DK1468692T3 - Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom - Google Patents

Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom

Info

Publication number
DK1468692T3
DK1468692T3 DK04016883T DK04016883T DK1468692T3 DK 1468692 T3 DK1468692 T3 DK 1468692T3 DK 04016883 T DK04016883 T DK 04016883T DK 04016883 T DK04016883 T DK 04016883T DK 1468692 T3 DK1468692 T3 DK 1468692T3
Authority
DK
Denmark
Prior art keywords
alkyl
xanthoma
silyl
phenols
treatment
Prior art date
Application number
DK04016883T
Other languages
Danish (da)
English (en)
Inventor
Simon Jen Tan Mao
Mark Thirston Yates
Roger Alan Parker
Original Assignee
Aventis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Inc filed Critical Aventis Inc
Application granted granted Critical
Publication of DK1468692T3 publication Critical patent/DK1468692T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK04016883T 1993-12-10 1994-11-03 Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom DK1468692T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16528193A 1993-12-10 1993-12-10
EP95901141A EP0732928B1 (fr) 1993-12-10 1994-11-03 Procede de reduction des taux de cholesterol dans le serum avec des 2,6-di-alkyl-4-silyl-phenols

Publications (1)

Publication Number Publication Date
DK1468692T3 true DK1468692T3 (da) 2006-08-28

Family

ID=22598245

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04016883T DK1468692T3 (da) 1993-12-10 1994-11-03 Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom
DK95901141T DK0732928T3 (da) 1993-12-10 1994-11-03 Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK95901141T DK0732928T3 (da) 1993-12-10 1994-11-03 Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Country Status (16)

Country Link
EP (3) EP1468692B1 (fr)
JP (1) JPH09511222A (fr)
CN (1) CN1092517C (fr)
AT (2) ATE285238T1 (fr)
AU (1) AU681731B2 (fr)
CA (1) CA2177968C (fr)
DE (2) DE69434720T2 (fr)
DK (2) DK1468692T3 (fr)
ES (2) ES2233937T3 (fr)
HU (1) HU220761B1 (fr)
IL (1) IL111905A (fr)
NO (1) NO311868B1 (fr)
NZ (1) NZ276285A (fr)
PT (2) PT1468692E (fr)
WO (1) WO1995015760A1 (fr)
ZA (1) ZA949663B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
CN1275596C (zh) * 1997-05-14 2006-09-20 阿特罗吉尼克斯公司 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
BR9810311A (pt) * 1997-06-24 2000-09-19 Hoechst Marion Roussel Inc Fenóis alquil-4-silil heterocìclicos e tiofenóis úteis como agentes antioxidantes
CA2295232A1 (fr) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyl-oxy]phenol et 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
WO1999001118A2 (fr) 1997-07-01 1999-01-14 Atherogenics, Inc. Amelioration au moyen d'antioxydants de la therapie destinee aux etats d'hyperproliferation
JP2002529740A (ja) * 1998-11-09 2002-09-10 アセロジエニクス・インコーポレイテツド 血漿コレステロールレベルを低下させるための方法及び組成物
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
WO2002040021A2 (fr) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Procedes d'inhibition de la transmission du vih au moyen de 6-benzyl-4-oxopyrimidines substituees a application topique
IL162533A0 (en) 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US7173129B2 (en) 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
JP2007509054A (ja) * 2003-10-17 2007-04-12 アミリン・ファーマシューティカルズ，インコーポレイテッド 血管健康を促進するシリルフェノール
WO2005112914A2 (fr) 2004-04-20 2005-12-01 Atherogenics, Inc. Antioxydants phénoliques pour le traitement de troubles incluant l’arthrite, l’asthme et les troubles des artères coronaires
EP2139320A4 (fr) 2007-03-26 2010-09-08 Salutria Pharmaceuticals Llc Procédés et compositions de dérivés de probucol pour le traitement du diabète

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE349046B (fr) * 1966-12-23 1972-09-18 C Guevne
FR2230376A1 (en) * 1973-05-24 1974-12-20 Gueyne Jean Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) * 1975-04-21 1976-11-19 Cortial Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) * 1982-07-12 1987-06-02 American Cyanamid Company Antiatherosclerotic silanes
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions

Also Published As

Publication number Publication date
HU9601590D0 (en) 1996-08-28
IL111905A (en) 2001-04-30
AU1049995A (en) 1995-06-27
PT1468692E (pt) 2006-09-29
NO311868B1 (no) 2002-02-11
HU220761B1 (hu) 2002-05-28
NO962415L (no) 1996-06-07
HUT74015A (en) 1996-10-28
EP1468692B1 (fr) 2006-04-26
DE69434198T2 (de) 2005-12-29
CA2177968A1 (fr) 1995-06-15
ATE324113T1 (de) 2006-05-15
ZA949663B (en) 1995-08-15
ES2263094T3 (es) 2006-12-01
DE69434720T2 (de) 2007-05-16
DK0732928T3 (da) 2005-04-18
IL111905A0 (en) 1995-03-15
ATE285238T1 (de) 2005-01-15
CA2177968C (fr) 2000-03-28
EP0732928B1 (fr) 2004-12-22
AU681731B2 (en) 1997-09-04
DE69434720D1 (de) 2006-06-01
DE69434198D1 (de) 2005-01-27
EP1468693A3 (fr) 2004-11-03
NZ276285A (en) 2004-11-26
EP0732928A1 (fr) 1996-09-25
PT732928E (pt) 2005-03-31
CN1140995A (zh) 1997-01-22
EP1468692A2 (fr) 2004-10-20
EP1468692A3 (fr) 2004-11-03
NO962415D0 (no) 1996-06-07
EP1468693A2 (fr) 2004-10-20
ES2233937T3 (es) 2005-06-16
WO1995015760A1 (fr) 1995-06-15
CN1092517C (zh) 2002-10-16
JPH09511222A (ja) 1997-11-11

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