Applied Research Systems Ars Holding N.V. Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders
AU2004271741A1 (en) * 2003-09-12 2005-03-24 Laboratoires Serono Sa Sulfonamide derivatives for the treatment of diabetes
US20060094753A1 (en) * 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
US7803824B2 (en) * 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
AU2011265521B8 (en) * 2005-07-15 2014-05-22 Merck Serono Sa JNK inhibitors for the treatment of endometreosis
US20070260951A1 (en) * 2006-05-03 2007-11-08 Texas Instruments Incorporated Uncompromised standard input set-up time with improved enable input set-up time characteristics in a storage circuit
WO2009131065A1 (ja) * 2008-04-24 2009-10-29 萬有製薬株式会社 アリールスルホニル誘導体を有効成分とする長鎖脂肪酸伸長酵素阻害剤
US8828924B2 (en) * 2009-05-14 2014-09-09 University Of Maryland, Baltimore Methods of treating a diabetic embryopathy
WO2011060321A1 (en) 2009-11-16 2011-05-19 Chdi, Inc. Transglutaminase tg2 inhibitors, pharmaceutical compositions, and methods of use thereof
PE20140011A1 (es) 2010-09-03 2014-01-31 Forma Tm Llc Compuestos y composiciones novedosos para la inhibicion de nampt
RU2017112522A (ru) 2011-05-04 2019-01-24 ФОРМА ТиЭм, ЭлЭлСИ Новые соединения и композиции для ингибирования nampt
US8889716B2 (en) 2011-05-10 2014-11-18 Chdi Foundation, Inc. Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
KR101592068B1 (ko) 2013-11-08 2016-02-05 순천향대학교 산학협력단 플라즈마 아포리포프로테인 h를 포함하는 아스피린 과민성 호흡계 질환 및 아스피린 내성 천식 구별 진단용 마커 및 구별 진단용 키트
EP3946301A4 (en) * 2019-04-02 2023-08-09 The University of Chicago REMODILINS FOR RESPIRATORY TRACT REMODELING AND ORGAN FIBROSIS
US12018016B2 (en) 2021-08-18 2024-06-25 Amgen Inc. Aryl sulfonyl (hydroxy) piperidines as CCR6 inhibitors
WO2023023534A2 (en) 2021-08-18 2023-02-23 Chemocentryx, Inc. Aryl sulfonyl compounds as ccr6 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812144A (en) * 1969-03-10 1974-05-21 Ciba Geigy Corp Derivatives of p-aminoalkylbenzene sulfonamide
FR2553414B1 (fr) * 1983-10-18 1986-08-14 Choay Sa Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques
US5744320A (en) * 1995-06-07 1998-04-28 Promega Corporation Quenching reagents and assays for enzyme-mediated luminescence
US6043083A (en) * 1997-04-28 2000-03-28 Davis; Roger J. Inhibitors of the JNK signal transduction pathway and methods of use
DE19743435A1 (de) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
CN1332943C (zh) * 1998-07-08 2007-08-22 萨诺费－阿文蒂斯德国有限公司 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂
EP1088821A1 (en) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
EP1193267A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases
EP1193268A1 (en) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases
EP1193256A1 (en) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins

Also Published As

Publication number Publication date
US20080255222A1 (en) 2008-10-16
SI1320526T1 (sl) 2010-11-30
EP1320526B1 (en) 2010-08-18
CA2420568A1 (en) 2002-04-04
AU8799201A (en) 2002-04-08
AU2001287992B9 (en) 2006-09-28
EP1193256A8 (en) 2002-08-28
JP4927303B2 (ja) 2012-05-09
US8008341B2 (en) 2011-08-30
EP1193256A1 (en) 2002-04-03
US20040053917A1 (en) 2004-03-18
CY1110904T1 (el) 2015-06-10
US7417058B2 (en) 2008-08-26
WO2002026711A1 (en) 2002-04-04
AU2001287992B2 (en) 2006-05-04
ATE478048T1 (de) 2010-09-15
EP1320526A1 (en) 2003-06-25
PT1320526E (pt) 2010-09-02
CA2420568C (en) 2010-09-21
ES2347136T3 (es) 2010-10-26
IL154964A0 (en) 2003-10-31
DE60142838D1 (de) 2010-09-30
IL154964A (en) 2010-11-30
JP2004523475A (ja) 2004-08-05

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