DK1328657T3 - Proces til påvisning af serin-/threoninkinaseaktivitet - Google Patents

Proces til påvisning af serin-/threoninkinaseaktivitet

Info

Publication number
DK1328657T3
DK1328657T3 DK01980238T DK01980238T DK1328657T3 DK 1328657 T3 DK1328657 T3 DK 1328657T3 DK 01980238 T DK01980238 T DK 01980238T DK 01980238 T DK01980238 T DK 01980238T DK 1328657 T3 DK1328657 T3 DK 1328657T3
Authority
DK
Denmark
Prior art keywords
kinase activity
threonine kinase
detecting
detecting serine
serine
Prior art date
Application number
DK01980238T
Other languages
Danish (da)
English (en)
Inventor
Pam Greengrass
Joachim Kraemer
Thomas Mander
Richard Bethell
Neil Benson
Helen Boyd
Ross Kinloch
Original Assignee
Evotec Ag
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Ag, Pfizer Ltd filed Critical Evotec Ag
Application granted granted Critical
Publication of DK1328657T3 publication Critical patent/DK1328657T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1016Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/9121Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK01980238T 2000-08-11 2001-08-08 Proces til påvisning af serin-/threoninkinaseaktivitet DK1328657T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00117457A EP1182263A1 (fr) 2000-08-11 2000-08-11 Procédé de détection d'une activité thréonine- ou sérine kinase

Publications (1)

Publication Number Publication Date
DK1328657T3 true DK1328657T3 (da) 2006-07-03

Family

ID=8169514

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01980238T DK1328657T3 (da) 2000-08-11 2001-08-08 Proces til påvisning af serin-/threoninkinaseaktivitet

Country Status (7)

Country Link
US (2) US20030235873A1 (fr)
EP (2) EP1182263A1 (fr)
AT (1) ATE318928T1 (fr)
AU (1) AU2002212133A1 (fr)
DE (1) DE60117591T2 (fr)
DK (1) DK1328657T3 (fr)
WO (1) WO2002014542A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7195884B2 (en) 2002-07-19 2007-03-27 Promega Corp. Methods and kits for transferases
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
KR20050122210A (ko) 2003-03-17 2005-12-28 다케다 샌디에고, 인코포레이티드 히스톤 탈아세틸화 효소 억제제
GB2402938B (en) * 2003-06-17 2005-11-09 Medical Res Council Kinase assay
JP2008524246A (ja) 2004-12-16 2008-07-10 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
WO2006122319A2 (fr) 2005-05-11 2006-11-16 Takeda San Diego, Inc. Inhibiteurs d'histone deacetylase
ZA200800901B (en) 2005-07-14 2010-05-26 Takeda San Diego Inc Histone deacetylase inhibitors
US20080227222A1 (en) * 2007-03-13 2008-09-18 Cullum Malford E Method for the detection of target molecules by fluorescence polarization using peptide mimics
GB0822010D0 (en) * 2008-12-02 2009-01-07 Imp Innovations Ltd Assay
US10239881B2 (en) 2014-10-27 2019-03-26 University Health Network RIPK2 inhibitors and method of treating cancer with same
CN108535309B (zh) * 2018-04-16 2020-06-09 安徽工业大学 一种原位测量低碳合金钢中Fe3C析出量的方法
CN114088945A (zh) * 2021-10-19 2022-02-25 山东师范大学 组蛋白乙酰化修饰酶的hat和/或hct活性的检测方法和抑制剂筛选方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US6596476B1 (en) * 1989-12-22 2003-07-22 Abbott Laboratories Hepatitis C assay
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
US20010004522A1 (en) * 1997-10-28 2001-06-21 Thomas J. Burke Kinase activity measurement using fluorescence polarization
PL195985B1 (pl) * 1997-11-07 2007-11-30 Vasopharm Gmbh Przeciwciało monoklonalne, jego zastosowanie, linia komórek hybrydom, zestaw diagnostyczny i sposóbdiagnostyczny in vitro
EP1036192B1 (fr) * 1997-12-05 2003-02-26 PHARMACIA & UPJOHN COMPANY Essais de criblage a haut rendement a base de fluorescence pour proteines kinases et phosphatases

Also Published As

Publication number Publication date
WO2002014542A3 (fr) 2003-05-08
EP1328657B1 (fr) 2006-03-01
WO2002014542A2 (fr) 2002-02-21
ATE318928T1 (de) 2006-03-15
AU2002212133A1 (en) 2002-02-25
DE60117591T2 (de) 2006-12-28
EP1328657A2 (fr) 2003-07-23
EP1182263A1 (fr) 2002-02-27
US20030235873A1 (en) 2003-12-25
US20100021939A1 (en) 2010-01-28
DE60117591D1 (de) 2006-04-27

Similar Documents

Publication Publication Date Title
DK1028729T3 (da) Fremgangsmåder til modulering af serin/threoninproteinkinasefunktion med 5-azaquinoxalinbaserede forbindelser
ATE295691T1 (de) Schutzelement, speziell für kurze hosen
DE60213710D1 (de) Vorrichtung zur Planarisierung von Wafern
DK1847611T3 (da) Rhamnose-inducerbart ekspressionssystem
DK1454992T3 (da) Anaplastisk lymfomakinaseassay, reagenser og sammensætninger deraf
DE60117591D1 (de) Verfahren zum nachweis von serine/threonine kinase aktivität
DK1335995T3 (da) Fremgangsmåde til fremstilling af en fordampningskilde
DE50202623D1 (de) Vorrichtung zur entgegennahme von banknoten
SV2003000981A (es) Fenil-heterociclil-eteres ref. pcs10973
DE60223967D1 (de) Pipettenmarkierungen
TR199903187A3 (tr) Kadife kumaslarin yüz-yüze dokunmasi için yöntem.
IT249369Y1 (it) Custodia perfezionata per telecamere.
DE60036670D1 (de) Schaltung zur Sin(x)/x-Kompensation
TW200636350A (en) Light source
ITTO20010715A0 (it) Coperchio per ispezione di piano stradale.
WO2002025322A3 (fr) Lentille d'agrandissement pour un microscope
ITCA20000011A0 (it) Bussola elettronica.
ITRM20000286A0 (it) Dispositivo per manipolare oggetti leggeri.
DK1051973T3 (da) Midler til forbedring af det optiske papillær-kredslöb
FI20000531L (fi) Järjestelmä diafragman kiinnittämiseksi
ITRM20010625A0 (it) Processo per essiccare morchie.
NL1016058A1 (nl) Kentekenplaathouder.
IT1310929B1 (it) Apparecchio distillatore automatico.
IT1304740B1 (it) Sistema di fissaggio di astine a fori di incernieramento dispostisulle lenti di occhiali.
IT1311502B1 (it) Feltro per feretri cosidetto feltrone.