DK149475C - Fremgangsmaade og reagens til bestemmelse af den biologiske aktivitet af herapin i plasma - Google Patents

Fremgangsmaade og reagens til bestemmelse af den biologiske aktivitet af herapin i plasma

Info

Publication number
DK149475C
DK149475C DK57079A DK57079A DK149475C DK 149475 C DK149475 C DK 149475C DK 57079 A DK57079 A DK 57079A DK 57079 A DK57079 A DK 57079A DK 149475 C DK149475 C DK 149475C
Authority
DK
Denmark
Prior art keywords
plasap
herapin
reagent
determining
biological activity
Prior art date
Application number
DK57079A
Other languages
English (en)
Other versions
DK149475B (da
DK57079A (da
Inventor
Knut Bartl
Helmut Lill
Joachim Ziegenhorn
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK57079A publication Critical patent/DK57079A/da
Publication of DK149475B publication Critical patent/DK149475B/da
Application granted granted Critical
Publication of DK149475C publication Critical patent/DK149475C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114—Kunitz type inhibitors
    • G01N2333/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444—Factor X (3.4.21.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK57079A 1978-03-23 1979-02-12 Fremgangsmaade og reagens til bestemmelse af den biologiske aktivitet af herapin i plasma DK149475C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2812943 1978-03-23
DE2812943A DE2812943C3 (de) 1978-03-23 1978-03-23 Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma

Publications (3)

Publication Number Publication Date
DK57079A DK57079A (da) 1979-09-24
DK149475B DK149475B (da) 1986-06-23
DK149475C true DK149475C (da) 1986-12-01

Family

ID=6035376

Family Applications (1)

Application Number Title Priority Date Filing Date
DK57079A DK149475C (da) 1978-03-23 1979-02-12 Fremgangsmaade og reagens til bestemmelse af den biologiske aktivitet af herapin i plasma

Country Status (22)

Country Link
US (1) US4234682A (da)
EP (1) EP0004271A3 (da)
JP (1) JPS54128796A (da)
AR (1) AR217503A1 (da)
AT (1) AT362080B (da)
AU (1) AU512206B2 (da)
BE (1) BE875014A (da)
CA (1) CA1111334A (da)
CH (1) CH642749A5 (da)
DD (1) DD141952A5 (da)
DE (1) DE2812943C3 (da)
DK (1) DK149475C (da)
FI (1) FI62859C (da)
FR (1) FR2420764A1 (da)
GB (1) GB2017298B (da)
HU (1) HU176068B (da)
IE (1) IE48067B1 (da)
IT (1) IT1112966B (da)
LU (1) LU81070A1 (da)
NL (1) NL7902259A (da)
SE (1) SE445560B (da)
ZA (1) ZA79622B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2903701C2 (de) * 1979-01-31 1980-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Kontrollreagens für die Bestimmung der Heparinaktivität
US4244865A (en) * 1979-12-03 1981-01-13 Abbott Laboratories α hydroxy tripeptide substrates
DE3005540A1 (de) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma
DE3019612A1 (de) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes thrombinpraeparat
JPH0258920B2 (da) * 1980-10-09 1990-12-11 Boehringer Mannheim Gmbh
US4473639A (en) * 1982-09-15 1984-09-25 Miles Laboratories, Inc. Reagent strip test for antithrombin-III
US4543335A (en) * 1982-12-20 1985-09-24 Miles Laboratories, Inc. Device and method for the quantitative determination of heparin in mammalian blood plasma
US4851336A (en) * 1985-09-05 1989-07-25 Yin E Thye Composition, kit, and method for assaying heparinano a method for making the composition
US4948724A (en) * 1985-09-05 1990-08-14 Yin E Thye Composition, kit and method for assaying heparin and a method for making the composition
US4946775A (en) * 1985-09-05 1990-08-07 Yin E Thye Composition, kit and method for assaying heparin and a method for making the composition
DE3679763D1 (de) * 1985-09-05 1991-07-18 E Thye Yin Verfahren und zusammensetzungen zur bestimmung von heparin.
US5939325A (en) * 1989-07-20 1999-08-17 Analytical Control Systems, Inc. Stable whole blood coagulation controls
EP0482088B1 (en) * 1989-07-20 1999-03-31 Analytical Control Systems, Inc. Improved stable coagulation controls
JP3094165B2 (ja) * 1990-11-05 2000-10-03 バクスター、ダイアグノスチックス、インコーポレイテッド 抗凝固剤濃度測定方法
US5308755A (en) * 1992-06-08 1994-05-03 Research Corporation Technologies, Inc. Method for measuring heparin
EP1325962A1 (en) * 2001-12-17 2003-07-09 Gentium S.p.A. A method for determining the biological activity of defibrotide
AU2005243161A1 (en) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit and one-step method for monitoring compounds having anti-factor Xa and/or anti factor iia activities
US7219827B2 (en) 2004-11-19 2007-05-22 General Electric Company Braze end isolation layer for generator armature winding bar and method for applying the isolation layer
DE102005038418A1 (de) * 2005-08-12 2007-02-15 Dade Behring Marburg Gmbh Faktor Xa-basierter Heparinassay unter Verwendung einer Heparin-modifizierenden Komponente
DK2637672T3 (da) 2010-11-12 2018-10-22 Gentium S R L Defibrotid til anvendelse i profylakse og/eller behandling af graft versus host sygdom (gvhd)
EP2484775A1 (de) 2011-02-07 2012-08-08 Siemens Healthcare Diagnostics Products GmbH Heparin-insensitives Verfahren zur Bestimmung von direkten Gerinnungsfaktorinhibitoren
KR102038357B1 (ko) 2012-06-22 2019-10-31 젠티엄 에스알엘 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
EP2843416A1 (de) 2013-09-02 2015-03-04 Siemens Healthcare Diagnostics Products GmbH Kontroll- und Kalibratormaterial für die Bestimmung von direkten Antikoagulanzien
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
EP3348649A1 (de) 2017-01-16 2018-07-18 Siemens Healthcare Diagnostics Products GmbH Universales kontrollmaterial für gerinnungsfaktorinhibitor-teste
EP4703478A1 (de) 2024-08-27 2026-03-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zum ausschluss von faktor xia-inhibitoren in patientenproben

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769617A (en) * 1971-12-09 1973-10-30 Rca Corp Transmission line using a pair of staggered broad metal strips
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
US4162941A (en) * 1974-12-05 1979-07-31 Ab Kabi Method for determining a proteolytic enzyme
CH587439A5 (da) * 1974-12-10 1977-04-29 Daimler Benz Ag
CH622286A5 (da) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407405B (sv) * 1975-07-11 1979-03-26 Kabi Ab Nya kromogena trombinsubstrat
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
DE2601372C3 (de) * 1976-01-15 1980-03-27 Behringwerke Ag, 3550 Marburg Verfahren zur Bestimmung von Antithrombin III
NL7602423A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Bepaling van heparine in bloedplasma.
US4067777A (en) * 1976-05-13 1978-01-10 Innerfield Irving Determination of heparin in the blood

Also Published As

Publication number Publication date
HU176068B (en) 1980-12-28
AT362080B (de) 1981-04-27
FI62859B (fi) 1982-11-30
FI790476A7 (fi) 1979-09-24
AR217503A1 (es) 1980-03-31
FI62859C (fi) 1983-03-10
DE2812943B2 (de) 1980-08-14
LU81070A1 (de) 1979-06-19
GB2017298A (en) 1979-10-03
AU512206B2 (en) 1980-09-25
DK149475B (da) 1986-06-23
NL7902259A (nl) 1979-09-25
EP0004271A2 (de) 1979-10-03
CH642749A5 (de) 1984-04-30
ZA79622B (en) 1980-03-26
IE790238L (en) 1979-09-23
US4234682A (en) 1980-11-18
SE7902555L (sv) 1979-09-24
EP0004271A3 (de) 1980-04-02
DK57079A (da) 1979-09-24
ATA32179A (de) 1980-09-15
IT7921220A0 (it) 1979-03-22
DE2812943A1 (de) 1979-10-04
IT1112966B (it) 1986-01-20
JPS54128796A (en) 1979-10-05
DE2812943C3 (de) 1981-05-14
FR2420764B1 (da) 1983-07-29
DD141952A5 (de) 1980-05-28
CA1111334A (en) 1981-10-27
AU4382579A (en) 1979-09-27
FR2420764A1 (fr) 1979-10-19
SE445560B (sv) 1986-06-30
BE875014A (fr) 1979-09-24
IE48067B1 (en) 1984-09-19
JPS5726120B2 (da) 1982-06-02
GB2017298B (en) 1982-07-07

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