DK1506963T3 - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram

Info

Publication number: DK1506963T3
Authority: DK; Denmark
Prior art keywords: citalopram; preparation; cyanophthalide; cyclized; bromine
Prior art date: 2003-10-28

Application number

DK03425693T

Other languages

English (en)

Inventor

Giovanni Cotticelli

Lernia Gianluca Di

Milanesi Silvia

Original Assignee

Adorkem Technology Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-28

Filing date

2003-10-28

Publication date

2005-08-01

2003-10-28 Application filed by Adorkem Technology Spa filed Critical Adorkem Technology Spa

2005-08-01 Application granted granted Critical

2005-08-01 Publication of DK1506963T3 publication Critical patent/DK1506963T3/da

Links

WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title abstract 2
229960001653 citalopram Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
XEEGWTLAFIZLSF-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carbonitrile Chemical compound N#CC1=CC=C2C(=O)OCC2=C1 XEEGWTLAFIZLSF-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
BRKADVNLTRCLOW-UHFFFAOYSA-M magnesium;fluorobenzene;bromide Chemical compound [Mg+2].[Br-].FC1=CC=[C-]C=C1 BRKADVNLTRCLOW-UHFFFAOYSA-M 0.000 abstract 1
NGPAITITALWALP-UHFFFAOYSA-M magnesium;n,n-dimethylpropan-1-amine;chloride Chemical compound [Mg+2].[Cl-].CN(C)CC[CH2-] NGPAITITALWALP-UHFFFAOYSA-M 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)

DK03425693T 2003-10-28 2003-10-28 Fremgangsmåde til fremstilling af citalopram DK1506963T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03425693A EP1506963B1 (en)	2003-10-28	2003-10-28	Method for the preparation of citalopram

Publications (1)

Publication Number	Publication Date
DK1506963T3 true DK1506963T3 (da)	2005-08-01

Family

ID=33560918

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK03425693T DK1506963T3 (da)	2003-10-28	2003-10-28	Fremgangsmåde til fremstilling af citalopram
DK04791287T DK1682526T3 (da)	2003-10-28	2004-10-22	Fremgangsmåde til fremstilling af citalopram

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK04791287T DK1682526T3 (da)	2003-10-28	2004-10-22	Fremgangsmåde til fremstilling af citalopram

Country Status (14)

Country	Link
US (1)	US20070060759A1 (da)
EP (2)	EP1506963B1 (da)
JP (1)	JP2007511477A (da)
CN (1)	CN1875013A (da)
AT (2)	ATE293106T1 (da)
BR (1)	BRPI0415778A (da)
CA (1)	CA2543155A1 (da)
DE (2)	DE60300502T2 (da)
DK (2)	DK1506963T3 (da)
ES (1)	ES2240931T3 (da)
PL (1)	PL379659A1 (da)
PT (1)	PT1506963E (da)
SI (1)	SI1506963T1 (da)
WO (1)	WO2005049595A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9006288B2 (en)	2009-01-12	2015-04-14	Biokier, Inc.	Composition and method for treatment of diabetes
US9314444B2 (en)	2009-01-12	2016-04-19	Biokier, Inc.	Composition and method for treatment of NASH
RS56054B1 (sr)	2009-01-12	2017-09-29	Biokier Inc	Smeša i metod za lečenje dijabetesa
CN102711800A (zh)	2009-09-23	2012-10-03	拜奥基尔公司	治疗糖尿病的组合物和方法
CN103702668A (zh)	2011-05-02	2014-04-02	拜奥基尔公司	治疗糖尿病的组合物和方法
US20150073057A1 (en)	2013-09-06	2015-03-12	Biokier, Inc.	Composition and method for treatment of diabetes
CN111302971B (zh)	2018-12-12	2023-08-22	上海奥博生物医药股份有限公司	一种连续制备5-氰二醇的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
WO1998019513A2 (en) *	1997-07-08	1998-05-14	H. Lundbeck A/S	Method for the preparation of citalopram
UA62985C2 (en) *	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
EP1042310B1 (en) *	1997-11-11	2002-07-31	H. Lundbeck A/S	Method for the preparation of citalopram
EP1355897A1 (en) *	2001-01-30	2003-10-29	Orion Corporation Fermion	Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US6967259B2 (en) *	2001-09-24	2005-11-22	Pharmachem Technologies Limited	Process for the preparation of Citalopram intermediate

2003
- 2003-10-28 ES ES03425693T patent/ES2240931T3/es not_active Expired - Lifetime
- 2003-10-28 AT AT03425693T patent/ATE293106T1/de not_active IP Right Cessation
- 2003-10-28 DK DK03425693T patent/DK1506963T3/da active
- 2003-10-28 SI SI200330042T patent/SI1506963T1/xx unknown
- 2003-10-28 EP EP03425693A patent/EP1506963B1/en not_active Expired - Lifetime
- 2003-10-28 DE DE60300502T patent/DE60300502T2/de not_active Expired - Fee Related
- 2003-10-28 PT PT03425693T patent/PT1506963E/pt unknown
2004
- 2004-10-22 EP EP04791287A patent/EP1682526B1/en not_active Expired - Lifetime
- 2004-10-22 BR BRPI0415778-8A patent/BRPI0415778A/pt not_active IP Right Cessation
- 2004-10-22 WO PCT/EP2004/052626 patent/WO2005049595A1/en not_active Ceased
- 2004-10-22 US US10/577,869 patent/US20070060759A1/en not_active Abandoned
- 2004-10-22 DE DE602004019127T patent/DE602004019127D1/de not_active Expired - Fee Related
- 2004-10-22 DK DK04791287T patent/DK1682526T3/da active
- 2004-10-22 AT AT04791287T patent/ATE420870T1/de not_active IP Right Cessation
- 2004-10-22 CN CNA200480031662XA patent/CN1875013A/zh active Pending
- 2004-10-22 PL PL379659A patent/PL379659A1/pl not_active Application Discontinuation
- 2004-10-22 JP JP2006537287A patent/JP2007511477A/ja active Pending
- 2004-10-22 CA CA002543155A patent/CA2543155A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60300502T2 (de)	2006-02-23
BRPI0415778A (pt)	2006-12-26
ATE293106T1 (de)	2005-04-15
HK1075041A1 (en)	2005-12-02
EP1682526B1 (en)	2009-01-14
PT1506963E (pt)	2005-08-31
DE602004019127D1 (de)	2009-03-05
EP1682526A1 (en)	2006-07-26
JP2007511477A (ja)	2007-05-10
SI1506963T1 (en)	2005-10-31
CN1875013A (zh)	2006-12-06
US20070060759A1 (en)	2007-03-15
WO2005049595A1 (en)	2005-06-02
DK1682526T3 (da)	2009-03-23
ATE420870T1 (de)	2009-01-15
EP1506963A1 (en)	2005-02-16
DE60300502D1 (de)	2005-05-19
CA2543155A1 (en)	2005-06-02
PL379659A1 (pl)	2006-10-30
ES2240931T3 (es)	2005-10-16
EP1506963B1 (en)	2005-04-13

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