IT1258781B - Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol - Google Patents

Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol

Info

Publication number
IT1258781B
IT1258781B ITMI920074A ITMI920074A IT1258781B IT 1258781 B IT1258781 B IT 1258781B IT MI920074 A ITMI920074 A IT MI920074A IT MI920074 A ITMI920074 A IT MI920074A IT 1258781 B IT1258781 B IT 1258781B
Authority
IT
Italy
Prior art keywords
pharmaceutical composition
polyvinyl alcohol
composition containing
acetylcistein
ophthalmic pharmaceutical
Prior art date
Application number
ITMI920074A
Other languages
English (en)
Inventor
Federico Stroppolo
Daniele Bonadeo
Annibale Gazzaniga
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ITMI920074A0 publication Critical patent/ITMI920074A0/it
Priority to ITMI920074A priority Critical patent/IT1258781B/it
Priority to ES93100278T priority patent/ES2197146T3/es
Priority to AT93100278T priority patent/ATE239485T1/de
Priority to DE69332939T priority patent/DE69332939T2/de
Priority to AU31136/93A priority patent/AU653091B2/en
Priority to EP93100278A priority patent/EP0551848B1/en
Priority to CA002087420A priority patent/CA2087420C/en
Priority to JP00615293A priority patent/JP3443128B2/ja
Publication of ITMI920074A1 publication Critical patent/ITMI920074A1/it
Priority to US08/214,232 priority patent/US5510101A/en
Priority to US08/253,587 priority patent/US5488069A/en
Application granted granted Critical
Publication of IT1258781B publication Critical patent/IT1258781B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Viene descritta una composizione farmaceutica oftalmica contenente un'associazione di N-acetilcisteina e di polivinilalcol utile nel trattamento della keratoconjunctivitis sicca.
ITMI920074A 1992-01-16 1992-01-16 Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol IT1258781B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ITMI920074A IT1258781B (it) 1992-01-16 1992-01-16 Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol
AU31136/93A AU653091B2 (en) 1992-01-16 1993-01-11 Ophthalmic pharmaceutical composition containing N-acetyl-cysteine and polyvinylalcohol
AT93100278T ATE239485T1 (de) 1992-01-16 1993-01-11 Ophthalmische pharmazeutische zubereitung die n- acetylcystein und polyvinylalkohol enthält
DE69332939T DE69332939T2 (de) 1992-01-16 1993-01-11 Ophthalmische pharmazeutische Zubereitung die N-Acetylcystein und Polyvinylalkohol enthält
ES93100278T ES2197146T3 (es) 1992-01-16 1993-01-11 Composicion oftalmica que contiene n-acetil-cisteina y alcohol de polivinilo.
EP93100278A EP0551848B1 (en) 1992-01-16 1993-01-11 Ophthalmic pharmaceutical composition containing N-acetyl-cysteine and polyvinylalcohol
CA002087420A CA2087420C (en) 1992-01-16 1993-01-15 Ophthalmic pharmaceutical composition containing n-acetyl-cisteine and polyvinylalcohol
JP00615293A JP3443128B2 (ja) 1992-01-16 1993-01-18 Ｎ−アセチル−システイン及びポリビニルアルコールを含有する乾性角結膜炎の処置用の組成物
US08/214,232 US5510101A (en) 1992-01-16 1994-03-17 Ophthalmic pharmaceutical composition containing N-acetyl-cysteine and polyvinylalcohol
US08/253,587 US5488069A (en) 1992-01-16 1994-06-03 Ophthalmic pharmaceutical composition containing N-acetyl-cysteine and polyvinylalcohol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920074A IT1258781B (it) 1992-01-16 1992-01-16 Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol

Publications (3)

Publication Number Publication Date
ITMI920074A0 ITMI920074A0 (it) 1992-01-16
ITMI920074A1 ITMI920074A1 (it) 1993-07-16
IT1258781B true IT1258781B (it) 1996-02-29

Family

ID=11361572

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI920074A IT1258781B (it) 1992-01-16 1992-01-16 Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol

Country Status (9)

Country Link
US (2) US5510101A (it)
EP (1) EP0551848B1 (it)
JP (1) JP3443128B2 (it)
AT (1) ATE239485T1 (it)
AU (1) AU653091B2 (it)
CA (1) CA2087420C (it)
DE (1) DE69332939T2 (it)
ES (1) ES2197146T3 (it)
IT (1) IT1258781B (it)

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AU7330200A (en) * 1999-08-09 2001-05-10 Webb-Waring Institute For Biomedical Research A method for the treatment of ocular oxidative stress
KR20030014208A (ko) * 2000-04-26 2003-02-15 오레곤 헬스 사이언시즈 유니버시티 티올계 화학보호제 화합물의 투여
JP4822652B2 (ja) * 2000-11-22 2011-11-24 エンド ファーマシューティカルズ インコーポレイテッド 粘膜炎の治療
FR2819186A1 (fr) * 2001-01-10 2002-07-12 L M D Cystine-voie orale-syndrome de l'oeil sec
ITRM20010438A1 (it) 2001-07-23 2003-01-23 Farmigea Spa Preparato oftalmico a base di n-acetilcisteina per il trattamento della sindrome dell'occhio secco.
GB0123115D0 (en) * 2001-09-26 2001-11-14 Pharma Sol Int Ltd Saline solutions for clinical use
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
US20070077303A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for providing oxidatively stable ophthalmic compositions
WO2007064755A2 (en) * 2005-11-30 2007-06-07 Endo Pharmaceuticals Inc. Treatment of xerostomia with a sulfur-containing antioxidant
HUE028588T2 (hu) 2005-12-13 2016-12-28 Incyte Holdings Corp Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
EP2740731B1 (en) 2007-06-13 2016-03-23 Incyte Holdings Corporation Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
BRPI1012108B8 (pt) 2009-05-22 2021-05-25 Incyte Corp composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico
NZ596479A (en) * 2009-05-22 2014-01-31 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
TW201113285A (en) * 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
CA2792508C (en) 2010-03-10 2018-01-16 Incyte Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
EA202091303A3 (ru) 2010-05-21 2021-05-31 Инсайт Холдингс Корпорейшн Композиция ингибитора jak для местного применения
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
ES2536415T3 (es) 2010-11-19 2015-05-25 Incyte Corporation Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
US8691807B2 (en) 2011-06-20 2014-04-08 Incyte Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
KR102242077B1 (ko) 2012-11-15 2021-04-20 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
EP3489239B1 (en) 2013-03-06 2021-09-15 Incyte Holdings Corporation Processes and intermediates for making a jak inhibitor
MX376856B (es) 2013-08-07 2025-03-07 Incyte Holdings Corp Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
EP3139903B1 (en) 2014-05-07 2019-07-03 Croma-Pharma Gesellschaft m.b.H. Aqueous ophthalmic solution and method for treating dry eye syndrome
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
CN108348455B (zh) 2015-10-30 2021-04-09 克罗马药品股份有限公司 无菌水性眼用溶液的治疗用途
PL3368006T3 (pl) 2015-10-30 2020-06-01 Croma-Pharma Gesellschaft M.B.H. Zastosowanie terapeutyczne sterylnego wodnego roztworu oftalmicznego
CA3057569A1 (en) 2017-03-29 2018-10-04 Azura Ophthalmics Ltd. Agents for increasing meibomian gland lipid secretion
WO2018202783A1 (en) 2017-05-03 2018-11-08 Croma-Pharma Gmbh Sterile aqueous ophthalmic solution containing n-(n-acetylcysteinyl)-chitosan for treating non-infectious corneal disorders
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
MD3746429T2 (ro) 2018-01-30 2022-08-31 Incyte Corp Procedee pentru prepararea de (1-(3-fluoro-2-(trifluorometil)izonicotinil)piperidin-4-onă)
KR20260080448A (ko) 2018-03-30 2026-06-02 인사이트 코포레이션 Jak 억제제를 사용하는 화농성 한선염의 치료
CA3157606A1 (en) * 2019-11-08 2021-05-14 Karl CSAKY Compounds and implants for treating ocular disorders
EP4087655A4 (en) 2020-01-10 2024-02-21 Azura Ophthalmics Ltd INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

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US4120949A (en) * 1977-10-05 1978-10-17 Cooper Laboratories, Inc. Ophthalmic solution
US4131651A (en) * 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) * 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
BE901885A (fr) * 1985-03-06 1985-07-01 Bruschettini Srl Composition pharmaceutique sous forme de lotion ophtalmique et son procede de preparation.
US4883658A (en) * 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
IT1249047B (it) * 1991-02-21 1995-02-11 Zambon Spa Composizione farmaceutica per il trattamento della cataratta
NZ242358A (en) * 1991-05-10 1994-03-25 Allergan Inc Use of thiol compounds to inhibit deposits on a contact lens

Also Published As

Publication number Publication date
US5510101A (en) 1996-04-23
JP3443128B2 (ja) 2003-09-02
DE69332939D1 (de) 2003-06-12
US5488069A (en) 1996-01-30
EP0551848A1 (en) 1993-07-21
AU3113693A (en) 1993-07-22
AU653091B2 (en) 1994-09-15
ES2197146T3 (es) 2004-01-01
DE69332939T2 (de) 2004-04-01
ITMI920074A1 (it) 1993-07-16
CA2087420A1 (en) 1993-07-17
EP0551848B1 (en) 2003-05-07
CA2087420C (en) 2004-04-20
ITMI920074A0 (it) 1992-01-16
JPH069383A (ja) 1994-01-18
ATE239485T1 (de) 2003-05-15

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