AR039988A1 - Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismos - Google Patents
Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismosInfo
- Publication number
- AR039988A1 AR039988A1 ARP030101624A ARP030101624A AR039988A1 AR 039988 A1 AR039988 A1 AR 039988A1 AR P030101624 A ARP030101624 A AR P030101624A AR P030101624 A ARP030101624 A AR P030101624A AR 039988 A1 AR039988 A1 AR 039988A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- haloalkyl
- hydrogen
- modulators
- Prior art date
Links
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical class C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004476 heterocycloamino group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula (1): una sal farmacéuticamente aceptable o un profármaco de las misma, en donde: m es un número entero de 0 a 3; cada uno de n y p son independientemente un número entero de 2 a 3; Y es -S(O2)- o -S(O2)-N(R10)-, donde R10 es hidrógeno o alquilo inferior; Z1 es CH o N; cada uno de R1 y R2 son independientemente hidrógeno o alquilo; R3 es alquilo, arilo, haloalquilo, heterociclilo, o heteroarilo; cada R4 son independientemente halo, alquilo, haloalquilo, alcoxilo, ciano, -SO2Ra, -C(=O)-NRbRc, -SO2-NRbRc, -SRb, -N(Rb)-C(=O)-Rc, -C(=O)-Rb, o -N(Rb)-SO2-Ra, donde: cada Ra son independientemente alquilo haloalquilo, y cada uno de Rb y Rc son independientemente hidrógeno, alquilo, o haloalquilo; cada uno de R5, R6, R7, y R8 son independientemente hidrógeno o alquilo; y R9 es hidrógeno, alquilo, cicloalquilo, cicloalquiloalquilo o bencilo; o R9 y uno de R5, R6, R7, ó R8 junto con los átomos con los que están unidos forman un anillo heterocicloamino con 5 a 7 átomos por anillo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37800302P | 2002-05-13 | 2002-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039988A1 true AR039988A1 (es) | 2005-03-09 |
Family
ID=29420358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101624A AR039988A1 (es) | 2002-05-13 | 2003-05-09 | Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismos |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US6867204B2 (es) |
| EP (1) | EP1506179B1 (es) |
| JP (1) | JP4307377B2 (es) |
| KR (1) | KR100636475B1 (es) |
| CN (1) | CN100429206C (es) |
| AR (1) | AR039988A1 (es) |
| AT (1) | ATE316523T1 (es) |
| AU (1) | AU2003233231B2 (es) |
| BR (1) | BRPI0310032B8 (es) |
| CA (1) | CA2485136C (es) |
| DE (1) | DE60303376T2 (es) |
| DK (1) | DK1506179T3 (es) |
| EA (1) | EA009982B1 (es) |
| EC (1) | ECSP045420A (es) |
| EG (1) | EG25683A (es) |
| ES (1) | ES2256744T3 (es) |
| GT (1) | GT200300108A (es) |
| HR (1) | HRP20041030B1 (es) |
| IL (1) | IL164928A0 (es) |
| JO (1) | JO2413B1 (es) |
| MA (1) | MA27118A1 (es) |
| MX (1) | MXPA04011254A (es) |
| MY (1) | MY139612A (es) |
| NO (1) | NO329380B1 (es) |
| NZ (1) | NZ536230A (es) |
| PA (1) | PA8573501A1 (es) |
| PE (1) | PE20040757A1 (es) |
| PL (1) | PL211057B1 (es) |
| PT (1) | PT1506179E (es) |
| RS (1) | RS51042B (es) |
| TN (1) | TNSN04225A1 (es) |
| TW (1) | TWI258479B (es) |
| UA (1) | UA76877C2 (es) |
| UY (1) | UY27803A1 (es) |
| WO (1) | WO2003095434A1 (es) |
| ZA (1) | ZA200408783B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2323451T7 (es) | 2001-07-20 | 2011-08-01 | Psychogenics Inc. | Tratamiento para el trastorno de hiperactividad con deficit de atencion. |
| RU2309154C9 (ru) | 2002-03-27 | 2016-09-27 | Глэксо Груп Лимитед | 3-фенилсульфонил-8-пиперазин-1-ил-хинолины, обладающие аффинностью к 5-нт6 рецептору, способы их получения (варианты) |
| PT1506179E (pt) * | 2002-05-13 | 2006-06-30 | Hoffmann La Roche | Derivados de benzoxazina como moduladores de 5-ht6 e suas utilizacoes |
| PL377770A1 (pl) * | 2002-11-08 | 2006-02-20 | F. Hoffmann-La Roche Ag | Podstawione benzoksazynony i ich zastosowanie |
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| ATE371653T1 (de) * | 2003-12-09 | 2007-09-15 | Hoffmann La Roche | Benzoxazinderivate und deren verwendungen |
| JP4533391B2 (ja) * | 2004-01-16 | 2010-09-01 | エフ．ホフマン−ラ ロシュ アーゲー | 中枢神経系疾患の処置のための５−ヒドロキシトリプタミンレセプター（５−ｈｔ）のモジュレーターとしての、１−ベンジル−５−ピペラジン−１−イル−３，４−ジヒドロ−１ｈ−キナゾリン−２−オン誘導体、ならびにそれぞれの１ｈ−ベンゾ（１，２，６）チアジアジン−２，２−ジオキシドおよび１，４−ジヒドロベンゾ（ｄ）（１，３）オキサジン−２−オン誘導体 |
| CA2566196A1 (en) * | 2004-05-05 | 2005-11-10 | F. Hoffmann-La Roche Ag | Arylsulfonyl benzodioxanes useful for modulating the 5-ht6 receptor, the 5-ht2a receptor or both |
| CN102114244A (zh) * | 2004-09-30 | 2011-07-06 | 弗·哈夫曼-拉罗切有限公司 | 治疗认知障碍的组合物和方法 |
| US7378415B2 (en) * | 2004-09-30 | 2008-05-27 | Roche Palo Alto Llc | Benzoxazine and quinoxaline derivatives and uses thereof |
| NZ553848A (en) * | 2004-09-30 | 2010-01-29 | Hoffmann La Roche | Benzoxazine and quinoxaline derivatives and their use in treating diseases associated with the central nervous system |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| AR078770A1 (es) * | 2009-10-27 | 2011-11-30 | Elara Pharmaceuticals Gmbh | Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas. |
| KR101293384B1 (ko) * | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| US9403800B2 (en) * | 2012-01-24 | 2016-08-02 | Chemregen, Inc. | Compounds for inhibition of cancer cell proliferation |
| US10087151B2 (en) | 2014-01-09 | 2018-10-02 | The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone | Substituted benzoxazine and related compounds |
| US10022355B2 (en) | 2015-06-12 | 2018-07-17 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder |
| BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1029479C (zh) * | 1989-11-08 | 1995-08-09 | 山之内制药株式会社 | 新型苯并噁嗪衍生物的制备方法 |
| US5492914A (en) * | 1994-07-28 | 1996-02-20 | Syntex (U.S.A.) Inc. | 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof |
| GB9507203D0 (en) | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
| DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| EP0975593A1 (en) | 1997-04-18 | 2000-02-02 | Smithkline Beecham Plc | Indole derivatives having combined 5ht1a, 5ht1b and 5ht1d receptor antagonist activity |
| EP0994862B1 (en) | 1997-07-11 | 2005-06-01 | SmithKline Beecham plc | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation |
| KR100545329B1 (ko) * | 1997-07-25 | 2006-01-24 | 하. 룬트벡 아크티에 셀스카브 | 인돌 및 2,3-디히드로인돌 유도체, 그들의 제조방법 및 사용 |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| HUP0101475A3 (en) * | 1998-06-19 | 2003-01-28 | Lundbeck & Co As H | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
| GB9818916D0 (en) * | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
| WO2001014330A2 (en) * | 1999-08-23 | 2001-03-01 | Solvay Pharmaceuticals B.V. | Phenylpiperazines as serotonin reuptake inhibitors |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| WO2001057003A1 (en) | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa |
| PT1506179E (pt) * | 2002-05-13 | 2006-06-30 | Hoffmann La Roche | Derivados de benzoxazina como moduladores de 5-ht6 e suas utilizacoes |
-
2003
- 2003-05-05 PT PT03727430T patent/PT1506179E/pt unknown
- 2003-05-05 BR BRPI0310032A patent/BRPI0310032B8/pt not_active IP Right Cessation
- 2003-05-05 ES ES03727430T patent/ES2256744T3/es not_active Expired - Lifetime
- 2003-05-05 DE DE60303376T patent/DE60303376T2/de not_active Expired - Lifetime
- 2003-05-05 WO PCT/EP2003/004671 patent/WO2003095434A1/en not_active Ceased
- 2003-05-05 AT AT03727430T patent/ATE316523T1/de active
- 2003-05-05 NZ NZ536230A patent/NZ536230A/en not_active IP Right Cessation
- 2003-05-05 HR HRP20041030AA patent/HRP20041030B1/hr not_active IP Right Cessation
- 2003-05-05 EP EP03727430A patent/EP1506179B1/en not_active Expired - Lifetime
- 2003-05-05 DK DK03727430T patent/DK1506179T3/da active
- 2003-05-05 JP JP2004503451A patent/JP4307377B2/ja not_active Expired - Lifetime
- 2003-05-05 CA CA2485136A patent/CA2485136C/en not_active Expired - Lifetime
- 2003-05-05 AU AU2003233231A patent/AU2003233231B2/en not_active Expired
- 2003-05-05 CN CNB038109972A patent/CN100429206C/zh not_active Expired - Lifetime
- 2003-05-05 RS YUP-970/04A patent/RS51042B/sr unknown
- 2003-05-05 EA EA200401455A patent/EA009982B1/ru not_active IP Right Cessation
- 2003-05-05 UA UA20041210144A patent/UA76877C2/uk unknown
- 2003-05-05 MX MXPA04011254A patent/MXPA04011254A/es active IP Right Grant
- 2003-05-05 KR KR1020047018299A patent/KR100636475B1/ko not_active Expired - Fee Related
- 2003-05-05 PL PL374019A patent/PL211057B1/pl unknown
- 2003-05-08 JO JO200352A patent/JO2413B1/en active
- 2003-05-08 TW TW092112575A patent/TWI258479B/zh not_active IP Right Cessation
- 2003-05-09 AR ARP030101624A patent/AR039988A1/es active IP Right Grant
- 2003-05-09 GT GT200300108A patent/GT200300108A/es unknown
- 2003-05-09 PE PE2003000452A patent/PE20040757A1/es active IP Right Grant
- 2003-05-09 PA PA20038573501A patent/PA8573501A1/es unknown
- 2003-05-09 US US10/435,732 patent/US6867204B2/en not_active Expired - Lifetime
- 2003-05-10 EG EG2003050432A patent/EG25683A/xx active
- 2003-05-12 UY UY27803A patent/UY27803A1/es not_active IP Right Cessation
- 2003-05-12 MY MYPI20031765A patent/MY139612A/en unknown
-
2004
- 2004-10-28 IL IL16492804A patent/IL164928A0/xx unknown
- 2004-10-28 NO NO20044665A patent/NO329380B1/no not_active IP Right Cessation
- 2004-10-29 ZA ZA2004/08783A patent/ZA200408783B/en unknown
- 2004-11-10 EC EC2004005420A patent/ECSP045420A/es unknown
- 2004-11-11 TN TNP2004000225A patent/TNSN04225A1/fr unknown
- 2004-11-12 MA MA27944A patent/MA27118A1/fr unknown
-
2005
- 2005-01-31 US US11/047,284 patent/US20050130962A1/en not_active Abandoned
-
2009
- 2009-09-04 US US12/584,373 patent/US8377931B2/en not_active Expired - Fee Related
-
2012
- 2012-12-13 US US13/713,484 patent/US20130123251A1/en not_active Abandoned
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