DK1465663T3 - Brugsfærdige paracetamol-injektionsoplösninger som indeholder propylenglycol som det eneste CO-oplösningsmiddel - Google Patents

Brugsfærdige paracetamol-injektionsoplösninger som indeholder propylenglycol som det eneste CO-oplösningsmiddel

Info

Publication number: DK1465663T3
Authority: DK; Denmark
Prior art keywords: ready; propylene glycol; solvent; solutions containing; injection solutions
Prior art date: 2001-10-16

Application number

DK02779486T

Other languages

Danish (da)

English (en)

Inventor

Thao Nguyen-Xuan

Original Assignee

Bioren S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-16

Filing date

2002-10-15

Publication date

2008-05-13

2002-10-15 Application filed by Bioren S A filed Critical Bioren S A

2008-05-13 Application granted granted Critical

2008-05-13 Publication of DK1465663T3 publication Critical patent/DK1465663T3/da

Links

DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 6
239000000243 solution Substances 0.000 title abstract 4
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 3
229960005489 paracetamol Drugs 0.000 title abstract 3
239000006184 cosolvent Substances 0.000 title 1
238000002347 injection Methods 0.000 title 1
239000007924 injection Substances 0.000 title 1
XTMOQAKCOFLCRZ-UHFFFAOYSA-N (4-acetamidophenyl) 4-nitrooxybutanoate Chemical compound CC(=O)NC1=CC=C(OC(=O)CCCO[N+]([O-])=O)C=C1 XTMOQAKCOFLCRZ-UHFFFAOYSA-N 0.000 abstract 1
238000007385 chemical modification Methods 0.000 abstract 1
239000007979 citrate buffer Substances 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02779486T 2001-10-16 2002-10-15 Brugsfærdige paracetamol-injektionsoplösninger som indeholder propylenglycol som det eneste CO-oplösningsmiddel DK1465663T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI002135A ITMI20012135A1 (it)	2001-10-16	2001-10-16	Soluzioni iniettabili pronte all'uso di paracetamolo
PCT/EP2002/011498 WO2003033026A1 (fr)	2001-10-16	2002-10-15	Solutions injectables a base de paracetamol pretes a l'emploi, contenant du propylene glycol utilise comme unique cosolvant

Publications (1)

Publication Number	Publication Date
DK1465663T3 true DK1465663T3 (da)	2008-05-13

Family

ID=11448506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02779486T DK1465663T3 (da)	2001-10-16	2002-10-15	Brugsfærdige paracetamol-injektionsoplösninger som indeholder propylenglycol som det eneste CO-oplösningsmiddel

Country Status (15)

Country	Link
US (1)	US8178121B2 (fr)
EP (1)	EP1465663B1 (fr)
JP (1)	JP4543679B2 (fr)
CN (1)	CN1274293C (fr)
AT (1)	ATE382369T1 (fr)
AU (1)	AU2002342826B2 (fr)
CA (1)	CA2463681C (fr)
DE (1)	DE60224449T2 (fr)
DK (1)	DK1465663T3 (fr)
ES (1)	ES2301685T3 (fr)
IL (2)	IL161390A0 (fr)
IT (1)	ITMI20012135A1 (fr)
NZ (1)	NZ532936A (fr)
PT (1)	PT1465663E (fr)
WO (1)	WO2003033026A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2851164B1 (fr) *	2003-02-14	2005-04-22	Xuan Tho Nguyen	Formulation liquide injectable de paracetamol
FR2862872A1 (fr) *	2003-12-02	2005-06-03	Palbian Snc	Composition a l'etat aqueux pour l'application perfusable d'un principe actif, notamment pharmacologique tel que le paracetamol.
US20090239817A1 (en) *	2006-04-17	2009-09-24	Goverment Of The United States Of America, As Represented By The Secretary, Dept Of Health	Organic thiophosphate antiretroviral agents
US9585849B2 (en) *	2006-04-17	2017-03-07	The Burlington Hc Research Group, Inc.	Broad spectrum antiviral and methods of use
RU2419421C2 (ru) *	2006-07-18	2011-05-27	Хенфарма Лабораторио С.Л.	Инъецируемая жидкая композиция парацетамола
EP1992334A1 (fr) *	2007-05-08	2008-11-19	Docpharma NV/SA	Formule stable pour le stockage de médicament phénolique sensible à l'oxydation, spécialement le paracétamol, et qui comprend une solution de médicament aqueuse désoxygénée par le processus de fabrication à température contrôlée de la formule
CN101809151B (zh) *	2007-08-30	2013-04-24	埃欧金能源公司	纤维素酶的生产方法
ES2321906B1 (es) *	2008-11-28	2010-02-09	Laboratorios Normon, S.A.	Composicion farmaceutica que comprende una solucion acuosa de paracetamol.
RU2406494C1 (ru) *	2009-03-16	2010-12-20	Открытое Акционерное Общество "Татхимфармпрепараты"	Фармацевтическая композиция, обладающая болеутоляющей и жаропонижающей активностью, и способ ее получения
EP2243477A1 (fr)	2009-04-22	2010-10-27	Fresenius Kabi Deutschland GmbH	Paracétamol destiné à l'administration parentérale
PT2377516E (pt)	2010-04-14	2012-07-02	Braun Melsungen Ag	Composição acetaminofeno
ES2414557B1 (es) *	2012-01-16	2014-06-10	Novocat Farma, S.A.	Composición acuosa de paracetamol para inyección
US20140303254A1 (en) *	2013-04-08	2014-10-09	InnoPharma Licensing LLC	Process Of Manufacturing A Stable, Ready To Use Infusion Bag For An Oxidation Sensitive Formulation
BR102014005885B1 (pt)	2014-03-13	2021-04-13	Biotec Biológica Indústria Farmacêutica Ltda E.P.P	Formulação farmacêutica líquida injetável estável de paracetamol em bolsa plástica pronta para uso
EA028075B1 (ru) *	2014-04-29	2017-10-31	Мыкола Ивановыч ГУМЕНЮК	Фармацевтическая композиция
EP3233055B1 (fr)	2014-12-20	2024-12-25	Troikaa Pharmaceuticals Ltd	Formulations injectables de paracétamol

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU573321B2 (en)	1984-03-14	1988-06-02	Jerome Corbiere	Process for solubilizing active principles and pharmaceuticalcompositions thus obtained
KR930011994B1 (ko) *	1991-08-16	1993-12-23	대광제약 주식회사	파라세타몰의 생체이용율을 높이는 방법 및 이 생체이용율이 높아진 파라세타몰을 함유한 제제
JP3430320B2 (ja)	1994-03-14	2003-07-28	あづま姿株式会社	衣紋掛
JP3913795B2 (ja) *	1995-09-28	2007-05-09	エスエス製薬株式会社	安定な解熱鎮痛剤配合液剤
JPH09286724A (ja) *	1996-04-19	1997-11-04	Takeda Chem Ind Ltd	経口用安定液剤
FR2751875B1 (fr)	1996-08-05	1998-12-24	Scr Newpharm	Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
US5766622A (en)	1996-08-14	1998-06-16	The Procter & Gamble Company	Inhibiting undesirable taste in oral compositions
IT1301976B1 (it)	1998-07-31	2000-07-20	Angelini Ricerche Spa	Composizione farmaceutica iniettabile a base di paracetamolo
US6006659A (en) *	1998-10-13	1999-12-28	Rosenthal; Richard A.	Personal pasteurization system
FR2809619B1 (fr)	2000-06-06	2004-09-24	Pharmatop	Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
DE10112325A1 (de)	2001-03-13	2002-10-02	Fresenius Kabi De Gmbh	Lagerstabile Fertiginfusionslösungen des Paracetamols

2001
- 2001-10-16 IT IT2001MI002135A patent/ITMI20012135A1/it unknown
2002
- 2002-10-15 CA CA2463681A patent/CA2463681C/fr not_active Expired - Fee Related
- 2002-10-15 EP EP02779486A patent/EP1465663B1/fr not_active Expired - Lifetime
- 2002-10-15 PT PT02779486T patent/PT1465663E/pt unknown
- 2002-10-15 CN CNB028205022A patent/CN1274293C/zh not_active Expired - Fee Related
- 2002-10-15 AU AU2002342826A patent/AU2002342826B2/en not_active Ceased
- 2002-10-15 AT AT02779486T patent/ATE382369T1/de active
- 2002-10-15 IL IL16139002A patent/IL161390A0/xx unknown
- 2002-10-15 JP JP2003535828A patent/JP4543679B2/ja not_active Expired - Fee Related
- 2002-10-15 WO PCT/EP2002/011498 patent/WO2003033026A1/fr not_active Ceased
- 2002-10-15 ES ES02779486T patent/ES2301685T3/es not_active Expired - Lifetime
- 2002-10-15 DK DK02779486T patent/DK1465663T3/da active
- 2002-10-15 NZ NZ532936A patent/NZ532936A/en not_active IP Right Cessation
- 2002-10-15 DE DE60224449T patent/DE60224449T2/de not_active Expired - Lifetime
- 2002-10-15 US US10/492,648 patent/US8178121B2/en not_active Expired - Fee Related
2004
- 2004-04-14 IL IL161390A patent/IL161390A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ITMI20012135A1 (it)	2003-04-16
WO2003033026A1 (fr)	2003-04-24
PT1465663E (pt)	2008-04-10
CA2463681C (fr)	2011-03-15
ATE382369T1 (de)	2008-01-15
JP4543679B2 (ja)	2010-09-15
DE60224449T2 (de)	2009-04-02
EP1465663B1 (fr)	2008-01-02
AU2002342826B2 (en)	2006-09-07
NZ532936A (en)	2007-04-27
CA2463681A1 (fr)	2003-04-24
DE60224449D1 (de)	2008-02-14
IL161390A (en)	2009-06-15
IL161390A0 (en)	2004-09-27
US8178121B2 (en)	2012-05-15
CN1571678A (zh)	2005-01-26
US20040247627A1 (en)	2004-12-09
EP1465663A1 (fr)	2004-10-13
ES2301685T3 (es)	2008-07-01
CN1274293C (zh)	2006-09-13
JP2005505609A (ja)	2005-02-24

Publication	Publication Date	Title
ATE382369T1 (de)	2008-01-15	Gebrauchsfertige paracetamol injektionslösungen enthaltend propylenglykol als einziges cosolvens
DK1273299T3 (da)	2006-02-06	Minoxidilinindeholdende praparater
PT1200426E (pt)	2004-06-30	Tieno-3-il-sulfonilamino (tio) carbonil-triazolino (ti) onas substituidas
DK1478394T3 (da)	2008-10-13	Stabiliseret TNFR-Fc formulation med arginin
BRPI0006823B8 (pt)	2021-05-25	composição farmacêutica estabilizada, preparação de injeção, e kit comercial
EP1771454A4 (fr)	2009-05-13	Analogues peptidiques inhibiteurs de l'hepatite c
ATE430589T1 (de)	2009-05-15	Wasserbehandlung zur kontrolle von biobewuchs mittels stabilisierter bromlösungen
EA200501302A1 (ru)	2006-04-28	Инъецируемый жидкий состав парацетамола
MY129957A (en)	2007-05-31	Aqueous liquid agricultural composition
ATE332873T1 (de)	2006-08-15	Zusammensetzung mit einer oxidierenden und komplexierenden verbindung
ATE420918T1 (de)	2009-01-15	Sauerstoffbarriereformulierungen
DE50209545D1 (de)	2007-04-05	Flüssigkristallines medium
NO20054787D0 (no)	2005-10-18	Indenderivater som farmasotiske midler
BR0001201A (pt)	2001-08-21	Composto ( poli ) tia-alcinóicos, composição cosmética, utilização de uma composição cosmética, utilização de um composto e composição farmacêutica
ATE295352T1 (de)	2005-05-15	Phenanthridine-n-oxide mit pde-iv hemmender wirkung
SE9903290D0 (sv)	1999-09-15	Novel compounds
NO20024664L (no)	2002-12-02	Sammensetning basert pÕ sulfid av sjeldent jordmetall med forbedret kjemisk stabilitet, fremgangsmÕte for fremstilling deravog anvendelse derav som pigment
BG105539A (bg)	2001-12-29	Елетриптан хидробромид монохидрат
BRPI0411664A (pt)	2006-08-08	composição oral antiplaca aquosa estável
DE602005016659D1 (de)	2009-10-29	Wässrige zusammensetzung mit einem thiazol-derivat
ATE286887T1 (de)	2005-01-15	Antibakterielle mittel
ATE294154T1 (de)	2005-05-15	Apfelsäureadditionssalze von terbinafin
DK351982A (da)	1983-02-08	Fremgangsmaade til fremstilling af aminoglycosidderivater
WO2006089954A3 (fr)	2006-12-28	Composes permettant de stabiliser des preparations polypeptidiques de facteurs vii
EA200400661A1 (ru)	2004-12-30	Фенилалкины