DK1330455T3 - Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling - Google Patents

Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling

Info

Publication number: DK1330455T3
Authority: DK; Denmark
Prior art keywords: azaindoles; phosphodiesterase; inhibitors; preparation; new
Prior art date: 2000-10-27

Application number

DK01988718T

Other languages

Danish (da)

English (en)

Inventor

Norbert Hoefgen

Ute Egerland

Thomas Kronbach

Degenhard Marx

Stefan Szelenyi

Hildegard Kuss

Emmanuel Polymeropoulos

Original Assignee

Elbion Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-27

Filing date

2001-10-25

Publication date

2005-12-05

2000-10-27 Priority claimed from DE10053275A external-priority patent/DE10053275A1/de

2001-10-25 Application filed by Elbion Ag filed Critical Elbion Ag

2005-12-05 Application granted granted Critical

2005-12-05 Publication of DK1330455T3 publication Critical patent/DK1330455T3/da

Links

MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical class C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 title 1
MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Animal Behavior & Ethology (AREA)
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General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
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Orthopedic Medicine & Surgery (AREA)
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DK01988718T 2000-10-27 2001-10-25 Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling DK1330455T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10053275A DE10053275A1 (de)	2000-10-27	2000-10-27	Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US24434200P	2000-10-30	2000-10-30

Publications (1)

Publication Number	Publication Date
DK1330455T3 true DK1330455T3 (da)	2005-12-05

Family

ID=26007507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01988718T DK1330455T3 (da)	2000-10-27	2001-10-25	Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling

Country Status (27)

Country	Link
US (3)	US7169787B2 (cs)
EP (1)	EP1330455B1 (cs)
JP (1)	JP4233322B2 (cs)
KR (2)	KR100837099B1 (cs)
CN (1)	CN1247576C (cs)
AR (1)	AR034269A1 (cs)
AT (1)	ATE301121T1 (cs)
AU (2)	AU2175302A (cs)
BG (1)	BG66169B1 (cs)
BR (1)	BR0114903A (cs)
CA (1)	CA2428468C (cs)
CZ (1)	CZ20031146A3 (cs)
DE (1)	DE50106993D1 (cs)
DK (1)	DK1330455T3 (cs)
EE (1)	EE05271B1 (cs)
ES (1)	ES2246349T3 (cs)
HR (1)	HRP20030427B1 (cs)
HU (1)	HUP0303034A3 (cs)
IL (2)	IL155386A0 (cs)
MX (1)	MXPA03003624A (cs)
NO (1)	NO324947B1 (cs)
NZ (1)	NZ525369A (cs)
PL (1)	PL213999B1 (cs)
PT (1)	PT1330455E (cs)
SK (1)	SK287774B6 (cs)
TW (1)	TWI262920B (cs)
WO (1)	WO2002034747A1 (cs)

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DE10318610A1 (de)	2003-04-24	2004-11-11	Elbion Ag	7-Azaindole und deren Verwendung als Therapeutika
US20050054691A1 (en) *	2003-08-29	2005-03-10	St. Jude Children's Research Hospital	Carboxylesterase inhibitors
SG146624A1 (en) *	2003-09-11	2008-10-30	Kemia Inc	Cytokine inhibitors
JP2008503446A (ja) *	2004-05-06	2008-02-07	プレキシコン，インコーポレーテッド	Ｐｄｅ４ｂ阻害剤及びその使用
MY144903A (en)	2004-06-17	2011-11-30	Novartis Ag	Pyrrolopyridine derivatives and their use as crth2 antagonists
CN101048407A (zh) *	2004-09-03	2007-10-03	普莱希科公司	双环杂芳基pde4b抑制剂
US8067433B2 (en)	2005-11-09	2011-11-29	Zalicus Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
GB0525143D0 (en)	2005-12-09	2006-01-18	Novartis Ag	Organic compounds
US8604031B2 (en)	2006-05-18	2013-12-10	Mannkind Corporation	Intracellular kinase inhibitors
US20100056791A1 (en) *	2006-09-01	2010-03-04	Yasushi Kohno	Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
US8012992B2 (en) *	2008-06-30	2011-09-06	Allergan, Inc.	Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
WO2010033981A2 (en) *	2008-09-22	2010-03-25	Isis Innovation Ltd.	5-azaindole bisphosphonates
JP2013503132A (ja) *	2009-08-26	2013-01-31	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	メチルピロロピリジンカルボキサミド
WO2012072727A1 (en) *	2010-12-03	2012-06-07	Biotie Therapies Gmbh	Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4
WO2012080329A1 (en)	2010-12-17	2012-06-21	Biotie Therapies Gmbh	Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide
CN102584842A (zh) *	2011-01-17	2012-07-18	北京大学	取代吲哚并内酰胺衍生物的制备及作为抗疟疾剂的用途
CA3139033A1 (en)	2012-08-22	2014-02-27	Cornell University	Methods for inhibiting fascin
WO2015127125A1 (en) *	2014-02-20	2015-08-27	Cornell University	Compounds and methods for inhibiting fascin
JP7598642B2 (ja)	2018-10-12	2024-12-12	ボードオブリージェンツオブザユニヴァーシティーオブネブラスカ	ホスホジエステラーゼ阻害剤
US12459938B2 (en)	2019-03-04	2025-11-04	Beth Israel Deaconess Medical Center, Inc.	ORAI channel inhibitors
CN120576911A (zh) *	2024-02-29	2025-09-02	歌尔科技有限公司	一种柔性压力传感器及头戴设备

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2001
- 2001-10-24 TW TW090126313A patent/TWI262920B/zh not_active IP Right Cessation
- 2001-10-25 BR BR0114903-2A patent/BR0114903A/pt not_active IP Right Cessation
- 2001-10-25 EP EP01988718A patent/EP1330455B1/de not_active Expired - Lifetime
- 2001-10-25 CN CNB018215351A patent/CN1247576C/zh not_active Expired - Fee Related
- 2001-10-25 IL IL15538601A patent/IL155386A0/xx active IP Right Grant
- 2001-10-25 DE DE50106993T patent/DE50106993D1/de not_active Expired - Lifetime
- 2001-10-25 PL PL362837A patent/PL213999B1/pl not_active IP Right Cessation
- 2001-10-25 AT AT01988718T patent/ATE301121T1/de active
- 2001-10-25 PT PT01988718T patent/PT1330455E/pt unknown
- 2001-10-25 WO PCT/EP2001/012376 patent/WO2002034747A1/de not_active Ceased
- 2001-10-25 SK SK509-2003A patent/SK287774B6/sk not_active IP Right Cessation
- 2001-10-25 KR KR1020037005801A patent/KR100837099B1/ko not_active Expired - Fee Related
- 2001-10-25 AU AU2175302A patent/AU2175302A/xx active Pending
- 2001-10-25 AU AU2002221753A patent/AU2002221753B2/en not_active Ceased
- 2001-10-25 JP JP2002537738A patent/JP4233322B2/ja not_active Expired - Fee Related
- 2001-10-25 HR HR20030427A patent/HRP20030427B1/xx not_active IP Right Cessation
- 2001-10-25 DK DK01988718T patent/DK1330455T3/da active
- 2001-10-25 CA CA2428468A patent/CA2428468C/en not_active Expired - Fee Related
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- 2001-10-25 EE EEP200300166A patent/EE05271B1/xx not_active IP Right Cessation
- 2001-10-25 MX MXPA03003624A patent/MXPA03003624A/es active IP Right Grant
- 2001-10-25 HU HU0303034A patent/HUP0303034A3/hu unknown
- 2001-10-25 US US10/399,051 patent/US7169787B2/en not_active Expired - Fee Related
- 2001-10-25 NZ NZ525369A patent/NZ525369A/en not_active IP Right Cessation
- 2001-10-25 KR KR1020087003517A patent/KR100880586B1/ko not_active Expired - Fee Related
- 2001-10-25 ES ES01988718T patent/ES2246349T3/es not_active Expired - Lifetime
- 2001-10-26 AR ARP010105014A patent/AR034269A1/es active IP Right Grant
2003
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- 2003-04-14 NO NO20031722A patent/NO324947B1/no not_active IP Right Cessation
- 2003-04-16 BG BG107725A patent/BG66169B1/bg unknown
2006
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2008
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Also Published As

Publication number	Publication date
BG66169B1 (bg)	2011-10-31
US20060258700A1 (en)	2006-11-16
NO324947B1 (no)	2008-01-07
AR034269A1 (es)	2004-02-18
HRP20030427A2 (en)	2003-08-31
IL155386A0 (en)	2003-11-23
CA2428468A1 (en)	2002-05-02
US7169787B2 (en)	2007-01-30
JP2004512337A (ja)	2004-04-22
CN1247576C (zh)	2006-03-29
IL155386A (en)	2008-06-05
PL213999B1 (pl)	2013-06-28
PT1330455E (pt)	2005-10-31
HUP0303034A3 (en)	2012-12-28
HUP0303034A2 (hu)	2003-12-29
MXPA03003624A (es)	2004-12-02
KR20030065499A (ko)	2003-08-06
WO2002034747A1 (de)	2002-05-02
US7419987B2 (en)	2008-09-02
BR0114903A (pt)	2003-10-14
KR100880586B1 (ko)	2009-01-30
US20040106641A1 (en)	2004-06-03
HRP20030427B1 (en)	2006-04-30
EP1330455A1 (de)	2003-07-30
ES2246349T3 (es)	2006-02-16
US20080207680A1 (en)	2008-08-28
ATE301121T1 (de)	2005-08-15
CN1484644A (zh)	2004-03-24
NO20031722L (no)	2003-04-14
SK5092003A3 (en)	2004-08-03
SK287774B6 (sk)	2011-09-05
US7683074B2 (en)	2010-03-23
DE50106993D1 (de)	2005-09-08
KR100837099B1 (ko)	2008-06-13
HK1053839A1 (en)	2003-11-07
EE200300166A (et)	2003-08-15
CZ20031146A3 (cs)	2003-10-15
BG107725A (bg)	2004-08-31
AU2002221753B2 (en)	2006-12-14
PL362837A1 (en)	2004-11-02
TWI262920B (en)	2006-10-01
EE05271B1 (et)	2010-02-15
NZ525369A (en)	2004-09-24
EP1330455B1 (de)	2005-08-03
CA2428468C (en)	2011-06-14
KR20080016758A (ko)	2008-02-21
JP4233322B2 (ja)	2009-03-04
AU2175302A (en)	2002-05-06
NO20031722D0 (no)	2003-04-14

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