ATE478048T1 - Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen - Google Patents
Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasenInfo
- Publication number
- ATE478048T1 ATE478048T1 AT01967623T AT01967623T ATE478048T1 AT E478048 T1 ATE478048 T1 AT E478048T1 AT 01967623 T AT01967623 T AT 01967623T AT 01967623 T AT01967623 T AT 01967623T AT E478048 T1 ATE478048 T1 AT E478048T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- benzsulfonamide
- formula
- derivatives
- unsubstituted
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00810888A EP1193256A1 (de) | 2000-09-27 | 2000-09-27 | Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren |
| PCT/IB2001/001773 WO2002026711A1 (en) | 2000-09-27 | 2001-09-27 | Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478048T1 true ATE478048T1 (de) | 2010-09-15 |
Family
ID=8174938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01967623T ATE478048T1 (de) | 2000-09-27 | 2001-09-27 | Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7417058B2 (de) |
| EP (2) | EP1193256A1 (de) |
| JP (1) | JP4927303B2 (de) |
| AT (1) | ATE478048T1 (de) |
| AU (2) | AU2001287992B9 (de) |
| CA (1) | CA2420568C (de) |
| CY (1) | CY1110904T1 (de) |
| DE (1) | DE60142838D1 (de) |
| DK (1) | DK1320526T3 (de) |
| ES (1) | ES2347136T3 (de) |
| IL (2) | IL154964A0 (de) |
| PT (1) | PT1320526E (de) |
| SI (1) | SI1320526T1 (de) |
| WO (1) | WO2002026711A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1193267A1 (de) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch wirksame hydrophile Sulfonamidderivate zur Verwendung als Proteinjunkinasehemmer |
| EP1193268A1 (de) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch aktive Sulfonamidderivate mit sowohl lipophilen als auch ionisierbaren Gruppen als Inhibitoren von Protein-JunKinasen |
| EP1193256A1 (de) | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren |
| JP4414219B2 (ja) * | 2001-07-23 | 2010-02-10 | メルク セローノ ソシエテ アノニム | Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）インヒビターとしてのアリールスルホンアミド誘導体 |
| RU2330637C2 (ru) * | 2001-07-23 | 2008-08-10 | Фос Холдинг С.А. | Аппарат для отделения слоя эпителия от поверхности роговицы глаза |
| JP4523289B2 (ja) | 2002-04-25 | 2010-08-11 | メルク セローノ ソシエテ アノニム | 脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール |
| ATE551997T1 (de) * | 2003-09-12 | 2012-04-15 | Merck Serono Sa | Sulfonamid-derivate zur behandlung von diabetes |
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060094753A1 (en) * | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| AU2011265521B8 (en) * | 2005-07-15 | 2014-05-22 | Merck Serono Sa | JNK inhibitors for the treatment of endometreosis |
| US20070260951A1 (en) * | 2006-05-03 | 2007-11-08 | Texas Instruments Incorporated | Uncompromised standard input set-up time with improved enable input set-up time characteristics in a storage circuit |
| ES2527589T3 (es) * | 2008-04-24 | 2015-01-27 | Msd K.K. | Inhibidor de la enzima de elongación de ácidos grasos de cadena larga que comprende un derivado de arilsulfonilo como principio activo |
| US8828924B2 (en) * | 2009-05-14 | 2014-09-09 | University Of Maryland, Baltimore | Methods of treating a diabetic embryopathy |
| US8946197B2 (en) | 2009-11-16 | 2015-02-03 | Chdi Foundation, Inc. | Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof |
| EP2611804A1 (de) | 2010-09-03 | 2013-07-10 | Forma TM, LLC. | Neue verbindungen und zusammensetzungen zur nampt-hemmung |
| RU2616612C2 (ru) | 2011-05-04 | 2017-04-18 | ФОРМА ТиЭм, ЭлЭлСИ | Новые соединения и композиции для ингибирования nampt |
| US8889716B2 (en) | 2011-05-10 | 2014-11-18 | Chdi Foundation, Inc. | Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof |
| KR101592068B1 (ko) | 2013-11-08 | 2016-02-05 | 순천향대학교 산학협력단 | 플라즈마 아포리포프로테인 h를 포함하는 아스피린 과민성 호흡계 질환 및 아스피린 내성 천식 구별 진단용 마커 및 구별 진단용 키트 |
| EP3946301A4 (de) * | 2019-04-02 | 2023-08-09 | The University of Chicago | Remodiline für atemwegsremodellierung und organfibrose |
| AU2022328634A1 (en) | 2021-08-18 | 2024-02-22 | Chemocentryx, Inc. | Aryl sulfonyl compounds as ccr6 inhibitors |
| WO2023023532A2 (en) * | 2021-08-18 | 2023-02-23 | Chemocentryx, Inc. | Aryl sulfonyl (hydroxy) piperidines as ccr6 inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3812144A (en) * | 1969-03-10 | 1974-05-21 | Ciba Geigy Corp | Derivatives of p-aminoalkylbenzene sulfonamide |
| FR2553414B1 (fr) * | 1983-10-18 | 1986-08-14 | Choay Sa | Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques |
| US5744320A (en) * | 1995-06-07 | 1998-04-28 | Promega Corporation | Quenching reagents and assays for enzyme-mediated luminescence |
| US6043083A (en) * | 1997-04-28 | 2000-03-28 | Davis; Roger J. | Inhibitors of the JNK signal transduction pathway and methods of use |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| CZ302691B6 (cs) * | 1998-07-08 | 2011-09-07 | Sanofi - Aventis Deutschland GmbH | N-Arylamidová sloucenina, zpusob její prípravy, farmaceutický prostredek tuto slouceninu obsahující, tato sloucenina pro použití jako aktivátor a pro použití k terapii nebo profylaxi |
| EP1088821A1 (de) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch wirksamer Sulfonamid Derivate |
| EP1193267A1 (de) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch wirksame hydrophile Sulfonamidderivate zur Verwendung als Proteinjunkinasehemmer |
| EP1193256A1 (de) | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren |
| EP1193268A1 (de) | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch aktive Sulfonamidderivate mit sowohl lipophilen als auch ionisierbaren Gruppen als Inhibitoren von Protein-JunKinasen |
-
2000
- 2000-09-27 EP EP00810888A patent/EP1193256A1/de not_active Withdrawn
-
2001
- 2001-09-27 SI SI200130978T patent/SI1320526T1/sl unknown
- 2001-09-27 JP JP2002531095A patent/JP4927303B2/ja not_active Expired - Fee Related
- 2001-09-27 DE DE60142838T patent/DE60142838D1/de not_active Expired - Lifetime
- 2001-09-27 AT AT01967623T patent/ATE478048T1/de active
- 2001-09-27 EP EP01967623A patent/EP1320526B1/de not_active Expired - Lifetime
- 2001-09-27 AU AU2001287992A patent/AU2001287992B9/en not_active Ceased
- 2001-09-27 IL IL15496401A patent/IL154964A0/xx unknown
- 2001-09-27 US US10/381,197 patent/US7417058B2/en not_active Expired - Fee Related
- 2001-09-27 DK DK01967623.8T patent/DK1320526T3/da active
- 2001-09-27 WO PCT/IB2001/001773 patent/WO2002026711A1/en not_active Ceased
- 2001-09-27 CA CA2420568A patent/CA2420568C/en not_active Expired - Fee Related
- 2001-09-27 ES ES01967623T patent/ES2347136T3/es not_active Expired - Lifetime
- 2001-09-27 PT PT01967623T patent/PT1320526E/pt unknown
- 2001-09-27 AU AU8799201A patent/AU8799201A/xx active Pending
-
2003
- 2003-03-18 IL IL154964A patent/IL154964A/en not_active IP Right Cessation
-
2008
- 2008-06-19 US US12/142,296 patent/US8008341B2/en not_active Expired - Fee Related
-
2010
- 2010-10-05 CY CY20101100883T patent/CY1110904T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1320526B1 (de) | 2010-08-18 |
| JP2004523475A (ja) | 2004-08-05 |
| EP1193256A8 (de) | 2002-08-28 |
| DK1320526T3 (da) | 2010-10-18 |
| IL154964A (en) | 2010-11-30 |
| EP1193256A1 (de) | 2002-04-03 |
| US20040053917A1 (en) | 2004-03-18 |
| WO2002026711A1 (en) | 2002-04-04 |
| CA2420568A1 (en) | 2002-04-04 |
| JP4927303B2 (ja) | 2012-05-09 |
| US7417058B2 (en) | 2008-08-26 |
| IL154964A0 (en) | 2003-10-31 |
| SI1320526T1 (sl) | 2010-11-30 |
| DE60142838D1 (de) | 2010-09-30 |
| AU2001287992B9 (en) | 2006-09-28 |
| CA2420568C (en) | 2010-09-21 |
| ES2347136T3 (es) | 2010-10-26 |
| CY1110904T1 (el) | 2015-06-10 |
| AU2001287992B2 (en) | 2006-05-04 |
| EP1320526A1 (de) | 2003-06-25 |
| PT1320526E (pt) | 2010-09-02 |
| US20080255222A1 (en) | 2008-10-16 |
| AU8799201A (en) | 2002-04-08 |
| US8008341B2 (en) | 2011-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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