DK1427732T3 - Spirocyclisk-6,7-dihydro-5H-pyrazolo[1,2-a] pyrazol-1-oner som kontrollerer inflammatoriske cytokiner - Google Patents

Spirocyclisk-6,7-dihydro-5H-pyrazolo[1,2-a] pyrazol-1-oner som kontrollerer inflammatoriske cytokiner

Info

Publication number: DK1427732T3
Authority: DK; Denmark
Prior art keywords: spirocyclic; pyrazolo; pyrazol; dihydro; inflammatory cytokines
Prior art date: 2001-09-20

Application number

DK02799017T

Other languages

English (en)

Inventor

Adam Golebiowski

Todd Andrew Brugel

Matthew John Laufersweiler

Michael Phillip Clark

Jane Far-Jine Djung

Biswanath De

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-20

Filing date

2002-09-20

Publication date

2006-10-30

2002-09-20 Application filed by Procter & Gamble filed Critical Procter & Gamble

2006-10-30 Application granted granted Critical

2006-10-30 Publication of DK1427732T3 publication Critical patent/DK1427732T3/da

Links

STKARFFXWORTNB-UHFFFAOYSA-N 2,3-dihydro-1h-pyrazolo[1,2-a]pyrazol-5-one Chemical class C1CCN2C(=O)C=CN21 STKARFFXWORTNB-UHFFFAOYSA-N 0.000 title 1
102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1
230000002757 inflammatory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK02799017T 2001-09-20 2002-09-20 Spirocyclisk-6,7-dihydro-5H-pyrazolo[1,2-a] pyrazol-1-oner som kontrollerer inflammatoriske cytokiner DK1427732T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US32362501P	2001-09-20	2001-09-20

Publications (1)

Publication Number	Publication Date
DK1427732T3 true DK1427732T3 (da)	2006-10-30

Family

ID=23259997

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02763693T DK1427728T3 (da)	2001-09-20	2002-09-20	6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner
DK02799017T DK1427732T3 (da)	2001-09-20	2002-09-20	Spirocyclisk-6,7-dihydro-5H-pyrazolo[1,2-a] pyrazol-1-oner som kontrollerer inflammatoriske cytokiner

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK02763693T DK1427728T3 (da)	2001-09-20	2002-09-20	6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner

Country Status (32)

Country	Link
US (2)	US6821971B2 (da)
EP (3)	EP1427732B1 (da)
JP (3)	JP2005504081A (da)
KR (4)	KR20040035837A (da)
CN (3)	CN1249066C (da)
AR (3)	AR037502A1 (da)
AT (3)	ATE287887T1 (da)
AU (2)	AU2002334641B2 (da)
BR (3)	BR0212673A (da)
CA (3)	CA2461073A1 (da)
CO (3)	CO5560590A2 (da)
CY (1)	CY1106398T1 (da)
CZ (3)	CZ2004361A3 (da)
DE (3)	DE60213108T2 (da)
DK (2)	DK1427728T3 (da)
EG (2)	EG24413A (da)
ES (3)	ES2237691T3 (da)
HU (3)	HUP0500752A2 (da)
IL (3)	IL160741A0 (da)
MA (3)	MA27065A1 (da)
MX (3)	MXPA04002574A (da)
MY (2)	MY129329A (da)
NO (2)	NO20041594L (da)
NZ (3)	NZ531123A (da)
PE (3)	PE20030430A1 (da)
PL (3)	PL370415A1 (da)
PT (3)	PT1427728E (da)
RU (3)	RU2299885C2 (da)
SA (1)	SA03230529B1 (da)
SK (3)	SK1492004A3 (da)
WO (3)	WO2003024973A1 (da)
ZA (3)	ZA200401260B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7087615B2 (en)	2001-09-20	2006-08-08	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US6849627B2 (en)	2001-09-20	2005-02-01	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6730668B2 (en) *	2001-09-20	2004-05-04	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7473695B2 (en) *	2001-10-22	2009-01-06	Mitsubishi Tanabe Pharma Corporation	4-imidazolin-2-one compounds
US6677337B2 (en) *	2002-03-19	2004-01-13	The Procter & Gamble Company	1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
US6967254B2 (en) *	2002-09-09	2005-11-22	Amgen Inc.	Substituted heterocyclic compounds and methods of use
CA2520894C (en) *	2003-04-03	2013-02-05	Werner Mederski	Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses
GB0308466D0 (en) *	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
US7482356B2 (en) *	2003-11-10	2009-01-27	The Procter & Gamble Company	Bicyclic pyrazolone cytokine inhibitors
KR20080111144A (ko) *	2006-04-18	2008-12-22	아보트 러보러터리즈	바닐로이드 수용체 서브타입 １(ｖｒ１)의 길항제 및 이의 용도
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2432767B1 (en) *	2009-05-19	2013-06-26	Dow AgroSciences LLC	Compounds and methods for controlling fungi
CN107636366B (zh)	2015-06-15	2021-03-12	卡明斯公司	燃烧室弹性装置
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
CN107033090B (zh) *	2017-05-16	2019-05-07	无锡捷化医药科技有限公司	一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) *	2019-09-06	2020-05-21	Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет"	Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
EP4422621A4 (en) *	2021-10-27	2025-08-27	Merck Sharp & Dohme Llc	SPIROTRICYCLIC RIPK1 INHIBITORS AND METHODS OF USE THEREOF

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Publication number	Priority date	Publication date	Assignee	Title
GB1054291A (da) *	1963-02-26
GB1124982A (en) *	1965-02-09	1968-08-21	Lepetit Spa	Diazabicyclo octanes and derivatives thereof
CH529154A (fr)	1969-10-27	1972-10-15	Lepetit Spa	Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) *	1991-03-21	1994-10-25	Bayer Aktiengesellschaft	3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
ATE182892T1 (de) *	1992-05-15	1999-08-15	Merrell Pharma Inc	Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
GB9303993D0 (en) *	1993-02-26	1993-04-14	Fujisawa Pharmaceutical Co	New heterocyclic derivatives
HU229958B1 (hu) *	1999-09-07	2015-03-30	Syngenta Participations Ag	Herbicid vegyületek, ezeket tartalmazó készítmények, eljárás a vegyületek előállítására, valamint eljárás gyomnövények irtására
US6730668B2 (en) *	2001-09-20	2004-05-04	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

2002
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 NZ NZ531123A patent/NZ531123A/en not_active IP Right Cessation
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
- 2002-09-20 EP EP02799017A patent/EP1427732B1/en not_active Expired - Lifetime
- 2002-09-20 NZ NZ531063A patent/NZ531063A/en not_active IP Right Cessation
- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 BR BR0212673-7A patent/BR0212673A/pt not_active IP Right Cessation
- 2002-09-20 BR BR0212716-4A patent/BR0212716A/pt not_active IP Right Cessation
- 2002-09-20 IL IL16074102A patent/IL160741A0/xx unknown
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 AU AU2002334641A patent/AU2002334641B2/en not_active Expired - Fee Related
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Ceased
- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active Expired - Fee Related
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/en not_active Ceased
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 AR ARP020103549A patent/AR037502A1/es not_active Application Discontinuation
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
- 2002-09-20 CN CNB028183800A patent/CN1249066C/zh not_active Expired - Fee Related
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 HU HU0402500A patent/HUP0402500A3/hu unknown
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 MY MYPI20023518A patent/MY129329A/en unknown
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 EP EP02763692A patent/EP1427727B1/en not_active Expired - Lifetime
- 2002-09-20 CZ CZ2004361A patent/CZ2004361A3/cs unknown
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active Expired - Fee Related
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 AT AT02799017T patent/ATE332901T1/de not_active IP Right Cessation
- 2002-09-20 CZ CZ2004358A patent/CZ2004358A3/cs unknown
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Ceased
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 ES ES02799017T patent/ES2268154T3/es not_active Expired - Lifetime
- 2002-09-20 NZ NZ531122A patent/NZ531122A/en unknown
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/en not_active Ceased
- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 CA CA002461073A patent/CA2461073A1/en not_active Abandoned
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 CA CA002461072A patent/CA2461072A1/en not_active Abandoned
- 2002-09-20 MY MYPI20023502A patent/MY129069A/en unknown
- 2002-09-20 EP EP02763693A patent/EP1427728B1/en not_active Expired - Lifetime
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/en not_active Ceased
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 CA CA002461071A patent/CA2461071A1/en not_active Abandoned
- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
- 2002-09-20 CZ CZ2004345A patent/CZ2004345A3/cs unknown
- 2002-09-20 MX MXPA04002570A patent/MXPA04002570A/es active IP Right Grant
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 AR ARP020103550A patent/AR037237A1/es not_active Application Discontinuation
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-21 EG EG2002091039A patent/EG24413A/xx active
- 2002-09-21 EG EG2002091037A patent/EG24363A/xx active
2003
- 2003-01-26 SA SA3230529A patent/SA03230529B1/ar unknown
2004
- 2004-02-17 ZA ZA200401260A patent/ZA200401260B/en unknown
- 2004-02-20 ZA ZA200401403A patent/ZA200401403B/en unknown
- 2004-02-20 ZA ZA200401402A patent/ZA200401402B/en unknown
- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
- 2004-03-09 CO CO04021424A patent/CO5560589A2/es not_active Application Discontinuation
- 2004-03-10 MA MA27568A patent/MA27065A1/fr unknown
- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
- 2004-03-10 MA MA27567A patent/MA27064A1/fr unknown
- 2004-03-12 CO CO04023010A patent/CO5560579A2/es not_active Application Discontinuation
- 2004-04-19 NO NO20041594A patent/NO20041594L/no not_active Application Discontinuation
- 2004-04-20 NO NO20041605A patent/NO20041605L/no not_active Application Discontinuation
2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown

Also Published As

Publication number	Publication date
PL370351A1 (en)	2005-05-16
HUP0402500A2 (hu)	2005-03-29
NZ531123A (en)	2006-08-31
NO20041605L (no)	2004-06-21
PL370415A1 (en)	2005-05-30
PE20030430A1 (es)	2003-06-24
ATE356126T1 (de)	2007-03-15
ZA200401403B (en)	2004-08-30
DK1427728T3 (da)	2007-07-09
CO5560590A2 (es)	2005-09-30
MXPA04002574A (es)	2004-06-18
RU2278864C2 (ru)	2006-06-27
DE60218704T2 (de)	2007-11-08
CZ2004358A3 (cs)	2004-07-14
CO5560579A2 (es)	2005-09-30
NZ531063A (en)	2007-08-31
KR20060036125A (ko)	2006-04-27
ZA200401260B (en)	2004-08-30
PE20030474A1 (es)	2003-07-22
KR100656126B1 (ko)	2006-12-12
ES2268154T3 (es)	2007-03-16
CN1555379A (zh)	2004-12-15
NZ531122A (en)	2005-09-30
EP1427727B1 (en)	2005-01-26
DE60213108T2 (de)	2007-02-08
SK1482004A3 (en)	2004-08-03
JP2005504083A (ja)	2005-02-10
BR0212905A (pt)	2004-10-13
AR037502A1 (es)	2004-11-17
AU2002327690B2 (en)	2006-07-20
MXPA04002570A (es)	2004-05-31
PT1427732E (pt)	2006-12-29
ATE332901T1 (de)	2006-08-15
HUP0402500A3 (en)	2008-10-28
NO20041594L (no)	2004-06-21
WO2003024973A1 (en)	2003-03-27
PT1427728E (pt)	2007-05-31
CN1250551C (zh)	2006-04-12
DE60213108D1 (de)	2006-08-24
CZ2004345A3 (cs)	2004-06-16
EP1427732B1 (en)	2006-07-12
HUP0402378A2 (hu)	2005-02-28
ES2237691T3 (es)	2005-08-01
IL160741A0 (en)	2004-08-31
US20030105084A1 (en)	2003-06-05
PT1427727E (pt)	2005-06-30
CN1555375A (zh)	2004-12-15
CN1249066C (zh)	2006-04-05
BR0212673A (pt)	2004-08-24
AR037237A1 (es)	2004-11-03
CA2461072A1 (en)	2003-03-27
AR037145A1 (es)	2004-10-27
EG24413A (en)	2009-05-25
DE60202782T2 (de)	2006-01-19
JP2005504081A (ja)	2005-02-10
US6821971B2 (en)	2004-11-23
RU2004111806A (ru)	2005-03-27
EP1427728B1 (en)	2007-03-07
KR20040035835A (ko)	2004-04-29
CA2461073A1 (en)	2003-03-27
SA03230529B1 (ar)	2008-06-21
BR0212716A (pt)	2004-08-03
AU2002334641B2 (en)	2007-03-29
CA2461071A1 (en)	2003-03-27
HUP0500752A2 (en)	2006-01-30
CY1106398T1 (el)	2011-10-12
ZA200401402B (en)	2004-08-27
SK1492004A3 (en)	2004-11-03
HK1071565A1 (en)	2005-07-22
SK1502004A3 (en)	2004-09-08
EP1427728A1 (en)	2004-06-16
CZ2004361A3 (cs)	2004-07-14
KR20040035837A (ko)	2004-04-29
MA27064A1 (fr)	2004-12-20
PL370362A1 (en)	2005-05-16
CN1556811A (zh)	2004-12-22
RU2004111805A (ru)	2005-04-10
RU2272040C2 (ru)	2006-03-20
MXPA04002569A (es)	2004-05-31
US6566357B1 (en)	2003-05-20
KR100623879B1 (ko)	2006-09-19
IL160682A0 (en)	2004-08-31
KR20040035836A (ko)	2004-04-29
MY129329A (en)	2007-03-30
WO2003024970A1 (en)	2003-03-27
JP2005504082A (ja)	2005-02-10
EG24363A (en)	2009-03-04
ATE287887T1 (de)	2005-02-15
ES2282459T3 (es)	2007-10-16
HK1071366A1 (en)	2005-07-15
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CO5560589A2 (es)	2005-09-30
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HUP0402378A3 (en)	2008-10-28
RU2299885C2 (ru)	2007-05-27
DE60218704D1 (de)	2007-04-19
MA27065A1 (fr)	2004-12-20
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MA27066A1 (fr)	2004-12-20

Publication	Publication Date	Title
DK1381363T3 (da)	2005-04-18	Imidazo[1,2-a]pyridinderivater som mGluR5-antagonister
NO20035476D0 (no)	2003-12-09	Azaindoler
NO20042755L (no)	2004-06-29	Amidsubstituerte imidazopyridiner
MXPA03008144A (es)	2003-12-12	Nuevos compuestos antiinflamatorios de triazolopiridinas.
DK1608654T3 (da)	2010-04-26	8-substituerede-6, 7, 8, 9-tetrahydropyrimido (1,2- a) pyrimidin-4-on-derivater
DE50202178D1 (de)	2005-03-10	Neue sulfonat-substituierte pyrazolopyridinderivate
DK1427728T3 (da)	2007-07-09	6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner
DK1608653T3 (da)	2009-10-05	Substituerede 8-perfluoroalkyl-6,7,8,9- tetrahydropyrimido (1,2-a) pyrimidin-4-on derivater
AU2002353719A1 (en)	2003-06-10	Heat controlled optoelectrical unit
DE60205921D1 (de)	2005-10-06	SUBSTITUIERTE 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDOç1,2-A!PYRIMIDIN-4-ON- UND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO-ç1,2-A!PYRIMIDIN-5(1H)ONDERIVATE
AU2003255323A1 (en)	2004-02-23	Imidazo`1,2-a!pyridines
MXPA03007623A (es)	2003-12-04	Derivado de piridopirimidina o naftiridina.
AU2002328883A1 (en)	2003-01-29	Thiazolo (4,5-b)pyridines as fungicides
PT1326866E (pt)	2005-08-31	3,4-di-hidropirido[1,2-a]pirimidinas substituidas
AUPR795101A0 (en)	2001-10-18	Central shutter controller
HK1080454A (en)	2006-04-28	6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
AU2002318478A1 (en)	2003-01-29	Zeolite ssz-59
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AU2002327093A1 (en)	2003-06-05	1,2-dihydro-2-oxo-1,8-naphthyridine derivative
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HK1063470A (en)	2004-12-31	Azaindoles
HK1073655A (en)	2005-10-14	Nitrosated imidazopyridines
DK1326866T3 (da)	2005-08-01	Substituerede 3,4-dihydro-pyrido[1,2-a]pyrimidiner