DK1343492T3 - Behandling af mucositis - Google Patents

Behandling af mucositis

Info

Publication number
DK1343492T3
DK1343492T3 DK01987093T DK01987093T DK1343492T3 DK 1343492 T3 DK1343492 T3 DK 1343492T3 DK 01987093 T DK01987093 T DK 01987093T DK 01987093 T DK01987093 T DK 01987093T DK 1343492 T3 DK1343492 T3 DK 1343492T3
Authority
DK
Denmark
Prior art keywords
mucositis
treatment
therapeutic composition
treating
biocompatible
Prior art date
Application number
DK01987093T
Other languages
English (en)
Inventor
Timothy C Rodell
Wren H Schauer
Adrian Samaniego
Gary J Rosenthal
Jeffrey B Etter
Original Assignee
Rxkinetix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rxkinetix Inc filed Critical Rxkinetix Inc
Application granted granted Critical
Publication of DK1343492T3 publication Critical patent/DK1343492T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
DK01987093T 2000-11-22 2001-11-21 Behandling af mucositis DK1343492T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72151600A 2000-11-22 2000-11-22

Publications (1)

Publication Number Publication Date
DK1343492T3 true DK1343492T3 (da) 2006-03-06

Family

ID=24898290

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01987093T DK1343492T3 (da) 2000-11-22 2001-11-21 Behandling af mucositis

Country Status (11)

Country Link
US (5) US6685917B2 (da)
EP (2) EP1343492B1 (da)
JP (1) JP4822652B2 (da)
AT (1) ATE316786T1 (da)
AU (1) AU2002239342A1 (da)
BR (1) BRPI0115531B1 (da)
DE (1) DE60117043T2 (da)
DK (1) DK1343492T3 (da)
ES (1) ES2254523T3 (da)
MX (1) MXPA03004546A (da)
WO (1) WO2002041837A2 (da)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
EP1343492B1 (en) * 2000-11-22 2006-02-01 Rxkinetix, Inc. Treatment of mucositis
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
EP1383527A4 (en) * 2001-04-24 2004-07-14 Gen Hospital Corp METHOD AND COMPOSITIONS FOR TREATING ORAL AND EYE EYE LESIONS
US7538082B2 (en) * 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
AU2002334886B2 (en) * 2001-10-05 2008-07-31 The General Hospital Corporation Methods and compositions for treating dermal lesions
US6620405B2 (en) * 2001-11-01 2003-09-16 3M Innovative Properties Company Delivery of hydrogel compositions as a fine mist
CA2480372A1 (en) * 2002-03-26 2003-10-09 The General Hospital Corporation Combination therapy using trefoil peptides
FR2837709B1 (fr) * 2002-03-26 2005-05-13 Innovations Pharma Ag Composition thermoreversible destinee a compenser les hyposialies et asialies provoquees par les xerostomies
US20060275370A1 (en) * 2002-07-25 2006-12-07 Yih-Lin Chung Method and compositions for treatment of epithelial damage
US20040057983A1 (en) 2002-09-25 2004-03-25 David Schmidt Biomolecular wearable apparatus
KR20040028336A (ko) * 2002-09-30 2004-04-03 김종국 신규한 질내 투여용 항균 온도감응성 겔 조성물
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
JP4493594B2 (ja) * 2003-03-04 2010-06-30 田辺三菱製薬株式会社 粉末経鼻投与製剤
US20040198841A1 (en) * 2003-03-13 2004-10-07 Oregon Health & Science University Use of thiol-based compositions in ameliorating mucosal injury
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
US6984628B2 (en) 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
WO2005039318A1 (en) * 2003-10-16 2005-05-06 Nestec S.A. Nutritional composition against side effects of chemotherapy of radiotherapy
US20050090551A1 (en) * 2003-10-27 2005-04-28 Board Of Trustees Of Southern Illinois University Therapeutic use of methionine for the treatment or prevention of mucositis
US20070003582A1 (en) * 2003-11-25 2007-01-04 Heng Madalene C Medicine for the treatment of acne and for reversing the signs of age and sun damage and method for using same
SI1708722T1 (sl) 2004-01-28 2014-10-30 The Regents Of The University Of California Nova intersticijska terapija za takojšnje simptome sprostitve in kronična terapija pri intersticijskem cistitisu
US7901707B2 (en) * 2004-03-15 2011-03-08 Christine Allen Biodegradable biocompatible implant and method of manufacturing same
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
ES2372499T3 (es) 2004-05-19 2012-01-20 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Uso de un detergente para la eliminación no quirúrgica de grasa.
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
BRPI0608154A2 (pt) * 2005-02-16 2016-10-11 Wyeth Corp métodos de tratar ou inibir mucosite, cistite por radiação em um indivíduo, e de tratar pelo menos um sintoma de exposição de um indivíduo a um agente citotóxico ou à radiação, e, composição farmacêutica
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
JP4732784B2 (ja) * 2005-04-21 2011-07-27 興和株式会社 パンテノール含有口腔内粘膜付着製剤
JP5032003B2 (ja) * 2005-06-15 2012-09-26 株式会社琉球バイオリソース開発 口腔粘膜用の鎮痛・抗炎症トローチ剤
CA2615319A1 (en) * 2005-07-13 2007-01-18 Al Czap Compositions for oral administration of sustained release glutathione, methods for their production and uses thereof
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
PT1965787E (pt) * 2005-11-30 2013-07-05 Endo Pharmaceuticals Inc Tratamento de xerostomia com um antioxidante que contém enxofre
CA2646486A1 (en) * 2006-03-23 2007-09-27 Citagenix Inc. Reverse phase osteoconductive composition
EP2918276A1 (en) * 2006-05-30 2015-09-16 Orahealth Corporation Cobalamin compositions and methods for treating or preventing mucositis
PT2035006E (pt) 2006-06-01 2010-04-22 Nobera Pharma Sl Utilização de alopurinol para o tratamento da eritrodisestesia palmo-plantar
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
EP2203152A4 (en) * 2007-10-03 2011-05-25 Myrex Pharmaceuticals Inc MOUTH BATH AND METHOD OF USING SAME FOR TREATING A MUCITE OR STOMATITIS
WO2009053892A1 (en) * 2007-10-22 2009-04-30 Koninklijke Philips Electronics, N.V. Interproximal teeth cleaning apparatus with an air-driven spray
CN101156834B (zh) * 2007-10-30 2010-08-11 深圳南粤药业有限公司 氨来呫诺温度敏感型凝胶及其制备方法
US20090131386A1 (en) * 2007-11-13 2009-05-21 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20090123551A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Gastrointestinal delivery systems
DK3354276T3 (da) 2007-11-13 2020-03-30 Meritage Pharma Inc Sammensætninger til behandlingen af gastrointestinal inflammation
US20090148530A1 (en) 2007-12-08 2009-06-11 Jamie Koufman Method for prevention and treatment of reflux injury in the aerodigestive tract and laryngopharynx caused by pepsin
WO2009111173A2 (en) * 2008-02-29 2009-09-11 Pluromed, Inc. Local embolization via heating of thermosensitive polymers
JP5836592B2 (ja) * 2008-02-29 2015-12-24 プルーロームド インコーポレイテッドＰｌｕｒｏｍｅｄ， Ｉｎｃ． 感熱性ポリマーを使用する局所塞栓
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
US8602961B2 (en) * 2008-05-15 2013-12-10 Lifewave Products Llc Apparatus and method of stimulating elevation of glutathione levels in a subject
US20100204286A1 (en) 2009-02-12 2010-08-12 Donahue Stephen R Method for reducing gastrointestinal adverse effects of cytotoxic agents
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
EP2246057A1 (en) * 2009-04-29 2010-11-03 Nobera Pharma, S.L. Use of allopurinol for the treatment of hand foot skin reaction
JP2012526840A (ja) * 2009-05-13 2012-11-01 プロテイン デリヴァリー ソリューションズ エルエルシー 膜貫通送達のための製剤系
WO2011094504A2 (en) * 2010-01-28 2011-08-04 Ora, Inc. Antimicrobial sinus irrigation compositions, methods, and devices
US10080718B2 (en) 2010-09-01 2018-09-25 Try This First, Inc. Method of treating ear infections
US12016950B2 (en) 2010-09-01 2024-06-25 Try This First, Inc. Devices and methods for treating ear pain
IT1401895B1 (it) 2010-10-18 2013-08-28 Straccia Presidio farmacologico naturale per la prevenzione delle malattie infiammatorie del parodonto.
IT1401894B1 (it) 2010-10-18 2013-08-28 Straccia Presidio farmacologico per la prevenzione della lesione cariosa incipiente e dell' ipersensibilita' dentinale
IT1405758B1 (it) * 2010-11-03 2014-01-24 Stewart Italia Srl Preparazione farmaceutica a base nac in soluzione ipertonica per il trattamento di affezioni rinofaringee
JP2012116818A (ja) * 2010-12-03 2012-06-21 Feng Chia Univ 泌尿器系疾患を治療する医薬組成物
CA2827643C (en) 2011-02-18 2019-05-07 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
FR2972327B1 (fr) * 2011-03-11 2017-08-11 Laboratoires Le Stum Composition nutraceutique mucoadhesive comprenant une association d'antioxydants
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
ES2857252T3 (es) 2011-04-29 2021-09-28 Moberg Pharma Ab Composiciones farmacéuticas que comprenden un anestésico local tal como bupivacaína para administración local en la boca o la garganta
ITMI20110954A1 (it) * 2011-05-26 2012-11-27 Professional Dietetics Srl Combinazioni per il trattamento delle mucositi vaginali o rettali
ITMI20111151A1 (it) * 2011-06-24 2012-12-25 Lo Li Pharma Srl N-acetil cisteina e sua composizione per uso nel trattamento di patologie vaginali.
FI20115680A7 (fi) * 2011-06-29 2012-12-30 Biohit Oyj Nestemäisiä farmaseuttisia koostumuksia tai yhdistelmätuotteita
US20130177599A1 (en) * 2012-01-06 2013-07-11 Insite Vision Incorporated Methods and kits for extending contact lens use
JP2013170156A (ja) * 2012-02-22 2013-09-02 Terumo Corp 固形組成物
EP2852571A4 (en) * 2012-05-23 2015-11-25 Cellix Bio Private Ltd COMPOSITIONS AND METHOD FOR THE TREATMENT OF MUCOSITIS
KR101320945B1 (ko) * 2012-07-03 2013-10-23 주식회사파마킹 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제
KR101423631B1 (ko) * 2012-08-17 2014-07-25 주식회사파마킹 에스-알릴엘-시스테인을 유효성분으로 포함하는 안질환 예방 또는 치료용 조성물 및 이를 포함하는 의약제제
CN103027891A (zh) * 2012-11-25 2013-04-10 天津坤健生物制药有限公司 用于治疗口腔溃疡的乙酰半胱氨酸含漱液及制备方法
CN105392478A (zh) * 2013-07-31 2016-03-09 味之素株式会社 癌症化学疗法时的副作用降低剂
US9457011B2 (en) * 2014-02-25 2016-10-04 Muslim D. Shahid Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor
WO2015143310A1 (en) 2014-03-21 2015-09-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
US20180050019A1 (en) * 2015-03-06 2018-02-22 Repoceuticals Aps Melatonin for Preventing and Treating Radiation Vaginitis and Proctitis
US20180055822A1 (en) * 2015-03-13 2018-03-01 Repoceuticals Aps Melatonin for Preventing and Treating Radiation Cystitis
MY187022A (en) * 2015-05-14 2021-08-26 Professional Dietetics Spa Compositions comprising amino acids for use in the treatment of mucositides in neoplasia patients undergoing radiation therapy and/or chemotherapy
CN108135967B (zh) 2015-08-05 2022-06-28 儿童医学中心公司 用于药物递送的具有渗透增强剂的组合物
CN105380957A (zh) * 2015-12-04 2016-03-09 天津坤健生物制药有限公司 一种乙酰半胱氨酸凝胶剂及制备方法与应用
US10239847B1 (en) 2016-03-03 2019-03-26 Cellactin Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione
US10973773B2 (en) * 2016-09-13 2021-04-13 Tiziana Life Sciences Plc Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
EP3512501A4 (en) * 2016-09-14 2020-04-29 Children's Medical Center Corporation COMPOSITIONS WITH PERMEATION CONVEYORS FOR RELEASE OF THE ACTIVE SUBSTANCE
EP3330251A1 (en) * 2016-11-30 2018-06-06 Clevexel Pharma Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol
EP4252842B1 (en) * 2017-03-02 2025-06-25 University of Pittsburgh- Of the Commonwealth System of Higher Education Ecm hydrogel for treating esophageal inflammation
EP3628314B1 (en) * 2017-04-19 2023-07-26 Otsuka Pharmaceutical Factory, Inc. Olanexidine as anti-inflammatory agent
IT201700124424A1 (it) * 2017-10-31 2019-05-01 Sofar Swiss Sa Compressa da succhiare e/o sciogliere in bocca a base di acido ialuronico e condroitina solfato e loro sali
WO2019124605A1 (ko) * 2017-12-22 2019-06-27 경상대학교병원 알파리포산을 유효성분으로 함유하는 구강염 예방 또는 치료용 약학 조성물
WO2019124609A1 (ko) * 2017-12-22 2019-06-27 경상대학교병원 알파리포산을 유효성분으로 함유하는 침샘염 예방 또는 치료용 약학 조성물
EP3834887A1 (en) * 2019-12-12 2021-06-16 Koninklijke Philips N.V. Topical oral composition
WO2022040584A1 (en) * 2020-08-21 2022-02-24 Neuronasal, Inc. Methods of administering glutathione precursors
JP7544345B2 (ja) * 2021-01-22 2024-09-03 三洋化成工業株式会社 食道冷却剤
US20240207292A1 (en) * 2021-03-24 2024-06-27 Trustees Of Tufts College Boronic acid compounds, compositions and methods
KR20250067738A (ko) * 2023-11-08 2025-05-15 아주대학교산학협력단 고농도 산소를 포함하는 비점막 질환의 예방 또는 치료용 조성물

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091569A (en) * 1960-08-26 1963-05-28 Mead Johnson & Co Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus
US3591686A (en) * 1967-08-01 1971-07-06 Mead Johnson & Co Anti-inflammatory compositions and methods utilizing n-acylcysteines and the beta-alkyl and carboxyl derivatives thereof
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4176197A (en) * 1978-02-03 1979-11-27 Dominion Pharmacal, Inc. Method for treating acne vulgaris
US4512968A (en) * 1982-11-30 1985-04-23 Lion Corporation Oral compositions
DE3486448T2 (de) * 1983-11-14 1997-10-09 Columbia Lab Inc Bioadhäsive Mittel
US4708965A (en) * 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
US4724239A (en) * 1985-09-16 1988-02-09 Morgan Lee R Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
US5300494A (en) 1986-06-06 1994-04-05 Union Carbide Chemicals & Plastics Technology Corporation Delivery systems for quaternary and related compounds
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US5508031A (en) * 1986-11-21 1996-04-16 Cetus Oncology Corporation Method for treating biological damage using a free-radial scavenger and interleukin-2
DE3727896A1 (de) * 1987-08-21 1989-03-02 Degussa Verfahren zur herstellung von salzen des n-acetylcysteins oder -homocysteins
US5061729A (en) * 1988-06-08 1991-10-29 Biogal Gyogyszergyar Pharmaceutical composition and process for preparing the same
SE462779B (sv) * 1988-10-10 1990-09-03 Lejus Medical Ab Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat
US5221722A (en) * 1988-11-28 1993-06-22 The B. F. Goodrich Company Crosslinked polyacrylic acid
US5580577A (en) * 1990-01-11 1996-12-03 Herzenberg; Leonard A. Method of treating the symptoms of human rhinovirus infection
US5256396A (en) * 1990-01-24 1993-10-26 Colgate-Palmolive Company Topical composition
US5593683A (en) * 1990-05-01 1997-01-14 Mdv Technologies, Inc. Method of making thermoreversible polyoxyalkylene gels
US5143731A (en) * 1990-08-07 1992-09-01 Mediventures Incorporated Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5071644A (en) * 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
US5346703A (en) * 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
IT1250421B (it) * 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5296500A (en) * 1991-08-30 1994-03-22 The Procter & Gamble Company Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy
BR9206630A (pt) * 1991-10-16 1995-04-25 Richardson Vicks Inc Gel cosmético aquoso de baixo pH contendo derivados não iônicos de poliacrilamida
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IT1258781B (it) * 1992-01-16 1996-02-29 Zambon Spa Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol
US5466680A (en) * 1992-03-26 1995-11-14 Cytologics, Inc. Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
US5286480A (en) 1992-06-29 1994-02-15 The Procter & Gamble Company Use of N-acetylated amino acid complexes in oral care compositions
IT1255460B (it) * 1992-07-28 1995-11-02 Poli Ind Chimica Spa Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive
US5817625A (en) * 1992-09-21 1998-10-06 Oncogene Science, Inc. Methods of prevention of oral mucositis with transforming growth factor beta
US5807894A (en) * 1992-12-02 1998-09-15 Zambon Group S.P.A. Syrup containing N-acetyl-cysteine
US5324746A (en) * 1993-02-12 1994-06-28 Mckee Rex N Method of treating damaged mucosal and epithelial tissues with misoprostol
US5637616A (en) * 1993-06-18 1997-06-10 Arcturus Pharmaceutical Corporation Method for treating diseases mediated by proteases
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5490978A (en) * 1993-10-15 1996-02-13 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Block copolymers of polysaccharides and polyalkylene oxides
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US5541181A (en) * 1994-05-26 1996-07-30 Bristol-Myers Squibb Company Compound produced by a strain of micromonospora
US5597849A (en) * 1994-11-14 1997-01-28 Medical Polymer Technologies, Inc. Stick formulations for topical drug delivery of therapeutic agents and uses thereof
ATE178953T1 (de) * 1994-12-23 1999-04-15 Cookson Group Plc Verfahren zur korrosionshemmung von kupfer- und kupferlegierungen
US5939485A (en) * 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
US6150472A (en) * 1995-12-22 2000-11-21 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
SE9601527D0 (sv) * 1996-04-23 1996-04-23 Pharmacia Ab Transdermally alministered acetylcysteine as mucolytic agent
US5869029A (en) * 1996-06-21 1999-02-09 Hercules Incorporated Dispersible water-soluble or water-swellable polymers and process for making toothpastes containing them
US6797729B1 (en) * 1996-06-28 2004-09-28 Baxter International Inc. Therapeutic glutamine and N-actyl-cysteine composition
IL127956A0 (en) * 1996-07-11 1999-11-30 Farmarc Nederland Bv Inclusion complex containing indole selective serotonin agonist
US5861174A (en) * 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
CA2264592C (en) * 1996-08-27 2012-02-21 University Of Utah Research Foundation Bioconjugates and delivery of bioactive agents
US6743422B1 (en) * 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
SE9604610D0 (sv) * 1996-12-16 1996-12-16 Noviscens Ab Medical composition
GB2320431B (en) * 1996-12-20 2000-08-30 Johnson & Johnson Medical Compositions for the treatment of chronic wounds
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
JP4578578B2 (ja) * 1997-01-13 2010-11-10 エモリー、ユニバーシティ インフルエンザ感染の治療用化合物及びそれらの組み合わせ
US6126930A (en) * 1997-02-13 2000-10-03 The Procter & Gamble Company Spray compositions
US5843881A (en) * 1997-02-13 1998-12-01 The Procter & Gamble Company Spray compositions
AU6436998A (en) * 1997-02-20 1998-09-09 Yale University Therapeutic uses for antioxidants
US5904927A (en) * 1997-03-14 1999-05-18 Northeastern University Drug delivery using pH-sensitive semi-interpenetrating network hydrogels
US6197331B1 (en) * 1997-07-24 2001-03-06 Perio Products Ltd. Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
KR20070069220A (ko) * 1997-10-22 2007-07-02 젠스 포니카우 진균류에 의한 점막염을 국소 치료하기 위한 항진균제의용도
WO1999026657A1 (en) * 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6228347B1 (en) * 1997-12-01 2001-05-08 Thione International, Inc. Antioxidant gel for gingival conditions
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
AU1905799A (en) * 1997-12-22 1999-07-12 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
EP0938896A1 (en) * 1998-01-15 1999-09-01 Novartis AG Autoclavable pharmaceutical compositions containing a chelating agent
GB9812426D0 (en) * 1998-06-10 1998-08-05 Reckitt & Colmann Prod Ltd Improvements in or relating to organic compositions
FR2781156B1 (fr) * 1998-07-20 2001-06-29 Lafon Labor Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites
BR9912627A (pt) * 1998-07-30 2002-02-13 Nutriceuticals Inc E Composição em suspensão lìquida estável, e, processos para preparação e uso da mesma e para tratamento de peso e de colesterol
US6316011B1 (en) * 1998-08-04 2001-11-13 Madash, Llc End modified thermal responsive hydrogels
US6319513B1 (en) * 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US6231889B1 (en) * 1998-09-21 2001-05-15 Chronorx, Llc Unit dosage forms for the treatment of herpes simplex
US5945089A (en) * 1998-11-05 1999-08-31 I-Dent International Corporation Method of treating mucositis
US6669927B2 (en) * 1998-11-12 2003-12-30 3M Innovative Properties Company Dental compositions
US6159485A (en) * 1999-01-08 2000-12-12 Yugenic Limited Partnership N-acetyl aldosamines, n-acetylamino acids and related n-acetyl compounds and their topical use
US6270781B1 (en) 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
US20030229141A1 (en) * 1999-01-08 2003-12-11 Yu Ruey J. N-acetyl cysteine and its topical use
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
US6194382B1 (en) * 1999-03-03 2001-02-27 Albert Einstein College Of Medicine Of Yeshiva University Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists
US6297337B1 (en) * 1999-05-19 2001-10-02 Pmd Holdings Corp. Bioadhesive polymer compositions
US6117415A (en) * 1999-06-17 2000-09-12 Alpharx Inc. Toothpaste comprising bioadhesive submicron emulsion for improved delivery of antibacterial and anticaries agents
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6391860B1 (en) * 1999-09-09 2002-05-21 Mcgrath Patrick D. Method for preparation and use of paste formed by controlled reaction of sucralfate with hydrochloric acid
CN1373674A (zh) * 1999-09-11 2002-10-09 宝洁公司 易流动液体载体
US6258342B1 (en) * 1999-11-03 2001-07-10 Hercules Incorporated Process for making toothpaste using agglomerated dispersible polymers
US6432415B1 (en) * 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
US20010025027A1 (en) * 2000-03-07 2001-09-27 Sonis Stephen T. Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation
IT1318447B1 (it) 2000-04-04 2003-08-25 Paolo Farina Formulazioni per la rimozione della placca dentale e del tartaro.
WO2001080832A2 (en) * 2000-04-26 2001-11-01 Oregon Health Sciences University Administration of a thiol-based chemoprotectant compound
PT1395289E (pt) * 2000-06-08 2011-03-16 Sang Dr Christine Tratamento da dor neuropática com antagonistas do receptor de n-metil-d-aspartato (nmda)
US20020013331A1 (en) 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US6479068B1 (en) * 2000-06-30 2002-11-12 Baxter International Inc. Therapeutic nutrient regimen for alleviating mucositis, stomatitis and cachexia in oncology patients
FI121528B (fi) 2000-10-30 2010-12-31 Biohit Oyj Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa
EP1343492B1 (en) * 2000-11-22 2006-02-01 Rxkinetix, Inc. Treatment of mucositis
DK1997478T3 (da) 2001-02-15 2013-12-09 Access Pharma Inc Flydende formuleringer til forebyggelse og behandling af slimhindesygdomme og -lidelser
US6623754B2 (en) * 2001-05-21 2003-09-23 Noveon Ip Holdings Corp. Dosage form of N-acetyl cysteine
AU2002341566A1 (en) 2001-08-16 2003-04-01 Mucosal Therapeutics, Inc. Treatment and prevention of mucositis in cancer patients
US20040062764A1 (en) * 2001-08-30 2004-04-01 Neuwelt Edward A Chemoprotectant for gastric toxicity
US6857784B2 (en) * 2002-09-30 2005-02-22 Reliance Electric Technologies, Llc. Adapter mounted bearing assembly

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EP1343492B1 (en) 2006-02-01
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JP2004513957A (ja) 2004-05-13
US20070071824A1 (en) 2007-03-29
ES2254523T3 (es) 2006-06-16
EP1343492A2 (en) 2003-09-17
JP4822652B2 (ja) 2011-11-24
WO2002041837A3 (en) 2003-03-06
BRPI0115531B1 (pt) 2015-10-13
MXPA03004546A (es) 2003-09-10
DE60117043D1 (de) 2006-04-13
US20020119104A1 (en) 2002-08-29
WO2002041837A2 (en) 2002-05-30
US20040141949A1 (en) 2004-07-22
US20070014861A1 (en) 2007-01-18
EP1609468A3 (en) 2006-01-25
AU2002239342A1 (en) 2002-06-03
ATE316786T1 (de) 2006-02-15
US6685917B2 (en) 2004-02-03
US20070014860A1 (en) 2007-01-18
DE60117043T2 (de) 2006-07-13
BR0115531A (pt) 2004-02-03

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