HRP20040108A2 - Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists - Google Patents

Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists Download PDF

Info

Publication number: HRP20040108A2
Authority: HR; Croatia
Prior art keywords: alkyl; optionally substituted; aryl; residue; cycloalkyl
Prior art date: 2001-08-01

Application number

HR20040108A

Other languages

English (en)

Croatian (hr)

Inventor

Volkmar Wehner

Stefanie Flohr

Horst Blum

Hartmut Ruetten

Hans Ulrich Stilz

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-01

Filing date

2002-07-20

Publication date

2004-06-30

2002-07-20 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2004-06-30 Publication of HRP20040108A2 publication Critical patent/HRP20040108A2/hr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Tropical Medicine & Parasitology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HR20040108A 2001-08-01 2002-07-20 Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists HRP20040108A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10137595A DE10137595A1 (de)	2001-08-01	2001-08-01	Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
PCT/EP2002/008106 WO2003011288A1 (en)	2001-08-01	2002-07-20	Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Publications (1)

Publication Number	Publication Date
HRP20040108A2 true HRP20040108A2 (en)	2004-06-30

Family

ID=7693930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20040108A HRP20040108A2 (en)	2001-08-01	2002-07-20	Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Country Status (29)

Country	Link
US (1)	US6962937B2 (de)
EP (1)	EP1414444B1 (de)
JP (1)	JP4676697B2 (de)
KR (1)	KR100910930B1 (de)
CN (1)	CN1537000B (de)
AR (1)	AR036349A1 (de)
AT (1)	ATE391504T1 (de)
AU (1)	AU2002328931B2 (de)
BR (1)	BR0211535A (de)
CA (1)	CA2455966C (de)
CO (1)	CO5550452A2 (de)
DE (2)	DE10137595A1 (de)
DK (1)	DK1414444T3 (de)
ES (1)	ES2301673T3 (de)
HR (1)	HRP20040108A2 (de)
HU (1)	HUP0401406A3 (de)
IL (2)	IL160093A0 (de)
MX (1)	MXPA04000041A (de)
MY (1)	MY133467A (de)
NO (1)	NO326696B1 (de)
NZ (1)	NZ530887A (de)
PE (1)	PE20030348A1 (de)
PL (1)	PL365396A1 (de)
PT (1)	PT1414444E (de)
RS (1)	RS6104A (de)
RU (1)	RU2318815C2 (de)
TW (1)	TWI325863B (de)
WO (1)	WO2003011288A1 (de)
ZA (1)	ZA200400194B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4617449B2 (ja)	2002-07-11	2011-01-26	ヴィキュロンファーマシューティカルズインコーポレイテッド	抗菌活性を有するｎ−ヒドロキシアミド誘導体
EP2093218A1 (de) *	2008-02-22	2009-08-26	Ruggero Fariello	Arylalkylsubstituierte Imidazolidinone
MX2010012080A (es) *	2008-05-05	2011-04-11	Univ Winthrop Hospital	Metodo para mejorar el perfil de riesgo cardiovascular de los inhibidores de cox.
ES2997080T3 (en)	2010-10-25	2025-02-14	Biogen Ma Inc	Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels
US12296054B2 (en)	2020-06-01	2025-05-13	Lg Chem, Ltd.	Method of preparing polymeric microparticles, polymeric microparticles, medical composition, cosmetic composition, medical articles and cosmetic articles using the same

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DE235866C (de)
DE4009506A1 (de) *	1990-03-24	1991-09-26	Hoechst Ag	Hydantoinderivate
DE4126277A1 (de) *	1991-08-08	1993-02-11	Cassella Ag	Hydantoinderivate
WO1993013798A1 (en)	1992-01-13	1993-07-22	Biogen, Inc.	Treatment for asthma
ES2103468T3 (es)	1992-02-12	1997-09-16	Biogen Inc	Tratamiento de la inflamacion intestinal.
DE4207254A1 (de)	1992-03-07	1993-09-09	Cassella Ag	4-oxo-2-thioxoimidazolidin-derivate
DE4213634A1 (de) *	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de) *	1992-07-24	1994-01-27	Cassella Ag	Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
DE4228717A1 (de) *	1992-08-28	1994-03-03	Cassella Ag	Imidazolidin-Derivate
WO1994015958A2 (en)	1993-01-08	1994-07-21	Tanabe Seiyaku Co., Ltd.	Peptide inhibitors of cell adhesion
CA2153692C (en)	1993-01-12	2011-11-08	Roy R. Lobb	Recombinant anti-vla4 antibody molecules
ES2114183T5 (es)	1993-02-09	2006-06-16	Biogen Idec Ma, Inc.	Anticuerpo para el tratamiento de la diabetes dependiente de la insulina.
DE4308034A1 (de) *	1993-03-13	1994-09-15	Cassella Ag	Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4427979A1 (de)	1993-11-15	1996-02-15	Cassella Ag	Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
AU693143B2 (en)	1993-12-06	1998-06-25	Cytel Corporation	CS-1 peptidomimetics, compositions and methods of using the same
AU703152B2 (en)	1994-01-25	1999-03-18	Biogen Ma Inc.	Humanized antibodies against leukocyte adhesion molecule VLA-4
AU2958195A (en)	1994-06-29	1996-01-25	Texas Biotechnology Corporation	Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
US5811391A (en)	1994-08-25	1998-09-22	Cytel Corporation	Cyclic CS-1 peptidomimetics, compositions and methods of using same
GB9524630D0 (en)	1994-12-24	1996-01-31	Zeneca Ltd	Chemical compounds
US6306840B1 (en)	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
DE19515177A1 (de)	1995-04-28	1996-10-31	Cassella Ag	Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe
US6248713B1 (en)	1995-07-11	2001-06-19	Biogen, Inc.	Cell adhesion inhibitors
DE59706273D1 (de) *	1996-03-20	2002-03-21	Hoechst Ag	Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
SG124234A1 (en)	1996-07-25	2006-08-30	Biogen Idec Inc	Cell adhesion inhibitors
DE19647382A1 (de) *	1996-11-15	1998-05-20	Hoechst Ag	Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647381A1 (de) *	1996-11-15	1998-05-20	Hoechst Ag	Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647380A1 (de)	1996-11-15	1998-05-20	Hoechst Ag	5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
WO1998042656A1 (en)	1997-03-21	1998-10-01	Cytel Corporation	Novel compounds
DE19741235A1 (de) *	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) *	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE69835688T2 (de)	1997-10-31	2007-10-04	Aventis Pharma Ltd., West Malling	Substituierte anilide
GB9723789D0 (en)	1997-11-12	1998-01-07	Zeneca Ltd	Chemical compounds
DE19751251A1 (de) *	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
WO1999054321A1 (en)	1998-04-21	1999-10-28	Aventis Pharma Limited	Substituted diamines and their use as cell adhesion inhibitors
DE19821483A1 (de)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CZ20004909A3 (cs)	1998-06-30	2002-04-17	Pfizer Products Inc.	Nepeptidové inhibitory VLA-4 dependentní buněčné vazby pouľitelné při léčení zánětlivých, autoimunitních a respiračních chorob
AU1915399A (en)	1998-07-10	2000-02-01	Cytel Corporation	Cs-1 peptidomimetics, compositions and methods of using the same
DE19922462A1 (de) *	1999-05-17	2000-11-23	Aventis Pharma Gmbh	Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate

2001
- 2001-08-01 DE DE10137595A patent/DE10137595A1/de not_active Withdrawn
2002
- 2002-07-20 IL IL16009302A patent/IL160093A0/xx unknown
- 2002-07-20 EP EP02764740A patent/EP1414444B1/de not_active Expired - Lifetime
- 2002-07-20 PL PL02365396A patent/PL365396A1/xx not_active Application Discontinuation
- 2002-07-20 BR BR0211535-2A patent/BR0211535A/pt active Search and Examination
- 2002-07-20 CA CA2455966A patent/CA2455966C/en not_active Expired - Fee Related
- 2002-07-20 CN CN028151046A patent/CN1537000B/zh not_active Expired - Fee Related
- 2002-07-20 HU HU0401406A patent/HUP0401406A3/hu unknown
- 2002-07-20 JP JP2003516518A patent/JP4676697B2/ja not_active Expired - Fee Related
- 2002-07-20 RS YU6104A patent/RS6104A/sr unknown
- 2002-07-20 HR HR20040108A patent/HRP20040108A2/hr not_active Application Discontinuation
- 2002-07-20 NZ NZ530887A patent/NZ530887A/en not_active IP Right Cessation
- 2002-07-20 PT PT02764740T patent/PT1414444E/pt unknown
- 2002-07-20 AU AU2002328931A patent/AU2002328931B2/en not_active Ceased
- 2002-07-20 DE DE60226032T patent/DE60226032T2/de not_active Expired - Lifetime
- 2002-07-20 KR KR1020047001524A patent/KR100910930B1/ko not_active Expired - Fee Related
- 2002-07-20 DK DK02764740T patent/DK1414444T3/da active
- 2002-07-20 WO PCT/EP2002/008106 patent/WO2003011288A1/en not_active Ceased
- 2002-07-20 MX MXPA04000041A patent/MXPA04000041A/es active IP Right Grant
- 2002-07-20 ES ES02764740T patent/ES2301673T3/es not_active Expired - Lifetime
- 2002-07-20 RU RU2004105966/04A patent/RU2318815C2/ru not_active IP Right Cessation
- 2002-07-20 AT AT02764740T patent/ATE391504T1/de active
- 2002-07-26 PE PE2002000672A patent/PE20030348A1/es not_active Application Discontinuation
- 2002-07-30 MY MYPI20022873A patent/MY133467A/en unknown
- 2002-07-30 AR ARP020102868A patent/AR036349A1/es active IP Right Grant
- 2002-07-30 TW TW091116941A patent/TWI325863B/zh not_active IP Right Cessation
- 2002-07-31 US US10/208,182 patent/US6962937B2/en not_active Expired - Lifetime
2004
- 2004-01-12 ZA ZA200400194A patent/ZA200400194B/xx unknown
- 2004-01-26 CO CO04005444A patent/CO5550452A2/es not_active Application Discontinuation
- 2004-01-27 IL IL160093A patent/IL160093A/en not_active IP Right Cessation
- 2004-01-30 NO NO20040426A patent/NO326696B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
TWI325863B (en)	2010-06-11
RU2004105966A (ru)	2005-06-27
US6962937B2 (en)	2005-11-08
MXPA04000041A (es)	2004-05-21
HK1066166A1 (zh)	2005-03-18
RU2318815C2 (ru)	2008-03-10
CO5550452A2 (es)	2005-08-31
BR0211535A (pt)	2004-07-13
WO2003011288A1 (en)	2003-02-13
PL365396A1 (en)	2005-01-10
AR036349A1 (es)	2004-09-01
DE10137595A1 (de)	2003-02-13
NO20040426L (no)	2004-03-26
DE60226032D1 (de)	2008-05-21
HUP0401406A3 (en)	2004-11-29
EP1414444B1 (de)	2008-04-09
US20030109497A1 (en)	2003-06-12
CA2455966A1 (en)	2003-02-13
AU2002328931B2 (en)	2008-04-24
ATE391504T1 (de)	2008-04-15
CA2455966C (en)	2011-09-20
NO326696B1 (no)	2009-02-02
PE20030348A1 (es)	2003-05-14
EP1414444A1 (de)	2004-05-06
CN1537000B (zh)	2010-05-12
PT1414444E (pt)	2008-05-27
ZA200400194B (en)	2005-03-14
DE60226032T2 (de)	2009-05-20
DK1414444T3 (da)	2008-08-04
KR20040020076A (ko)	2004-03-06
IL160093A0 (en)	2004-06-20
ES2301673T3 (es)	2008-07-01
JP4676697B2 (ja)	2011-04-27
KR100910930B1 (ko)	2009-08-06
MY133467A (en)	2007-11-30
RS6104A (sr)	2006-10-27
JP2005504033A (ja)	2005-02-10
IL160093A (en)	2009-05-04
CN1537000A (zh)	2004-10-13
NZ530887A (en)	2005-09-30
HUP0401406A2 (hu)	2004-10-28

Legal Events

Date	Code	Title	Description
2004-06-30	A1OB	Publication of a patent application
2004-12-27	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-02-09	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE
2008-07-18	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20080718 Year of fee payment: 7
2009-05-29	OBST	Application withdrawn

Publication	Publication Date	Title
US5998447A (en)	1999-12-07	Heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists
CA2254420C (en)	2009-05-26	Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
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