DK149290A - Tumorhaemmende saccharidkonjugater - Google Patents

Tumorhaemmende saccharidkonjugater Download PDF

Info

Publication number: DK149290A
Authority: DK; Denmark
Prior art keywords: sugar; tumor; mustard; function; saccharide conjugates
Prior art date: 1988-10-20

Application number

DK149290A

Other languages

English (en)

Other versions

DK149290D0 (da

DK170422B1 (da

Inventor

Manfred Wiessler

Michael Dickes

Original Assignee

Deutsches Krebsforsch

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-20

Filing date

1990-06-19

Publication date

1990-08-07

1990-06-19 Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch

1990-06-19 Publication of DK149290D0 publication Critical patent/DK149290D0/da

1990-08-07 Publication of DK149290A publication Critical patent/DK149290A/da

1993-10-18 Priority to DK199301170A priority Critical patent/DK174539B1/da

1995-08-28 Application granted granted Critical

1995-08-28 Publication of DK170422B1 publication Critical patent/DK170422B1/da

Links

206010028980 Neoplasm Diseases 0.000 title 1
150000001720 carbohydrates Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
BKCJZNIZRWYHBN-UHFFFAOYSA-N Isophosphamide mustard Chemical group ClCCNP(=O)(O)NCCCl BKCJZNIZRWYHBN-UHFFFAOYSA-N 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001268 conjugating effect Effects 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
RJXQSIKBGKVNRT-UHFFFAOYSA-N phosphoramide mustard Chemical group ClCCN(P(O)(=O)N)CCCl RJXQSIKBGKVNRT-UHFFFAOYSA-N 0.000 abstract 1
150000008039 phosphoramides Chemical class 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
150000003018 phosphorus compounds Chemical class 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

DK149290A 1988-10-20 1990-06-19 Glycokonjugater af N,N'-di(chlorethyl)phosphorsyrediamid DK170422B1 (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK199301170A DK174539B1 (da)	1988-10-20	1993-10-18	Fremgangsmåde til fremstilling af glycokonjugater af mustardforbindelser

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE3835772A DE3835772A1 (de)	1988-10-20	1988-10-20	Tumorhemmende saccharid-konjugate
DE3835772		1988-10-20
EP8901251		1989-10-19
PCT/EP1989/001251 WO1990004597A1 (de)	1988-10-20	1989-10-19	Tumorhemmende saccharid-konjugate

Publications (3)

Publication Number	Publication Date
DK149290D0 DK149290D0 (da)	1990-06-19
DK149290A true DK149290A (da)	1990-08-07
DK170422B1 DK170422B1 (da)	1995-08-28

Family

ID=6365559

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK149290A DK170422B1 (da)	1988-10-20	1990-06-19	Glycokonjugater af N,N'-di(chlorethyl)phosphorsyrediamid

Country Status (16)

Country	Link
US (1)	US5622936A (da)
EP (1)	EP0369182B1 (da)
JP (2)	JP2518739B2 (da)
AT (1)	ATE120465T1 (da)
CA (1)	CA2001129C (da)
DE (2)	DE3835772A1 (da)
DK (1)	DK170422B1 (da)
ES (1)	ES2072881T3 (da)
FI (1)	FI95268C (da)
GR (1)	GR3015566T3 (da)
HK (1)	HK157495A (da)
HU (1)	HU206124B (da)
IE (1)	IE67529B1 (da)
NO (1)	NO173548C (da)
PT (1)	PT92034B (da)
WO (1)	WO1990004597A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19524515A1 (de)	1995-07-05	1997-01-09	Deutsches Krebsforsch	Saccharid-Konjugate
US20040072889A1 (en) *	1997-04-21	2004-04-15	Pharmacia Corporation	Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
US6506739B1 (en)	2001-05-01	2003-01-14	Telik, Inc.	Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
WO2003079980A2 (en) *	2002-03-19	2003-10-02	A & D Bioscience, Inc.	Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
US7001888B2 (en) *	2002-03-29	2006-02-21	Threshold Pharmaceuticals, Inc.	Compositions and methods for treating cancer
CN1771334A (zh) *	2003-03-07	2006-05-10	施瑞修德制药公司	用于确定肿瘤对抗肿瘤药剂的治疗的敏感性的方法
ZA200507752B (en) *	2003-03-28	2007-01-31	Threshold Pharmaceuticals Inc	Compositions and methods for treating cancer
WO2004110255A2 (en) *	2003-06-09	2004-12-23	Gang Zheng	Antineoplastic agents targeted via glut transporters
EP1711188B1 (en)	2004-02-06	2012-06-06	Threshold Pharmaceuticals, Inc.	Anti-cancer therapies
EP1883298A1 (en) *	2005-05-11	2008-02-06	Threshold Pharmaceuticals, Inc.	Glufosfamide combination therapy
CN102746336B (zh)	2005-06-29	2015-08-19	施瑞修德制药公司	氨基磷酸酯烷化剂前体药物
CN100358910C (zh) *	2006-02-14	2008-01-02	海南天源康泽医药科技有限公司	葡膦酰胺结晶及其制备方法与应用
WO2008011588A2 (en) *	2006-07-20	2008-01-24	Threshold Pharmaceuticals, Inc.	Glycoconjugates of phosphoramidate alkylators for treatment of cancer
EP2114157B1 (en) *	2006-12-26	2021-05-26	ImmunoGenesis, Inc.	Phosphoramidate alkylator prodrug for the treatment of cancer
US8765690B2 (en) *	2007-04-05	2014-07-01	Threshold Pharmaceuticals, Inc.	Treatment of cancer with glufosfamide in patients not receiving insulin therapy
US20090118031A1 (en) *	2007-11-01	2009-05-07	Qualizza Gregory K	Shaft Structure with Configurable Bending Profile
CN101481394B (zh) *	2008-01-09	2013-01-30	苏州天人合生物技术有限公司	2,3,4,6-四-o-乙酰基-d-吡喃葡萄糖基-[n, n′-双(2-氯乙基)]-磷酸二酰胺的制备方法
US20110207680A1 (en) *	2008-08-13	2011-08-25	Curd John G	Administration of Glufosfamide For The Treatment of Cancer
CN102115483B (zh) *	2009-12-30	2014-12-17	苏州天人合生物技术有限公司	卤代双去氧糖衍生物及其制备方法与应用
CN103142626B (zh) *	2010-07-21	2014-08-20	苏州天人合生物技术有限公司	三乙酰葡萄烯糖在制备抗肿瘤药物中的应用
CN105002235B (zh) *	2015-07-10	2019-02-22	江苏九旭药业有限公司	一种利用酶制备葡磷酰胺及其类似物的方法
CN105153251B (zh) *	2015-09-29	2018-03-20	浙江合糖科技有限公司	一种单糖甲苷的苄基化方法
AU2024317010A1 (en)	2023-07-28	2026-02-26	Ascentawits Pharmaceuticals, Ltd.	Treatment of p53 gene mutation or defect negative cancer and tumor patients

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE122386C (da) *
DD122386A1 (da) *	1975-06-24	1976-10-05
DE3225227A1 (de) *	1982-07-06	1984-01-12	Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen	Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
US5015733A (en) *	1983-12-20	1991-05-14	California Institute Of Technology	Nucleosides possessing blocked aliphatic amino groups
US4849513A (en) *	1983-12-20	1989-07-18	California Institute Of Technology	Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
ZA851062B (en) *	1984-03-01	1985-11-27	Asta Werke Ag Chem Fab	Salts of oxazaphosphorine derivatives and process for their production
US5194428A (en) *	1986-05-23	1993-03-16	Worcester Foundation For Experimental Biology	Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US5055459A (en) *	1986-06-30	1991-10-08	Board Of Regents, The University Of Texas	Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates

1988
- 1988-10-20 DE DE3835772A patent/DE3835772A1/de not_active Ceased
1989
- 1989-10-19 AT AT89119408T patent/ATE120465T1/de not_active IP Right Cessation
- 1989-10-19 US US07/499,522 patent/US5622936A/en not_active Expired - Lifetime
- 1989-10-19 HU HU896841A patent/HU206124B/hu unknown
- 1989-10-19 JP JP2500030A patent/JP2518739B2/ja not_active Expired - Lifetime
- 1989-10-19 ES ES89119408T patent/ES2072881T3/es not_active Expired - Lifetime
- 1989-10-19 EP EP89119408A patent/EP0369182B1/de not_active Expired - Lifetime
- 1989-10-19 DE DE58909141T patent/DE58909141D1/de not_active Expired - Lifetime
- 1989-10-19 PT PT92034A patent/PT92034B/pt not_active IP Right Cessation
- 1989-10-19 WO PCT/EP1989/001251 patent/WO1990004597A1/de not_active Ceased
- 1989-10-19 IE IE336089A patent/IE67529B1/en not_active IP Right Cessation
- 1989-10-20 CA CA002001129A patent/CA2001129C/en not_active Expired - Lifetime
1990
- 1990-06-19 DK DK149290A patent/DK170422B1/da not_active IP Right Cessation
- 1990-06-19 NO NO902717A patent/NO173548C/no unknown
- 1990-06-20 FI FI903123A patent/FI95268C/fi active IP Right Grant
1995
- 1995-03-30 GR GR940403849T patent/GR3015566T3/el unknown
- 1995-10-05 HK HK157495A patent/HK157495A/xx not_active IP Right Cessation
- 1995-11-10 JP JP7317538A patent/JP3056408B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HUT54702A (en)	1991-03-28
ES2072881T3 (es)	1995-08-01
WO1990004597A1 (de)	1990-05-03
DE3835772A1 (de)	1990-04-26
HU206124B (en)	1992-08-28
FI903123A0 (fi)	1990-06-20
NO902717D0 (no)	1990-06-19
ATE120465T1 (de)	1995-04-15
IE67529B1 (en)	1996-04-03
IE893360L (en)	1990-04-20
EP0369182A1 (de)	1990-05-23
JP3056408B2 (ja)	2000-06-26
DK149290D0 (da)	1990-06-19
GR3015566T3 (en)	1995-06-30
FI95268C (fi)	1996-01-10
DE58909141D1 (de)	1995-05-04
HU896841D0 (en)	1990-12-28
CA2001129A1 (en)	1990-04-20
HK157495A (en)	1995-10-13
JP2518739B2 (ja)	1996-07-31
DK170422B1 (da)	1995-08-28
CA2001129C (en)	2000-06-27
JPH03502934A (ja)	1991-07-04
PT92034B (pt)	1995-05-31
NO902717L (no)	1990-08-20
NO173548B (no)	1993-09-20
US5622936A (en)	1997-04-22
FI95268B (fi)	1995-09-29
PT92034A (pt)	1990-04-30
EP0369182B1 (de)	1995-03-29
NO173548C (no)	1993-12-29
JPH08208680A (ja)	1996-08-13

Legal Events

Date	Code	Title	Description
1995-08-28	B1	Patent granted (law 1993)
2009-11-09	PUP	Patent expired

Publication	Publication Date	Title
ATE120465T1 (de)	1995-04-15	Tumorhemmende saccharid-konjugate.
IL86040A0 (en)	1988-09-30	Acid stable dideoxynucleosides,their preparation and pharmaceutical compositions containing them
ES8106134A1 (es)	1981-07-16	Un procedimiento para la preparacion de carboxialquil-dipep-tidos
RU2004127136A (ru)	2006-02-27	Способ получения гамма-амидов глутамовой кислоты
FI833730A0 (fi)	1983-10-13	Antivirala kompositioner
DK72686A (da)	1986-08-16	Aminosyrederivat og antikonvulsant praeparat som indeholder derivatet
ATE86866T1 (de)	1993-04-15	Antikrebs-zusammensetzung.
EG15762A (en)	1986-12-30	Substituted hydroxy-malonic acid diamides,a process for their preparation,and their use as pest combating agents
SE8102489L (sv)	1981-10-23	Sett att framstella adenosinderivat
DK0478194T3 (da)	1995-08-28	Bis-(2-aminocarbonylcykloalk-1-enyl)-disulfider, fremstilling og anvendelse heraf
FR2381035A1 (fr)	1978-09-15	Urees substituees utiles comme medicaments et procedes pour leur preparation
DK192388A (da)	1988-10-12	Rhodomyciner, deres fremstilling og anvendelse.
ES470383A1 (es)	1979-09-16	Un metodo de preparacion de un derivado de 9-hidroxietoxime-til-guanina
FR2378518A1 (fr)	1978-08-25	Nouveaux medicaments a base de derives de tetrahydrodibenzopyranne
DK1001943T3 (da)	2004-03-29	Polyhydroxyalkylpyrazinderivater, deres fremstilling samt medikamenter indeholdende disse forbindelser
NO842345L (no)	1984-12-27	Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
ATE86629T1 (de)	1993-03-15	4-piperidincarboxamid-derivate.
ES8502675A1 (es)	1985-01-16	Un metodo para preparar productos intermedios para la obtencion de 4-fenil-1,3-benzodiazepinas
KR850007063A (ko)	1985-10-30	글리세롤 에테르 포스파타이드의 제조방법
DE3762622D1 (de)	1990-06-13	Verbindungen des cyclophosphazen-typs, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
FR2570380B1 (fr)	1987-09-11	Procede de preparation de o-alcoyle s (alcoyle ramifie en alpha) alcoyl phosphonothioate
EP0041577A4 (en)	1982-03-22	OXAZOLYL ACETIC ACID DERIVATIVES.
IL92456A0 (en)	1990-08-31	Preparation of optically active 2-oxoimidazolidine derivatives