DK1414444T3 - Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister - Google Patents

Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister

Info

Publication number: DK1414444T3
Authority: DK; Denmark
Prior art keywords: sup; formula; compounds; vla; cell
Prior art date: 2001-08-01

Application number

DK02764740T

Other languages

Danish (da)

English (en)

Inventor

Volkmar Wehner

Horst Blum

Hartmut Ruetten

Stefanie Flohr

Hans Ulrich Stilz

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-01

Filing date

2002-07-20

Publication date

2008-08-04

2002-07-20 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2008-08-04 Application granted granted Critical

2008-08-04 Publication of DK1414444T3 publication Critical patent/DK1414444T3/da

Links

108010008212 Integrin alpha4beta1 Proteins 0.000 title abstract 3
239000005557 antagonist Substances 0.000 title abstract 2
150000002461 imidazolidines Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 5
210000000265 leukocyte Anatomy 0.000 abstract 2
230000005012 migration Effects 0.000 abstract 2
238000013508 migration Methods 0.000 abstract 2
208000026935 allergic disease Diseases 0.000 abstract 1
230000008619 cell matrix interaction Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
108010044426 integrins Proteins 0.000 abstract 1
102000006495 integrins Human genes 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
230000008611 intercellular interaction Effects 0.000 abstract 1
230000023404 leukocyte cell-cell adhesion Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK02764740T 2001-08-01 2002-07-20 Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister DK1414444T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10137595A DE10137595A1 (de)	2001-08-01	2001-08-01	Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
PCT/EP2002/008106 WO2003011288A1 (en)	2001-08-01	2002-07-20	Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Publications (1)

Publication Number	Publication Date
DK1414444T3 true DK1414444T3 (da)	2008-08-04

Family

ID=7693930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02764740T DK1414444T3 (da)	2001-08-01	2002-07-20	Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister

Country Status (29)

Country	Link
US (1)	US6962937B2 (de)
EP (1)	EP1414444B1 (de)
JP (1)	JP4676697B2 (de)
KR (1)	KR100910930B1 (de)
CN (1)	CN1537000B (de)
AR (1)	AR036349A1 (de)
AT (1)	ATE391504T1 (de)
AU (1)	AU2002328931B2 (de)
BR (1)	BR0211535A (de)
CA (1)	CA2455966C (de)
CO (1)	CO5550452A2 (de)
DE (2)	DE10137595A1 (de)
DK (1)	DK1414444T3 (de)
ES (1)	ES2301673T3 (de)
HR (1)	HRP20040108A2 (de)
HU (1)	HUP0401406A3 (de)
IL (2)	IL160093A0 (de)
MX (1)	MXPA04000041A (de)
MY (1)	MY133467A (de)
NO (1)	NO326696B1 (de)
NZ (1)	NZ530887A (de)
PE (1)	PE20030348A1 (de)
PL (1)	PL365396A1 (de)
PT (1)	PT1414444E (de)
RS (1)	RS6104A (de)
RU (1)	RU2318815C2 (de)
TW (1)	TWI325863B (de)
WO (1)	WO2003011288A1 (de)
ZA (1)	ZA200400194B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101011373B1 (ko)	2002-07-11	2011-01-28	비큐론 파마슈티컬스 인코포레이티드	항균작용을 갖는 ｎ-히드록시아미드 유도체
EP2093218A1 (de) *	2008-02-22	2009-08-26	Ruggero Fariello	Arylalkylsubstituierte Imidazolidinone
CA2723358A1 (en) *	2008-05-05	2009-11-12	Allison B. Reiss	Method for improving cardiovascular risk profile of cox inhibitors
HUE050713T2 (hu)	2010-10-25	2020-12-28	Biogen Ma Inc	Módszerek az ALFA-4 integrin aktivitás eltéréseinek meghatározásához, a sVCAM ÉS/VAGY sMAdCAM szintek egymáshoz viszonyításával
US12296054B2 (en)	2020-06-01	2025-05-13	Lg Chem, Ltd.	Method of preparing polymeric microparticles, polymeric microparticles, medical composition, cosmetic composition, medical articles and cosmetic articles using the same

Family Cites Families (38)

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DE235866C (de)
DE4009506A1 (de) *	1990-03-24	1991-09-26	Hoechst Ag	Hydantoinderivate
DE4126277A1 (de) *	1991-08-08	1993-02-11	Cassella Ag	Hydantoinderivate
DK0626861T4 (da)	1992-01-13	2004-08-16	Biogen Inc	Behandling af astma.
JPH07506566A (ja)	1992-02-12	1995-07-20	バイオゲン　インコーポレイテッド	炎症性胃腸病の処置
DE4207254A1 (de)	1992-03-07	1993-09-09	Cassella Ag	4-oxo-2-thioxoimidazolidin-derivate
DE4213634A1 (de) *	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de) *	1992-07-24	1994-01-27	Cassella Ag	Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
DE4228717A1 (de) *	1992-08-28	1994-03-03	Cassella Ag	Imidazolidin-Derivate
SG52262A1 (en)	1993-01-08	1998-09-28	Tanabe Seiyaku Co	Peptide inhibitors of cell adhesion
DK0678122T3 (da)	1993-01-12	2000-03-06	Biogen Inc	Rekombinante anti-VLA4 antistofmolekyler
WO1994017828A2 (en)	1993-02-09	1994-08-18	Biogen, Inc.	Treatment for insulin dependent diabetes
DE4308034A1 (de) *	1993-03-13	1994-09-15	Cassella Ag	Neue Heterocyclen, ihre Herstellung und ihre Verwendung
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EP0804237B8 (de)	1994-01-25	2006-11-08	Elan Pharmaceuticals, Inc.	Humanisierte antikörper gegen das leukozytenadhäsionsmolekül vla-4
WO1996000581A1 (en)	1994-06-29	1996-01-11	Texas Biotechnology Corporation	Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
US5811391A (en)	1994-08-25	1998-09-22	Cytel Corporation	Cyclic CS-1 peptidomimetics, compositions and methods of using same
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US6248713B1 (en)	1995-07-11	2001-06-19	Biogen, Inc.	Cell adhesion inhibitors
EP0796855B1 (de) *	1996-03-20	2002-02-06	Hoechst Aktiengesellschaft	Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
SG124234A1 (en)	1996-07-25	2006-08-30	Biogen Idec Inc	Cell adhesion inhibitors
DE19647381A1 (de) *	1996-11-15	1998-05-20	Hoechst Ag	Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
PL323130A1 (en) *	1996-11-15	1998-05-25	Hoechst Ag	Application of heterocyclic compounds in production of a pharmaceutic agent, novel heterocyclic compounds and pharmaceutic agent as such
DE19647380A1 (de)	1996-11-15	1998-05-20	Hoechst Ag	5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
WO1998042656A1 (en)	1997-03-21	1998-10-01	Cytel Corporation	Novel compounds
DE19741235A1 (de) *	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de)	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
BR9813331A (pt)	1997-10-31	2000-08-22	Aventis Pharma Ltd	Composto, uso do mesmo, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano que sofra ou esteja sujeito a condições que possam ser melhoradas pela administração de um inibidor da adesão celular mediada pela a4b1, e, resina
GB9723789D0 (en)	1997-11-12	1998-01-07	Zeneca Ltd	Chemical compounds
DE19751251A1 (de) *	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
WO1999054321A1 (en)	1998-04-21	1999-10-28	Aventis Pharma Limited	Substituted diamines and their use as cell adhesion inhibitors
DE19821483A1 (de)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
KR20010083081A (ko)	1998-06-30	2001-08-31	실버스타인 아써 에이.	염증성질환, 자가면역질환 및 호흡기질환을 치료하는데유용한 브이엘에이-4-의존성 세포 결합의 비-펩티딜 억제제
AU1915399A (en)	1998-07-10	2000-02-01	Cytel Corporation	Cs-1 peptidomimetics, compositions and methods of using the same
DE19922462A1 (de) *	1999-05-17	2000-11-23	Aventis Pharma Gmbh	Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate

2001
- 2001-08-01 DE DE10137595A patent/DE10137595A1/de not_active Withdrawn
2002
- 2002-07-20 NZ NZ530887A patent/NZ530887A/en not_active IP Right Cessation
- 2002-07-20 BR BR0211535-2A patent/BR0211535A/pt active Search and Examination
- 2002-07-20 RS YU6104A patent/RS6104A/sr unknown
- 2002-07-20 ES ES02764740T patent/ES2301673T3/es not_active Expired - Lifetime
- 2002-07-20 PL PL02365396A patent/PL365396A1/xx not_active Application Discontinuation
- 2002-07-20 RU RU2004105966/04A patent/RU2318815C2/ru not_active IP Right Cessation
- 2002-07-20 EP EP02764740A patent/EP1414444B1/de not_active Expired - Lifetime
- 2002-07-20 PT PT02764740T patent/PT1414444E/pt unknown
- 2002-07-20 DE DE60226032T patent/DE60226032T2/de not_active Expired - Lifetime
- 2002-07-20 HU HU0401406A patent/HUP0401406A3/hu unknown
- 2002-07-20 IL IL16009302A patent/IL160093A0/xx unknown
- 2002-07-20 KR KR1020047001524A patent/KR100910930B1/ko not_active Expired - Fee Related
- 2002-07-20 DK DK02764740T patent/DK1414444T3/da active
- 2002-07-20 AT AT02764740T patent/ATE391504T1/de active
- 2002-07-20 AU AU2002328931A patent/AU2002328931B2/en not_active Ceased
- 2002-07-20 HR HR20040108A patent/HRP20040108A2/hr not_active Application Discontinuation
- 2002-07-20 WO PCT/EP2002/008106 patent/WO2003011288A1/en not_active Ceased
- 2002-07-20 CA CA2455966A patent/CA2455966C/en not_active Expired - Fee Related
- 2002-07-20 MX MXPA04000041A patent/MXPA04000041A/es active IP Right Grant
- 2002-07-20 CN CN028151046A patent/CN1537000B/zh not_active Expired - Fee Related
- 2002-07-20 JP JP2003516518A patent/JP4676697B2/ja not_active Expired - Fee Related
- 2002-07-26 PE PE2002000672A patent/PE20030348A1/es not_active Application Discontinuation
- 2002-07-30 MY MYPI20022873A patent/MY133467A/en unknown
- 2002-07-30 TW TW091116941A patent/TWI325863B/zh not_active IP Right Cessation
- 2002-07-30 AR ARP020102868A patent/AR036349A1/es active IP Right Grant
- 2002-07-31 US US10/208,182 patent/US6962937B2/en not_active Expired - Lifetime
2004
- 2004-01-12 ZA ZA200400194A patent/ZA200400194B/xx unknown
- 2004-01-26 CO CO04005444A patent/CO5550452A2/es not_active Application Discontinuation
- 2004-01-27 IL IL160093A patent/IL160093A/en not_active IP Right Cessation
- 2004-01-30 NO NO20040426A patent/NO326696B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PE20030348A1 (es)	2003-05-14
EP1414444A1 (de)	2004-05-06
HUP0401406A3 (en)	2004-11-29
JP2005504033A (ja)	2005-02-10
BR0211535A (pt)	2004-07-13
ZA200400194B (en)	2005-03-14
JP4676697B2 (ja)	2011-04-27
KR20040020076A (ko)	2004-03-06
HUP0401406A2 (hu)	2004-10-28
MXPA04000041A (es)	2004-05-21
ES2301673T3 (es)	2008-07-01
US20030109497A1 (en)	2003-06-12
NO326696B1 (no)	2009-02-02
IL160093A (en)	2009-05-04
CA2455966C (en)	2011-09-20
WO2003011288A1 (en)	2003-02-13
MY133467A (en)	2007-11-30
DE10137595A1 (de)	2003-02-13
IL160093A0 (en)	2004-06-20
ATE391504T1 (de)	2008-04-15
AU2002328931B2 (en)	2008-04-24
DE60226032T2 (de)	2009-05-20
NZ530887A (en)	2005-09-30
EP1414444B1 (de)	2008-04-09
CO5550452A2 (es)	2005-08-31
RS6104A (sr)	2006-10-27
RU2318815C2 (ru)	2008-03-10
AR036349A1 (es)	2004-09-01
DE60226032D1 (de)	2008-05-21
HK1066166A1 (zh)	2005-03-18
US6962937B2 (en)	2005-11-08
NO20040426L (no)	2004-03-26
CN1537000B (zh)	2010-05-12
KR100910930B1 (ko)	2009-08-06
HRP20040108A2 (en)	2004-06-30
RU2004105966A (ru)	2005-06-27
PT1414444E (pt)	2008-05-27
PL365396A1 (en)	2005-01-10
TWI325863B (en)	2010-06-11
CN1537000A (zh)	2004-10-13
CA2455966A1 (en)	2003-02-13

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MY118313A (en)	2004-09-30	Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
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NZ514477A (en)	2003-04-29	Adamantane derivatives
BR0307351A (pt)	2004-12-14	Composto, composição farmacêutica, método para tratar uma condição ou estado de doença mediados pela atividade de p38 quinase ou mediados por citocinas produzidas pela atividade de p38 quinase, uso de um composto, e, processo para preparar um composto
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TNSN04199A1 (en)	2007-03-12	Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
EA200501516A1 (ru)	2006-04-28	Производные 2,3,6-тризамещённого-4-пиримидона
BRPI0512703A (pt)	2008-04-01	composto ou um sal ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para o tratamento de uma condição ou doença inflamatória ou imune em um indivìduo e para a modulação da função cxcr3
DE60221505D1 (de)	2007-09-13	FAKTOR Xa BENZAMIDIN INHIBITOREN
DE60041763D1 (de)	2009-04-23	Inhibitoren von c-jun n-terminal kinasen (jnk)
TR200103856T2 (tr)	2002-06-21	Naftiridin türevleri, bunların preparasyon işlemleri, kullanımları ve farmasötik kompozisyonlar.
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TR200103789T2 (tr)	2002-04-22	Tirozin kinaz inhibitörleri olarak ikameli 1,4-dihidroindeno[1,2-C]pirazoller.
DK1414444T3 (da)	2008-08-04	Hidtil ukendte imidasolidinderivater, deres fremstilling og deres anvendelse som VLA-4-antagonister
MA29258B1 (fr)	2008-02-01	Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TR200103858T2 (tr)	2002-06-21	Hücre yapışmasının önleyicileri olarak ikame edilmiş purin türevleri
YU70803A (sh)	2006-05-25	Derivati imidazolidina, njihovo dobijanje i njihova upotreba kao antiinflamatornih agensa
TWI256386B (en)	2006-06-11	Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
EA201070040A1 (ru)	2010-06-30	Новые соединения, соединения, которые влияют на клеточные везикулярные системы, фармацевтические композиции и их применение