DK141729B - Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. - Google Patents

Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. Download PDF

Info

Publication number: DK141729B
Authority: DK; Denmark
Prior art keywords: cephalexin; complexing; aqueous solution; recovering; solution containing
Prior art date: 1975-06-17

Application number

DK272975A

Other languages

Danish (da)

English (en)

Other versions

DK272975A (2

DK141729C (2

Inventor

Peter Faarup

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-06-17

Filing date

1975-06-17

Publication date

1980-06-02

1975-06-17 Application filed by Novo Industri As filed Critical Novo Industri As

1975-06-17 Priority to DK272975A priority Critical patent/DK141729B/da

1976-06-17 Priority to BE168011A priority patent/BE843055R/fr

1976-12-18 Publication of DK272975A publication Critical patent/DK272975A/da

1980-06-02 Publication of DK141729B publication Critical patent/DK141729B/da

1980-10-20 Application granted granted Critical

1980-10-20 Publication of DK141729C publication Critical patent/DK141729C/da

Links

229940106164 cephalexin Drugs 0.000 title description 15
238000000034 method Methods 0.000 title description 7
239000007864 aqueous solution Substances 0.000 title description 5
230000000536 complexating effect Effects 0.000 title description 4
ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 title 2
AVGYWQBCYZHHPN-CYJZLJNKSA-N cephalexin monohydrate Chemical compound O.C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 AVGYWQBCYZHHPN-CYJZLJNKSA-N 0.000 description 14
229940047526 cephalexin monohydrate Drugs 0.000 description 13
YGZIWEZFFBPCLN-UHFFFAOYSA-N n,3-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine Chemical compound OOC1CCOP(=O)(NCCCl)N1CCCl YGZIWEZFFBPCLN-UHFFFAOYSA-N 0.000 description 13
DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
239000000243 solution Substances 0.000 description 8
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
239000013078 crystal Substances 0.000 description 5
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
235000011114 ammonium hydroxide Nutrition 0.000 description 3
238000002329 infrared spectrum Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
125000002252 acyl group Chemical group 0.000 description 1
150000001491 aromatic compounds Chemical class 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
125000004356 hydroxy functional group Chemical group O* 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1

Landscapes

Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)

DK272975A 1973-12-18 1975-06-17 Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse. DK141729B (da)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
DK272975A DK141729B (da)	1975-06-17	1975-06-17	Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse.
BE168011A BE843055R (fr)	1973-12-18	1976-06-17	Procede de preparation d'un complexe peu soluble de cephalexine

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK272975		1975-06-17
DK272975A DK141729B (da)	1975-06-17	1975-06-17	Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse.

Publications (3)

Publication Number	Publication Date
DK272975A DK272975A (2)	1976-12-18
DK141729B true DK141729B (da)	1980-06-02
DK141729C DK141729C (2)	1980-10-20

Family

ID=8115141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK272975A DK141729B (da)	1973-12-18	1975-06-17	Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse.

Country Status (1)

Country	Link
DK (1)	DK141729B (2)

1975
- 1975-06-17 DK DK272975A patent/DK141729B/da unknown

Also Published As

Publication number	Publication date
DK272975A (2)	1976-12-18
DK141729C (2)	1980-10-20

Similar Documents

Publication	Publication Date	Title
RO107257B1 (ro)	1993-10-30	Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
US2528267A (en)	1950-10-31	Eobeet j
EP0024181B1 (en)	1983-05-18	Process for the isolation of a solid salt of p-hydroxymandelic acid; some salts of p-hydroxymandelic acid
KR20070105299A (ko)	2007-10-30	레트로졸의 제조를 위한 개선된 방법
ITRM930147A1 (it)	1994-09-10	Procedimento per la preparazione di sali dell'acido clavulanico.
CN104628724B (zh)	2017-02-01	一种阿哌沙班制备方法
DK141729B (da)	1980-06-02	Fremgangsmåde til udvinding af cephalexin fra en vandholdig opløsning indeholdende cephalexin ved kompleksdannelse.
EP0112629B1 (en)	1987-04-29	Plant growth regulators
US3049536A (en)	1962-08-14	Method for producing inosine
US5349074A (en)	1994-09-20	Process for pharmaceutical grade high purity hyodeoxycholic acid preparation
DK148961B (da)	1985-12-02	Fremgangsmaade til fremstilling af vindesin
KR950010597B1 (ko)	1995-09-20	세팔로스포린 유도체의 신규한 제조방법
EP1768980B1 (en)	2008-11-26	Improved process for the manufacture of mirtazapine
CN113735792A (zh)	2021-12-03	氯苯唑酸葡胺及其中间体的制备方法
AU776674B2 (en)	2004-09-16	Method for preparing and isolating 9-deoxo-9(Z)-hydroxyiminoerythromycin
US3115518A (en)	1963-12-24	Production of cyclohexylideneaminooxyacetic acid, its esters, and its salts
KR860001900B1 (ko)	1986-10-24	β-클로로 아라닌의 제조법
US2678312A (en)	1954-05-11	Preparation of thiamin chloride
CN108863888B (zh)	2021-10-12	一种(s)-1-(叔丁氧羰基)-5-氧吡咯烷-2-羧酸乙酯的制备方法
SE437828B (sv)	1985-03-18	Forfarande for framstellning av cis-isomeren av n,n-dimetyl-9-/3-(4-metyl-1-piperazinyl)-propyliden/-tioxanten-2-sulfonamid
US4331607A (en)	1982-05-25	Process for the purification of chenodeoxycholic acid
US4186133A (en)	1980-01-29	Process for the preparation of an indole-3-acetohydroxamic acid
HUP0004932A2 (hu)	2001-05-28	Eljárás egy édesítőszer elkülönítésére vagy tisztítására
IL292141B1 (en)	2026-01-01	Processes for preparing tetrazolinone compounds
CN121226426A (zh)	2025-12-30	一种草甘膦的合成方法