NO20031722L - Nye 7-azaindoler, anvendelse av de samme som fosfodiesterase- 4-inhibitorerog fremgangsmåte for fremstilling av de samme - Google Patents

Nye 7-azaindoler, anvendelse av de samme som fosfodiesterase- 4-inhibitorerog fremgangsmåte for fremstilling av de samme

Info

Publication number: NO20031722L
Authority: NO; Norway
Prior art keywords: same; azaindoles; phosphodiesterase; inhibitors; preparing
Prior art date: 2000-10-27

Application number

NO20031722A

Other languages

English (en)

Other versions

NO324947B1 (no

NO20031722D0 (no

Inventor

Norbert Hoefgren

Ute Egerland

Thomas Kronbach

Degenhard Marx

Stefan Szelenyi

Hildegard Kuss

Emmanuel Polymeropoulos

Original Assignee

Elbion Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-27

Filing date

2003-04-14

Publication date

2003-04-14

2000-10-27 Priority claimed from DE10053275A external-priority patent/DE10053275A1/de

2003-04-14 Application filed by Elbion Ag filed Critical Elbion Ag

2003-04-14 Publication of NO20031722L publication Critical patent/NO20031722L/no

2003-04-14 Publication of NO20031722D0 publication Critical patent/NO20031722D0/no

2008-01-07 Publication of NO324947B1 publication Critical patent/NO324947B1/no

Links

MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical class C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 title 1
239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Hematology (AREA)
Transplantation (AREA)
Toxicology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)

NO20031722A 2000-10-27 2003-04-14 7-azaindoler,legemiddel inneholdende slike, anvendelser derav samt fremgangsmate for deres fremstilling NO324947B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10053275A DE10053275A1 (de)	2000-10-27	2000-10-27	Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US24434200P	2000-10-30	2000-10-30
PCT/EP2001/012376 WO2002034747A1 (de)	2000-10-27	2001-10-25	Neue 7-azaindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung

Publications (3)

Publication Number	Publication Date
NO20031722L true NO20031722L (no)	2003-04-14
NO20031722D0 NO20031722D0 (no)	2003-04-14
NO324947B1 NO324947B1 (no)	2008-01-07

Family

ID=26007507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031722A NO324947B1 (no)	2000-10-27	2003-04-14	7-azaindoler,legemiddel inneholdende slike, anvendelser derav samt fremgangsmate for deres fremstilling

Country Status (27)

Country	Link
US (3)	US7169787B2 (no)
EP (1)	EP1330455B1 (no)
JP (1)	JP4233322B2 (no)
KR (2)	KR100837099B1 (no)
CN (1)	CN1247576C (no)
AR (1)	AR034269A1 (no)
AT (1)	ATE301121T1 (no)
AU (2)	AU2175302A (no)
BG (1)	BG66169B1 (no)
BR (1)	BR0114903A (no)
CA (1)	CA2428468C (no)
CZ (1)	CZ20031146A3 (no)
DE (1)	DE50106993D1 (no)
DK (1)	DK1330455T3 (no)
EE (1)	EE05271B1 (no)
ES (1)	ES2246349T3 (no)
HR (1)	HRP20030427B1 (no)
HU (1)	HUP0303034A3 (no)
IL (2)	IL155386A0 (no)
MX (1)	MXPA03003624A (no)
NO (1)	NO324947B1 (no)
NZ (1)	NZ525369A (no)
PL (1)	PL213999B1 (no)
PT (1)	PT1330455E (no)
SK (1)	SK287774B6 (no)
TW (1)	TWI262920B (no)
WO (1)	WO2002034747A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040014761A1 (en) *	1997-10-28	2004-01-22	Place Virgil A.	Treatment of female sexual dysfunction with phosphodiesterase inhibitors
WO2004043378A2 (en) *	2002-11-06	2004-05-27	Celgene Corporation	Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
DE10318610A1 (de)	2003-04-24	2004-11-11	Elbion Ag	7-Azaindole und deren Verwendung als Therapeutika
US20050054691A1 (en) *	2003-08-29	2005-03-10	St. Jude Children's Research Hospital	Carboxylesterase inhibitors
SG146624A1 (en) *	2003-09-11	2008-10-30	Kemia Inc	Cytokine inhibitors
JP2008503446A (ja) *	2004-05-06	2008-02-07	プレキシコン，インコーポレーテッド	Ｐｄｅ４ｂ阻害剤及びその使用
MY144903A (en)	2004-06-17	2011-11-30	Novartis Ag	Pyrrolopyridine derivatives and their use as crth2 antagonists
CN101048407A (zh) *	2004-09-03	2007-10-03	普莱希科公司	双环杂芳基pde4b抑制剂
US8067433B2 (en)	2005-11-09	2011-11-29	Zalicus Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
GB0525143D0 (en)	2005-12-09	2006-01-18	Novartis Ag	Organic compounds
US8604031B2 (en)	2006-05-18	2013-12-10	Mannkind Corporation	Intracellular kinase inhibitors
US20100056791A1 (en) *	2006-09-01	2010-03-04	Yasushi Kohno	Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
US8012992B2 (en) *	2008-06-30	2011-09-06	Allergan, Inc.	Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
WO2010033981A2 (en) *	2008-09-22	2010-03-25	Isis Innovation Ltd.	5-azaindole bisphosphonates
JP2013503132A (ja) *	2009-08-26	2013-01-31	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	メチルピロロピリジンカルボキサミド
WO2012072727A1 (en) *	2010-12-03	2012-06-07	Biotie Therapies Gmbh	Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4
WO2012080329A1 (en)	2010-12-17	2012-06-21	Biotie Therapies Gmbh	Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide
CN102584842A (zh) *	2011-01-17	2012-07-18	北京大学	取代吲哚并内酰胺衍生物的制备及作为抗疟疾剂的用途
CA3139033A1 (en)	2012-08-22	2014-02-27	Cornell University	Methods for inhibiting fascin
WO2015127125A1 (en) *	2014-02-20	2015-08-27	Cornell University	Compounds and methods for inhibiting fascin
JP7598642B2 (ja)	2018-10-12	2024-12-12	ボードオブリージェンツオブザユニヴァーシティーオブネブラスカ	ホスホジエステラーゼ阻害剤
US12459938B2 (en)	2019-03-04	2025-11-04	Beth Israel Deaconess Medical Center, Inc.	ORAI channel inhibitors
CN120576911A (zh) *	2024-02-29	2025-09-02	歌尔科技有限公司	一种柔性压力传感器及头戴设备

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1141949A (en) *	1966-02-23	1969-02-05	Sterling Drug Inc	7-azaindole derivatives
WO1991009598A1 (en)	1990-01-05	1991-07-11	Pfizer Inc.	Azaoxindole derivatives
US5023265A (en) *	1990-06-01	1991-06-11	Schering Corporation	Substituted 1-H-pyrrolopyridine-3-carboxamides
US5811432A (en) *	1990-11-09	1998-09-22	Pfizer Inc	Azaoxindole derivatives
IL106517A0 (en)	1992-07-28	1994-08-26	Rhone Poulenc Rorer Ltd	Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group
EP0654024A1 (en)	1992-08-06	1995-05-24	Warner-Lambert Company	2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties
JP3119758B2 (ja) *	1993-02-24	2000-12-25	日清製粉株式会社	７−アザインドール誘導体及びこれを有効成分とする抗潰瘍薬
DE69532238T2 (de)	1994-04-21	2004-10-21	Schering Ag	Pde iv-inhibitoren zur behandlung der multiplen sklerose
GB9420521D0 (en) *	1994-10-12	1994-11-30	Smithkline Beecham Plc	Novel compounds
GB9507297D0 (en)	1995-04-07	1995-05-31	Rh Ne Poulenc Rorer Limited	New composition of matter
JPH09169665A (ja)	1995-12-21	1997-06-30	Kenichi Miyamoto	骨粗鬆症治療剤
JP3601898B2 (ja)	1996-02-14	2004-12-15	俊隆鍋島	薬物依存形成抑制剤
AUPO282996A0 (en) *	1996-10-07	1996-10-31	Fujisawa Pharmaceutical Co., Ltd.	Novel compounds
EP1161431A4 (en) *	1999-03-10	2002-04-24	Merck & Co Inc	6-AZAINDOL COMPOUNDS AS AN ANTAGONISTS OF THE GONADOTROPIN RELEASE HORMONES

2001
- 2001-10-24 TW TW090126313A patent/TWI262920B/zh not_active IP Right Cessation
- 2001-10-25 BR BR0114903-2A patent/BR0114903A/pt not_active IP Right Cessation
- 2001-10-25 EP EP01988718A patent/EP1330455B1/de not_active Expired - Lifetime
- 2001-10-25 CN CNB018215351A patent/CN1247576C/zh not_active Expired - Fee Related
- 2001-10-25 IL IL15538601A patent/IL155386A0/xx active IP Right Grant
- 2001-10-25 DE DE50106993T patent/DE50106993D1/de not_active Expired - Lifetime
- 2001-10-25 PL PL362837A patent/PL213999B1/pl not_active IP Right Cessation
- 2001-10-25 AT AT01988718T patent/ATE301121T1/de active
- 2001-10-25 PT PT01988718T patent/PT1330455E/pt unknown
- 2001-10-25 WO PCT/EP2001/012376 patent/WO2002034747A1/de not_active Ceased
- 2001-10-25 SK SK509-2003A patent/SK287774B6/sk not_active IP Right Cessation
- 2001-10-25 KR KR1020037005801A patent/KR100837099B1/ko not_active Expired - Fee Related
- 2001-10-25 AU AU2175302A patent/AU2175302A/xx active Pending
- 2001-10-25 AU AU2002221753A patent/AU2002221753B2/en not_active Ceased
- 2001-10-25 JP JP2002537738A patent/JP4233322B2/ja not_active Expired - Fee Related
- 2001-10-25 HR HR20030427A patent/HRP20030427B1/xx not_active IP Right Cessation
- 2001-10-25 DK DK01988718T patent/DK1330455T3/da active
- 2001-10-25 CA CA2428468A patent/CA2428468C/en not_active Expired - Fee Related
- 2001-10-25 CZ CZ20031146A patent/CZ20031146A3/cs unknown
- 2001-10-25 EE EEP200300166A patent/EE05271B1/xx not_active IP Right Cessation
- 2001-10-25 MX MXPA03003624A patent/MXPA03003624A/es active IP Right Grant
- 2001-10-25 HU HU0303034A patent/HUP0303034A3/hu unknown
- 2001-10-25 US US10/399,051 patent/US7169787B2/en not_active Expired - Fee Related
- 2001-10-25 NZ NZ525369A patent/NZ525369A/en not_active IP Right Cessation
- 2001-10-25 KR KR1020087003517A patent/KR100880586B1/ko not_active Expired - Fee Related
- 2001-10-25 ES ES01988718T patent/ES2246349T3/es not_active Expired - Lifetime
- 2001-10-26 AR ARP010105014A patent/AR034269A1/es active IP Right Grant
2003
- 2003-04-10 IL IL155386A patent/IL155386A/en not_active IP Right Cessation
- 2003-04-14 NO NO20031722A patent/NO324947B1/no not_active IP Right Cessation
- 2003-04-16 BG BG107725A patent/BG66169B1/bg unknown
2006
- 2006-01-10 US US11/329,400 patent/US7419987B2/en not_active Expired - Fee Related
2008
- 2008-03-10 US US12/075,312 patent/US7683074B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BG66169B1 (bg)	2011-10-31
US20060258700A1 (en)	2006-11-16
NO324947B1 (no)	2008-01-07
AR034269A1 (es)	2004-02-18
HRP20030427A2 (en)	2003-08-31
DK1330455T3 (da)	2005-12-05
IL155386A0 (en)	2003-11-23
CA2428468A1 (en)	2002-05-02
US7169787B2 (en)	2007-01-30
JP2004512337A (ja)	2004-04-22
CN1247576C (zh)	2006-03-29
IL155386A (en)	2008-06-05
PL213999B1 (pl)	2013-06-28
PT1330455E (pt)	2005-10-31
HUP0303034A3 (en)	2012-12-28
HUP0303034A2 (hu)	2003-12-29
MXPA03003624A (es)	2004-12-02
KR20030065499A (ko)	2003-08-06
WO2002034747A1 (de)	2002-05-02
US7419987B2 (en)	2008-09-02
BR0114903A (pt)	2003-10-14
KR100880586B1 (ko)	2009-01-30
US20040106641A1 (en)	2004-06-03
HRP20030427B1 (en)	2006-04-30
EP1330455A1 (de)	2003-07-30
ES2246349T3 (es)	2006-02-16
US20080207680A1 (en)	2008-08-28
ATE301121T1 (de)	2005-08-15
CN1484644A (zh)	2004-03-24
SK5092003A3 (en)	2004-08-03
SK287774B6 (sk)	2011-09-05
US7683074B2 (en)	2010-03-23
DE50106993D1 (de)	2005-09-08
KR100837099B1 (ko)	2008-06-13
HK1053839A1 (en)	2003-11-07
EE200300166A (et)	2003-08-15
CZ20031146A3 (cs)	2003-10-15
BG107725A (bg)	2004-08-31
AU2002221753B2 (en)	2006-12-14
PL362837A1 (en)	2004-11-02
TWI262920B (en)	2006-10-01
EE05271B1 (et)	2010-02-15
NZ525369A (en)	2004-09-24
EP1330455B1 (de)	2005-08-03
CA2428468C (en)	2011-06-14
KR20080016758A (ko)	2008-02-21
JP4233322B2 (ja)	2009-03-04
AU2175302A (en)	2002-05-06
NO20031722D0 (no)	2003-04-14

Legal Events

Date	Code	Title	Description
2014-05-26	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20031722D0 (no)	2003-04-14	Nye 7-azaindoler, anvendelse av de samme som fosfodiesterase- 4-inhibitorerog fremgangsmåte for fremstilling av de samme
DK1399444T3 (da)	2007-06-04	Nye heterocycliske forbindelser, fremgangsmåde til fremstilling af samme samt anvendelse deraf som lægemidler, især som antibakterielle midler
LTPA2014013I1 (lt)	2014-04-25	Fenilpiperazino dariniai, kaip serotonino grįžtamos absorbcijos inhibitoriai
NO20014960D0 (no)	2001-10-12	Nye fremgangsmåter for behandling
NO20043174L (no)	2004-07-26	Pyrido[2,1-a]isokinolinderivater som DPP-IV inhibitorer
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
ZA200505522B (en)	2007-11-28	Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the faah enzyme
NO20012156L (no)	2001-07-02	Pyrazolopyridinderivater som selektive COX-2 inhibitorer
NO20021239L (no)	2002-03-13	Pteridinoner som kinase-inhibitorer
IT1317757B1 (it)	2003-07-15	Metodo per la preparazione di idrocarburi idrogenati.
ATE371647T1 (de)	2007-09-15	3-cyanochinoline, 3-cyano-1,6-naphthyridine und 3-cyano-1,7-naphthyridine als protein- kinaseinhibitoren
NO20051957L (no)	2005-10-06	Ny fremgangsmate for fremstillingen av roflumilast
NO20031672D0 (no)	2003-04-11	Aza- og polyaza-naftalenylkarboksamider for anvendelse som HIV-integraseinhibitorer
AP2005003452A0 (en)	2005-12-31	Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors.
PL364580A1 (en)	2004-12-13	Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
NO20054006D0 (no)	2005-08-29	Cykliske ureaderivater, fremstillingsfremgangsmate derav og farmasoytisk anvendelse av samme som kinaseinhibitorer
DK1104420T3 (da)	2003-01-13	Substituerede 1,8-naphthyridin-4(1H)-oner som phosphodiesterase-4-inhibitorer
NO20033618L (no)	2003-10-15	Ftalayinon-piperidino-derivater som PDE-4-inhibitorer
AU2002221753A1 (en)	2002-07-11	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
DK1226143T3 (da)	2003-06-30	Imidazopyridinderivater som phosphodiesterase VII-inhibitorer
NO20030842D0 (no)	2003-02-24	Fenoksybenzylamin-derivater som selektive serotonin- gjenopptaksinhibitorer
DK1534707T5 (da)	2010-01-11	Substituerede 2,4-dihydropyrrolo[3,4-b]quinolin-9-on-derivater egnede som phosphodiesteraseinhibitorer
NO20021959L (no)	2002-05-29	Tetrahydrotiopyranftalazinon-derivater som PDE4-inhibitorer
NO20022123D0 (no)	2002-05-03	Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
NO20020308D0 (no)	2002-01-21	Fremgangsmåte for fremstilling av epothiolon B og derivater, såvel som mellomprodukter for fremgangsmåten