ATE44384T1 - Methode zur selektiven methylierung von erythromycin a-derivaten. - Google Patents

Methode zur selektiven methylierung von erythromycin a-derivaten.

Info

Publication number: ATE44384T1
Authority: AT; Austria
Prior art keywords: erythromycin; derivatives; selective methylation; methylation; selective
Prior art date: 1984-04-06

Application number

AT85301997T

Other languages

English (en)

Inventor

Yoshiaki Watanabe

Shigeo Morimoto

Masami Goi

Morihiro Mitsukuchi

Takashi Adachi

Jozi Nakagami

Toshifumi Asaka

Tadashi Eguchi

Kaoru Sota

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-06

Filing date

1985-03-22

Publication date

1989-07-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13375748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE44384(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-03-22 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

1989-07-15 Application granted granted Critical

1989-07-15 Publication of ATE44384T1 publication Critical patent/ATE44384T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
238000011935 selective methylation Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT85301997T 1984-04-06 1985-03-22 Methode zur selektiven methylierung von erythromycin a-derivaten. ATE44384T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP59068509A JPS60214796A (ja)	1984-04-06	1984-04-06	６−０−メチルエリスロマイシン類の製法
EP85301997A EP0158467B1 (de)	1984-04-06	1985-03-22	Methode zur selektiven Methylierung von Erythromycin A-Derivaten

Publications (1)

Publication Number	Publication Date
ATE44384T1 true ATE44384T1 (de)	1989-07-15

Family

ID=13375748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85301997T ATE44384T1 (de)	1984-04-06	1985-03-22	Methode zur selektiven methylierung von erythromycin a-derivaten.

Country Status (17)

Country	Link
US (1)	US4672109A (de)
EP (1)	EP0158467B1 (de)
JP (1)	JPS60214796A (de)
KR (1)	KR910007572B1 (de)
AR (1)	AR240833A1 (de)
AT (1)	ATE44384T1 (de)
AU (1)	AU567803B2 (de)
CA (1)	CA1225637A (de)
DE (1)	DE3571323D1 (de)
DK (1)	DK172481B1 (de)
ES (1)	ES8602839A1 (de)
FI (1)	FI77250C (de)
GE (1)	GEP19960318B (de)
HK (1)	HK99694A (de)
PT (1)	PT80237B (de)
SU (1)	SU1577700A3 (de)
ZA (1)	ZA852349B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
EP0201166B1 (de)	1985-03-12	1990-02-07	Beecham Group Plc	Erythromycin-Derivate
GB8506380D0 (en) *	1985-03-12	1985-04-11	Beecham Group Plc	Chemical compounds
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
JPS63107994A (ja) *	1986-05-02	1988-05-12	Taisho Pharmaceut Co Ltd	エリスロマイシン誘導体
EP0260938B1 (de) *	1986-09-18	1992-12-09	Taisho Pharmaceutical Co. Ltd	Erythromycin-A-Derivate und Verfahren zu ihrer Herstellung
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法
US5302705A (en) *	1989-10-07	1994-04-12	Taisho Pharmaceutical Co., Ltd.	6-O-methylerythromycin a oxime derivatives
IT1276901B1 (it) *	1994-12-13	1997-11-03	Zambon Spa	Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
ZA966601B (en) *	1995-08-03	1997-02-19	Chugai Pharmaceutical Co Ltd	Process for producing erythromycin derivatives.
US5872229A (en) *	1995-11-21	1999-02-16	Abbott Laboratories	Process for 6-O-alkylation of erythromycin derivatives
US5756473A (en) *	1995-11-21	1998-05-26	Abbott Laboratories	6-O-methyl erythromycin D and process for making
US5719272A (en) *	1996-04-02	1998-02-17	Abbott Laboratories	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5808017A (en) *	1996-04-10	1998-09-15	Abbott Laboratories	Process for preparing erythromycin A oxime
ES2173057T3 (es) *	1996-07-29	2004-11-16	Abbott Laboratories	Preparacion de la forma ii cristalina de claritromicina.
US5858986A (en) *	1996-07-29	1999-01-12	Abbott Laboratories	Crystal form I of clarithromycin
US5945405A (en) *	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
US5864023A (en) *	1997-02-13	1999-01-26	Abbott Laboratories	3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) *	1997-09-10	1999-07-27	Abbott Laboratories	9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) *	1997-11-17	1998-12-22	Abbott Laboratories	Chemical synthesis of 6-O-alkyl erythromycin A
IL135792A0 (en) *	1997-12-01	2001-05-20	Abbott Lab	6-o-alkyl derivatives of erythronolide b
US5932710A (en)	1997-12-01	1999-08-03	Abbott Laboratories	Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL124084A0 (en) *	1998-04-14	1999-04-11	Chemagis Ltd	Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) *	1998-07-15	1999-03-12	Chemagis Ltd	Erythromycin derivatives and methods for the preparation thereof
KR100283990B1 (ko) *	1998-12-29	2001-03-02	민경윤	에리스로마이신 a 유도체 및 그의 제조방법
SI20150A (sl) *	1999-02-19	2000-08-31	Lek, Tovarna Farmacevtskih In	Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) *	1999-07-01	2001-02-05	유충식	6-오-메틸 에리트로마이신의 제조방법
US6627743B1 (en)	1999-12-03	2003-09-30	Abbott Laboratories	6-O-methylerythromycin A crystal form III
WO2001044262A1 (en)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph iv
AU2001222619C1 (en)	2000-01-11	2006-01-12	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
EP1313486A1 (de)	2000-02-29	2003-05-28	Teva Pharmaceutical Industries Ltd.	Verfahren zur herstellung des clarithromycins und eines clarithromycin-zwischenprodukt; clarithromycin wesentlich frei von oxime; und pharmazeutische zusammensetzung die sie enthalten
MXPA02008861A (es) *	2000-03-15	2003-02-10	Hanmi Pharm Ind Co Ltd	Metodo para preparar claritromicina de cristales de forma ii.
ES2217153T3 (es)	2000-05-15	2004-11-01	Ranbaxy Laboratories, Ltd.	Procedimiento eficaz en coste para la metilacion selectiva de derivados de eritromicina a.
ATE306491T1 (de)	2000-08-23	2005-10-15	Wockhardt Ltd	Verfahren zur herstellung von wasserfreiem azithromycin
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20050163857A1 (en) *	2002-04-03	2005-07-28	Ashok Rampal	Clarithromycin formulations having improved bioavailability
US6843854B2 (en)	2002-05-31	2005-01-18	Purdue Research Foundation	Method and apparatus for separating a component from a mixture
ES2221807B1 (es) *	2003-06-24	2005-12-16	Ercros Industrial, S.A.	Un procedimiento para la obtencion de claritromicina.
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528190A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
EP1653925A1 (de)	2003-08-11	2006-05-10	Advancis Pharmaceutical Corporation	Robustes pellet
WO2005016278A2 (en)	2003-08-12	2005-02-24	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
WO2005023184A2 (en)	2003-08-29	2005-03-17	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
US8460710B2 (en)	2003-09-15	2013-06-11	Shionogi, Inc.	Antibiotic product, use and formulation thereof
AU2005269981A1 (en)	2004-07-02	2006-02-09	Bonck, John A	Tablet for pulsed delivery
US20060111560A1 (en) *	2004-11-01	2006-05-25	Glenmark Pharmaceuticals Limited	Process for the preparation of crystalline form II of clarithromycin
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
CN103193840A (zh)	2006-05-01	2013-07-10	大正制药株式会社	大环内酯衍生物
US8299052B2 (en) *	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4166901A (en) *	1978-01-03	1979-09-04	Pfizer Inc.	4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters
FR2473525A1 (fr) *	1980-01-11	1981-07-17	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS5896095A (ja) *	1981-11-30	1983-06-07	Taisho Pharmaceut Co Ltd	１１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) *	1981-12-01	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンｂ誘導体
JPS5896098A (ja) *	1981-12-03	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンａ誘導体
US4382085A (en) *	1982-03-01	1983-05-03	Pfizer Inc.	4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
IL75908A0 (en) *	1984-08-31	1985-12-31	Abbott Lab	Macrolide alkylation process

1984
- 1984-04-06 JP JP59068509A patent/JPS60214796A/ja active Granted
1985
- 1985-03-22 EP EP85301997A patent/EP0158467B1/de not_active Expired
- 1985-03-22 DE DE8585301997T patent/DE3571323D1/de not_active Expired
- 1985-03-22 AT AT85301997T patent/ATE44384T1/de not_active IP Right Cessation
- 1985-03-26 AU AU40378/85A patent/AU567803B2/en not_active Expired
- 1985-03-26 CA CA000477464A patent/CA1225637A/en not_active Expired
- 1985-03-28 ZA ZA852349A patent/ZA852349B/xx unknown
- 1985-04-02 ES ES541898A patent/ES8602839A1/es not_active Expired
- 1985-04-03 DK DK198501523A patent/DK172481B1/da not_active IP Right Cessation
- 1985-04-03 AR AR299984A patent/AR240833A1/es active
- 1985-04-04 FI FI851376A patent/FI77250C/fi not_active IP Right Cessation
- 1985-04-04 PT PT80237A patent/PT80237B/pt unknown
- 1985-04-05 SU SU853878949A patent/SU1577700A3/ru active
- 1985-04-05 US US06/720,383 patent/US4672109A/en not_active Expired - Lifetime
- 1985-04-06 KR KR1019850002325A patent/KR910007572B1/ko not_active Expired
1993
- 1993-07-28 GE GEAP19931269A patent/GEP19960318B/en unknown
1994
- 1994-09-15 HK HK99694A patent/HK99694A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA852349B (en)	1985-11-27
FI851376L (fi)	1985-10-07
JPH053475B2 (de)	1993-01-14
AU4037885A (en)	1985-10-10
US4672109A (en)	1987-06-09
DK152385D0 (da)	1985-04-03
DE3571323D1 (en)	1989-08-10
PT80237A (en)	1985-05-01
DK172481B1 (da)	1998-11-23
FI77250B (fi)	1988-10-31
KR850007434A (ko)	1985-12-04
AR240833A1 (es)	1991-02-28
GEP19960318B (en)	1996-06-24
DK152385A (da)	1985-10-07
CA1225637A (en)	1987-08-18
KR910007572B1 (ko)	1991-09-28
SU1577700A3 (ru)	1990-07-07
ES541898A0 (es)	1985-12-01
EP0158467A2 (de)	1985-10-16
HK99694A (en)	1994-09-23
FI77250C (fi)	1989-02-10
AU567803B2 (en)	1987-12-03
EP0158467B1 (de)	1989-07-05
PT80237B (pt)	1987-06-17
JPS60214796A (ja)	1985-10-28
FI851376A0 (fi)	1985-04-04
EP0158467A3 (en)	1986-03-19
ES8602839A1 (es)	1985-12-01

Legal Events

Date	Code	Title	Description
2005-06-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE44384T1 (de)	1989-07-15	Methode zur selektiven methylierung von erythromycin a-derivaten.
FI861722L (fi)	1986-10-26	Flockulationsprocess.
DE3574789D1 (de)	1990-01-18	Prozessregler.
ES541846A0 (es)	1986-07-16	Metodo de cristalizacion
FI851587A7 (fi)	1985-10-26	Menetelmä lämpötilan valvomiseksi.
FI860044L (fi)	1986-07-08	Laett filterfilt.
KR890701022A (ko)	1989-12-19	에치아이브의 선택적 저해방법
FI865255A7 (fi)	1987-06-24	Kontinuerlig process foer behandling av en kolvaetechargestroem innehaollande merkaptaner.
FI851476A7 (fi)	1985-10-13	Menetelmä maun modifioimiseksi.
DE3577050D1 (de)	1990-05-17	Wendeschneidplatte.
DE3577759D1 (de)	1990-06-21	Prozessregler.
DE3579633D1 (de)	1990-10-18	Selbststeuernde drehgestelle.
FI863776A7 (fi)	1987-03-24	Menetelmä 7-aminomitosaanijohdannaisten valmistamiseksi.
KR860001770U (ko)	1986-03-05	내달은 창
DE3584202D1 (de)	1991-10-31	Numerisches steuerungsverfahren.
FI860861A7 (fi)	1986-09-02	Värinpoistomenetelmä.
NO853376L (no)	1986-03-03	Broenn-testemetode.
FI861897A7 (fi)	1986-11-11	Menetelmä rakenne-elementtien valmistamiseksi.
DE3773992D1 (de)	1991-11-28	Elektrophotographische methode.
DE3676715D1 (de)	1991-02-14	Photolackentfern-verfahren.
FR2564854B1 (fr)	1986-11-14	Photobioreacteur.
DE3676753D1 (de)	1991-02-14	Stranggiessverfahren.
DE3689295D1 (de)	1993-12-23	Programmierbare Folgesteuerung.
FI860078A7 (fi)	1986-01-08	Kemiallinen menetelmä.
DE3680222D1 (de)	1991-08-22	Methode zur justierung einer zeitverzoegerung.