DK1490482T3 - Værtsceller, der har forbedret celleoverlevelsesegenskaber og fremgangsmåder til at generere sådanne celler - Google Patents

Værtsceller, der har forbedret celleoverlevelsesegenskaber og fremgangsmåder til at generere sådanne celler

Info

Publication number
DK1490482T3
DK1490482T3 DK03718706.9T DK03718706T DK1490482T3 DK 1490482 T3 DK1490482 T3 DK 1490482T3 DK 03718706 T DK03718706 T DK 03718706T DK 1490482 T3 DK1490482 T3 DK 1490482T3
Authority
DK
Denmark
Prior art keywords
cells
generating
methods
cell survival
enhanced cell
Prior art date
Application number
DK03718706.9T
Other languages
English (en)
Inventor
Martin Fussenegger
Barbara Enenkel
Heiko Meents
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK1490482T3 publication Critical patent/DK1490482T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK03718706.9T 2002-03-28 2003-03-25 Værtsceller, der har forbedret celleoverlevelsesegenskaber og fremgangsmåder til at generere sådanne celler DK1490482T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02007144A EP1348758A1 (en) 2002-03-28 2002-03-28 Host cells having improved cell survival properties and methods to generate such cells
PCT/EP2003/003063 WO2003083093A1 (en) 2002-03-28 2003-03-25 Host cells having improved cell survival properties and methods to generate such cells

Publications (1)

Publication Number Publication Date
DK1490482T3 true DK1490482T3 (da) 2010-07-05

Family

ID=27798823

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03718706.9T DK1490482T3 (da) 2002-03-28 2003-03-25 Værtsceller, der har forbedret celleoverlevelsesegenskaber og fremgangsmåder til at generere sådanne celler

Country Status (19)

Country Link
EP (2) EP1348758A1 (da)
JP (1) JP2005521406A (da)
KR (1) KR101080626B1 (da)
CN (1) CN1646683A (da)
AR (1) AR039185A1 (da)
AT (1) ATE459705T1 (da)
AU (1) AU2003222777A1 (da)
BR (1) BR0308810A (da)
CA (1) CA2480684C (da)
DE (1) DE60331529D1 (da)
DK (1) DK1490482T3 (da)
ES (1) ES2339760T3 (da)
IL (1) IL163599A0 (da)
MX (1) MXPA04009336A (da)
NZ (1) NZ536077A (da)
PE (1) PE20040166A1 (da)
TW (2) TWI332990B (da)
UY (1) UY27739A1 (da)
WO (1) WO2003083093A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4435563B2 (ja) 2001-07-10 2010-03-17 バイオジェン アイデック インク アポトーシスプロセスの阻害および細胞性能の改善
KR100454016B1 (ko) * 2002-01-05 2004-10-26 한국과학기술원 항예정사 유전자로 형질전환되고 ｄｈｆｒ 유전자가결핍된 신규한 ｃｈｏ 세포주, 그의 제조 방법 및 상기형질전환된 ｃｈｏ 숙주 세포를 이용한 목적단백질의 생산방법
EP1563073A4 (en) * 2002-06-26 2007-09-19 Biogen Idec Inc PROTEIN PRODUCTION METHODS AND MODIFIED CELLS FOR USE IN SUCH METHODS
WO2004062554A2 (en) * 2003-01-08 2004-07-29 Nsgene A/S Enhancement of dopaminergic neuron generation and survital
EP2180045B1 (en) * 2003-10-24 2015-12-23 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Novel protein highly producing recombinant animal cell, method for preparing the same and method for mass-producing protein using the same
US7608425B2 (en) 2004-07-23 2009-10-27 Immunomedics, Inc. Methods for protein expression in mammalian cells in serum-free medium
US7531327B2 (en) 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
US7537930B2 (en) 2004-07-23 2009-05-26 Immunomedics, Inc. Mammalian cell lines for increasing longevity and protein yield from a cell culture
EP1953222A1 (en) * 2007-01-24 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Improvement of cell growth
WO2009062789A1 (en) * 2007-11-13 2009-05-22 Boehringer Ingelheim Pharma Gmbh & Co Kg Improving the secretory capacity in host cells
WO2009152413A1 (en) * 2008-06-13 2009-12-17 Centocor Ortho Biotech Inc. Methods for obtaining high viable cell density in mammalian cell culture
WO2010010108A1 (en) * 2008-07-23 2010-01-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Improved production host cell lines
CN104066837B (zh) 2011-12-02 2020-12-08 菲特治疗公司 增强的干细胞组合物
CN104673754B (zh) * 2015-02-14 2018-03-02 百泰生物药业有限公司 重组骨髓瘤细胞克隆的筛选方法及由此获得的抗体分子
JP7214962B2 (ja) * 2018-01-17 2023-01-31 東ソー株式会社 アルカリホスファターゼ高発現動物細胞
CN116064398B (zh) * 2022-07-04 2026-07-17 上海倍谙基生物科技有限公司 定点同步敲入和敲除基因的抗凋亡细胞改造方法及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143291A (en) * 1995-05-04 2000-11-07 Us Navy Methods for modulating T cell survival by modulating bcl-XL protein level
WO2000075291A2 (en) * 1999-06-08 2000-12-14 Novartis Ag Cells with enforced expression of bcl-xl

Also Published As

Publication number Publication date
UY27739A1 (es) 2003-10-31
TWI332991B (en) 2010-11-11
IL163599A0 (en) 2005-12-18
EP1490482A1 (en) 2004-12-29
ATE459705T1 (de) 2010-03-15
CA2480684C (en) 2011-01-25
CN1646683A (zh) 2005-07-27
NZ536077A (en) 2006-04-28
AR039185A1 (es) 2005-02-09
JP2005521406A (ja) 2005-07-21
TW201000633A (en) 2010-01-01
PE20040166A1 (es) 2004-05-20
EP1348758A1 (en) 2003-10-01
ES2339760T3 (es) 2010-05-25
BR0308810A (pt) 2005-06-28
EP1490482B1 (en) 2010-03-03
TWI332990B (en) 2010-11-11
WO2003083093A1 (en) 2003-10-09
TW200307044A (en) 2003-12-01
KR101080626B1 (ko) 2011-11-08
KR20040099373A (ko) 2004-11-26
DE60331529D1 (de) 2010-04-15
AU2003222777A1 (en) 2003-10-13
CA2480684A1 (en) 2003-10-09
MXPA04009336A (es) 2005-01-25

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