DK136579A - Thioetiansyrederivater - Google Patents

Thioetiansyrederivater

Info

Publication number
DK136579A
DK136579A DK136579A DK136579A DK136579A DK 136579 A DK136579 A DK 136579A DK 136579 A DK136579 A DK 136579A DK 136579 A DK136579 A DK 136579A DK 136579 A DK136579 A DK 136579A
Authority
DK
Denmark
Prior art keywords
thioetianic
acid derivatives
derivatives
acid
thioetianic acid
Prior art date
Application number
DK136579A
Other languages
English (en)
Other versions
DK147735B (da
DK147735C (da
Inventor
J A Edwards
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK136579A publication Critical patent/DK136579A/da
Publication of DK147735B publication Critical patent/DK147735B/da
Application granted granted Critical
Publication of DK147735C publication Critical patent/DK147735C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK136579A 1978-04-05 1979-04-03 Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere DK147735C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89338878 1978-04-05
US05/893,388 US4188385A (en) 1978-04-05 1978-04-05 Thioetianic acid derivatives

Publications (3)

Publication Number Publication Date
DK136579A true DK136579A (da) 1979-10-06
DK147735B DK147735B (da) 1984-11-26
DK147735C DK147735C (da) 1985-08-19

Family

ID=25401484

Family Applications (1)

Application Number Title Priority Date Filing Date
DK136579A DK147735C (da) 1978-04-05 1979-04-03 Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere

Country Status (28)

Country Link
US (1) US4188385A (da)
EP (1) EP0004741B1 (da)
JP (2) JPS54141758A (da)
AR (1) AR226035A1 (da)
AT (1) AT368168B (da)
AU (1) AU526025B2 (da)
CA (1) CA1134345A (da)
CS (1) CS203956B2 (da)
DE (2) DE2960096D1 (da)
DK (1) DK147735C (da)
ES (1) ES479271A1 (da)
FI (1) FI66393C (da)
FR (1) FR2421912A1 (da)
GB (1) GB2018256B (da)
GR (1) GR67275B (da)
HK (1) HK41284A (da)
HU (1) HU179314B (da)
IL (1) IL56972A0 (da)
IT (1) IT1120954B (da)
MY (1) MY8500575A (da)
NO (1) NO152935C (da)
NZ (1) NZ190076A (da)
PL (1) PL121469B1 (da)
PT (1) PT69409A (da)
SG (1) SG6786G (da)
SU (1) SU1052161A3 (da)
YU (1) YU40929B (da)
ZA (1) ZA791635B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4310466A (en) * 1979-08-31 1982-01-12 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
NZ196260A (en) * 1980-02-15 1983-11-30 Glaxo Group Ltd Androstane carbothioates anti-inflammatory compositions
BE887518A (fr) * 1980-02-15 1981-08-13 Glaxo Group Ltd Cartothioates d'androstanes
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
GB9225923D0 (en) * 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
DE69311742T2 (de) * 1992-12-24 1998-01-08 Rhone Poulenc Rorer Ltd Neue steroide
CN1133643C (zh) 1995-12-29 2004-01-07 葛兰素集团有限公司 17-β-羧基,羰基硫代以及酰胺雄甾烷衍生物的内酯衍生物
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
SI1775305T1 (sl) * 2000-08-05 2015-01-30 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
KR100831534B1 (ko) * 2001-04-30 2008-05-22 글락소 그룹 리미티드 17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
ES2307751T3 (es) * 2001-06-12 2008-12-01 Glaxo Group Limited Nuevos esteres heterociclicos centi-inflamatorios 17 alfa de derivados 17 beta de carbotioato de androstano.
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
WO2004087731A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
TWI374147B (en) * 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
WO2009085879A2 (en) * 2007-12-21 2009-07-09 Schering Corporation C20-c21 substituted glucocorticoid receptor agonists
CN102834406A (zh) 2009-06-16 2012-12-19 默沙东公司 作为糖皮质激素受体激动剂的新的[3.2-c]杂芳基甾体、其组合物和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2509171A (en) * 1946-02-06 1950-05-23 Ciba Ltd Primary alcohols from thiocarboxylic acids and esters
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

Also Published As

Publication number Publication date
AT368168B (de) 1982-09-27
IL56972A0 (en) 1979-05-31
MY8500575A (en) 1985-12-31
NO152935C (no) 1985-12-18
ES479271A1 (es) 1980-01-16
JPS611038B2 (da) 1986-01-13
EP0004741A2 (en) 1979-10-17
AU4558379A (en) 1979-10-18
GB2018256A (en) 1979-10-17
JPS54141758A (en) 1979-11-05
ATA251979A (de) 1982-01-15
DE2912331A1 (de) 1979-10-18
HK41284A (en) 1984-05-18
FI791081A7 (fi) 1979-10-06
EP0004741A3 (en) 1979-11-14
NO152935B (no) 1985-09-09
JPS6069019A (ja) 1985-04-19
IT7967652A0 (it) 1979-03-28
NZ190076A (en) 1984-07-31
CS203956B2 (en) 1981-03-31
EP0004741B1 (en) 1981-01-28
PL214676A1 (da) 1980-01-02
NO791140L (no) 1979-10-08
FR2421912A1 (fr) 1979-11-02
FI66393C (fi) 1984-10-10
GB2018256B (en) 1983-02-02
DK147735B (da) 1984-11-26
FR2421912B1 (da) 1981-03-20
DK147735C (da) 1985-08-19
PL121469B1 (en) 1982-05-31
SU1052161A3 (ru) 1983-10-30
AU526025B2 (en) 1982-12-16
IT1120954B (it) 1986-03-26
PT69409A (en) 1979-04-01
SG6786G (en) 1986-08-01
CA1134345A (en) 1982-10-26
GR67275B (da) 1981-06-26
JPS6140648B2 (da) 1986-09-10
AR226035A1 (es) 1982-05-31
YU80379A (en) 1983-04-30
YU40929B (en) 1986-08-31
ZA791635B (en) 1980-11-26
DE2960096D1 (en) 1981-03-19
US4188385A (en) 1980-02-12
FI66393B (fi) 1984-06-29
HU179314B (en) 1982-09-28

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Legal Events

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PBP Patent lapsed