DK1341533T3 - Synergistiske kombinationer omfattende en renininhibitor til cardiovaskulære sygdomme - Google Patents

Synergistiske kombinationer omfattende en renininhibitor til cardiovaskulære sygdomme

Info

Publication number: DK1341533T3
Authority: DK; Denmark
Prior art keywords: renin inhibitor; cardiovascular disease; synergistic combinations; pharmaceutically acceptable; acceptable salt
Prior art date: 2000-11-17

Application number

DK01996377T

Other languages

Danish (da)

English (en)

Inventor

William Hewitt

Daniel Lucius Vasella

Randy Lee Webb

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-17

Filing date

2001-11-15

Publication date

2006-05-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9903412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1341533(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-11-15 Application filed by Novartis Ag filed Critical Novartis Ag

2006-05-08 Application granted granted Critical

2006-05-08 Publication of DK1341533T3 publication Critical patent/DK1341533T3/da

Links

239000002461 renin inhibitor Substances 0.000 title abstract 2
229940086526 renin-inhibitors Drugs 0.000 title abstract 2
208000024172 Cardiovascular disease Diseases 0.000 title 1
239000011885 synergistic combination Substances 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 abstract 1
229960004601 aliskiren Drugs 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
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- A61P7/10—Antioedematous agents; Diuretics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Biomedical Technology (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

DK01996377T 2000-11-17 2001-11-15 Synergistiske kombinationer omfattende en renininhibitor til cardiovaskulære sygdomme DK1341533T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB0028151A GB0028151D0 (en)	2000-11-17	2000-11-17	Combination of organic compounds

Publications (1)

Publication Number	Publication Date
DK1341533T3 true DK1341533T3 (da)	2006-05-08

Family

ID=9903412

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK01996377T DK1341533T3 (da)	2000-11-17	2001-11-15	Synergistiske kombinationer omfattende en renininhibitor til cardiovaskulære sygdomme
DK08002401T DK1915993T3 (da)	2000-11-17	2001-11-15	Synergistiske kombinationer omfattende en renininhibitor til hjertekarsygdomme
DK05015603T DK1602370T3 (da)	2000-11-17	2001-11-15	Synergistiske kombinationer omfattende en renininhibitor til hjerte-kredslöbs-sygdomme

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK08002401T DK1915993T3 (da)	2000-11-17	2001-11-15	Synergistiske kombinationer omfattende en renininhibitor til hjertekarsygdomme
DK05015603T DK1602370T3 (da)	2000-11-17	2001-11-15	Synergistiske kombinationer omfattende en renininhibitor til hjerte-kredslöbs-sygdomme

Country Status (31)

Country	Link
US (4)	US8168616B1 (pt)
EP (7)	EP1602370B1 (pt)
JP (6)	JP2004513920A (pt)
KR (6)	KR20030051753A (pt)
CN (4)	CN100404024C (pt)
AT (2)	ATE317692T1 (pt)
AU (2)	AU2002223680B2 (pt)
BR (1)	BR0115411A (pt)
CA (2)	CA2428647A1 (pt)
CY (5)	CY1105603T1 (pt)
CZ (2)	CZ299749B6 (pt)
DE (3)	DE60134349D1 (pt)
DK (3)	DK1341533T3 (pt)
EC (1)	ECSP034603A (pt)
ES (4)	ES2429292T3 (pt)
GB (1)	GB0028151D0 (pt)
HU (2)	HU230882B1 (pt)
IL (3)	IL155707A (pt)
LU (2)	LU91563I2 (pt)
MX (1)	MXPA03004358A (pt)
NL (2)	NL300385I1 (pt)
NO (2)	NO334002B1 (pt)
NZ (6)	NZ537691A (pt)
PL (3)	PL400915A1 (pt)
PT (3)	PT1341533E (pt)
RU (2)	RU2310443C2 (pt)
SG (1)	SG135969A1 (pt)
SI (3)	SI1915993T1 (pt)
SK (1)	SK287881B6 (pt)
WO (1)	WO2002040007A1 (pt)
ZA (1)	ZA200303497B (pt)

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2000
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Also Published As

Publication number	Publication date
RU2310443C2 (ru)	2007-11-20
DE122009000021I1 (de)	2009-08-06
JP2017019876A (ja)	2017-01-26
NO334002B1 (no)	2013-11-11
HK1059212A1 (en)	2004-06-25
SK5842003A3 (en)	2003-11-04
KR101258365B1 (ko)	2013-04-30
DK1915993T3 (da)	2013-10-14
SI1341533T1 (sl)	2006-08-31
CY1105603T1 (el)	2010-07-28
NO20032233L (no)	2003-05-16
US8168616B1 (en)	2012-05-01
SI1915993T1 (sl)	2013-10-30
EP2305231A1 (en)	2011-04-06
RU2346703C2 (ru)	2009-02-20
JP6603757B2 (ja)	2019-11-06
KR20030051753A (ko)	2003-06-25
EP1602370A3 (en)	2005-12-14
IL217847A0 (en)	2012-03-29
HU1400409D0 (hu)	2003-09-29
MXPA03004358A (es)	2003-08-19
CZ299749B6 (cs)	2008-11-12
NZ525795A (en)	2005-03-24
PL361404A1 (en)	2004-10-04
EP1602370A2 (en)	2005-12-07
JP2018030894A (ja)	2018-03-01
HUP0301841A2 (hu)	2003-09-29
DE60117295D1 (de)	2006-04-20
CN1474690A (zh)	2004-02-11
IL155707A0 (en)	2003-11-23
US9023893B2 (en)	2015-05-05
KR20080011355A (ko)	2008-02-01
CY2013045I2 (el)	2015-11-04
US20120010295A1 (en)	2012-01-12
NL301005I2 (nl)	2019-10-29
LU92315I2 (fr)	2014-01-27
ATE317692T1 (de)	2006-03-15
SI1602370T1 (sl)	2008-10-31
KR20080096715A (ko)	2008-10-31
CA2763223A1 (en)	2002-05-23
EP1930000A1 (en)	2008-06-11
DK1602370T3 (da)	2008-09-22
ECSP034603A (es)	2003-06-25
ES2308347T3 (es)	2008-12-01
EP2305233A1 (en)	2011-04-06
PT1602370E (pt)	2008-09-10
ATE397445T1 (de)	2008-06-15
IL212075A (en)	2013-08-29
IL155707A (en)	2012-02-29
CA2428647A1 (en)	2002-05-23
IL212075A0 (en)	2011-06-30
NZ550897A (en)	2008-03-28
KR20110063596A (ko)	2011-06-10
NL300385I1 (nl)	2009-07-01
CZ305341B6 (cs)	2015-08-05
NZ550896A (en)	2008-06-30
PT1915993E (pt)	2013-10-14
US8618174B2 (en)	2013-12-31
BR0115411A (pt)	2004-08-17
WO2002040007A1 (en)	2002-05-23
KR20100114904A (ko)	2010-10-26
JP2018131465A (ja)	2018-08-23
RU2006132668A (ru)	2008-03-20
NZ537691A (en)	2007-01-26
NO2013019I2 (no)	2013-12-17
JP2004513920A (ja)	2004-05-13
EP1341533A1 (en)	2003-09-10
PL400915A1 (pl)	2012-12-17
AU2002223680B2 (en)	2005-04-07
CY1108305T1 (el)	2012-01-25
JP2013213061A (ja)	2013-10-17
NL301005I1 (pt)	2019-09-10
NZ550898A (en)	2008-07-31
CN101091703A (zh)	2007-12-26
US9023894B2 (en)	2015-05-05
US20120016035A1 (en)	2012-01-19
NO2013019I1 (no)	2014-06-02
KR20080097488A (ko)	2008-11-05
GB0028151D0 (en)	2001-01-03
CY2009005I2 (el)	2012-01-25
JP6373931B2 (ja)	2018-08-15
EP2305232B1 (en)	2019-07-17
JP6089278B2 (ja)	2017-03-08
DE60134349D1 (de)	2008-07-17
ZA200303497B (en)	2004-04-28
ES2429292T3 (es)	2013-11-14
EP1341533B1 (en)	2006-02-15
PL227576B1 (pl)	2017-12-29
CY2009005I1 (el)	2012-01-25
US20120004312A1 (en)	2012-01-05
ES2734523T3 (es)	2019-12-10
CN101264073A (zh)	2008-09-17
HUP0301841A3 (en)	2010-07-28
HU230882B1 (hu)	2018-11-29
HK1115544A1 (en)	2008-12-05
HK1089356A1 (en)	2006-12-01
CY1114829T1 (el)	2015-11-04
KR101008752B1 (ko)	2011-01-14
DE60117295T2 (de)	2006-08-17
ES2256335T3 (es)	2006-07-16
JP2009235107A (ja)	2009-10-15
EP2305232A1 (en)	2011-04-06
CY2013045I1 (el)	2015-11-04
CN100404024C (zh)	2008-07-23
EP1602370B1 (en)	2008-06-04
SK287881B6 (sk)	2012-02-03
EP1915993B1 (en)	2013-07-10
CN101264072A (zh)	2008-09-17
PT1341533E (pt)	2006-06-30
NO20032233D0 (no)	2003-05-16
JP6577994B2 (ja)	2019-09-18
PL400914A1 (pl)	2012-12-17
AU2368002A (en)	2002-05-27
LU91563I2 (fr)	2009-07-06
SG135969A1 (en)	2007-10-29
NZ568764A (en)	2009-11-27
EP1915993A1 (en)	2008-04-30

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