|
US4039653A
(en)
*
|
1974-01-23 |
1977-08-02 |
Defoney, Brenman, Mayes & Baron |
Long-acting articles for oral delivery and process
|
|
CH653021A5
(fr)
|
1981-04-24 |
1985-12-13 |
Delalande Sa |
Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
|
|
FR2524312B1
(fr)
*
|
1982-04-01 |
1985-10-04 |
Tech Cuir Centre |
Nouvelles formes de micro-encapsulation de substances medicamenteuses par des couches homogenes de collagene natif
|
|
NZ209876A
(en)
|
1983-10-17 |
1988-03-30 |
Duphar Int Res |
Piperazines and pharmaceutical compositions
|
|
EP0185429A1
(en)
|
1984-12-21 |
1986-06-25 |
Duphar International Research B.V |
New bicyclic heteroaryl piperazines
|
|
DE3586794T2
(de)
|
1984-12-21 |
1993-05-27 |
Duphar Int Res |
Arzneimittel mit psychotroper wirkung.
|
|
GB8521494D0
(en)
*
|
1985-08-29 |
1985-10-02 |
Zyma Sa |
Controlled release tablet
|
|
US4797286A
(en)
*
|
1985-11-12 |
1989-01-10 |
Eli Lilly And Company |
Orally administerable sustained release pharmaceutical formulations
|
|
EP0241053B1
(en)
|
1986-02-27 |
1992-11-11 |
Duphar International Research B.V |
Aryl-substituted (n-piperidinyl)-methyl- and (n-piperazinyl) methylazoles having antipsychotic properties
|
|
GB8613689D0
(en)
*
|
1986-06-05 |
1986-07-09 |
Euro Celtique Sa |
Pharmaceutical composition
|
|
MX173362B
(es)
|
1987-03-02 |
1994-02-23 |
Pfizer |
Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
|
|
DK172628B1
(da)
|
1987-09-11 |
1999-08-02 |
Duphar Int Res |
Anvendelse af piperazinderivater til fremstilling af lægemidler til behandling af syndromer, der involverer frygt eller fry
|
|
US4831031A
(en)
|
1988-01-22 |
1989-05-16 |
Pfizer Inc. |
Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
|
|
IL92544A0
(en)
|
1988-12-08 |
1990-08-31 |
Duphar Int Res |
Piperazine derivatives,their preparation and pharmaceutical compositions containing them
|
|
GB8830312D0
(en)
|
1988-12-28 |
1989-02-22 |
Lundbeck & Co As H |
Heterocyclic compounds
|
|
SE8904361D0
(sv)
|
1989-12-22 |
1989-12-22 |
Astra Ab |
New chroman and thiochroman derivatives
|
|
FR2670491B1
(fr)
|
1990-12-14 |
1993-02-05 |
Adir |
Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
|
|
AU645681B2
(en)
|
1991-05-02 |
1994-01-20 |
John Wyeth & Brother Limited |
Piperazine derivatives
|
|
IT1251144B
(it)
|
1991-07-30 |
1995-05-04 |
Boehringer Ingelheim Italia |
Derivati del benzimidazolone
|
|
GB9125900D0
(en)
|
1991-12-05 |
1992-02-05 |
Wyeth John & Brother Ltd |
Piperazine derivatives
|
|
EP0556889A1
(en)
|
1992-02-18 |
1993-08-25 |
Duphar International Research B.V |
Method of preparing aryl(homo)piperazines
|
|
FR2692264B1
(fr)
|
1992-06-12 |
1994-08-05 |
Adir |
Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
|
|
DK148392D0
(da)
|
1992-12-09 |
1992-12-09 |
Lundbeck & Co As H |
Heterocykliske forbindelser
|
|
DE69325698T2
(de)
|
1992-12-21 |
2000-01-27 |
Duphar International Research B.V., Weesp |
Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols
|
|
RU2118322C1
(ru)
|
1993-07-05 |
1998-08-27 |
Дюфар Интернэшнл Рисерч Б.В. |
2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
|
|
US5652249A
(en)
*
|
1993-07-28 |
1997-07-29 |
Nippon Shinyaku Co., Inc. |
Method of treating depression
|
|
EP0724580A1
(en)
|
1993-10-19 |
1996-08-07 |
Smithkline Beecham Plc |
Benzanilide derivatives as 5ht-1d receptor antagonists
|
|
EP0650964A1
(en)
|
1993-11-02 |
1995-05-03 |
Duphar International Research B.V |
1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives
|
|
IL112764A0
(en)
|
1994-03-18 |
1995-05-26 |
Ferrer Int |
New chromene derivatives
|
|
FI965238A7
(fi)
|
1994-06-29 |
1996-12-27 |
Pfizer |
Aryyli- ja heteroaryylialkoksinaftaleenijohdannaiset
|
|
FR2725623A1
(fr)
*
|
1994-10-18 |
1996-04-19 |
Flamel Tech Sa |
Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
|
|
EP0710481A1
(en)
|
1994-11-02 |
1996-05-08 |
Duphar International Research B.V |
Use of flesinoxan for cognition enhancement
|
|
WO1996017831A1
(de)
|
1994-12-07 |
1996-06-13 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Uracilderivate
|
|
US5741789A
(en)
|
1995-01-17 |
1998-04-21 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
EP0839144B1
(en)
|
1995-07-13 |
2001-09-19 |
Knoll GmbH |
Piperazine derivatives as therapeutic agents
|
|
GB9514901D0
(en)
|
1995-07-20 |
1995-09-20 |
American Home Prod |
Piperazine derivatives
|
|
JPH11511156A
(ja)
|
1995-08-11 |
1999-09-28 |
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー |
ビフェニル(チオ)アミドおよびビフェニルエタン(チオ)オン誘導体、その製造方法ならびに5−ht▲下1d▼ 受容体拮抗薬としてのその使用
|
|
SE9601110D0
(sv)
|
1996-03-22 |
1996-03-22 |
Astra Ab |
Substituted 1,2,3,4-tetrahydronaphthalene derivatives
|
|
ES2271967T3
(es)
|
1996-03-29 |
2007-04-16 |
Duphar International Research B.V |
Compuestos de piperazina y piperidina.
|
|
US5846982A
(en)
*
|
1996-06-14 |
1998-12-08 |
Eli Lilly And Company |
Inhibition of serotonin reuptake
|
|
JP2001502327A
(ja)
|
1996-10-15 |
2001-02-20 |
アメリカン・ホーム・プロダクツ・コーポレイション |
2,3,8,9―テトラヒドロ―7H―1,4―ジオキシノ[2,3―e]インドール―8―オンのアザヘテロサイクリルメチル誘導体
|
|
JPH10269708A
(ja)
|
1997-03-25 |
1998-10-09 |
Hiroshi Fukuda |
多信号用メモリーシステム
|
|
FR2760014B1
(fr)
|
1997-02-27 |
1999-04-09 |
Adir |
Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9706089D0
(en)
*
|
1997-03-24 |
1997-05-14 |
Scherer Ltd R P |
Pharmaceutical composition
|
|
DE19730989A1
(de)
*
|
1997-07-18 |
1999-01-21 |
Merck Patent Gmbh |
Piperazin-Derivate
|
|
ATE252575T1
(de)
|
1997-07-25 |
2003-11-15 |
Lundbeck & Co As H |
Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung
|
|
US5942244A
(en)
*
|
1997-07-31 |
1999-08-24 |
Farmo-Nat Ltd. |
Local oral herbal slow release tablets
|
|
DE69819266T2
(de)
|
1997-09-02 |
2004-07-29 |
Duphar International Research B.V. |
Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
|
|
SE9703376D0
(sv)
|
1997-09-18 |
1997-09-18 |
Astra Ab |
A new combination
|
|
SE9703378D0
(sv)
*
|
1997-09-18 |
1997-09-18 |
Astra Ab |
New compounds
|
|
SE9703374D0
(sv)
|
1997-09-18 |
1997-09-18 |
Astra Ab |
A new combination
|
|
SE9703375D0
(sv)
|
1997-09-18 |
1997-09-18 |
Astra Ab |
A new combination
|
|
TW530054B
(en)
|
1997-09-24 |
2003-05-01 |
Duphar Int Res |
New piperazine and piperidine compounds
|
|
FR2769312B1
(fr)
|
1997-10-03 |
1999-12-03 |
Adir |
Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
IL127497A
(en)
|
1997-12-18 |
2002-07-25 |
Pfizer Prod Inc |
Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
|
|
US6310066B1
(en)
|
1998-04-29 |
2001-10-30 |
American Home Products Corp. |
Antipsychotic indolyl derivatives
|
|
US6387904B2
(en)
|
1998-05-18 |
2002-05-14 |
Pfizer Inc |
Method of treating glaucoma and ischemic retinopathy
|
|
ATE247963T1
(de)
|
1998-05-26 |
2003-09-15 |
Pfizer Prod Inc |
Medikament zur behandlung von glaukoma und ischämischer retinopathie
|
|
GB9812523D0
(en)
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
|
CN1312802A
(zh)
|
1998-06-15 |
2001-09-12 |
美国家用产品公司 |
作为5-羟色胺能药物的环烷基取代的芳基哌嗪、哌啶和四氢吡啶
|
|
US6376494B1
(en)
|
1998-06-15 |
2002-04-23 |
American Home Products Corporation |
Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
|
|
UA71590C2
(en)
|
1998-11-13 |
2004-12-15 |
Duphar Int Res |
Piperazine and piperidine derivatives
|
|
US6242448B1
(en)
|
1998-12-17 |
2001-06-05 |
American Home Products Corporation |
Trisubstituted-oxazole derivatives as serotonin ligands
|
|
EP1147083B1
(en)
|
1999-01-07 |
2004-06-16 |
Wyeth |
Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
|
|
US6313126B1
(en)
|
1999-01-07 |
2001-11-06 |
American Home Products Corp |
Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
|
|
AR022303A1
(es)
|
1999-01-22 |
2002-09-04 |
Lundbeck & Co As H |
Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
|
|
US6306859B1
(en)
|
1999-03-02 |
2001-10-23 |
American Home Products Corporation |
N-substituted imide derivatives with serotonergic activity
|
|
ES2162731B1
(es)
|
1999-06-04 |
2003-02-16 |
Faes Fabrica Espanola De Produ |
Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.
|
|
DE60002583T2
(de)
|
1999-07-29 |
2004-03-25 |
Eli Lilly And Co., Indianapolis |
Benzofurylpiperazine als serotonin-agonisten
|
|
DE60004066T2
(de)
*
|
1999-07-29 |
2004-04-15 |
Eli Lilly And Co., Indianapolis |
Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten
|
|
ATE299142T1
(de)
|
1999-08-23 |
2005-07-15 |
Solvay Pharm Bv |
Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme
|
|
AR027133A1
(es)
|
1999-12-30 |
2003-03-12 |
Lundbeck & Co As H |
Derivados de heteroarilo, su preparacion y uso.
|
|
ATE255578T1
(de)
|
2000-05-12 |
2003-12-15 |
Solvay Pharm Bv |
Piperazin- und piperidinverbindungen
|
|
JP2003532676A
(ja)
|
2000-05-12 |
2003-11-05 |
ソルベイ・フアーマシユーチカルズ・ベー・ブイ |
CNS障害を治療するための組合せられたドーパミンD2、5−HT1Aおよびαアドレノレセプターアゴニスト作用、を有する化合物の使用
|
|
US20020016334A1
(en)
|
2000-07-31 |
2002-02-07 |
Coe Jotham Wadsworth |
Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
|
|
DE10041574A1
(de)
|
2000-08-24 |
2002-03-07 |
Merck Patent Gmbh |
Chromenonderivate
|
|
DE10043659A1
(de)
|
2000-09-05 |
2002-03-14 |
Merck Patent Gmbh |
Arylpiperazinderivate
|
|
EP2298738B1
(en)
|
2000-11-02 |
2012-09-19 |
Wyeth LLC |
1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
|
|
US7034029B2
(en)
|
2000-11-02 |
2006-04-25 |
Wyeth |
1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
|
|
US6469007B2
(en)
|
2000-11-28 |
2002-10-22 |
Wyeth |
Serotonergic agents
|
|
ES2188344B1
(es)
|
2000-11-29 |
2004-09-16 |
Laboratorios Vita, S.A. |
Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
|
|
AR032711A1
(es)
|
2001-02-21 |
2003-11-19 |
Solvay Pharm Bv |
Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
|
|
WO2003002556A1
(en)
|
2001-06-29 |
2003-01-09 |
H. Lundbeck A/S |
Novel heteroaryl derivatives, their preparation and use
|
|
DK1408976T5
(da)
|
2001-07-20 |
2011-01-10 |
Psychogenics Inc |
Behandling af ADHD (Attention deficit hyperactivity disorder)
|
|
HU227237B1
(en)
|
2001-09-27 |
2010-12-28 |
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag |
Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
|
|
ITMI20012060A1
(it)
|
2001-10-05 |
2003-04-05 |
Recordati Chem Pharm |
Nuovi eterocilcli n-acilati
|
|
EP1336406A1
(en)
|
2002-02-14 |
2003-08-20 |
Solvay Pharmaceuticals B.V. |
Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity
|
|
WO2003074518A1
(en)
|
2002-03-06 |
2003-09-12 |
Merck Patent Gmbh |
Thiazole derivatives and their use d2- and 5-ht1a-receptor ligands
|
|
JP2005527530A
(ja)
|
2002-03-12 |
2005-09-15 |
ワイス |
キラル1,4−二置換ピペラジン
|
|
US6713626B2
(en)
|
2002-03-12 |
2004-03-30 |
Wyeth |
Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
|
|
TWI288642B
(en)
|
2002-03-12 |
2007-10-21 |
Wyeth Corp |
Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
|
|
KR100636475B1
(ko)
|
2002-05-13 |
2006-10-18 |
에프. 호프만-라 로슈 아게 |
5-ht6 조절제로서 벤족사진 유도체 및 이의 용도
|
|
US20040072839A1
(en)
|
2002-06-14 |
2004-04-15 |
Amedeo Leonardi |
1-Phenylalkylpiperazines
|
|
US20040002500A1
(en)
|
2002-06-28 |
2004-01-01 |
Fabre Kramer Pharmaceutical, Inc. |
Methods for treating attention deficit disorder
|
|
US7067518B2
(en)
|
2002-09-05 |
2006-06-27 |
Wyeth |
Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
|
|
US7153849B2
(en)
|
2002-09-12 |
2006-12-26 |
Wyeth |
Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
|
|
PT1562918E
(pt)
|
2002-11-08 |
2008-03-12 |
Hoffmann La Roche |
Benzoxazinonas substituídas e as suas utilizações
|
|
HU227592B1
(en)
|
2002-11-13 |
2011-09-28 |
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag |
Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
|
|
US20040147581A1
(en)
|
2002-11-18 |
2004-07-29 |
Pharmacia Corporation |
Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
|
|
GB0227240D0
(en)
|
2002-11-21 |
2002-12-31 |
Glaxo Group Ltd |
Compounds
|
|
DE10259244A1
(de)
|
2002-12-17 |
2004-07-01 |
Merck Patent Gmbh |
N-(Indolethyl-)cycloamin-Verbindungen
|
|
US20050004105A1
(en)
|
2003-01-29 |
2005-01-06 |
Emer Leahy |
Treatment for a attention-deficit hyperactivity disorder
|
|
CN100395237C
(zh)
|
2003-03-03 |
2008-06-18 |
弗·哈夫曼-拉罗切有限公司 |
用作5-ht6调节剂的2,5-取代的四氢异喹啉
|
|
BRPI0410419A
(pt)
|
2003-05-16 |
2006-05-30 |
Pfizer Prod Inc |
tratamento para a ansiedade com ziprasidona
|
|
EP1626722A1
(en)
|
2003-05-16 |
2006-02-22 |
Pfizer Products Inc. |
Method for enhancing cognition using ziprasidone
|
|
JP2007502856A
(ja)
|
2003-05-16 |
2007-02-15 |
ファイザー・プロダクツ・インク |
精神病性障害および抑うつ性障害の治療
|
|
CN1780626A
(zh)
|
2003-05-16 |
2006-05-31 |
辉瑞产品公司 |
双相性精神障碍和相关症状的治疗
|
|
US20050065158A1
(en)
|
2003-07-16 |
2005-03-24 |
Pfizer Inc. |
Treatment of sexual dysfunction
|
|
GB0316915D0
(en)
|
2003-07-18 |
2003-08-20 |
Glaxo Group Ltd |
Compounds
|
|
US7435738B2
(en)
|
2003-08-18 |
2008-10-14 |
Solvay Pharmaceuticals, Inc. |
Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
|
|
US7160888B2
(en)
|
2003-08-22 |
2007-01-09 |
Warner Lambert Company Llc |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
|
|
AU2004299201B2
(en)
|
2003-12-09 |
2009-12-03 |
F. Hoffmann-La Roche Ag |
Benzoxazine derivatives and uses thereof
|
|
WO2005063296A2
(en)
|
2003-12-23 |
2005-07-14 |
Pfizer Products Inc. |
Therapeutic combination for cognition enhancement and psychotic disorders
|