DK1469741T3 - Fremgangsmåde til ekstraktion, oprensning og enzymatisk modifikation af soja 7S globulin alfa'-underenhed til anvendelse som hypocholesterolæmisk middel - Google Patents

Fremgangsmåde til ekstraktion, oprensning og enzymatisk modifikation af soja 7S globulin alfa'-underenhed til anvendelse som hypocholesterolæmisk middel

Info

Publication number: DK1469741T3
Authority: DK; Denmark
Prior art keywords: subunit; soy; extraction; purification; enzymatic modification
Prior art date: 2002-01-29

Application number

DK03706387T

Other languages

English (en)

Inventor

Paolo Morazzoni

Marcello Duranti

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-29

Filing date

2003-01-27

Publication date

2007-02-19

2003-01-27 Application filed by Indena Spa filed Critical Indena Spa

2007-02-19 Application granted granted Critical

2007-02-19 Publication of DK1469741T3 publication Critical patent/DK1469741T3/da

Links

238000000605 extraction Methods 0.000 title abstract 2
101000767750 Carya illinoinensis Vicilin Car i 2.0101 Proteins 0.000 title 1
101000767759 Corylus avellana Vicilin Cor a 11.0101 Proteins 0.000 title 1
101000622316 Juglans regia Vicilin Jug r 2.0101 Proteins 0.000 title 1
101000767757 Pinus koraiensis Vicilin Pin k 2.0101 Proteins 0.000 title 1
101000767758 Pistacia vera Vicilin Pis v 3.0101 Proteins 0.000 title 1
239000003529 anticholesteremic agent Substances 0.000 title 1
230000009144 enzymatic modification Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
101710094135 Beta-conglycinin alpha' subunit Proteins 0.000 abstract 1
108090000317 Chymotrypsin Proteins 0.000 abstract 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 abstract 1
238000001042 affinity chromatography Methods 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
229960002376 chymotrypsin Drugs 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/16—Vegetable proteins from soybean
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K1/00—Glucose; Glucose-containing syrups
- C13K1/06—Glucose; Glucose-containing syrups obtained by saccharification of starch or raw materials containing starch
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Organic Chemistry (AREA)
Nutrition Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Wood Science & Technology (AREA)
Hematology (AREA)
Botany (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Mycology (AREA)
Zoology (AREA)
Obesity (AREA)
Microbiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

DK03706387T 2002-01-29 2003-01-27 Fremgangsmåde til ekstraktion, oprensning og enzymatisk modifikation af soja 7S globulin alfa'-underenhed til anvendelse som hypocholesterolæmisk middel DK1469741T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2002MI000147A ITMI20020147A1 (it)	2002-01-29	2002-01-29	Estrazione purificazione e modificazione di polipeptidi da seme di soia
PCT/EP2003/000798 WO2003063608A1 (en)	2002-01-29	2003-01-27	A process for the extraction, purification and enzymatic modification of soy 7s globulin alpha' subunit for use as hypocholesterolemizing agent

Publications (1)

Publication Number	Publication Date
DK1469741T3 true DK1469741T3 (da)	2007-02-19

Family

ID=11449014

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03706387T DK1469741T3 (da)	2002-01-29	2003-01-27	Fremgangsmåde til ekstraktion, oprensning og enzymatisk modifikation af soja 7S globulin alfa'-underenhed til anvendelse som hypocholesterolæmisk middel

Country Status (20)

Country	Link
US (3)	US7465467B2 (da)
EP (1)	EP1469741B1 (da)
JP (1)	JP4522706B2 (da)
KR (1)	KR100991641B1 (da)
CN (1)	CN100558243C (da)
AT (1)	ATE341943T1 (da)
AU (1)	AU2003208346B8 (da)
CA (1)	CA2474106C (da)
CY (1)	CY1107514T1 (da)
DE (1)	DE60308994T2 (da)
DK (1)	DK1469741T3 (da)
ES (1)	ES2274208T3 (da)
IL (1)	IL163225A (da)
IT (1)	ITMI20020147A1 (da)
NO (1)	NO327156B1 (da)
PL (1)	PL209342B1 (da)
PT (1)	PT1469741E (da)
RU (1)	RU2300898C2 (da)
SG (1)	SG152048A1 (da)
WO (1)	WO2003063608A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6171640B1 (en) *	1997-04-04	2001-01-09	Monsanto Company	High beta-conglycinin products and their use
AU2003275628B2 (en) *	2002-11-12	2008-04-03	Fuji Oil Company, Limited	Fractionated soybean protein and process for producing the same
WO2005055735A1 (ja) *	2003-12-11	2005-06-23	Fuji Oil Company, Limited	改良大豆７ｓたん白及びその製造法
JP5382840B2 (ja) *	2005-08-23	2014-01-08	特定非営利活動法人プライメイト・アゴラ	サルモデルで薬効が確認された骨粗鬆症の予防又は治療剤
BRPI0918680A2 (pt) *	2008-12-31	2015-08-25	Solae Llc	"composição de proteína de soja hidrolisada, fração da proteína, produto alimentício, processo para a fabricação de uma fração de proteína, processo para a produção de um produto de proteína e produto alimentício"
EP2264054A1 (en) *	2009-06-17	2010-12-22	Indena S.p.A.	Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis
PL2264055T3 (pl) *	2009-06-17	2014-09-30	Indena Spa	Klonowanie, ekspresja w drożdżach i aktywność biologiczna regionu wydłużenia podjednostki alfa globuliny sojowej 7S zaangażowanej w homeostazę cholesterolu w komórkach HepG2
CN101904406B (zh) *	2010-07-02	2012-07-25	山西大学	一种葵花籽多肽的制备方法和用途
CN104163767B (zh) *	2014-07-25	2017-01-18	湖北泓肽生物科技有限公司	一种氨基酸和多肽水溶性物质的纯化方法
CN114874301A (zh) *	2022-05-10	2022-08-09	吉林农业大学	不同亚基组成β-伴大豆球蛋白的制备方法及应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4409248A (en)	1981-08-10	1983-10-11	A. E. Staley Manufacturing Company	Heat-gelling and foam-stabilizing enzymatically modified vegetable isolates
JPH06197788A (ja) *	1993-01-06	1994-07-19	Fuji Oil Co Ltd	蛋白質の製造法
ES2139420T3 (es)	1996-03-28	2000-02-01	Fuji Oil Co Ltd	Un procedimiento para producir un hidrolizado de proteina de soja.
JP3928811B2 (ja) *	1996-06-14	2007-06-13	イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー	特定のクラスのダイズ種子タンパク質遺伝子の抑制
US6171640B1 (en) *	1997-04-04	2001-01-09	Monsanto Company	High beta-conglycinin products and their use
US6365802B2 (en) *	1998-08-14	2002-04-02	Calgene Llc	Methods for increasing stearate content in soybean oil
FR2784029B1 (fr) *	1998-10-05	2001-01-05	Pharmascience Lab	Methode de prevention et/ou de traitement cosmetique des vergetures de la peau et utilisation en dermatologie
PT1190068E (pt) *	1999-04-15	2006-06-30	Calgene Llc	Sequencias de acidos nucleicos para proteinas envolvidas na sintese de tocoferol
CA2274414A1 (en) *	1999-06-11	2000-12-11	Universite Laval	Dietary fish protein for use in restoring normal insulin function insulin-resistant individuals
AUPQ877300A0 (en)	2000-07-13	2000-08-03	Johnson & Johnson Pacific Pty Limited	Topical treatment of skin
BRPI0309421B8 (pt) *	2002-04-18	2021-05-25	Monsanto Technology Llc	método de preparar um gênero alimentício e composição para tratar ou prevenir hipercolesterolemia
CA2477922C (en) *	2003-08-20	2010-10-26	Seikagaku Corporation	Stabilizing agent for enzymes
MX2007008496A (es) *	2005-01-14	2007-09-14	Solae Llc	Proteina de soya para formula infantil.

2002
- 2002-01-29 IT IT2002MI000147A patent/ITMI20020147A1/it unknown
2003
- 2003-01-27 DK DK03706387T patent/DK1469741T3/da active
- 2003-01-27 AU AU2003208346A patent/AU2003208346B8/en not_active Ceased
- 2003-01-27 JP JP2003563319A patent/JP4522706B2/ja not_active Expired - Fee Related
- 2003-01-27 AT AT03706387T patent/ATE341943T1/de active
- 2003-01-27 ES ES03706387T patent/ES2274208T3/es not_active Expired - Lifetime
- 2003-01-27 EP EP03706387A patent/EP1469741B1/en not_active Expired - Lifetime
- 2003-01-27 WO PCT/EP2003/000798 patent/WO2003063608A1/en not_active Ceased
- 2003-01-27 KR KR1020047011441A patent/KR100991641B1/ko not_active Expired - Fee Related
- 2003-01-27 DE DE60308994T patent/DE60308994T2/de not_active Expired - Lifetime
- 2003-01-27 CN CNB038028050A patent/CN100558243C/zh not_active Expired - Fee Related
- 2003-01-27 RU RU2004123201/13A patent/RU2300898C2/ru not_active IP Right Cessation
- 2003-01-27 PL PL370294A patent/PL209342B1/pl unknown
- 2003-01-27 SG SG200506973-7A patent/SG152048A1/en unknown
- 2003-01-27 CA CA2474106A patent/CA2474106C/en not_active Expired - Fee Related
- 2003-01-27 US US10/502,582 patent/US7465467B2/en not_active Expired - Fee Related
- 2003-01-27 PT PT03706387T patent/PT1469741E/pt unknown
2004
- 2004-07-27 NO NO20043186A patent/NO327156B1/no not_active IP Right Cessation
- 2004-07-27 IL IL163225A patent/IL163225A/en not_active IP Right Cessation
2006
- 2006-11-28 CY CY20061101709T patent/CY1107514T1/el unknown
2008
- 2008-04-17 US US12/104,473 patent/US7901718B2/en not_active Expired - Fee Related
2011
- 2011-01-26 US US13/013,966 patent/US8257758B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE341943T1 (de)	2006-11-15
CA2474106A1 (en)	2003-08-07
KR20040077786A (ko)	2004-09-06
SG152048A1 (en)	2009-05-29
ITMI20020147A0 (it)	2002-01-29
RU2300898C2 (ru)	2007-06-20
US7901718B2 (en)	2011-03-08
US8257758B2 (en)	2012-09-04
ES2274208T3 (es)	2007-05-16
PL209342B1 (pl)	2011-08-31
CN100558243C (zh)	2009-11-11
IL163225A (en)	2007-06-17
KR100991641B1 (ko)	2010-11-04
US20080261885A1 (en)	2008-10-23
CY1107514T1 (el)	2013-03-13
CN1622760A (zh)	2005-06-01
ITMI20020147A1 (it)	2003-07-29
NO20043186L (no)	2004-07-26
PL370294A1 (en)	2005-05-16
AU2003208346A2 (en)	2003-09-02
US20050164337A1 (en)	2005-07-28
AU2003208346B2 (en)	2008-03-06
JP4522706B2 (ja)	2010-08-11
EP1469741B1 (en)	2006-10-11
DE60308994T2 (de)	2007-06-14
US7465467B2 (en)	2008-12-16
AU2003208346B8 (en)	2008-07-10
RU2004123201A (ru)	2005-10-27
EP1469741A1 (en)	2004-10-27
PT1469741E (pt)	2007-01-31
NO327156B1 (no)	2009-05-04
CA2474106C (en)	2011-11-22
JP2005516043A (ja)	2005-06-02
DE60308994D1 (de)	2006-11-23
WO2003063608A1 (en)	2003-08-07
HK1073590A1 (zh)	2005-10-14
US20110118182A1 (en)	2011-05-19

Publication	Publication Date	Title
EP1350842A3 (de)	2004-01-02	Rekombinante terminale Deoxynukleotidyltransferase mit verbesserter Funktionalität
NO20043186L (no)	2004-07-26	Fremgangsmate ved ekstraksjon, opprenskning og enzymatrisk modifisering av soya 7S-globulin alfa-subenheten for anvendelse som hypokolesterolemiserende middel
DK1415965T3 (da)	2007-04-30	Fremgangsmåde til regenerering af en saltholdig vandig glycoloplösning
DK1680507T3 (da)	2011-10-10	Bakterieekspression af proteaseinhibitorer og varianter deraf
DE60124918D1 (de)	2007-01-11	Kodon-optimierte papillomavirussequenzen
UA103496C2 (uk)	2013-10-25	Комбінація інгібітора протеази ns3 hcv з інтерфероном і рибавірином
HRP20090003T3 (en)	2009-02-28	Oligopeptides for reducing elevated blood urea concentration
NO20062104L (no)	2006-05-10	Kombinasjonsterapi for HCV-infeksjon
DE60228847D1 (da)	2008-10-23
EA200700215A1 (ru)	2007-06-29	Протеиновые гидролизаты, снижающие давление крови
DK1329462T3 (da)	2007-01-22	Fremgangsmåde til fremstilling af human serumalbumin, som inddrager opvarmningstrin
GB0216001D0 (en)	2002-08-21	Process and composition
BRPI0608273A2 (pt)	2009-12-15	peptìdeos para diminuição da pressão sanguìnea a partir de glicomacropeptìdeo
NO20080966L (no)	2008-02-26	Dykkerdrakt
NZ541231A (en)	2009-03-31	A method of treatment or prophylaxis of symptoms of herpes viral infection
JP2005516043A5 (da)	2006-03-09
FR2855984B1 (fr)	2005-07-22	Procede de traitement de fumees
TW200517368A (en)	2005-06-01	Process
WO2006067163A3 (en)	2007-05-10	Blood pressure lowering oligopeptides in a single enzymatic step
SE0203551D0 (sv)	2002-12-02	Prothrombin purification
ITMI20022409A1 (it)	2004-05-15	Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
WO2001066713A8 (en)	2002-08-15	Activation of pure prothrombin to thrombin with sodium citrate
BRPI0502744A (pt)	2006-05-02	processo para reduzir a atividade do ativador de pré-calicreìna (pka) em soluções de albumina purificada de origem humana e para estabilizá-la temporalmente; processo para obter albumina; e solução purificada de albumina de origem humana com baixa atividade do ativador de pré-calicreìna (pka) e com estabilidade temporal
Au et al.	2005	Differential Maturation of SUMO Precursors by SUMO-specific Protease, SENP1
NO984365D0 (no)	1998-09-18	IgAl proteasefragment som bµrerpeptid