DK1356030T3 - RUNX3 gen, som udviser anti-tumor aktivitet, og anvendelse deraf - Google Patents

RUNX3 gen, som udviser anti-tumor aktivitet, og anvendelse deraf

Info

Publication number: DK1356030T3
Authority: DK; Denmark
Prior art keywords: runx3; development; cancer; present; runx3 gene
Prior art date: 2001-01-29

Application number

DK01902862T

Other languages

Danish (da)

English (en)

Inventor

Suk-Chul Bae

Yoshiaki Ito

Original Assignee

Suk-Chul Bae

Yoshiaki Ito

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-29

Filing date

2001-01-30

Publication date

2008-11-03

2001-01-30 Application filed by Suk-Chul Bae, Yoshiaki Ito filed Critical Suk-Chul Bae

2008-11-03 Application granted granted Critical

2008-11-03 Publication of DK1356030T3 publication Critical patent/DK1356030T3/da

Links

101100476219 Homo sapiens RUNX3 gene Proteins 0.000 title abstract 5
230000000259 anti-tumor effect Effects 0.000 title abstract 2
230000001747 exhibiting effect Effects 0.000 title 1
102000012666 Core Binding Factor Alpha 3 Subunit Human genes 0.000 abstract 3
108010079362 Core Binding Factor Alpha 3 Subunit Proteins 0.000 abstract 3
230000014509 gene expression Effects 0.000 abstract 3
230000007067 DNA methylation Effects 0.000 abstract 2
230000002159 abnormal effect Effects 0.000 abstract 2
239000002246 antineoplastic agent Substances 0.000 abstract 2
108091029523 CpG island Proteins 0.000 abstract 1
206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
238000003782 apoptosis assay Methods 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
206010017758 gastric cancer Diseases 0.000 abstract 1
230000014200 hypermethylation of CpG island Effects 0.000 abstract 1
201000005202 lung cancer Diseases 0.000 abstract 1
208000020816 lung neoplasm Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000005522 programmed cell death Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
201000011549 stomach cancer Diseases 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Wood Science & Technology (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

DK01902862T 2001-01-29 2001-01-30 RUNX3 gen, som udviser anti-tumor aktivitet, og anvendelse deraf DK1356030T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR10-2001-0004018A KR100475649B1 (ko)	2001-01-29	2001-01-29	항암활성을 나타내는 ｒｕｎｘ３ 유전자 및 그의 용도
PCT/KR2001/000121 WO2002061069A1 (fr)	2001-01-29	2001-01-30	Gene runx3 montrant une activite antitumorale et utilisation

Publications (1)

Publication Number	Publication Date
DK1356030T3 true DK1356030T3 (da)	2008-11-03

Family

ID=19705043

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01902862T DK1356030T3 (da)	2001-01-29	2001-01-30	RUNX3 gen, som udviser anti-tumor aktivitet, og anvendelse deraf

Country Status (10)

Country	Link
US (2)	US7368255B2 (fr)
EP (1)	EP1356030B1 (fr)
JP (1)	JP4018542B2 (fr)
KR (1)	KR100475649B1 (fr)
AT (1)	ATE402256T1 (fr)
DE (1)	DE60135022D1 (fr)
DK (1)	DK1356030T3 (fr)
ES (1)	ES2310545T3 (fr)
PT (1)	PT1356030E (fr)
WO (1)	WO2002061069A1 (fr)

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US20050221339A1 (en)	2004-03-31	2005-10-06	Medical Research Council Harvard University	Compartmentalised screening by microfluidic control
US7968287B2 (en)	2004-10-08	2011-06-28	Medical Research Council Harvard University	In vitro evolution in microfluidic systems
WO2006057623A1 (fr) *	2004-11-29	2006-06-01	National University Of Singapore	Anticorps runx3 et procede de collecte
KR100748185B1 (ko) *	2005-01-31	2007-08-10	한국생명공학연구원	Ｌｒｒｃ3ｂ 유전자를 포함하는 항암용 조성물 및 상기유전자를 이용한 진단방법
US8268572B2 (en) *	2005-03-04	2012-09-18	Dana-Farber Cancer Institute, Inc.	Methods to identify inhibitors of Runx1-mediated expression of nociceptive receptors and ion channels
US7611847B2 (en)	2005-06-01	2009-11-03	Agency For Science, Technology And Research	Method for identifying an intestinal phenotype
WO2006132248A1 (fr) *	2005-06-07	2006-12-14	Daiichi Pharmaceutical Co., Ltd.	Procédé d’ubiquitination du runx
EP2363205A3 (fr)	2006-01-11	2014-06-04	Raindance Technologies, Inc.	Dispositifs Microfluidiques Et Leurs Procédés D'utilisation Dans La Formation Et Le Contrôle De Nanoréacteurs
EP2004860A4 (fr) *	2006-03-29	2009-12-30	Wayne John Cancer Inst	Methylation du recepteur alpha d'oestrogene et utilisations correspondantes
US9562837B2 (en)	2006-05-11	2017-02-07	Raindance Technologies, Inc.	Systems for handling microfludic droplets
EP2530168B1 (fr)	2006-05-11	2015-09-16	Raindance Technologies, Inc.	Dispositifs microfluidiques
EP2077912B1 (fr)	2006-08-07	2019-03-27	The President and Fellows of Harvard College	Tensioactifs fluorocarbonés stabilisateurs d'émulsions
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WO2008130623A1 (fr)	2007-04-19	2008-10-30	Brandeis University	Manipulation de fluides, composants fluidiques et réactions dans des systèmes microfluidiques
DK2198042T3 (en)	2007-09-17	2017-01-23	Mdxhealth Sa	New markers for bladder cancer detection
WO2009061130A2 (fr) *	2007-11-06	2009-05-14	Procell Therapeutics Inc.	Protéines runx3 recombinées à perméabilité cellulaire, polynucléotides codant pour ces protéines, et compositions anticancéreuses les contenant
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US10520500B2 (en)	2009-10-09	2019-12-31	Abdeslam El Harrak	Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (fr)	2009-12-23	2019-11-27	Bio-Rad Laboratories, Inc.	Procédés pour réduire l'échange de molécules entre des gouttelettes
US10351905B2 (en)	2010-02-12	2019-07-16	Bio-Rad Laboratories, Inc.	Digital analyte analysis
JP5934657B2 (ja)	2010-02-12	2016-06-15	レインダンステクノロジーズ，インコーポレイテッド	デジタル検体分析
US9366632B2 (en)	2010-02-12	2016-06-14	Raindance Technologies, Inc.	Digital analyte analysis
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WO2012045012A2 (fr)	2010-09-30	2012-04-05	Raindance Technologies, Inc.	Dosages sandwich dans des gouttelettes
EP3859011A1 (fr)	2011-02-11	2021-08-04	Bio-Rad Laboratories, Inc.	Procédés permettant de former des gouttelettes mélangées
EP2675819B1 (fr)	2011-02-18	2020-04-08	Bio-Rad Laboratories, Inc.	Compositions et méthodes de marquage moléculaire
DE202012013668U1 (de)	2011-06-02	2019-04-18	Raindance Technologies, Inc.	Enzymquantifizierung
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US9845471B2 (en)	2013-01-15	2017-12-19	Fred Hutchinson Cancer Research Center	Compositions and methods for treating pancreatic cancer
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US11901041B2 (en)	2013-10-04	2024-02-13	Bio-Rad Laboratories, Inc.	Digital analysis of nucleic acid modification
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US10647981B1 (en)	2015-09-08	2020-05-12	Bio-Rad Laboratories, Inc.	Nucleic acid library generation methods and compositions
CN106011263B (zh) *	2016-06-28	2020-01-07	宁波大学	用于检测与胃癌相关的ndrg4基因甲基化程度的试剂盒及其应用
WO2018021200A1 (fr) *	2016-07-29	2018-02-01	国立大学法人京都大学	Inhibiteur de runx
US10998178B2 (en)	2017-08-28	2021-05-04	Purdue Research Foundation	Systems and methods for sample analysis using swabs
KR101994957B1 (ko)	2017-11-30	2019-07-01	고려대학교 산학협력단	Runx3 단백질 또는 이를 코딩하는 runx3 유전자를 포함하는 trail의 항암 효과 증진용 약학 조성물
CN112074600A (zh) *	2018-05-03	2020-12-11	科济生物医药（上海）有限公司	免疫效应细胞及其应用
JP7144037B2 (ja) *	2018-07-25	2022-09-29	国立大学法人山口大学	がんの診断用バイオマーカー
WO2020145465A1 (fr) *	2019-01-08	2020-07-16	주식회사바이오러넥스	Composition pharmaceutique comprenant un gène ou une protéine runx3 en tant que principe actif pour la prévention ou le traitement d'un cancer du poumon avec mutation du gène k-ras
CN112662764A (zh) *	2020-03-17	2021-04-16	博尔诚（北京）科技有限公司	一种检测11种癌症的探针组合物
KR102854745B1 (ko)	2020-04-23	2025-09-04	진크래프트 주식회사	R-point 조절 단백질 복합체를 유효성분으로 포함하는 폐암 치료용 약학적 조성물, 상기 복합체의 형성 여부를 이용한 폐암 치료제 스크리닝 방법 및 폐암 진단 방법
US11767541B1 (en) *	2023-03-27	2023-09-26	Genecraft, Inc.	Adeno-associated virus complex with improved expression of RUNX3 gene and uses for preventing or treating KRAS mutated lung cancer

2001
- 2001-01-29 KR KR10-2001-0004018A patent/KR100475649B1/ko not_active Expired - Fee Related
- 2001-01-30 ES ES01902862T patent/ES2310545T3/es not_active Expired - Lifetime
- 2001-01-30 DE DE60135022T patent/DE60135022D1/de not_active Expired - Lifetime
- 2001-01-30 US US10/466,938 patent/US7368255B2/en not_active Expired - Fee Related
- 2001-01-30 PT PT01902862T patent/PT1356030E/pt unknown
- 2001-01-30 AT AT01902862T patent/ATE402256T1/de not_active IP Right Cessation
- 2001-01-30 JP JP2002561626A patent/JP4018542B2/ja not_active Expired - Fee Related
- 2001-01-30 DK DK01902862T patent/DK1356030T3/da active
- 2001-01-30 EP EP01902862A patent/EP1356030B1/fr not_active Expired - Lifetime
- 2001-01-30 WO PCT/KR2001/000121 patent/WO2002061069A1/fr not_active Ceased
2008
- 2008-03-19 US US12/051,649 patent/US20080261883A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1356030A1 (fr)	2003-10-29
JP2004529619A (ja)	2004-09-30
US20080261883A1 (en)	2008-10-23
EP1356030A4 (fr)	2005-02-02
KR20020063387A (ko)	2002-08-03
PT1356030E (pt)	2008-10-30
JP4018542B2 (ja)	2007-12-05
ATE402256T1 (de)	2008-08-15
US7368255B2 (en)	2008-05-06
EP1356030B1 (fr)	2008-07-23
ES2310545T3 (es)	2009-01-16
WO2002061069A1 (fr)	2002-08-08
KR100475649B1 (ko)	2005-03-10
DE60135022D1 (de)	2008-09-04
US20040146986A1 (en)	2004-07-29

Publication	Publication Date	Title
DE60135022D1 (de)	2008-09-04	Antitumoraktivität zeigendes runx3-gen und dessen verwendung
SG142154A1 (en)	2008-05-28	Methods for genomic analysis
BR0007527A (pt)	2001-12-04	Fenilfenantridinas com atividade inibitória depde-iv
CY1113306T1 (el)	2016-04-13	Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
EP1466179A4 (fr)	2006-09-20	Procede permettant de diagnostiquer des cancers en mesurant des modifications dans la glycosilation de proteines liees a la tumorigenese et aux metastases et trousse de diagnostic du cancer faisant appel a ce procede
TR200003159T2 (tr)	2001-09-21	Antipicornaviral bileşikler, hazırlanışları ve kullanımları
DE60336734D1 (de)	2011-05-26	Sidasen
HUP0101146A2 (hu)	2001-08-28	Foszfolipáz enzim inhibitor hatású indolszármazékok, valamint a vegyületeket tartalmazó gyógyászati készítmények
NO970626L (no)	1997-04-14	Fremgangsmåte for å diagnostisere disponering for bryst- og ovariekreft
DK1465626T3 (da)	2008-11-17	Farmaceutiske præparater (kit) der omfatter dihydropyridinonforbindelser og et immunregulatorisk (eller et antiinflammatorisk) middel samt anvendelser deraf
EP1784639A4 (fr)	2008-05-07	Procedes permettant de preparer des plaquettes lyophilisees, compositions contenant lesdites plaquettes lyophilisees, et procedes d'utilisation associes
PT1140944E (pt)	2004-01-30	Derivados de epotilona e sua utilizacao como agentes antitumorais
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DE60235005D1 (de)	2010-02-25	Nachweis der instabilität von mikrosatelliten und
BR9811589A (pt)	2000-09-19	Derivados de hidroxicumaranona o-substituìda como agentes antitumores e antimetastáticos
ATE282607T1 (de)	2004-12-15	Tryptase-inhibitoren
AU2001233913A1 (en)	2001-09-03	Bcmp 84, a protein associated to breast cancer
DK1334123T3 (da)	2009-01-12	Eukaryotiske celledelingsgener og deres anvendelse til diagnose og behandling af proliferative sygdomme
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DE60329326D1 (de)	2009-10-29	Tace inhibitoren
ATE384065T1 (de)	2008-02-15	4-(pyrrolopyrimidin-6-yl)benzolsulfonamidderiva e
HRP20050382B1 (hr)	2013-09-30	Novi pirimidin-4,6-dikarboksamidi za selektivnu inhibiciju kolagenaza
DE60316128D1 (de)	2007-10-18	N-sulfonylurea-apoptosis-förderer