DK1330455T3 - Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling - Google Patents

Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling

Info

Publication number: DK1330455T3
Authority: DK; Denmark
Prior art keywords: azaindoles; phosphodiesterase; inhibitors; preparation; new
Prior art date: 2000-10-27

Application number

DK01988718T

Other languages

Danish (da)

English (en)

Inventor

Norbert Hoefgen

Ute Egerland

Thomas Kronbach

Degenhard Marx

Stefan Szelenyi

Hildegard Kuss

Emmanuel Polymeropoulos

Original Assignee

Elbion Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-27

Filing date

2001-10-25

Publication date

2005-12-05

2000-10-27 Priority claimed from DE10053275A external-priority patent/DE10053275A1/de

2001-10-25 Application filed by Elbion Ag filed Critical Elbion Ag

2005-12-05 Application granted granted Critical

2005-12-05 Publication of DK1330455T3 publication Critical patent/DK1330455T3/da

Links

MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical class C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 title 1
MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Virology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
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DK01988718T 2000-10-27 2001-10-25 Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling DK1330455T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10053275A DE10053275A1 (de)	2000-10-27	2000-10-27	Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US24434200P	2000-10-30	2000-10-30

Publications (1)

Publication Number	Publication Date
DK1330455T3 true DK1330455T3 (da)	2005-12-05

Family

ID=26007507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01988718T DK1330455T3 (da)	2000-10-27	2001-10-25	Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling

Country Status (27)

Country	Link
US (3)	US7169787B2 (cs)
EP (1)	EP1330455B1 (cs)
JP (1)	JP4233322B2 (cs)
KR (2)	KR100837099B1 (cs)
CN (1)	CN1247576C (cs)
AR (1)	AR034269A1 (cs)
AT (1)	ATE301121T1 (cs)
AU (2)	AU2175302A (cs)
BG (1)	BG66169B1 (cs)
BR (1)	BR0114903A (cs)
CA (1)	CA2428468C (cs)
CZ (1)	CZ20031146A3 (cs)
DE (1)	DE50106993D1 (cs)
DK (1)	DK1330455T3 (cs)
EE (1)	EE05271B1 (cs)
ES (1)	ES2246349T3 (cs)
HR (1)	HRP20030427B1 (cs)
HU (1)	HUP0303034A3 (cs)
IL (2)	IL155386A0 (cs)
MX (1)	MXPA03003624A (cs)
NO (1)	NO324947B1 (cs)
NZ (1)	NZ525369A (cs)
PL (1)	PL213999B1 (cs)
PT (1)	PT1330455E (cs)
SK (1)	SK287774B6 (cs)
TW (1)	TWI262920B (cs)
WO (1)	WO2002034747A1 (cs)

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US20040014761A1 (en) *	1997-10-28	2004-01-22	Place Virgil A.	Treatment of female sexual dysfunction with phosphodiesterase inhibitors
KR20090048520A (ko) *	2002-11-06	2009-05-13	셀진 코포레이션	암 및 다른 질환의 치료 및 관리를 위한 선택적 시토킨 억제 약물의 사용 방법 및 그 조성물
DE10318610A1 (de) *	2003-04-24	2004-11-11	Elbion Ag	7-Azaindole und deren Verwendung als Therapeutika
US20050054691A1 (en) *	2003-08-29	2005-03-10	St. Jude Children's Research Hospital	Carboxylesterase inhibitors
MXPA06002853A (es) *	2003-09-11	2006-06-14	Kemia Inc	Inhibidores citoquina.
JP2008503446A (ja)	2004-05-06	2008-02-07	プレキシコン，インコーポレーテッド	Ｐｄｅ４ｂ阻害剤及びその使用
MY144903A (en)	2004-06-17	2011-11-30	Novartis Ag	Pyrrolopyridine derivatives and their use as crth2 antagonists
EP1786813A2 (en) *	2004-09-03	2007-05-23	Plexxikon, Inc.	Bicyclic heteroaryl pde4b inhibitors
ZA200804550B (en)	2005-11-09	2009-08-26	Combinatorx Inc	Methods, compositions, and kits for the treatment of medical conditions
GB0525143D0 (en)	2005-12-09	2006-01-18	Novartis Ag	Organic compounds
AU2007254179B2 (en)	2006-05-18	2013-03-21	Pharmacyclics Llc	Intracellular kinase inhibitors
US20100056791A1 (en) *	2006-09-01	2010-03-04	Yasushi Kohno	Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
US8012992B2 (en)	2008-06-30	2011-09-06	Allergan, Inc.	Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
US8252774B2 (en) *	2008-09-22	2012-08-28	Isis Innovation Ltd.	5-azaindole bisphosphonates
US8816085B2 (en) *	2009-08-26	2014-08-26	Takeda Gmbh	Methylpyrrolopyridinecarboxamides
WO2012072727A1 (en)	2010-12-03	2012-06-07	Biotie Therapies Gmbh	Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4
WO2012080329A1 (en)	2010-12-17	2012-06-21	Biotie Therapies Gmbh	Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide
CN102584842A (zh) *	2011-01-17	2012-07-18	北京大学	取代吲哚并内酰胺衍生物的制备及作为抗疟疾剂的用途
DK2888010T3 (da)	2012-08-22	2021-06-28	Univ Cornell	Fremgangsmåder til at hæmme fascin
WO2015127125A1 (en) *	2014-02-20	2015-08-27	Cornell University	Compounds and methods for inhibiting fascin
ES2987854T3 (es)	2018-10-12	2024-11-18	Board Of Regents Of Theuniversity Of Nebraska	Inhibidores de fosfodiesterasa
US12459938B2 (en)	2019-03-04	2025-11-04	Beth Israel Deaconess Medical Center, Inc.	ORAI channel inhibitors

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GB1141949A (en) *	1966-02-23	1969-02-05	Sterling Drug Inc	7-azaindole derivatives
FI922347L (fi)	1990-01-05	1992-05-22	Pfizer	Azaoxindolderivat.
US5023265A (en)	1990-06-01	1991-06-11	Schering Corporation	Substituted 1-H-pyrrolopyridine-3-carboxamides
US5811432A (en)	1990-11-09	1998-09-22	Pfizer Inc	Azaoxindole derivatives
ES2227519T3 (es)	1992-07-28	2005-04-01	Aventis Pharma Limited	Inhibidores de c-amp-fosfodiesterasa.
CA2140440A1 (en)	1992-08-06	1994-02-17	Ellen M. Dobrusin	2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties
JP3119758B2 (ja) *	1993-02-24	2000-12-25	日清製粉株式会社	７−アザインドール誘導体及びこれを有効成分とする抗潰瘍薬
WO1995028926A1 (en)	1994-04-21	1995-11-02	Schering Aktiengesellschaft	Pde iv inhibitors for treating multiple sclerosis
GB9420521D0 (en) *	1994-10-12	1994-11-30	Smithkline Beecham Plc	Novel compounds
GB9507297D0 (en)	1995-04-07	1995-05-31	Rh Ne Poulenc Rorer Limited	New composition of matter
JPH09169665A (ja)	1995-12-21	1997-06-30	Kenichi Miyamoto	骨粗鬆症治療剤
JP3601898B2 (ja)	1996-02-14	2004-12-15	俊隆鍋島	薬物依存形成抑制剤
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CA2366615A1 (en) *	1999-03-10	2000-09-14	Merck & Co., Inc.	6-azaindole compounds as antagonists of gonadotropin releasing hormone

2001
- 2001-10-24 TW TW090126313A patent/TWI262920B/zh not_active IP Right Cessation
- 2001-10-25 EE EEP200300166A patent/EE05271B1/xx not_active IP Right Cessation
- 2001-10-25 PL PL362837A patent/PL213999B1/pl not_active IP Right Cessation
- 2001-10-25 US US10/399,051 patent/US7169787B2/en not_active Expired - Fee Related
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- 2001-10-25 ES ES01988718T patent/ES2246349T3/es not_active Expired - Lifetime
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- 2001-10-25 DK DK01988718T patent/DK1330455T3/da active
- 2001-10-25 WO PCT/EP2001/012376 patent/WO2002034747A1/de not_active Ceased
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Also Published As

Publication number	Publication date
AU2175302A (en)	2002-05-06
NO20031722D0 (no)	2003-04-14
US20040106641A1 (en)	2004-06-03
HUP0303034A2 (hu)	2003-12-29
NZ525369A (en)	2004-09-24
KR100837099B1 (ko)	2008-06-13
CA2428468C (en)	2011-06-14
US20080207680A1 (en)	2008-08-28
BR0114903A (pt)	2003-10-14
CN1484644A (zh)	2004-03-24
EP1330455A1 (de)	2003-07-30
US7169787B2 (en)	2007-01-30
BG66169B1 (bg)	2011-10-31
PL213999B1 (pl)	2013-06-28
CA2428468A1 (en)	2002-05-02
MXPA03003624A (es)	2004-12-02
WO2002034747A1 (de)	2002-05-02
SK5092003A3 (en)	2004-08-03
SK287774B6 (sk)	2011-09-05
US7419987B2 (en)	2008-09-02
KR100880586B1 (ko)	2009-01-30
AU2002221753B2 (en)	2006-12-14
EE05271B1 (et)	2010-02-15
HUP0303034A3 (en)	2012-12-28
PL362837A1 (en)	2004-11-02
CZ20031146A3 (cs)	2003-10-15
HK1053839A1 (en)	2003-11-07
CN1247576C (zh)	2006-03-29
BG107725A (bg)	2004-08-31
JP2004512337A (ja)	2004-04-22
TWI262920B (en)	2006-10-01
US20060258700A1 (en)	2006-11-16
KR20030065499A (ko)	2003-08-06
AR034269A1 (es)	2004-02-18
HRP20030427B1 (en)	2006-04-30
EP1330455B1 (de)	2005-08-03
PT1330455E (pt)	2005-10-31
EE200300166A (et)	2003-08-15
IL155386A (en)	2008-06-05
DE50106993D1 (de)	2005-09-08
NO20031722L (no)	2003-04-14
NO324947B1 (no)	2008-01-07
IL155386A0 (en)	2003-11-23
ES2246349T3 (es)	2006-02-16
HRP20030427A2 (en)	2003-08-31
KR20080016758A (ko)	2008-02-21
ATE301121T1 (de)	2005-08-15
US7683074B2 (en)	2010-03-23
JP4233322B2 (ja)	2009-03-04

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