BG108179A - Pyridazinone aldose reductase inhibitors - Google Patents

Pyridazinone aldose reductase inhibitors

Info

Publication number: BG108179A
Authority: BG; Bulgaria
Prior art keywords: diabetic; inhibitors; aldose reductase; relates; compositions
Prior art date: 2001-03-30

Application number

BG108179A

Other languages

Bulgarian (bg)

English (en)

Inventor

Banavara L. Mylari

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-30

Filing date

2003-09-17

Publication date

2004-09-30

2003-09-17 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2004-09-30 Publication of BG108179A publication Critical patent/BG108179A/xx

Links

239000003288 aldose reductase inhibitor Substances 0.000 title abstract 3
AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical compound OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract 2
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 3
229940118148 Aldose reductase inhibitor Drugs 0.000 abstract 2
208000002249 Diabetes Complications Diseases 0.000 abstract 2
206010012655 Diabetic complications Diseases 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
-1 3-hydroxy-3-methylglutaryl Chemical group 0.000 abstract 1
239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 abstract 1
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
208000032781 Diabetic cardiomyopathy Diseases 0.000 abstract 1
206010063547 Diabetic macroangiopathy Diseases 0.000 abstract 1
206010054044 Diabetic microangiopathy Diseases 0.000 abstract 1
206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
102100038509 E3 ubiquitin-protein ligase ARIH1 Human genes 0.000 abstract 1
229930091371 Fructose Natural products 0.000 abstract 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
239000005715 Fructose Substances 0.000 abstract 1
102000007390 Glycogen Phosphorylase Human genes 0.000 abstract 1
108010046163 Glycogen Phosphorylase Proteins 0.000 abstract 1
102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 abstract 1
229940123659 Sorbitol dehydrogenase inhibitor Drugs 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
201000009101 diabetic angiopathy Diseases 0.000 abstract 1
208000033679 diabetic kidney disease Diseases 0.000 abstract 1
230000010030 glucose lowering effect Effects 0.000 abstract 1
MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 abstract 1
108010093115 growth factor-activatable Na-H exchanger NHE-1 Proteins 0.000 abstract 1
239000002590 phosphodiesterase V inhibitor Substances 0.000 abstract 1
239000003379 purinergic P1 receptor agonist Substances 0.000 abstract 1
239000012896 selective serotonin reuptake inhibitor Substances 0.000 abstract 1
229940124834 selective serotonin reuptake inhibitor Drugs 0.000 abstract 1
239000000600 sorbitol Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BG108179A 2001-03-30 2003-09-17 Pyridazinone aldose reductase inhibitors BG108179A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28005101P	2001-03-30	2001-03-30
PCT/IB2002/000320 WO2002079198A1 (fr)	2001-03-30	2002-01-31	Inhibiteurs pyridazinone d'aldose réductase

Publications (1)

Publication Number	Publication Date
BG108179A true BG108179A (en)	2004-09-30

Family

ID=23071435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108179A BG108179A (en)	2001-03-30	2003-09-17	Pyridazinone aldose reductase inhibitors

Country Status (43)

Country	Link
US (2)	US6579879B2 (fr)
EP (3)	EP1373259B1 (fr)
JP (1)	JP2004528319A (fr)
KR (1)	KR100586138B1 (fr)
CN (1)	CN1215067C (fr)
AP (1)	AP2002002461A0 (fr)
AR (1)	AR035798A1 (fr)
AT (3)	ATE352551T1 (fr)
AU (1)	AU2002226634B2 (fr)
BG (1)	BG108179A (fr)
BR (1)	BR0208571A (fr)
CA (1)	CA2442476A1 (fr)
CZ (1)	CZ20032563A3 (fr)
DE (3)	DE60202452C5 (fr)
DK (2)	DK1491540T3 (fr)
EA (1)	EA006023B1 (fr)
EC (1)	ECSP034671A (fr)
EE (1)	EE200300470A (fr)
ES (2)	ES2231681T3 (fr)
GE (1)	GEP20053675B (fr)
HR (1)	HRP20030752A2 (fr)
HU (1)	HUP0303644A3 (fr)
IL (1)	IL156462A0 (fr)
IS (3)	IS2205B (fr)
MA (1)	MA27003A1 (fr)
MX (1)	MXPA03008850A (fr)
MY (1)	MY134304A (fr)
NO (1)	NO20034345D0 (fr)
NZ (1)	NZ528406A (fr)
OA (1)	OA12453A (fr)
PA (1)	PA8541801A1 (fr)
PE (1)	PE20030007A1 (fr)
PL (1)	PL365294A1 (fr)
PT (2)	PT1491540E (fr)
SI (1)	SI1373259T1 (fr)
SK (1)	SK11852003A3 (fr)
TN (1)	TNSN02037A1 (fr)
TW (1)	TWI245762B (fr)
UA (1)	UA73236C2 (fr)
UY (1)	UY27237A1 (fr)
WO (1)	WO2002079198A1 (fr)
YU (1)	YU71403A (fr)
ZA (1)	ZA200304671B (fr)

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US20040092522A1 (en) *	2002-08-15	2004-05-13	Field Mark John	Synergistic combinations
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CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
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JP2010043063A (ja)	2008-05-09	2010-02-25	Agency For Science Technology & Research	川崎病の診断及び治療
EP2509596B1 (fr)	2009-12-08	2019-08-28	Case Western Reserve University	Gamma acides aminés pour le traitement de troubles oculaires
US8916563B2 (en)	2010-07-16	2014-12-23	The Trustees Of Columbia University In The City Of New York	Aldose reductase inhibitors and uses thereof
CA2848877A1 (fr) *	2011-09-15	2013-03-21	Taipei Medical University	Utilisation d'indolyl et d'hydroxamates d'indolinyl pour le traitement d'une defaillance cardiaque ou d'une lesion neuronale
US9339542B2 (en) *	2013-04-16	2016-05-17	John L Couvaras	Hypertension reducing composition
MX2015014666A (es)	2013-04-17	2016-03-01	Pfizer	Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
CN103739547B (zh) *	2014-01-03	2015-09-02	沈阳药科大学	2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法
WO2016055901A1 (fr)	2014-10-08	2016-04-14	Pfizer Inc.	Composés d'amide substitué
JP2018511616A (ja) *	2015-04-14	2018-04-26	ケースウエスタンリザーブユニバーシティ	短鎖デヒドロゲナーゼ活性を調節する組成物および方法
WO2017168174A1 (fr)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	Nouvelles formes pharmaceutiques du sildénafil
DK3352754T3 (da)	2016-06-21	2020-12-07	Univ Columbia	Aldosereduktaseinhibitorer og fremgangsmåder til anvendelse deraf
WO2018002673A1 (fr)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Nouvelles formulations d'antagonistes du récepteur de l'angiotensine ii
WO2018058109A1 (fr) *	2016-09-26	2018-03-29	Nusirt Sciences, Inc.	Compositions et méthodes pour le traitement de troubles métaboliques
JP7595413B2 (ja)	2016-11-30	2024-12-06	ケースウエスタンリザーブユニバーシティ	１５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用
WO2018145080A1 (fr)	2017-02-06	2018-08-09	Case Western Reserve University	Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte
IL272246B2 (en)	2017-07-28	2026-01-01	Applied Therapeutics Inc	History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
CN120463721A (zh)	2018-11-21	2025-08-12	卡斯西部储备大学	调节短链脱氢酶活性的组合物和方法
SG11202107614PA (en)	2019-01-18	2021-08-30	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof
CN113840825A (zh)	2019-04-01	2021-12-24	应用治疗公司	醛糖还原酶抑制剂
WO2020227430A1 (fr)	2019-05-07	2020-11-12	University Of Miami	Traitement et détection de neuropathies héréditaires et de troubles associés
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IE47592B1 (en)	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
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FR2822827B1 (fr) *	2001-03-28	2003-05-16	Sanofi Synthelabo	Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
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2002
- 2002-01-31 CA CA002442476A patent/CA2442476A1/fr not_active Abandoned
- 2002-01-31 WO PCT/IB2002/000320 patent/WO2002079198A1/fr not_active Ceased
- 2002-01-31 JP JP2002577823A patent/JP2004528319A/ja active Pending
- 2002-01-31 DK DK04023149T patent/DK1491540T3/da active
- 2002-01-31 DK DK02716247T patent/DK1373259T3/da active
- 2002-01-31 SI SI200230071T patent/SI1373259T1/xx unknown
- 2002-01-31 PL PL02365294A patent/PL365294A1/xx not_active Application Discontinuation
- 2002-01-31 DE DE60202452T patent/DE60202452C5/de not_active Expired - Fee Related
- 2002-01-31 PT PT04023149T patent/PT1491540E/pt unknown
- 2002-01-31 HR HR20030752A patent/HRP20030752A2/hr not_active Application Discontinuation
- 2002-01-31 DE DE60217930T patent/DE60217930T2/de not_active Expired - Fee Related
- 2002-01-31 AT AT04023150T patent/ATE352551T1/de not_active IP Right Cessation
- 2002-01-31 EE EEP200300470A patent/EE200300470A/xx unknown
- 2002-01-31 EP EP02716247A patent/EP1373259B1/fr not_active Expired - Lifetime
- 2002-01-31 OA OA1200300222A patent/OA12453A/en unknown
- 2002-01-31 MX MXPA03008850A patent/MXPA03008850A/es active IP Right Grant
- 2002-01-31 EP EP04023150A patent/EP1491541B1/fr not_active Expired - Lifetime
- 2002-01-31 SK SK1185-2003A patent/SK11852003A3/sk unknown
- 2002-01-31 AU AU2002226634A patent/AU2002226634B2/en not_active Ceased
- 2002-01-31 KR KR1020037012753A patent/KR100586138B1/ko not_active Expired - Fee Related
- 2002-01-31 HU HU0303644A patent/HUP0303644A3/hu unknown
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- 2002-01-31 BR BR0208571-2A patent/BR0208571A/pt not_active IP Right Cessation
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- 2002-01-31 DE DE60216823T patent/DE60216823T2/de not_active Expired - Fee Related
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- 2002-01-31 AT AT02716247T patent/ATE286049T1/de active
- 2002-01-31 EP EP04023149A patent/EP1491540B1/fr not_active Expired - Lifetime
- 2002-01-31 ES ES02716247T patent/ES2231681T3/es not_active Expired - Lifetime
- 2002-01-31 UA UA2003098846A patent/UA73236C2/uk unknown
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- 2002-01-31 EA EA200300673A patent/EA006023B1/ru not_active IP Right Cessation
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- 2002-03-29 TN TNTNSN02037A patent/TNSN02037A1/fr unknown
- 2002-03-31 CZ CZ20032563A patent/CZ20032563A3/cs unknown
2003
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- 2003-09-17 BG BG108179A patent/BG108179A/xx unknown
- 2003-09-17 MA MA27314A patent/MA27003A1/fr unknown
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2006
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Also Published As

Publication number	Publication date
UY27237A1 (es)	2002-12-31
PT1491540E (pt)	2007-01-31
BR0208571A (pt)	2004-03-23
IS2205B (is)	2007-02-15
WO2002079198A1 (fr)	2002-10-10
CN1500087A (zh)	2004-05-26
NZ528406A (en)	2004-03-26
SI1373259T1 (en)	2005-04-30
EP1373259A1 (fr)	2004-01-02
EP1491541A1 (fr)	2004-12-29
DE60216823D1 (de)	2007-01-25
EP1491540A1 (fr)	2004-12-29
EP1373259B1 (fr)	2004-12-29
CA2442476A1 (fr)	2002-10-10
DE60202452C5 (de)	2006-11-23
CZ20032563A3 (cs)	2004-05-12
NO20034345L (no)	2003-09-29
AU2002226634B2 (en)	2007-01-25
IS6845A (is)	2003-06-16
US6849629B2 (en)	2005-02-01
KR100586138B1 (ko)	2006-06-07
PE20030007A1 (es)	2003-01-28
DK1373259T3 (da)	2005-03-29
OA12453A (en)	2006-05-24
ATE348100T1 (de)	2007-01-15
KR20030088484A (ko)	2003-11-19
EA200300673A1 (ru)	2003-12-25
MA27003A1 (fr)	2004-12-20
DE60202452D1 (de)	2005-02-03
HRP20030752A2 (en)	2005-06-30
YU71403A (sh)	2006-05-25
JP2004528319A (ja)	2004-09-16
IS8250A (is)	2006-01-23
NO20034345D0 (no)	2003-09-29
SK11852003A3 (sk)	2004-07-07
US20030162784A1 (en)	2003-08-28
DK1491540T3 (da)	2007-03-26
DE60202452T2 (de)	2006-02-09
ES2274369T3 (es)	2007-05-16
IS8251A (is)	2006-01-23
UA73236C2 (en)	2005-06-15
DE60217930D1 (de)	2007-03-15
EP1491541B1 (fr)	2007-01-24
ES2231681T3 (es)	2005-05-16
CN1215067C (zh)	2005-08-17
PL365294A1 (en)	2004-12-27
ATE352551T1 (de)	2007-02-15
ECSP034671A (es)	2003-08-29
DE60217930T2 (de)	2007-10-18
TNSN02037A1 (fr)	2005-12-23
AR035798A1 (es)	2004-07-14
AP2002002461A0 (en)	2002-06-30
HK1061678A1 (en)	2004-09-30
EP1491540B1 (fr)	2006-12-13
EE200300470A (et)	2004-02-16
US20020143017A1 (en)	2002-10-03
ATE286049T1 (de)	2005-01-15
DE60216823T2 (de)	2007-10-04
ZA200304671B (en)	2004-06-25
TWI245762B (en)	2005-12-21
MXPA03008850A (es)	2003-12-04
PA8541801A1 (es)	2002-10-28
PT1373259E (pt)	2005-03-31
HUP0303644A3 (en)	2008-06-30
US6579879B2 (en)	2003-06-17
MY134304A (en)	2007-12-31
EA006023B1 (ru)	2005-08-25
HUP0303644A2 (hu)	2004-03-01
GEP20053675B (en)	2005-11-25
IL156462A0 (en)	2004-01-04

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