DK1358182T3 - Diazocin-derivater og anvendelsen deraf som tryptase-inhibitorer - Google Patents

Diazocin-derivater og anvendelsen deraf som tryptase-inhibitorer

Info

Publication number: DK1358182T3
Authority: DK; Denmark
Prior art keywords: diazocin; derivatives; tryptase inhibitors; inhibitors; tryptase
Prior art date: 2001-01-31

Application number

DK02704674T

Other languages

English (en)

Inventor

Wolf-Ruediger Ulrich

Thomas Baer

Thomas Martin

Josef Stadlwieser

Stefan-Lutz Wollin

Karl Zech

Christian P Sommerhoff

Original Assignee

Altana Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-31

Filing date

2002-01-26

Publication date

2004-12-20

2002-01-26 Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag

2004-12-20 Application granted granted Critical

2004-12-20 Publication of DK1358182T3 publication Critical patent/DK1358182T3/da

Links

239000002750 tryptase inhibitor Substances 0.000 title abstract 2
YZTFIKANQHTFDZ-UHFFFAOYSA-N diazocine Chemical class C1=CC=CN=NC=C1 YZTFIKANQHTFDZ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

DK02704674T 2001-01-31 2002-01-26 Diazocin-derivater og anvendelsen deraf som tryptase-inhibitorer DK1358182T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01102098		2001-01-31
PCT/EP2002/000831 WO2002060895A1 (en)	2001-01-31	2002-01-26	Diazocine derivatives and their use as tryptase inhibitors

Publications (1)

Publication Number	Publication Date
DK1358182T3 true DK1358182T3 (da)	2004-12-20

Family

ID=8176347

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02704674T DK1358182T3 (da)	2001-01-31	2002-01-26	Diazocin-derivater og anvendelsen deraf som tryptase-inhibitorer

Country Status (12)

Country	Link
US (1)	US6924305B2 (da)
EP (1)	EP1358182B1 (da)
JP (1)	JP2004517943A (da)
AT (1)	ATE273302T1 (da)
AU (1)	AU2002238522B8 (da)
CA (1)	CA2438594A1 (da)
DE (1)	DE60200935T2 (da)
DK (1)	DK1358182T3 (da)
ES (1)	ES2225758T3 (da)
PT (1)	PT1358182E (da)
SI (1)	SI1358182T1 (da)
WO (1)	WO2002060895A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2278928T3 (es)	2001-06-19	2007-08-16	Altana Pharma Ag	Inhibidores de triptasa.
WO2006044133A1 (en) *	2004-09-24	2006-04-27	Axys Pharmaceuticals, Inc.	Active ketone inhibitors of tryptase

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995032945A1 (en)	1994-06-01	1995-12-07	Arris Pharmaceutical Corporation	Compositions and methods for treating mast-cell mediated conditions
KR970706267A (ko) *	1994-09-23	1997-11-03	다니엘 에이치. 페트리	비만 세포 염증성 질환 치료용 조성물 및 방법(compositions and methods for treating mast-cell inflammatory condition)
AU733621B2 (en) *	1996-07-30	2001-05-17	Axys Pharmaceuticals, Inc.	Novel compounds and compositions for treating diseases associated with tryptase activity
AU8997498A (en)	1997-09-05	1999-03-29	Yoshitomi Pharmaceutical Industries, Ltd.	Tryptase inhibitor
US6221914B1 (en)	1997-11-10	2001-04-24	Array Biopharma Inc.	Sulfonamide bridging compounds that inhibit tryptase activity
EP1030844A1 (en)	1997-11-10	2000-08-30	Array Biopharma Inc.	Compounds which inhibit tryptase activity
ES2233025T3 (es)	1998-02-06	2005-06-01	Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V.	Agente inhibidores de la triptasa.
EP1060171A2 (de)	1998-02-06	2000-12-20	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Tryptase-inhibitoren
WO2000014097A2 (de)	1998-09-04	2000-03-16	Byk Gulden Lomberg Chemische Fabrik Gmbh	Neue pyranosen
JP2003506442A (ja)	1999-08-10	2003-02-18	アルタナファルマアクチエンゲゼルシャフト	新規トリプターゼインヒビター
DE19937721A1 (de)	1999-08-10	2001-02-15	Max Planck Gesellschaft	Neue Diketopiperazine
JP2003509417A (ja)	1999-09-14	2003-03-11	アルタナファルマアクチエンゲゼルシャフト	トリプターゼインヒビター
TR200402322T4 (tr)	1999-12-20	2004-12-21	Altana Pharma Ag	Triptaz inhibitörler
JP2003518087A (ja)	1999-12-20	2003-06-03	アルタナファルマアクチエンゲゼルシャフト	トリプターゼインヒビター

2002
- 2002-01-26 PT PT02704674T patent/PT1358182E/pt unknown
- 2002-01-26 US US10/466,906 patent/US6924305B2/en not_active Expired - Fee Related
- 2002-01-26 AT AT02704674T patent/ATE273302T1/de not_active IP Right Cessation
- 2002-01-26 EP EP02704674A patent/EP1358182B1/en not_active Expired - Lifetime
- 2002-01-26 DK DK02704674T patent/DK1358182T3/da active
- 2002-01-26 DE DE60200935T patent/DE60200935T2/de not_active Expired - Fee Related
- 2002-01-26 AU AU2002238522A patent/AU2002238522B8/en not_active Ceased
- 2002-01-26 JP JP2002561044A patent/JP2004517943A/ja not_active Withdrawn
- 2002-01-26 SI SI200230037T patent/SI1358182T1/xx unknown
- 2002-01-26 ES ES02704674T patent/ES2225758T3/es not_active Expired - Lifetime
- 2002-01-26 CA CA002438594A patent/CA2438594A1/en not_active Abandoned
- 2002-01-26 WO PCT/EP2002/000831 patent/WO2002060895A1/en not_active Ceased

Also Published As

Publication number	Publication date
SI1358182T1 (en)	2005-02-28
AU2002238522B2 (en)	2006-12-21
EP1358182A1 (en)	2003-11-05
CA2438594A1 (en)	2002-08-08
US6924305B2 (en)	2005-08-02
US20040072762A1 (en)	2004-04-15
DE60200935T2 (de)	2005-09-01
AU2002238522B8 (en)	2007-01-18
PT1358182E (pt)	2004-12-31
DE60200935D1 (de)	2004-09-16
EP1358182B1 (en)	2004-08-11
JP2004517943A (ja)	2004-06-17
ATE273302T1 (de)	2004-08-15
WO2002060895A1 (en)	2002-08-08
ES2225758T3 (es)	2005-03-16
AU2002238522A1 (en)	2002-08-12

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DE60011300D1 (de)	2004-07-08	Inhibitoren der tryptase
ATE348803T1 (de)	2007-01-15	Tryptase-inhibitoren
PT1358182E (pt)	2004-12-31	Derivados de diazocinas e sua utilizacao como inibidores de triptase
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