DK1491540T3 - Intermediater, der er anvendelige til syntese af pyridazinon-aldosereduktase inhibitorer - Google Patents

Intermediater, der er anvendelige til syntese af pyridazinon-aldosereduktase inhibitorer

Info

Publication number: DK1491540T3
Authority: DK; Denmark
Prior art keywords: pyridazinone; synthesis; reductase inhibitors; aldose reductase; intermediates useful
Prior art date: 2001-03-30

Application number

DK04023149T

Other languages

Danish (da)

English (en)

Inventor

Banavara Lakshman Mylari

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-30

Filing date

2002-01-31

Publication date

2007-03-26

2002-01-31 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2007-03-26 Application granted granted Critical

2007-03-26 Publication of DK1491540T3 publication Critical patent/DK1491540T3/da

Links

239000003288 aldose reductase inhibitor Substances 0.000 title 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK04023149T 2001-03-30 2002-01-31 Intermediater, der er anvendelige til syntese af pyridazinon-aldosereduktase inhibitorer DK1491540T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28005101P	2001-03-30	2001-03-30
PCT/IB2002/000320 WO2002079198A1 (fr)	2001-03-30	2002-01-31	Inhibiteurs pyridazinone d'aldose réductase

Publications (1)

Publication Number	Publication Date
DK1491540T3 true DK1491540T3 (da)	2007-03-26

Family

ID=23071435

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK04023149T DK1491540T3 (da)	2001-03-30	2002-01-31	Intermediater, der er anvendelige til syntese af pyridazinon-aldosereduktase inhibitorer
DK02716247T DK1373259T3 (da)	2001-03-30	2002-01-31	Pyridazinonaldosereduktaseinhibitorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK02716247T DK1373259T3 (da)	2001-03-30	2002-01-31	Pyridazinonaldosereduktaseinhibitorer

Country Status (43)

Country	Link
US (2)	US6579879B2 (fr)
EP (3)	EP1491541B1 (fr)
JP (1)	JP2004528319A (fr)
KR (1)	KR100586138B1 (fr)
CN (1)	CN1215067C (fr)
AP (1)	AP2002002461A0 (fr)
AR (1)	AR035798A1 (fr)
AT (3)	ATE348100T1 (fr)
AU (1)	AU2002226634B2 (fr)
BG (1)	BG108179A (fr)
BR (1)	BR0208571A (fr)
CA (1)	CA2442476A1 (fr)
CZ (1)	CZ20032563A3 (fr)
DE (3)	DE60217930T2 (fr)
DK (2)	DK1491540T3 (fr)
EA (1)	EA006023B1 (fr)
EC (1)	ECSP034671A (fr)
EE (1)	EE200300470A (fr)
ES (2)	ES2274369T3 (fr)
GE (1)	GEP20053675B (fr)
HR (1)	HRP20030752A2 (fr)
HU (1)	HUP0303644A3 (fr)
IL (1)	IL156462A0 (fr)
IS (3)	IS2205B (fr)
MA (1)	MA27003A1 (fr)
MX (1)	MXPA03008850A (fr)
MY (1)	MY134304A (fr)
NO (1)	NO20034345L (fr)
NZ (1)	NZ528406A (fr)
OA (1)	OA12453A (fr)
PA (1)	PA8541801A1 (fr)
PE (1)	PE20030007A1 (fr)
PL (1)	PL365294A1 (fr)
PT (2)	PT1373259E (fr)
SI (1)	SI1373259T1 (fr)
SK (1)	SK11852003A3 (fr)
TN (1)	TNSN02037A1 (fr)
TW (1)	TWI245762B (fr)
UA (1)	UA73236C2 (fr)
UY (1)	UY27237A1 (fr)
WO (1)	WO2002079198A1 (fr)
YU (1)	YU71403A (fr)
ZA (1)	ZA200304671B (fr)

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US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
DE602005025755D1 (de)	2004-06-04	2011-02-17	Teva Pharma	Irbesartan enthaltende pharmazeutische zusammensetzung
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
WO2006028565A2 (fr) *	2004-06-30	2006-03-16	Whitehead Institute For Biomedical Research	Procedes pour analyse de site haut rendement au niveau du genome
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
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US7645752B2 (en) *	2006-01-13	2010-01-12	Wyeth Llc	Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
RS53230B (sr)	2006-06-27	2014-08-29	Takeda Pharmaceutical Company Limited	Kondenzovana ciklična jedinjenja kao modulatori gpr40 receptora
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8173645B2 (en) *	2007-03-21	2012-05-08	Takeda San Diego, Inc.	Glucokinase activators
SG157299A1 (en)	2008-05-09	2009-12-29	Agency Science Tech & Res	Diagnosis and treatment of kawasaki disease
ES2758554T3 (es)	2009-12-08	2020-05-05	Univ Case Western Reserve	Aminoácidos gama para tratamiento de trastornos oculares
US8916563B2 (en)	2010-07-16	2014-12-23	The Trustees Of Columbia University In The City Of New York	Aldose reductase inhibitors and uses thereof
US9296692B2 (en) *	2011-09-15	2016-03-29	Taipei Medical University	Use of indolyl and indolinyl hydroxamates for treating heart failure of neuronal injury
US9339542B2 (en) *	2013-04-16	2016-05-17	John L Couvaras	Hypertension reducing composition
EP2986599A1 (fr)	2013-04-17	2016-02-24	Pfizer Inc.	Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
CN103739547B (zh) *	2014-01-03	2015-09-02	沈阳药科大学	2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法
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AU2016248080A1 (en) *	2015-04-14	2017-11-02	Board Of Regents Of The University Of Texas System	Compositions and methods of modulating short-chain dehydrogenase activity
WO2017168174A1 (fr)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	Nouvelles formes pharmaceutiques du sildénafil
RS61239B1 (sr)	2016-06-21	2021-01-29	Univ Columbia	Inhibitori aldozne reduktaze i postupci korišćenja
WO2018002673A1 (fr)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Nouvelles formulations d'antagonistes du récepteur de l'angiotensine ii
US10344002B2 (en)	2016-09-26	2019-07-09	Nusirt Sciences, Inc.	Compositions and methods for treating metabolic disorders
EP3548035A4 (fr)	2016-11-30	2020-07-22	Case Western Reserve University	Combinaisons d'inhibiteurs de 15-pgdh avec des corcostéroïdes et/ou des inhibiteurs du tnf et leurs utilisations
JP2020514323A (ja)	2017-02-06	2020-05-21	ケースウエスタンリザーブユニバーシティ	短鎖デヒドロゲナーゼ活性を調節する組成物と方法
IL272246B2 (en)	2017-07-28	2026-01-01	Applied Therapeutics Inc	History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
KR102921276B1 (ko)	2018-11-21	2026-02-03	케이스 웨스턴 리저브 유니버시티	단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법
BR112021013807A2 (pt)	2019-01-18	2021-11-30	Astrazeneca Ab	Inibidores de pcsk9 e seus métodos de uso
CA3132136A1 (fr)	2019-04-01	2020-10-08	Andrew Wasmuth	Inhibiteurs de l'aldose reductase
JP2022531466A (ja)	2019-05-07	2022-07-06	ユニバーシティオブマイアミ	遺伝性ニューロパチーおよび関連障害の処置および検出
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2002
- 2002-01-31 EP EP04023150A patent/EP1491541B1/fr not_active Expired - Lifetime
- 2002-01-31 DK DK04023149T patent/DK1491540T3/da active
- 2002-01-31 SK SK1185-2003A patent/SK11852003A3/sk unknown
- 2002-01-31 ES ES04023149T patent/ES2274369T3/es not_active Expired - Lifetime
- 2002-01-31 GE GE5314A patent/GEP20053675B/en unknown
- 2002-01-31 HR HR20030752A patent/HRP20030752A2/hr not_active Application Discontinuation
- 2002-01-31 AT AT04023149T patent/ATE348100T1/de not_active IP Right Cessation
- 2002-01-31 SI SI200230071T patent/SI1373259T1/xx unknown
- 2002-01-31 EP EP04023149A patent/EP1491540B1/fr not_active Expired - Lifetime
- 2002-01-31 EP EP02716247A patent/EP1373259B1/fr not_active Expired - Lifetime
- 2002-01-31 MX MXPA03008850A patent/MXPA03008850A/es active IP Right Grant
- 2002-01-31 CN CNB028076001A patent/CN1215067C/zh not_active Expired - Fee Related
- 2002-01-31 DE DE60217930T patent/DE60217930T2/de not_active Expired - Fee Related
- 2002-01-31 PL PL02365294A patent/PL365294A1/xx not_active Application Discontinuation
- 2002-01-31 AU AU2002226634A patent/AU2002226634B2/en not_active Ceased
- 2002-01-31 DK DK02716247T patent/DK1373259T3/da active
- 2002-01-31 DE DE60202452T patent/DE60202452C5/de not_active Expired - Fee Related
- 2002-01-31 AT AT02716247T patent/ATE286049T1/de active
- 2002-01-31 EA EA200300673A patent/EA006023B1/ru not_active IP Right Cessation
- 2002-01-31 HU HU0303644A patent/HUP0303644A3/hu unknown
- 2002-01-31 NZ NZ528406A patent/NZ528406A/en unknown
- 2002-01-31 PT PT02716247T patent/PT1373259E/pt unknown
- 2002-01-31 DE DE60216823T patent/DE60216823T2/de not_active Expired - Fee Related
- 2002-01-31 IL IL15646202A patent/IL156462A0/xx unknown
- 2002-01-31 OA OA1200300222A patent/OA12453A/en unknown
- 2002-01-31 KR KR1020037012753A patent/KR100586138B1/ko not_active Expired - Fee Related
- 2002-01-31 UA UA2003098846A patent/UA73236C2/uk unknown
- 2002-01-31 AT AT04023150T patent/ATE352551T1/de not_active IP Right Cessation
- 2002-01-31 EE EEP200300470A patent/EE200300470A/xx unknown
- 2002-01-31 CA CA002442476A patent/CA2442476A1/fr not_active Abandoned
- 2002-01-31 YU YU71403A patent/YU71403A/sh unknown
- 2002-01-31 PT PT04023149T patent/PT1491540E/pt unknown
- 2002-01-31 ES ES02716247T patent/ES2231681T3/es not_active Expired - Lifetime
- 2002-01-31 WO PCT/IB2002/000320 patent/WO2002079198A1/fr not_active Ceased
- 2002-01-31 JP JP2002577823A patent/JP2004528319A/ja active Pending
- 2002-01-31 BR BR0208571-2A patent/BR0208571A/pt not_active IP Right Cessation
- 2002-03-21 US US10/104,664 patent/US6579879B2/en not_active Expired - Fee Related
- 2002-03-22 PA PA20028541801A patent/PA8541801A1/es unknown
- 2002-03-27 MY MYPI20021093A patent/MY134304A/en unknown
- 2002-03-27 AR ARP020101134A patent/AR035798A1/es unknown
- 2002-03-27 UY UY27237A patent/UY27237A1/es not_active Application Discontinuation
- 2002-03-27 PE PE2002000246A patent/PE20030007A1/es not_active Application Discontinuation
- 2002-03-28 AP APAP/P/2002/002461A patent/AP2002002461A0/en unknown
- 2002-03-29 TN TNTNSN02037A patent/TNSN02037A1/fr unknown
- 2002-03-29 TW TW091106386A patent/TWI245762B/zh not_active IP Right Cessation
- 2002-03-31 CZ CZ20032563A patent/CZ20032563A3/cs unknown
2003
- 2003-02-20 US US10/370,895 patent/US6849629B2/en not_active Expired - Fee Related
- 2003-06-16 IS IS6845A patent/IS2205B/is unknown
- 2003-06-17 ZA ZA200304671A patent/ZA200304671B/en unknown
- 2003-06-25 EC EC2003004671A patent/ECSP034671A/es unknown
- 2003-09-17 MA MA27314A patent/MA27003A1/fr unknown
- 2003-09-17 BG BG108179A patent/BG108179A/xx unknown
- 2003-09-29 NO NO20034345A patent/NO20034345L/no unknown
2006
- 2006-01-23 IS IS8250A patent/IS8250A/is unknown
- 2006-01-23 IS IS8251A patent/IS8251A/is unknown

Also Published As

Publication number	Publication date
EP1491540B1 (fr)	2006-12-13
DE60202452T2 (de)	2006-02-09
OA12453A (en)	2006-05-24
CN1500087A (zh)	2004-05-26
PT1491540E (pt)	2007-01-31
IS6845A (is)	2003-06-16
WO2002079198A1 (fr)	2002-10-10
YU71403A (sh)	2006-05-25
DE60202452D1 (de)	2005-02-03
US20020143017A1 (en)	2002-10-03
AR035798A1 (es)	2004-07-14
EP1491541A1 (fr)	2004-12-29
PA8541801A1 (es)	2002-10-28
US6849629B2 (en)	2005-02-01
GEP20053675B (en)	2005-11-25
EE200300470A (et)	2004-02-16
EA006023B1 (ru)	2005-08-25
PE20030007A1 (es)	2003-01-28
ATE286049T1 (de)	2005-01-15
ES2231681T3 (es)	2005-05-16
ZA200304671B (en)	2004-06-25
DK1373259T3 (da)	2005-03-29
BG108179A (en)	2004-09-30
CZ20032563A3 (cs)	2004-05-12
DE60216823D1 (de)	2007-01-25
IS2205B (is)	2007-02-15
UA73236C2 (en)	2005-06-15
TWI245762B (en)	2005-12-21
KR20030088484A (ko)	2003-11-19
IS8251A (is)	2006-01-23
ATE348100T1 (de)	2007-01-15
CN1215067C (zh)	2005-08-17
HK1061678A1 (en)	2004-09-30
ES2274369T3 (es)	2007-05-16
MY134304A (en)	2007-12-31
AP2002002461A0 (en)	2002-06-30
TNSN02037A1 (fr)	2005-12-23
PT1373259E (pt)	2005-03-31
IS8250A (is)	2006-01-23
EA200300673A1 (ru)	2003-12-25
HUP0303644A2 (hu)	2004-03-01
MA27003A1 (fr)	2004-12-20
AU2002226634B2 (en)	2007-01-25
EP1373259A1 (fr)	2004-01-02
NZ528406A (en)	2004-03-26
ATE352551T1 (de)	2007-02-15
SI1373259T1 (en)	2005-04-30
EP1491541B1 (fr)	2007-01-24
US20030162784A1 (en)	2003-08-28
UY27237A1 (es)	2002-12-31
DE60216823T2 (de)	2007-10-04
JP2004528319A (ja)	2004-09-16
NO20034345D0 (no)	2003-09-29
HUP0303644A3 (en)	2008-06-30
PL365294A1 (en)	2004-12-27
ECSP034671A (es)	2003-08-29
DE60217930D1 (de)	2007-03-15
US6579879B2 (en)	2003-06-17
CA2442476A1 (fr)	2002-10-10
MXPA03008850A (es)	2003-12-04
EP1491540A1 (fr)	2004-12-29
DE60202452C5 (de)	2006-11-23
BR0208571A (pt)	2004-03-23
KR100586138B1 (ko)	2006-06-07
HRP20030752A2 (en)	2005-06-30
EP1373259B1 (fr)	2004-12-29
NO20034345L (no)	2003-09-29
DE60217930T2 (de)	2007-10-18
IL156462A0 (en)	2004-01-04
SK11852003A3 (sk)	2004-07-07

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