DK1355940T3 - Urotensin II-agonister og -antagonister - Google Patents

Urotensin II-agonister og -antagonister

Info

Publication number: DK1355940T3
Authority: DK; Denmark
Prior art keywords: urotensin; agonists; antagonists; features; antagonist
Prior art date: 2000-10-20

Application number

DK01987763T

Other languages

English (en)

Inventor

David H Coy

Wojciech J Rossowski

John E Taylor

Original Assignee

Univ Tulane

Sod Conseils Rech Applic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-20

Filing date

2001-10-19

Publication date

2008-01-07

2001-10-19 Application filed by Univ Tulane, Sod Conseils Rech Applic filed Critical Univ Tulane

2008-01-07 Application granted granted Critical

2008-01-07 Publication of DK1355940T3 publication Critical patent/DK1355940T3/da

Links

102000050488 Urotensin II Human genes 0.000 title abstract 2
108010018369 Urotensin II Proteins 0.000 title abstract 2
239000000556 agonist Substances 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
HFNHAPQMXICKCF-USJMABIRSA-N urotensin-ii Chemical compound N([C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O HFNHAPQMXICKCF-USJMABIRSA-N 0.000 title abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000009452 underexpressoin Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Zoology (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Psychology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

DK01987763T 2000-10-20 2001-10-19 Urotensin II-agonister og -antagonister DK1355940T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24189600P	2000-10-20	2000-10-20
PCT/US2001/050724 WO2002032932A2 (en)	2000-10-20	2001-10-19	Urotensin-ii agonists and antagonists

Publications (1)

Publication Number	Publication Date
DK1355940T3 true DK1355940T3 (da)	2008-01-07

Family

ID=22912605

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01987763T DK1355940T3 (da)	2000-10-20	2001-10-19	Urotensin II-agonister og -antagonister

Country Status (21)

Country	Link
US (2)	US7241737B2 (da)
EP (1)	EP1355940B1 (da)
JP (2)	JP4081369B2 (da)
KR (3)	KR100820896B1 (da)
AT (1)	ATE374786T1 (da)
AU (2)	AU3290302A (da)
BR (1)	BR0114737A (da)
CA (1)	CA2425804A1 (da)
CZ (1)	CZ299402B6 (da)
DE (1)	DE60130802T2 (da)
DK (1)	DK1355940T3 (da)
ES (1)	ES2291372T3 (da)
HU (1)	HUP0301384A3 (da)
IL (2)	IL155127A0 (da)
MX (1)	MXPA03003297A (da)
NO (1)	NO20031699L (da)
PL (1)	PL366327A1 (da)
PT (1)	PT1355940E (da)
RU (1)	RU2263679C2 (da)
WO (1)	WO2002032932A2 (da)
ZA (1)	ZA200302505B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050014198A1 (en) *	2002-07-11	2005-01-20	Leong Ng	Assays and kits for detecting and monitoring heart disease
US7939052B2 (en) *	2005-05-12	2011-05-10	Janssen Pharmaceutica Nv	Method of measuring the biological activity of an urotensin II receptor
CA2666642C (en)	2006-10-16	2015-11-17	The Salk Institute For Biological Studies	Receptor(sstr2)-selective somatostatin antagonists
US8691761B2 (en)	2006-10-16	2014-04-08	Jean E. F. Rivier	Somatostatin receptor 2 antagonists
AU2008360223B2 (en) *	2008-08-08	2014-06-19	Polyphor Ag	Template-fixed peptidomimetics
RU2558921C1 (ru) *	2014-06-26	2015-08-10	Анатолий Петрович Бахтинов	Способ прекращения течки у самок и остро проявляющейся охоты у самцов млекопитающих животных

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3881467T2 (de) *	1987-10-09	1993-10-21	Agency Ind Science Techn	Vasokonstriktor-Peptid.
DE19534177A1 (de) *	1995-09-15	1997-03-20	Merck Patent Gmbh	Cyclische Adhäsionsinhibitoren
US20020107187A1 (en) *	1996-05-22	2002-08-08	Kingston David J.	Modulating the activity of hormones or their receptors - peptides, antibodies, vaccines and uses thereof
US6262229B1 (en) *	1996-12-04	2001-07-17	Biomeasure Incorporated	Somatostatin antagonists
US6159700A (en) *	1997-01-27	2000-12-12	Smithkline Beecham Corporation	Method of finding agonist and antagonist to human and rat GPR14
FR2786489B1 (fr)	1998-11-26	2002-12-27	Inst Nat Sante Rech Med	Urotensines ii de mammiferes et leurs appications
EP1233774A4 (en) *	1999-11-29	2004-06-16	Smithkline Beecham Corp	UROTENSIN II ANALOGS
CZ299362B6 (cs) *	2001-03-08	2008-07-02	The Administrators Of The Tulane Educational Fund	Antagonisté somatostatinu
EP1397150A4 (en) *	2001-04-09	2005-01-26	Administrators Ofthe Tulane Ed	Somatostatin agonists

2001
- 2001-10-19 CA CA002425804A patent/CA2425804A1/en not_active Abandoned
- 2001-10-19 RU RU2003114734/04A patent/RU2263679C2/ru not_active IP Right Cessation
- 2001-10-19 KR KR1020067014786A patent/KR100820896B1/ko not_active Expired - Fee Related
- 2001-10-19 AU AU3290302A patent/AU3290302A/xx active Pending
- 2001-10-19 MX MXPA03003297A patent/MXPA03003297A/es active IP Right Grant
- 2001-10-19 JP JP2002536313A patent/JP4081369B2/ja not_active Expired - Fee Related
- 2001-10-19 PT PT01987763T patent/PT1355940E/pt unknown
- 2001-10-19 KR KR1020037004970A patent/KR100707408B1/ko not_active Expired - Fee Related
- 2001-10-19 US US10/399,542 patent/US7241737B2/en not_active Expired - Fee Related
- 2001-10-19 CZ CZ20030900A patent/CZ299402B6/cs not_active IP Right Cessation
- 2001-10-19 ES ES01987763T patent/ES2291372T3/es not_active Expired - Lifetime
- 2001-10-19 WO PCT/US2001/050724 patent/WO2002032932A2/en not_active Ceased
- 2001-10-19 EP EP01987763A patent/EP1355940B1/en not_active Expired - Lifetime
- 2001-10-19 DK DK01987763T patent/DK1355940T3/da active
- 2001-10-19 IL IL15512701A patent/IL155127A0/xx unknown
- 2001-10-19 KR KR1020067014787A patent/KR100795427B1/ko not_active Expired - Fee Related
- 2001-10-19 BR BR0114737-4A patent/BR0114737A/pt not_active IP Right Cessation
- 2001-10-19 AT AT01987763T patent/ATE374786T1/de not_active IP Right Cessation
- 2001-10-19 PL PL01366327A patent/PL366327A1/xx unknown
- 2001-10-19 HU HU0301384A patent/HUP0301384A3/hu unknown
- 2001-10-19 AU AU2002232903A patent/AU2002232903B2/en not_active Ceased
- 2001-10-19 DE DE60130802T patent/DE60130802T2/de not_active Expired - Fee Related
2003
- 2003-03-31 ZA ZA200302505A patent/ZA200302505B/en unknown
- 2003-04-11 NO NO20031699A patent/NO20031699L/no not_active Application Discontinuation
2006
- 2006-07-05 JP JP2006185286A patent/JP2006342170A/ja active Pending
2007
- 2007-06-21 IL IL184121A patent/IL184121A0/en unknown
- 2007-06-26 US US11/821,823 patent/US20070287665A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20030081316A (ko)	2003-10-17
JP2005500244A (ja)	2005-01-06
KR100820896B1 (ko)	2008-04-11
US20070287665A1 (en)	2007-12-13
DE60130802D1 (de)	2007-11-15
US7241737B2 (en)	2007-07-10
EP1355940B1 (en)	2007-10-03
NO20031699D0 (no)	2003-04-11
JP2006342170A (ja)	2006-12-21
HK1059938A1 (en)	2004-07-23
ZA200302505B (en)	2005-05-30
ES2291372T3 (es)	2008-03-01
JP4081369B2 (ja)	2008-04-23
KR20060090768A (ko)	2006-08-16
KR20060090843A (ko)	2006-08-16
US20050075480A1 (en)	2005-04-07
HUP0301384A3 (en)	2010-04-28
AU2002232903B2 (en)	2005-06-30
CZ299402B6 (cs)	2008-07-16
RU2263679C2 (ru)	2005-11-10
ATE374786T1 (de)	2007-10-15
BR0114737A (pt)	2005-06-07
WO2002032932A2 (en)	2002-04-25
MXPA03003297A (es)	2004-05-04
HUP0301384A2 (en)	2007-11-28
AU3290302A (en)	2002-04-29
EP1355940A2 (en)	2003-10-29
NO20031699L (no)	2003-06-18
PT1355940E (pt)	2007-11-08
CZ2003900A3 (cs)	2003-12-17
IL184121A0 (en)	2007-10-31
KR100795427B1 (ko)	2008-01-17
CA2425804A1 (en)	2002-04-25
WO2002032932A3 (en)	2003-09-04
KR100707408B1 (ko)	2007-04-13
PL366327A1 (en)	2005-01-24
DE60130802T2 (de)	2008-07-03
IL155127A0 (en)	2003-10-31

Publication	Publication Date	Title
ATE293989T1 (de)	2005-05-15	Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
ATE286897T1 (de)	2005-01-15	Morpholinderivate als antagonisten an orexinrezeptoren
DE60309481D1 (de)	2006-12-14	Cyclische n-aroylamine als orexinrezeptorantagonisten
EA200200208A1 (ru)	2002-08-29	Синергитическая композиция
EA200001176A1 (ru)	2001-06-25	Гетероциклические ингибиторы p38
DE69532162D1 (de)	2003-12-24	Cannabinoid-rezeptor-antagonisten
DE69728585D1 (de)	2004-05-13	Mittel gegen Juckreiz
ATE312811T1 (de)	2005-12-15	Benzamidinderivate als antagonisten von orexinrezeptoren
IL184121A0 (en)	2007-10-31	Urotensin-ii agonists polypeptide and its use for manufacture of medicaments
DE60226161D1 (de)	2008-05-29	3-azabicyclo(3.1.0)hexan derivative als antagonisten der opioid rezeptoren
ATE406159T1 (de)	2008-09-15	Behandlung von hyperlipidämie
ATE284398T1 (de)	2004-12-15	N-imidazolyl-alkyl substituierte cyklische amine als histamin-h3 agonisten oder antagonisten
ATE366572T1 (de)	2007-08-15	5-ht 1b/1d rezeptor agonisten zur behandlung von kopfschmerz der aus der verabreichung von endothelin rezeptor antagonisten resultiert
DE60015187D1 (de)	2004-11-25	Urotensin-ii rezeptorantagonisten
EA200401137A1 (ru)	2005-04-28	Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора
TR200002072T2 (tr)	2000-12-21	Spiropiperidin türevleri
EP1878743A3 (en)	2008-05-28	Urotensin-II agonists and antagonists
SE0001373D0 (sv)	2000-04-13	NPY Y1 receptor agonists and antagonists
IS8388A (is)	2006-03-30	Blandan af serótónín endurupptökuhindra og histamín 3 viðtaka mótlyfi, öflugum verka eða hlutaverka
DK1420789T3 (da)	2007-09-17	Anvendelse af aktivstoffer med my-opioid-receptoragonistisk virkning og opioid-receptorantagonistisk virkning som kombinationslægemidler til cancerbehandling
EA200400116A1 (ru)	2004-08-26	Сочетание действующих веществ для фармакологического лечения никотиновой зависимости
ITFI20030238A1 (it)	2005-03-12	Peptidi ciclici antagonisti dell'urotensina-ii
EP1463817A4 (en)	2005-07-20	HISTAMINE RECEPTOR H3 POLYNUCLEOTIDES
ATE320005T1 (de)	2006-03-15	Testverfahren für agonisten oder antagonisten der bindung von dynorphin a an den mas-rezeptor
MX2007013207A (es)	2008-04-02	Agente para la profilaxis y tratamiento de la pancreatitis.