DK1446128T3 - Anvendelse af östrogenforbindelser i kombination med progestogenforbindelser i hormonsubstitutionsbehandling - Google Patents
Anvendelse af östrogenforbindelser i kombination med progestogenforbindelser i hormonsubstitutionsbehandlingInfo
- Publication number
- DK1446128T3 DK1446128T3 DK02738962T DK02738962T DK1446128T3 DK 1446128 T3 DK1446128 T3 DK 1446128T3 DK 02738962 T DK02738962 T DK 02738962T DK 02738962 T DK02738962 T DK 02738962T DK 1446128 T3 DK1446128 T3 DK 1446128T3
- Authority
- DK
- Denmark
- Prior art keywords
- component
- compounds
- aforementioned
- hormone replacement
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 229940011871 estrogen Drugs 0.000 title 1
- 239000000262 estrogen Substances 0.000 title 1
- 238000002657 hormone replacement therapy Methods 0.000 title 1
- 239000000583 progesterone congener Substances 0.000 title 1
- 230000001076 estrogenic effect Effects 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 230000000757 progestagenic effect Effects 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204377 | 2001-11-15 | ||
| EP02075695 | 2002-02-21 | ||
| PCT/NL2002/000332 WO2003041718A1 (fr) | 2001-11-15 | 2002-05-23 | Utilisation de composes oestrogenes combines a des composes progestogenes en therapie de substitution hormonale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1446128T3 true DK1446128T3 (da) | 2007-04-02 |
Family
ID=26077031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02738962T DK1446128T3 (da) | 2001-11-15 | 2002-05-23 | Anvendelse af östrogenforbindelser i kombination med progestogenforbindelser i hormonsubstitutionsbehandling |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8026228B2 (fr) |
| EP (1) | EP1446128B1 (fr) |
| AT (1) | ATE347365T1 (fr) |
| CA (1) | CA2467222C (fr) |
| CY (1) | CY1105957T1 (fr) |
| DE (1) | DE60216630T2 (fr) |
| DK (1) | DK1446128T3 (fr) |
| ES (1) | ES2278925T3 (fr) |
| PT (1) | PT1446128E (fr) |
| WO (1) | WO2003041718A1 (fr) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040214807A1 (en) * | 1993-08-06 | 2004-10-28 | D'amato Robert J. | Estrogenic compounds as anti-mitotic agents |
| US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| EP1390042B1 (fr) * | 2001-05-23 | 2007-11-28 | Pantarhei Bioscience B.V. | Systeme d'administration de medicament comprenant un oestrogene tetrahydroxyle destine a une contraception hormonale |
| DK1562976T3 (da) | 2002-11-08 | 2010-08-16 | Pantarhei Bioscience Bv | Syntese af estetrol via estron-afledte steroider |
| JP2006526025A (ja) * | 2003-05-28 | 2006-11-16 | エントレメッド インコーポレイテッド | 抗血管新生剤 |
| DE602004018921D1 (de) * | 2003-06-25 | 2009-02-26 | Bayer Schering Pharma Ag | D dienogest |
| US7498322B2 (en) * | 2004-03-12 | 2009-03-03 | Entremed, Inc. | Antiangiogenic agents |
| US20070004689A1 (en) * | 2004-03-12 | 2007-01-04 | Agoston Gregory E | Antiangiogenic agents |
| WO2006058298A2 (fr) * | 2004-11-29 | 2006-06-01 | Entremed, Inc. | Procede d'administration d'agents anti-angiogeniques, et methode de traitement d'une maladie utilisant lesdits agents |
| US20070185069A1 (en) * | 2005-11-14 | 2007-08-09 | Plum Stacy M | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| US20070176403A1 (en) * | 2006-02-01 | 2007-08-02 | Dennis Calderone | Air adjustable seat |
| WO2007109312A2 (fr) * | 2006-03-20 | 2007-09-27 | Entremed, Inc. | 2-méthoxyestradiol présentant une activité anti-arthritique pouvant modifier l'évolution de la maladie |
| WO2008019048A1 (fr) * | 2006-08-04 | 2008-02-14 | Meditrina Pharmaceuticals | Utilisation d'inhibiteurs d'aromatase pour amincir l'endomètre ou traiter la ménorragie |
| CN101583363B (zh) * | 2007-01-08 | 2013-08-21 | 潘塔希生物科学股份有限公司 | 治疗或预防雌性哺乳动物不育症的方法和此类方法中使用的药物试剂盒 |
| US20080234243A1 (en) * | 2007-01-31 | 2008-09-25 | Lavallee Theresa M | Method of treating amyloidosis mediated diseases |
| US20100292150A1 (en) * | 2007-12-10 | 2010-11-18 | Meditrina Pharmaceuticals, Inc. | Treatment of Menorrhagia with Aromatase Inhibitor |
| US9446051B2 (en) * | 2009-10-19 | 2016-09-20 | The Population Council, Inc. | Neuroprotection and myelin repair using nestorone® |
| WO2011049948A2 (fr) | 2009-10-19 | 2011-04-28 | The Population Council, Inc. | Neuroprotection et réparation de la myéline au moyen de la nestorone® |
| SG195121A1 (en) | 2011-06-01 | 2013-12-30 | Estetra S A | Process for the production of estetrol intermediates |
| HUE029252T2 (en) | 2011-06-01 | 2017-02-28 | Estetra Sprl | Process for the preparation of intermediates of estetrol |
| EP2383279A1 (fr) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Procédé de préparation d'estetrol |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2013034780A2 (fr) | 2012-12-20 | 2013-03-14 | Crystal Pharma, S.A.U. | Procédé de préparation de l'estétrol et de composés analogues |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| EP3046928B1 (fr) | 2013-09-18 | 2017-02-08 | Crystal Pharma, S.A.U. | Procédé de préparation d'estetrol |
| NO3079671T3 (fr) | 2013-12-12 | 2018-03-24 | ||
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| RS61777B1 (sr) | 2015-06-18 | 2021-06-30 | Estetra Sprl | Oralno-disperzibilna tableta koja sadrži estetrol |
| MD3310333T2 (ro) * | 2015-06-18 | 2020-06-30 | Estetra Sprl | Unitate de dozare orodispersabilă care conține un component estetrol |
| HUE054589T2 (hu) | 2015-06-18 | 2021-09-28 | Estetra Sprl | Szájban diszpergálódó esztetrol tartalmú tabletta |
| CN116077454A (zh) * | 2015-06-18 | 2023-05-09 | 埃斯特拉有限责任公司 | 含雌四醇组分的口腔分散剂量单位 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| CA3178291A1 (fr) | 2016-08-05 | 2018-04-12 | Estetra Srl | Methode de prise en charge de la dysmenorrhee et des douleurs menstruelles |
| US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| DK3781171T3 (da) * | 2018-04-19 | 2022-05-02 | Estetra Srl | Sammensætninger og deres anvendelser til lindring af menopause-associerede symptomer |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| AU2022397887A1 (en) * | 2021-11-29 | 2024-05-16 | Estetra Srl | Compositions for preventing or treating skin aging |
| US12233074B2 (en) | 2022-02-10 | 2025-02-25 | Estetra Srl | Contraceptive methods with improved pearl index |
| HUP2400151A1 (hu) | 2024-02-28 | 2025-09-28 | Richter Gedeon Nyrt | Ösztetrol-monohidrát kristályosítási eljárás |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3440320A (en) | 1964-06-18 | 1969-04-22 | Mortimer D Sackler | Chelated suppository and method of using same |
| US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| DE2336434A1 (de) * | 1973-07-13 | 1975-04-17 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| DE2336433A1 (de) * | 1973-07-13 | 1975-04-03 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| DE2426779A1 (de) | 1974-05-31 | 1975-12-18 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
| US4722941A (en) | 1978-06-07 | 1988-02-02 | Kali-Chemie Pharma Gmbh | Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof |
| US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| US4573996A (en) | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
| US4624665A (en) | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
| US4937238A (en) | 1986-03-04 | 1990-06-26 | The Board Of Regents Of The University Of Nebraska | Prevention of mammary carcinoma |
| US4762717A (en) | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
| US5223261A (en) | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
| US5043331A (en) * | 1989-06-15 | 1991-08-27 | Orion-Yhtyma Oy | Treatment of postmenopausal disorders |
| US5130137A (en) | 1989-08-09 | 1992-07-14 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders |
| JPH04235171A (ja) | 1990-07-26 | 1992-08-24 | Sumitomo Chem Co Ltd | スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤 |
| US5063507A (en) | 1990-09-14 | 1991-11-05 | Plains Cotton Cooperative Association | Goods database employing electronic title or documentary-type title |
| US5340586A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
| US5211952A (en) | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| US5340585A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
| US5468736A (en) | 1993-02-25 | 1995-11-21 | The Medical College Of Hampton Road | Hormone replacement therapy |
| NL9301562A (nl) | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
| DE4344405C2 (de) * | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
| WO1996003929A1 (fr) | 1994-08-04 | 1996-02-15 | Biex, Inc. | Procede de prediction d'un accouchement premature a l'aide d'estetrol (e4) comme indicatuer |
| DE4429374C1 (de) | 1994-08-12 | 1996-02-01 | Jenapharm Gmbh | Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente |
| WO1998058657A1 (fr) | 1997-06-20 | 1998-12-30 | Akzo Nobel N.V. | Antagoniste de gonadoliberine |
| DE19739916C2 (de) | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
| US20020013304A1 (en) * | 1997-10-28 | 2002-01-31 | Wilson Leland F. | As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness |
| US6214815B1 (en) * | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
| DE19917930A1 (de) | 1999-04-15 | 2000-10-19 | Schering Ag | Ent-Steroide als selektiv wirksame Estrogene |
| EP1171091A1 (fr) | 1999-04-16 | 2002-01-16 | Jenapharm GmbH & Co. KG | Preparations pharmaceutiques ou cosmetiques pour l'application locale intradermique d'hormones |
| US7273932B1 (en) | 1999-05-28 | 2007-09-25 | The University Of Cincinnati | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
| WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
| AU5984701A (en) | 2000-05-12 | 2001-11-20 | Univ Oregon Health & Science | Method of treating immune pathologies with low dose estrogen |
| US6936599B2 (en) | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| EP1260225A1 (fr) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | Compositions pharmaceutiques pour le traitement hormonal substitutif |
-
2002
- 2002-05-23 DE DE60216630T patent/DE60216630T2/de not_active Expired - Lifetime
- 2002-05-23 CA CA2467222A patent/CA2467222C/fr not_active Expired - Lifetime
- 2002-05-23 ES ES02738962T patent/ES2278925T3/es not_active Expired - Lifetime
- 2002-05-23 WO PCT/NL2002/000332 patent/WO2003041718A1/fr not_active Ceased
- 2002-05-23 US US10/495,707 patent/US8026228B2/en not_active Expired - Lifetime
- 2002-05-23 EP EP02738962A patent/EP1446128B1/fr not_active Expired - Lifetime
- 2002-05-23 PT PT02738962T patent/PT1446128E/pt unknown
- 2002-05-23 AT AT02738962T patent/ATE347365T1/de not_active IP Right Cessation
- 2002-05-23 DK DK02738962T patent/DK1446128T3/da active
-
2007
- 2007-01-29 CY CY20071100107T patent/CY1105957T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8026228B2 (en) | 2011-09-27 |
| EP1446128B1 (fr) | 2006-12-06 |
| CA2467222C (fr) | 2010-06-08 |
| ATE347365T1 (de) | 2006-12-15 |
| CY1105957T1 (el) | 2011-04-06 |
| CA2467222A1 (fr) | 2003-05-22 |
| PT1446128E (pt) | 2007-03-30 |
| US20050070488A1 (en) | 2005-03-31 |
| DE60216630T2 (de) | 2007-09-20 |
| EP1446128A1 (fr) | 2004-08-18 |
| DE60216630D1 (de) | 2007-01-18 |
| WO2003041718A1 (fr) | 2003-05-22 |
| ES2278925T3 (es) | 2007-08-16 |
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