DK137083D0 - Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholecalciferol og mellemprodukter til brug herved - Google Patents

Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholecalciferol og mellemprodukter til brug herved

Info

Publication number: DK137083D0
Authority: DK; Denmark
Prior art keywords: hexafluorlalfa; dihydroxycholecalciferol; intermediates; preparing
Prior art date: 1981-07-27

Application number

DK1370/83A

Other languages

English (en)

Other versions

DK162282B (da

DK162282C (da

DK137083A (da

Inventor

Hector F Deluca

Yoko Tanaka

Nobuo Ikekawa

Yoshiro Kobayashi

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-07-27

Filing date

1983-03-25

Publication date

1983-03-25

1983-03-25 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1983-03-25 Publication of DK137083A publication Critical patent/DK137083A/da

1983-03-25 Publication of DK137083D0 publication Critical patent/DK137083D0/da

1984-11-22 Priority to DK554084A priority Critical patent/DK165695C/da

1991-10-07 Publication of DK162282B publication Critical patent/DK162282B/da

1992-03-16 Application granted granted Critical

1992-03-16 Publication of DK162282C publication Critical patent/DK162282C/da

Links

GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Nutrition Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK137083A 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden DK162282C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK554084A DK165695C (da)	1981-07-27	1984-11-22	26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US28679081		1981-07-27
US06/286,790 US4358406A (en)	1981-07-27	1981-07-27	26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
PCT/US1982/000909 WO1983000335A1 (en)	1981-07-27	1982-07-06	26,26,26,27,27,27-HEXAFLUORO-1'alpha',25-DIHYDROXYCHOLECALCIFEROL AND PROCESS FOR PREPARING SAME
US8200909		1982-07-06

Publications (4)

Publication Number	Publication Date
DK137083A DK137083A (da)	1983-03-25
DK137083D0 true DK137083D0 (da)	1983-03-25
DK162282B DK162282B (da)	1991-10-07
DK162282C DK162282C (da)	1992-03-16

Family

ID=23100174

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK137083A DK162282C (da)	1981-07-27	1983-03-25	Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden
DK554084A DK165695C (da)	1981-07-27	1984-11-22	26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK554084A DK165695C (da)	1981-07-27	1984-11-22	26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Country Status (14)

Country	Link
US (1)	US4358406A (da)
JP (1)	JPS58501176A (da)
AU (2)	AU552210B2 (da)
BE (1)	BE893943A (da)
CH (2)	CH656134A5 (da)
DE (2)	DE3250034C2 (da)
DK (2)	DK162282C (da)
FR (1)	FR2510566B1 (da)
GB (2)	GB2102806B (da)
IE (2)	IE54370B1 (da)
IL (5)	IL76090A (da)
IT (1)	IT1157309B (da)
NL (1)	NL8220265A (da)
WO (1)	WO1983000335A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4634692A (en) *	1981-08-28	1987-01-06	Hoffmann-La Roche Inc.	Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) *	1982-05-26	1983-10-25	Wisconsin Alumni Research Foundation	Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) *	1983-05-11	1984-05-15	Wisconsin Alumni Research Foundation	Ring A- and triene-modified vitamin D compounds
US4613594A (en) *	1984-11-16	1986-09-23	Hoffmann-La Roche Inc.	Fluorinated vitamin D3 compounds
ZA859138B (en) *	1984-12-19	1986-08-27	Hoffmann La Roche	Cholecalciferol derivatives
EP0205025A1 (en) *	1985-05-27	1986-12-17	Sumitomo Pharmaceuticals Company, Limited	Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) *	1985-09-16	1986-10-28	Wisconsin Alumni Research Foundation	26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) *	1986-04-25	1995-07-12	住友製薬株式会社	活性型ビタミンｄ３のフッ素誘導体
CA1314872C (en)	1986-04-25	1993-03-23	Toshio Nishizawa	Fluorine derivatives of vitamin d _and process for producing the same
US4853378A (en) *	1986-10-20	1989-08-01	Sumitomo Chemical Company, Limited	Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
US5316770A (en) *	1989-02-16	1994-05-31	University Of Georgia Research Foundation, Inc.	Vitamin D derivative feed compositions and methods of use
US5366736A (en) *	1989-02-16	1994-11-22	University Of Georgia Research Foundation, Inc.	Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (en) *	1989-02-16	1990-08-23	University Of Georgia Research Foundation, Inc.	Treatment of tibial dyschondroplasia
AU666313B2 (en) *	1991-05-06	1996-02-08	Procter & Gamble Company, The	Combined calcium and vitamin D supplements
US5753638A (en) *	1992-10-07	1998-05-19	Hoffmann-La Roche Inc.	Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) *	1992-10-07	1994-04-08	Enrico Giuseppe Baggiolini (Deceased)	Vitamin d3 fluorinated analogs
PT665221E (pt) *	1992-10-16	2000-06-30	Chugai Pharmaceutical Co Ltd	Derivado da vitamina d e processo para a sua producao
AU6247194A (en) *	1993-02-19	1994-09-14	Wisconsin Alumni Research Foundation	Use of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife rol for the treatment of calcium metabolism disorders
US5547947A (en) *	1993-03-11	1996-08-20	Hoffmann-La Roche Inc.	Methods of treatment
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
IL139241A0 (en)	1998-05-13	2001-11-25	Novo Nordisk As	Meiosis regulating compounds
US6080879A (en) *	1998-05-19	2000-06-27	Tetrionics, Inc.	Hexafluoro-vitamin synthesis and crystallization method, solvent and product
JP2011508743A (ja) *	2007-12-28	2011-03-17	ウィスコンシンアラムナイリサーチファンデーション	（２０ｓ）−２３，２３−ジフルオロ−２−メチレン−１９−ノル−ビスホモプレグナカルシフェロール−ビタミンｄ類縁体
AU2010208323B2 (en)	2009-01-27	2016-03-10	Berg Llc	Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en)	2009-08-14	2019-05-22	Berg LLC	Vitamin d3 and analogs thereof for treating alopecia
FI2753632T3 (fi) *	2011-09-08	2023-08-02	Sage Therapeutics Inc	Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä
RS67266B1 (sr)	2013-03-13	2025-10-31	Sage Therapeutics Inc	Neuroaktivni steroidi i postupci za njihovu upotrebu
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
ES2536256B2 (es)	2013-11-20	2016-02-01	Universidade De Santiago De Compostela	Análogos de vitamina d con interés farmacéutico
FI3828194T3 (fi)	2015-07-06	2025-07-17	Sage Therapeutics Inc	Oxysteroleita ja menetelmiä niiden käyttämiseksi
US20190330259A1 (en)	2016-04-01	2019-10-31	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
JP7149266B2 (ja)	2016-09-30	2022-10-06	セージセラピューティクス，インコーポレイテッド	Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
MA46566A (fr)	2016-10-18	2019-08-28	Sage Therapeutics Inc	Oxystérols et leurs procédés d'utilisation
CN111960938B (zh) *	2020-08-20	2022-06-17	甘肃皓天医药科技有限责任公司	用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL45897A (en) *	1974-10-22	1978-12-17	Yeda Res & Dev	Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) *	1978-03-30	1980-04-22	Diamond Shamrock Corporation	1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) *	1978-11-07	1984-05-04	Res Inst Medicine Chem	Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) *	1979-03-28	1980-10-07	Wisconsin Alumni Research Foundation	24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) *	1980-02-04	1981-02-03	Wisconsin Alumni Research Foundation	25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

1981
- 1981-07-27 US US06/286,790 patent/US4358406A/en not_active Expired - Lifetime
1982
- 1982-07-06 DE DE3250034A patent/DE3250034C2/de not_active Expired - Lifetime
- 1982-07-06 CH CH2891/85A patent/CH656134A5/de not_active IP Right Cessation
- 1982-07-06 CH CH1788/83A patent/CH655307A5/de not_active IP Right Cessation
- 1982-07-06 NL NL8220265A patent/NL8220265A/nl not_active Application Discontinuation
- 1982-07-06 JP JP57502411A patent/JPS58501176A/ja active Granted
- 1982-07-06 AU AU87605/82A patent/AU552210B2/en not_active Ceased
- 1982-07-06 DE DE823248900T patent/DE3248900T1/de active Granted
- 1982-07-06 WO PCT/US1982/000909 patent/WO1983000335A1/en not_active Ceased
- 1982-07-19 IL IL76090A patent/IL76090A/xx not_active IP Right Cessation
- 1982-07-19 IL IL76091A patent/IL76091A/xx not_active IP Right Cessation
- 1982-07-19 IL IL66351A patent/IL66351A/xx not_active IP Right Cessation
- 1982-07-26 IE IE1226/89A patent/IE54370B1/en not_active IP Right Cessation
- 1982-07-26 FR FR8212994A patent/FR2510566B1/fr not_active Expired
- 1982-07-26 IT IT22574/82A patent/IT1157309B/it active
- 1982-07-26 BE BE0/208679A patent/BE893943A/fr not_active IP Right Cessation
- 1982-07-26 GB GB08221573A patent/GB2102806B/en not_active Expired
- 1982-07-26 IE IE1797/82A patent/IE54369B1/en not_active IP Right Cessation
1983
- 1983-03-25 DK DK137083A patent/DK162282C/da not_active IP Right Cessation
- 1983-04-27 GB GB08311517A patent/GB2118556B/en not_active Expired
1984
- 1984-11-22 DK DK554084A patent/DK165695C/da not_active IP Right Cessation
1985
- 1985-08-14 IL IL76091A patent/IL76091A0/xx unknown
- 1985-08-14 IL IL76090A patent/IL76090A0/xx unknown
1986
- 1986-07-25 AU AU60560/86A patent/AU586267B2/en not_active Ceased

Also Published As

Publication number	Publication date
IL66351A0 (en)	1982-11-30
DE3248900T1 (de)	1983-07-07
IL76091A (en)	1987-12-31
IT8222574A0 (it)	1982-07-26
IL76091A0 (en)	1985-12-31
WO1983000335A1 (en)	1983-02-03
US4358406A (en)	1982-11-09
NL8220265A (nl)	1983-06-01
IL66351A (en)	1987-12-31
AU586267B2 (en)	1989-07-06
DK554084D0 (da)	1984-11-22
IL76090A0 (en)	1985-12-31
DK162282B (da)	1991-10-07
CH656134A5 (de)	1986-06-13
IE821797L (en)	1983-01-27
DK162282C (da)	1992-03-16
FR2510566A1 (fr)	1983-02-04
JPS58501176A (ja)	1983-07-21
CH655307A5 (de)	1986-04-15
IL76090A (en)	1987-12-31
AU552210B2 (en)	1986-05-22
GB8311517D0 (en)	1983-06-02
IE54370B1 (en)	1989-09-13
DK165695C (da)	1993-06-07
AU8760582A (en)	1983-03-17
AU6056086A (en)	1986-12-18
JPH0348903B2 (da)	1991-07-25
GB2118556B (en)	1985-02-27
GB2102806B (en)	1985-02-27
DE3250034C2 (da)	1991-02-28
DK165695B (da)	1993-01-04
FR2510566B1 (fr)	1985-06-28
DK137083A (da)	1983-03-25
DE3248900C2 (da)	1990-12-13
GB2118556A (en)	1983-11-02
DK554084A (da)	1984-11-22
IE891226L (en)	1983-01-27
IT1157309B (it)	1987-02-11
GB2102806A (en)	1983-02-09
IE54369B1 (en)	1989-09-13
BE893943A (fr)	1982-11-16

Legal Events

Date	Code	Title	Description
1986-03-17	PBP	Patent lapsed

Publication	Publication Date	Title
DK164684D0 (da)	1984-03-23	4-substituerede-2-azetidinon-forbindelser,fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved
DK516182A (da)	1983-05-21	Fremgangsmaade til fremstilling af 3-hydroxy-ml-236b derivater, betegnet m-4 og m-4'
DK172485A (da)	1985-06-18	23,23-difluor-1,25-dihydroxycholecalciferol og derivater deraf, fremgangsmaade til fremstilling af disse og mellemprodukter til brug herved
NO164506C (no)	1990-10-10	Strippemiddel og anvendelse derav.
DK56782A (da)	1983-02-14	Fremgangsmaade og middel til boelgning eller udretning af haar
DK261782A (da)	1982-12-12	Overfladebehandlingsmetode og praeparat til cement
DK32684D0 (da)	1984-01-25	Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholesterol og mellemprodukter til brug herfor
DK116282A (da)	1982-09-18	Kosmetisk praeparat og fremgangsmaade til dets fremstilling
DK288679A (da)	1980-01-11	Fremgangsmaade til fremstilling af d-camphorat af l-carnitinamid og d-camphorat af d-carnitinamid
DK145983D0 (da)	1983-03-30	Fremgangsmade til fremstilling af quinolonforbindelser og mellemprodukter til brug herved
DK436981A (da)	1981-10-02	Fremgangsmaade til fremstilling af 25-hydroxy26,26,26,27,27,27,-hexafluor-cholecalciferol og mellemprodukter herved
DK215490A (da)	1990-09-07	Fremgangsmaade til fremstilling af 10-substituerede 1,8-dihydroxy-9-anthroner
DK505080A (da)	1980-11-27	Fremgangsmaade til fremstilling af 24,24-difluor1alfa,25-dihydroxycholecalciferol og mellemprodukter til brug ved fremgangsmaaden
DK145885D0 (da)	1985-04-01	Stroemningsreaktor og fremgangsmaade til fremstilling deraf
DK13786A (da)	1986-07-15	1,6-naphthyridin-2(1h)oner, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved
DK459579A (da)	1980-05-04	Fremgangsmaade til fremstilling af 1,2,3-thiadiazol-5-ylurinstoffer
PL238064A1 (en)	1983-05-09	Herbicide and method of manufacture of fluorine containing 4,6-diamino-s-triazines and their intermediates
DK127182A (da)	1982-09-24	Fremgangsmaade til fremstilling af 1,1-dioxopenicillanoyloxymethyl-6-(2-phenylacetamido)penicillanater og mellemprodukter herved
DK501582A (da)	1983-05-12	Fremgangsmaade til fremstilling af acylcyanider
DK274882A (da)	1982-12-20	Fremgangsmaade til fremstilling af 4alfa,5alfa-epoxy-3,20-dioxopregnen-2alfa,16alfa-dicarbonitril og mellemprodukt herved
DK232184A (da)	1984-11-13	Fremgangsmaade til fremstilling af 4-halogenmethylthiazoler og mellemprodukt til brug ved fremgangsmaaden
DK326082A (da)	1983-01-22	Heptadecapeptid og fremgangsmaade til fremstilling heraf
IT8212605A0 (it)	1982-08-04	Metodo ed apparecchio per la deodo rizzazione di ambienti
DK157365C (da)	1990-05-21	Fremgangsmaade til fremstilling af 1,2,4-triazol
DK76482A (da)	1982-08-24	Fremgangsmaade til fremstilling af antibiotikaene ll-b01208alfa og ll-b01208beta