DK152385A - Fremgangsmaade til selektiv methylering af erythromycin-a derivater - Google Patents

Fremgangsmaade til selektiv methylering af erythromycin-a derivater Download PDF

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Publication number
DK152385A
DK152385A DK152385A DK152385A DK152385A DK 152385 A DK152385 A DK 152385A DK 152385 A DK152385 A DK 152385A DK 152385 A DK152385 A DK 152385A DK 152385 A DK152385 A DK 152385A
Authority
DK
Denmark
Prior art keywords
erythromycin
derivatives
procedure
selective methylation
methylation
Prior art date
Application number
DK152385A
Other languages
English (en)
Other versions
DK172481B1 (da
DK152385D0 (da
Inventor
Yoshiaki Watanabe
Shigeo Morimoto
Masami Goi
Takashi Adachi
Jozi Nakagami
Morihiro Mitsukuchi
Toshifumi Asaka
Tadashi Eguchi
Kaoru Sota
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13375748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK152385(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of DK152385D0 publication Critical patent/DK152385D0/da
Publication of DK152385A publication Critical patent/DK152385A/da
Application granted granted Critical
Publication of DK172481B1 publication Critical patent/DK172481B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198501523A 1984-04-06 1985-04-03 Fremgangsmåde til selektiv methylering af erythromycin A-derivater DK172481B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59068509A JPS60214796A (ja) 1984-04-06 1984-04-06 ６−０−メチルエリスロマイシン類の製法
JP6850984 1984-04-06

Publications (3)

Publication Number Publication Date
DK152385D0 DK152385D0 (da) 1985-04-03
DK152385A true DK152385A (da) 1985-10-07
DK172481B1 DK172481B1 (da) 1998-11-23

Family

ID=13375748

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198501523A DK172481B1 (da) 1984-04-06 1985-04-03 Fremgangsmåde til selektiv methylering af erythromycin A-derivater

Country Status (17)

Country Link
US (1) US4672109A (da)
EP (1) EP0158467B1 (da)
JP (1) JPS60214796A (da)
KR (1) KR910007572B1 (da)
AR (1) AR240833A1 (da)
AT (1) ATE44384T1 (da)
AU (1) AU567803B2 (da)
CA (1) CA1225637A (da)
DE (1) DE3571323D1 (da)
DK (1) DK172481B1 (da)
ES (1) ES541898A0 (da)
FI (1) FI77250C (da)
GE (1) GEP19960318B (da)
HK (1) HK99694A (da)
PT (1) PT80237B (da)
SU (1) SU1577700A3 (da)
ZA (1) ZA852349B (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
GB8506380D0 (en) * 1985-03-12 1985-04-11 Beecham Group Plc Chemical compounds
PT82162B (en) 1985-03-12 1987-08-06 Beecham Group Plc Chemical compounds
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS63107994A (ja) * 1986-05-02 1988-05-12 Taisho Pharmaceut Co Ltd エリスロマイシン誘導体
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
IT1276901B1 (it) * 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
ZA966601B (en) * 1995-08-03 1997-02-19 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivatives.
US5756473A (en) * 1995-11-21 1998-05-26 Abbott Laboratories 6-O-methyl erythromycin D and process for making
US5872229A (en) * 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5719272A (en) * 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5808017A (en) * 1996-04-10 1998-09-15 Abbott Laboratories Process for preparing erythromycin A oxime
PT915899E (pt) 1996-07-29 2004-11-30 Abbott Lab Preparacao da forma cristalina ii da eritromicina
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
US5945405A (en) 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5864023A (en) * 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) * 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) * 1997-11-17 1998-12-22 Abbott Laboratories Chemical synthesis of 6-O-alkyl erythromycin A
US5932710A (en) * 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL135792A0 (en) * 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
IL124084A0 (en) * 1998-04-14 1999-04-11 Chemagis Ltd Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) * 1998-07-15 1999-03-12 Chemagis Ltd Erythromycin derivatives and methods for the preparation thereof
KR100283990B1 (ko) * 1998-12-29 2001-03-02 민경윤 에리스로마이신 a 유도체 및 그의 제조방법
SI20150A (sl) * 1999-02-19 2000-08-31 Lek, Tovarna Farmacevtskih In Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
PT1254146E (pt) * 1999-12-16 2005-10-31 Teva Pharma Processos de preparacao de polimeros de claritromicina e novo polimorfo iv
PL356645A1 (en) 2000-01-11 2004-06-28 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
AU2578701A (en) 2000-02-29 2001-09-12 Teva Pharma Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
CN1193036C (zh) * 2000-03-15 2005-03-16 韩美药品工业株式会社 制备甲红霉素－克拉霉素ⅱ型晶体的方法
TR200401093T4 (tr) * 2000-05-15 2004-11-22 Ranbaxy Laboratories, Ltd. Eritromisin türevlerinin selektif metilasyonu için maliyet etkin bir metot
DE60114028T2 (de) 2000-08-23 2006-07-13 Wockhardt Ltd. Verfahren zur herstellung von wasserfreiem azithromycin
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
CN1652753A (zh) * 2002-04-03 2005-08-10 兰贝克赛实验室有限公司 具有改进的生物利用度的克拉霉素制剂
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
ES2221807B1 (es) * 2003-06-24 2005-12-16 Ercros Industrial, S.A. Un procedimiento para la obtencion de claritromicina.
EP1648418A4 (en) 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
EP1648415A4 (en) 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
CA2533292C (en) 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005016311A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
EP1658034A4 (en) 2003-08-29 2011-06-22 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
WO2005027877A1 (en) 2003-09-15 2005-03-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US8715727B2 (en) 2004-07-02 2014-05-06 Shionogi Inc. Tablet for pulsed delivery
US20060111560A1 (en) * 2004-11-01 2006-05-25 Glenmark Pharmaceuticals Limited Process for the preparation of crystalline form II of clarithromycin
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
EP2077271A4 (en) 2006-05-01 2010-09-15 Taisho Pharmaceutical Co Ltd Macrolide derivative
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1100504A (en) * 1967-08-16 1968-01-24 Pliva Pharm & Chem Works Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4166901A (en) * 1978-01-03 1979-09-04 Pfizer Inc. 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters
FR2473525A1 (fr) * 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS5896095A (ja) * 1981-11-30 1983-06-07 Taisho Pharmaceut Co Ltd １１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) * 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
JPS5896098A (ja) * 1981-12-03 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
IL75908A0 (en) * 1984-08-31 1985-12-31 Abbott Lab Macrolide alkylation process

Also Published As

Publication number Publication date
AU4037885A (en) 1985-10-10
KR910007572B1 (ko) 1991-09-28
HK99694A (en) 1994-09-23
JPH053475B2 (da) 1993-01-14
ES8602839A1 (es) 1985-12-01
EP0158467A3 (en) 1986-03-19
PT80237B (pt) 1987-06-17
DK172481B1 (da) 1998-11-23
ES541898A0 (es) 1985-12-01
FI77250C (fi) 1989-02-10
GEP19960318B (en) 1996-06-24
FI77250B (fi) 1988-10-31
JPS60214796A (ja) 1985-10-28
KR850007434A (ko) 1985-12-04
SU1577700A3 (ru) 1990-07-07
DE3571323D1 (en) 1989-08-10
FI851376L (fi) 1985-10-07
EP0158467A2 (en) 1985-10-16
CA1225637A (en) 1987-08-18
AU567803B2 (en) 1987-12-03
PT80237A (en) 1985-05-01
ATE44384T1 (de) 1989-07-15
AR240833A1 (es) 1991-02-28
EP0158467B1 (en) 1989-07-05
FI851376A0 (fi) 1985-04-04
US4672109A (en) 1987-06-09
ZA852349B (en) 1985-11-27
DK152385D0 (da) 1985-04-03

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