NO20041605L - 6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner - Google Patents

6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner

Info

Publication number
NO20041605L
NO20041605L NO20041605A NO20041605A NO20041605L NO 20041605 L NO20041605 L NO 20041605L NO 20041605 A NO20041605 A NO 20041605A NO 20041605 A NO20041605 A NO 20041605A NO 20041605 L NO20041605 L NO 20041605L
Authority
NO
Norway
Prior art keywords
pyrazolo
pyrazol
dihydro
ones
inflammatory cytokines
Prior art date
Application number
NO20041605A
Other languages
English (en)
Inventor
Biswanath De
Matthew John Laufersweiler
Michael Phillip Clark
Jane Far-Jine Djung
Michael George Natchus
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO20041605L publication Critical patent/NO20041605L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20041605A 2001-09-20 2004-04-20 6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner NO20041605L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20
PCT/US2002/030135 WO2003024971A1 (en) 2001-09-20 2002-09-20 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Publications (1)

Publication Number Publication Date
NO20041605L true NO20041605L (no) 2004-06-21

Family

ID=23259997

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20041594A NO20041594L (no) 2001-09-20 2004-04-19 Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner
NO20041605A NO20041605L (no) 2001-09-20 2004-04-20 6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20041594A NO20041594L (no) 2001-09-20 2004-04-19 Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner

Country Status (32)

Country Link
US (2) US6821971B2 (no)
EP (3) EP1427732B1 (no)
JP (3) JP2005504081A (no)
KR (4) KR20040035837A (no)
CN (3) CN1249066C (no)
AR (3) AR037502A1 (no)
AT (3) ATE287887T1 (no)
AU (2) AU2002334641B2 (no)
BR (3) BR0212673A (no)
CA (3) CA2461073A1 (no)
CO (3) CO5560590A2 (no)
CY (1) CY1106398T1 (no)
CZ (3) CZ2004361A3 (no)
DE (3) DE60213108T2 (no)
DK (2) DK1427728T3 (no)
EG (2) EG24413A (no)
ES (3) ES2237691T3 (no)
HU (3) HUP0500752A2 (no)
IL (3) IL160741A0 (no)
MA (3) MA27065A1 (no)
MX (3) MXPA04002574A (no)
MY (2) MY129329A (no)
NO (2) NO20041594L (no)
NZ (3) NZ531123A (no)
PE (3) PE20030430A1 (no)
PL (3) PL370415A1 (no)
PT (3) PT1427728E (no)
RU (3) RU2299885C2 (no)
SA (1) SA03230529B1 (no)
SK (3) SK1492004A3 (no)
WO (3) WO2003024973A1 (no)
ZA (3) ZA200401260B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7473695B2 (en) * 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
US6967254B2 (en) * 2002-09-09 2005-11-22 Amgen Inc. Substituted heterocyclic compounds and methods of use
CA2520894C (en) * 2003-04-03 2013-02-05 Werner Mederski Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7482356B2 (en) * 2003-11-10 2009-01-27 The Procter & Gamble Company Bicyclic pyrazolone cytokine inhibitors
KR20080111144A (ko) * 2006-04-18 2008-12-22 아보트 러보러터리즈 바닐로이드 수용체 서브타입 1(vr1)의 길항제 및 이의 용도
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2432767B1 (en) * 2009-05-19 2013-06-26 Dow AgroSciences LLC Compounds and methods for controlling fungi
CN107636366B (zh) 2015-06-15 2021-03-12 卡明斯公司 燃烧室弹性装置
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CN107033090B (zh) * 2017-05-16 2019-05-07 无锡捷化医药科技有限公司 一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) * 2019-09-06 2020-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
EP4422621A4 (en) * 2021-10-27 2025-08-27 Merck Sharp & Dohme Llc SPIROTRICYCLIC RIPK1 INHIBITORS AND METHODS OF USE THEREOF

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054291A (no) * 1963-02-26
GB1124982A (en) * 1965-02-09 1968-08-21 Lepetit Spa Diazabicyclo octanes and derivatives thereof
CH529154A (fr) 1969-10-27 1972-10-15 Lepetit Spa Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) * 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
GB9303993D0 (en) * 1993-02-26 1993-04-14 Fujisawa Pharmaceutical Co New heterocyclic derivatives
HU229958B1 (hu) * 1999-09-07 2015-03-30 Syngenta Participations Ag Herbicid vegyületek, ezeket tartalmazó készítmények, eljárás a vegyületek előállítására, valamint eljárás gyomnövények irtására
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Also Published As

Publication number Publication date
PL370351A1 (en) 2005-05-16
HUP0402500A2 (hu) 2005-03-29
NZ531123A (en) 2006-08-31
PL370415A1 (en) 2005-05-30
PE20030430A1 (es) 2003-06-24
ATE356126T1 (de) 2007-03-15
ZA200401403B (en) 2004-08-30
DK1427728T3 (da) 2007-07-09
CO5560590A2 (es) 2005-09-30
MXPA04002574A (es) 2004-06-18
RU2278864C2 (ru) 2006-06-27
DE60218704T2 (de) 2007-11-08
CZ2004358A3 (cs) 2004-07-14
CO5560579A2 (es) 2005-09-30
NZ531063A (en) 2007-08-31
KR20060036125A (ko) 2006-04-27
ZA200401260B (en) 2004-08-30
PE20030474A1 (es) 2003-07-22
KR100656126B1 (ko) 2006-12-12
ES2268154T3 (es) 2007-03-16
CN1555379A (zh) 2004-12-15
NZ531122A (en) 2005-09-30
EP1427727B1 (en) 2005-01-26
DE60213108T2 (de) 2007-02-08
SK1482004A3 (en) 2004-08-03
JP2005504083A (ja) 2005-02-10
BR0212905A (pt) 2004-10-13
AR037502A1 (es) 2004-11-17
AU2002327690B2 (en) 2006-07-20
MXPA04002570A (es) 2004-05-31
PT1427732E (pt) 2006-12-29
ATE332901T1 (de) 2006-08-15
HUP0402500A3 (en) 2008-10-28
NO20041594L (no) 2004-06-21
WO2003024973A1 (en) 2003-03-27
PT1427728E (pt) 2007-05-31
CN1250551C (zh) 2006-04-12
DE60213108D1 (de) 2006-08-24
CZ2004345A3 (cs) 2004-06-16
EP1427732B1 (en) 2006-07-12
HUP0402378A2 (hu) 2005-02-28
ES2237691T3 (es) 2005-08-01
IL160741A0 (en) 2004-08-31
US20030105084A1 (en) 2003-06-05
PT1427727E (pt) 2005-06-30
CN1555375A (zh) 2004-12-15
CN1249066C (zh) 2006-04-05
BR0212673A (pt) 2004-08-24
AR037237A1 (es) 2004-11-03
CA2461072A1 (en) 2003-03-27
DK1427732T3 (da) 2006-10-30
AR037145A1 (es) 2004-10-27
EG24413A (en) 2009-05-25
DE60202782T2 (de) 2006-01-19
JP2005504081A (ja) 2005-02-10
US6821971B2 (en) 2004-11-23
RU2004111806A (ru) 2005-03-27
EP1427728B1 (en) 2007-03-07
KR20040035835A (ko) 2004-04-29
CA2461073A1 (en) 2003-03-27
SA03230529B1 (ar) 2008-06-21
BR0212716A (pt) 2004-08-03
AU2002334641B2 (en) 2007-03-29
CA2461071A1 (en) 2003-03-27
HUP0500752A2 (en) 2006-01-30
CY1106398T1 (el) 2011-10-12
ZA200401402B (en) 2004-08-27
SK1492004A3 (en) 2004-11-03
HK1071565A1 (en) 2005-07-22
SK1502004A3 (en) 2004-09-08
EP1427728A1 (en) 2004-06-16
CZ2004361A3 (cs) 2004-07-14
KR20040035837A (ko) 2004-04-29
MA27064A1 (fr) 2004-12-20
PL370362A1 (en) 2005-05-16
CN1556811A (zh) 2004-12-22
RU2004111805A (ru) 2005-04-10
RU2272040C2 (ru) 2006-03-20
MXPA04002569A (es) 2004-05-31
US6566357B1 (en) 2003-05-20
KR100623879B1 (ko) 2006-09-19
IL160682A0 (en) 2004-08-31
KR20040035836A (ko) 2004-04-29
MY129329A (en) 2007-03-30
WO2003024970A1 (en) 2003-03-27
JP2005504082A (ja) 2005-02-10
EG24363A (en) 2009-03-04
ATE287887T1 (de) 2005-02-15
ES2282459T3 (es) 2007-10-16
HK1071366A1 (en) 2005-07-15
DE60202782D1 (de) 2005-03-03
CO5560589A2 (es) 2005-09-30
CN1257905C (zh) 2006-05-31
PE20030446A1 (es) 2003-07-21
WO2003024971A1 (en) 2003-03-27
EP1427732A1 (en) 2004-06-16
EP1427727A1 (en) 2004-06-16
IL160742A0 (en) 2004-08-31
HUP0402378A3 (en) 2008-10-28
RU2299885C2 (ru) 2007-05-27
DE60218704D1 (de) 2007-04-19
MA27065A1 (fr) 2004-12-20
RU2004111803A (ru) 2005-10-10
MY129069A (en) 2007-03-30
MA27066A1 (fr) 2004-12-20

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