ATE478048T1 - Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen - Google Patents

Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen

Info

Publication number: ATE478048T1
Authority: AT; Austria
Prior art keywords: substituted; benzsulfonamide; formula; derivatives; unsubstituted
Prior art date: 2000-09-27

Application number

AT01967623T

Other languages

English (en)

Inventor

Serge Halazy

Dennis Church

Montserrat Camps

Jean-Pierre Gotteland

Thomas Rueckle

Marco Biamonte

Stephen Arkinstall

Original Assignee

Merck Serono Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-27

Filing date

2001-09-27

Publication date

2010-09-15

2001-09-27 Application filed by Merck Serono Sa filed Critical Merck Serono Sa

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE478048T1 publication Critical patent/ATE478048T1/de

Links

108091000080 Phosphotransferase Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
102000020233 phosphotransferase Human genes 0.000 title 1
102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000037361 pathway Effects 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Cardiology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

AT01967623T 2000-09-27 2001-09-27 Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen ATE478048T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00810888A EP1193256A1 (de)	2000-09-27	2000-09-27	Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
PCT/IB2001/001773 WO2002026711A1 (en)	2000-09-27	2001-09-27	Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases

Publications (1)

Publication Number	Publication Date
ATE478048T1 true ATE478048T1 (de)	2010-09-15

Family

ID=8174938

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01967623T ATE478048T1 (de)	2000-09-27	2001-09-27	Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen

Country Status (14)

Country	Link
US (2)	US7417058B2 (de)
EP (2)	EP1193256A1 (de)
JP (1)	JP4927303B2 (de)
AT (1)	ATE478048T1 (de)
AU (2)	AU8799201A (de)
CA (1)	CA2420568C (de)
CY (1)	CY1110904T1 (de)
DE (1)	DE60142838D1 (de)
DK (1)	DK1320526T3 (de)
ES (1)	ES2347136T3 (de)
IL (2)	IL154964A0 (de)
PT (1)	PT1320526E (de)
SI (1)	SI1320526T1 (de)
WO (1)	WO2002026711A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1193268A1 (de) *	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch aktive Sulfonamidderivate mit sowohl lipophilen als auch ionisierbaren Gruppen als Inhibitoren von Protein-JunKinasen
EP1193256A1 (de)	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
EP1193267A1 (de) *	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch wirksame hydrophile Sulfonamidderivate zur Verwendung als Proteinjunkinasehemmer
CA2454662A1 (en) *	2001-07-23	2003-02-06	Fos Holding S.A.	Device for separating the epithelium layer from the surface of the cornea of an eye
WO2003010164A1 (en) *	2001-07-23	2003-02-06	Applied Research Systems Ars Holding N.V.	Arylsulfonamide derivatives as c-jun-n-terminal kinases (jnk's) inhibitors
DE60318567T2 (de) *	2002-04-25	2009-02-19	Laboratoires Serono S.A., Coinsins	Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems
ES2385219T3 (es) *	2003-09-12	2012-07-19	Merck Serono Sa	Derivados de sulfonamida para el tratamiento de diabetes
US20060094753A1 (en) *	2004-10-29	2006-05-04	Alcon, Inc.	Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
US7803824B2 (en) *	2004-10-29	2010-09-28	Alcon, Inc.	Use of inhibitors of Jun N-terminal kinases to treat glaucoma
AU2011265521B8 (en) *	2005-07-15	2014-05-22	Merck Serono Sa	JNK inhibitors for the treatment of endometreosis
US20070260951A1 (en) *	2006-05-03	2007-11-08	Texas Instruments Incorporated	Uncompromised standard input set-up time with improved enable input set-up time characteristics in a storage circuit
CN104352492B (zh) *	2008-04-24	2017-12-05	Msd K.K.公司	以芳基磺酰基衍生物作为有效成分的长链脂肪酸延长酶抑制剂
US8828924B2 (en) *	2009-05-14	2014-09-09	University Of Maryland, Baltimore	Methods of treating a diabetic embryopathy
US8946197B2 (en)	2009-11-16	2015-02-03	Chdi Foundation, Inc.	Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
AR082885A1 (es)	2010-09-03	2013-01-16	Genentech Inc	Compuestos y composiciones para la inhibicion de nampt
JP5978293B2 (ja)	2011-05-04	2016-08-24	フォーマティーエム，エルエルシー．	Ｎａｍｐｔを阻害するための新規な化合物および組成物
US8889716B2 (en)	2011-05-10	2014-11-18	Chdi Foundation, Inc.	Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
KR101592068B1 (ko)	2013-11-08	2016-02-05	순천향대학교 산학협력단	플라즈마 아포리포프로테인 h를 포함하는 아스피린 과민성 호흡계 질환 및 아스피린 내성 천식 구별 진단용 마커 및 구별 진단용 키트
US12281060B2 (en)	2019-04-02	2025-04-22	The University Of Chicago	Remodilins for airway remodeling and organ fibrosis
MX2024002173A (es)	2021-08-18	2024-03-26	Chemocentryx Inc	Compuestos de arilsulfonilo como inhibidores de ccr6.
IL310368A (en) *	2021-08-18	2024-03-01	Chemocentryx Inc	Arylsulfonyl(hydroxy)piperidines as CCR6 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3812144A (en) *	1969-03-10	1974-05-21	Ciba Geigy Corp	Derivatives of p-aminoalkylbenzene sulfonamide
FR2553414B1 (fr) *	1983-10-18	1986-08-14	Choay Sa	Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques
US5744320A (en)	1995-06-07	1998-04-28	Promega Corporation	Quenching reagents and assays for enzyme-mediated luminescence
US6043083A (en) *	1997-04-28	2000-03-28	Davis; Roger J.	Inhibitors of the JNK signal transduction pathway and methods of use
DE19743435A1 (de) *	1997-10-01	1999-04-08	Merck Patent Gmbh	Benzamidinderivate
CZ302691B6 (cs) *	1998-07-08	2011-09-07	Sanofi - Aventis Deutschland GmbH	N-Arylamidová sloucenina, zpusob její prípravy, farmaceutický prostredek tuto slouceninu obsahující, tato sloucenina pro použití jako aktivátor a pro použití k terapii nebo profylaxi
EP1088821A1 (de) *	1999-09-28	2001-04-04	Applied Research Systems ARS Holding N.V.	Pharmazeutisch wirksamer Sulfonamid Derivate
EP1193267A1 (de) *	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch wirksame hydrophile Sulfonamidderivate zur Verwendung als Proteinjunkinasehemmer
EP1193256A1 (de)	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
EP1193268A1 (de) *	2000-09-27	2002-04-03	Applied Research Systems ARS Holding N.V.	Pharmazeutisch aktive Sulfonamidderivate mit sowohl lipophilen als auch ionisierbaren Gruppen als Inhibitoren von Protein-JunKinasen

2000
- 2000-09-27 EP EP00810888A patent/EP1193256A1/de not_active Withdrawn
2001
- 2001-09-27 US US10/381,197 patent/US7417058B2/en not_active Expired - Fee Related
- 2001-09-27 EP EP01967623A patent/EP1320526B1/de not_active Expired - Lifetime
- 2001-09-27 JP JP2002531095A patent/JP4927303B2/ja not_active Expired - Fee Related
- 2001-09-27 AT AT01967623T patent/ATE478048T1/de active
- 2001-09-27 CA CA2420568A patent/CA2420568C/en not_active Expired - Fee Related
- 2001-09-27 IL IL15496401A patent/IL154964A0/xx unknown
- 2001-09-27 DE DE60142838T patent/DE60142838D1/de not_active Expired - Lifetime
- 2001-09-27 ES ES01967623T patent/ES2347136T3/es not_active Expired - Lifetime
- 2001-09-27 DK DK01967623.8T patent/DK1320526T3/da active
- 2001-09-27 AU AU8799201A patent/AU8799201A/xx active Pending
- 2001-09-27 PT PT01967623T patent/PT1320526E/pt unknown
- 2001-09-27 WO PCT/IB2001/001773 patent/WO2002026711A1/en not_active Ceased
- 2001-09-27 AU AU2001287992A patent/AU2001287992B9/en not_active Ceased
- 2001-09-27 SI SI200130978T patent/SI1320526T1/sl unknown
2003
- 2003-03-18 IL IL154964A patent/IL154964A/en not_active IP Right Cessation
2008
- 2008-06-19 US US12/142,296 patent/US8008341B2/en not_active Expired - Fee Related
2010
- 2010-10-05 CY CY20101100883T patent/CY1110904T1/el unknown

Also Published As

Publication number	Publication date
DE60142838D1 (de)	2010-09-30
JP4927303B2 (ja)	2012-05-09
AU2001287992B2 (en)	2006-05-04
ES2347136T3 (es)	2010-10-26
JP2004523475A (ja)	2004-08-05
CA2420568C (en)	2010-09-21
CY1110904T1 (el)	2015-06-10
US20080255222A1 (en)	2008-10-16
WO2002026711A1 (en)	2002-04-04
SI1320526T1 (sl)	2010-11-30
DK1320526T3 (da)	2010-10-18
IL154964A (en)	2010-11-30
AU8799201A (en)	2002-04-08
US8008341B2 (en)	2011-08-30
EP1193256A8 (de)	2002-08-28
CA2420568A1 (en)	2002-04-04
US7417058B2 (en)	2008-08-26
US20040053917A1 (en)	2004-03-18
PT1320526E (pt)	2010-09-02
EP1193256A1 (de)	2002-04-03
IL154964A0 (en)	2003-10-31
EP1320526B1 (de)	2010-08-18
EP1320526A1 (de)	2003-06-25
AU2001287992B9 (en)	2006-09-28

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2010-12-15

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