DK1406876T3 - 2-anilinopyrimidinderivater som inhibitorer af cyclinafhængige kinaser - Google Patents

2-anilinopyrimidinderivater som inhibitorer af cyclinafhængige kinaser

Info

Publication number: DK1406876T3
Authority: DK; Denmark
Prior art keywords: sup; cyclin; inhibitors; dependent kinases; anilinopyrimidine derivatives
Prior art date: 2001-05-30

Application number

DK02730448T

Other languages

English (en)

Inventor

Nicholas John Newcombe

Andrew Peter Thomas

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-30

Filing date

2002-05-24

Publication date

2007-04-02

2002-05-24 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2007-04-02 Application granted granted Critical

2007-04-02 Publication of DK1406876T3 publication Critical patent/DK1406876T3/da

Links

108091007914 CDKs Proteins 0.000 title 1
102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical class N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 abstract 2
230000022131 cell cycle Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Oncology (AREA)
Dermatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02730448T 2001-05-30 2002-05-24 2-anilinopyrimidinderivater som inhibitorer af cyclinafhængige kinaser DK1406876T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0113041.8A GB0113041D0 (en)	2001-05-30	2001-05-30	Chemical compounds
PCT/GB2002/002428 WO2002096887A1 (en)	2001-05-30	2002-05-24	2-anilino-pyrimidine derivatives as cyclin dependent kinase inhibitors

Publications (1)

Publication Number	Publication Date
DK1406876T3 true DK1406876T3 (da)	2007-04-02

Family

ID=9915495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02730448T DK1406876T3 (da)	2001-05-30	2002-05-24	2-anilinopyrimidinderivater som inhibitorer af cyclinafhængige kinaser

Country Status (19)

Country	Link
US (1)	US6939872B2 (da)
EP (1)	EP1406876B1 (da)
JP (1)	JP2004533458A (da)
KR (1)	KR20040030644A (da)
CN (1)	CN1286821C (da)
AT (1)	ATE349432T1 (da)
BR (1)	BR0210071A (da)
CA (1)	CA2448305A1 (da)
DE (1)	DE60217118T2 (da)
DK (1)	DK1406876T3 (da)
ES (1)	ES2278023T3 (da)
GB (1)	GB0113041D0 (da)
IL (1)	IL158975A0 (da)
MX (1)	MXPA03010877A (da)
NO (1)	NO20035210L (da)
NZ (1)	NZ529763A (da)
PT (1)	PT1406876E (da)
WO (1)	WO2002096887A1 (da)
ZA (1)	ZA200309165B (da)

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AU2011260323A1 (en)	2010-06-04	2012-11-15	F. Hoffmann-La Roche Ag	Aminopyrimidine derivatives as LRRK2 modulators
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2001
- 2001-05-30 GB GBGB0113041.8A patent/GB0113041D0/en not_active Ceased
2002
- 2002-05-24 CN CNB028149637A patent/CN1286821C/zh not_active Expired - Fee Related
- 2002-05-24 WO PCT/GB2002/002428 patent/WO2002096887A1/en not_active Ceased
- 2002-05-24 NZ NZ529763A patent/NZ529763A/en unknown
- 2002-05-24 DE DE60217118T patent/DE60217118T2/de not_active Expired - Lifetime
- 2002-05-24 US US10/479,041 patent/US6939872B2/en not_active Expired - Fee Related
- 2002-05-24 ES ES02730448T patent/ES2278023T3/es not_active Expired - Lifetime
- 2002-05-24 CA CA002448305A patent/CA2448305A1/en not_active Abandoned
- 2002-05-24 KR KR10-2003-7015587A patent/KR20040030644A/ko not_active Ceased
- 2002-05-24 JP JP2003500066A patent/JP2004533458A/ja active Pending
- 2002-05-24 AT AT02730448T patent/ATE349432T1/de not_active IP Right Cessation
- 2002-05-24 DK DK02730448T patent/DK1406876T3/da active
- 2002-05-24 MX MXPA03010877A patent/MXPA03010877A/es active IP Right Grant
- 2002-05-24 PT PT02730448T patent/PT1406876E/pt unknown
- 2002-05-24 IL IL15897502A patent/IL158975A0/xx unknown
- 2002-05-24 EP EP02730448A patent/EP1406876B1/en not_active Expired - Lifetime
- 2002-05-24 BR BR0210071-1A patent/BR0210071A/pt not_active IP Right Cessation
2003
- 2003-11-24 NO NO20035210A patent/NO20035210L/no unknown
- 2003-11-25 ZA ZA200309165A patent/ZA200309165B/en unknown

Also Published As

Publication number	Publication date
GB0113041D0 (en)	2001-07-18
NZ529763A (en)	2006-01-27
DE60217118D1 (de)	2007-02-08
JP2004533458A (ja)	2004-11-04
KR20040030644A (ko)	2004-04-09
NO20035210L (no)	2003-11-27
ES2278023T3 (es)	2007-08-01
CN1286821C (zh)	2006-11-29
NO20035210D0 (no)	2003-11-24
MXPA03010877A (es)	2004-02-17
BR0210071A (pt)	2004-06-22
EP1406876B1 (en)	2006-12-27
ZA200309165B (en)	2005-03-10
US6939872B2 (en)	2005-09-06
PT1406876E (pt)	2007-02-28
US20040198757A1 (en)	2004-10-07
DE60217118T2 (de)	2007-06-28
EP1406876A1 (en)	2004-04-14
ATE349432T1 (de)	2007-01-15
CA2448305A1 (en)	2002-12-05
CN1541208A (zh)	2004-10-27
IL158975A0 (en)	2004-05-12
WO2002096887A1 (en)	2002-12-05

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