DK1545574T3 - Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi - Google Patents
Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografiInfo
- Publication number
- DK1545574T3 DK1545574T3 DK03754547.2T DK03754547T DK1545574T3 DK 1545574 T3 DK1545574 T3 DK 1545574T3 DK 03754547 T DK03754547 T DK 03754547T DK 1545574 T3 DK1545574 T3 DK 1545574T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptides
- cleaning
- procedure
- simulated moving
- bed chromatography
- Prior art date
Links
- 238000004587 chromatography analysis Methods 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/185—Simulated moving beds characterised by the components to be separated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/468—Flow patterns using more than one column involving switching between different column configurations
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Sustainable Development (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41050602P | 2002-09-13 | 2002-09-13 | |
| PCT/US2003/028809 WO2004024284A2 (en) | 2002-09-13 | 2003-09-12 | Method of purifying polypeptides by simulated moving bed chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1545574T3 true DK1545574T3 (da) | 2014-09-08 |
Family
ID=31994146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03754547.2T DK1545574T3 (da) | 2002-09-13 | 2003-09-12 | Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7220356B2 (da) |
| EP (1) | EP1545574B8 (da) |
| JP (1) | JP2006507249A (da) |
| CN (2) | CN102050865B (da) |
| AU (2) | AU2003272368C1 (da) |
| CA (1) | CA2498725C (da) |
| DK (1) | DK1545574T3 (da) |
| NZ (2) | NZ539297A (da) |
| SI (1) | SI1545574T1 (da) |
| WO (1) | WO2004024284A2 (da) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1545574T3 (da) | 2002-09-13 | 2014-09-08 | Biogen Idec Inc | Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi |
| BRPI0408978B8 (pt) * | 2003-04-08 | 2021-07-27 | Novo Nordisk As | processos para regenerar uma fase estacionária cromatográfica |
| EP2821135A1 (en) | 2004-02-05 | 2015-01-07 | EMD Millipore Corporation | Porous adsorptive or chromatographic media |
| EP1812131A1 (en) | 2004-10-01 | 2007-08-01 | 3M Innovative Properties Company | Method and apparatus for separating a target molecule from a liquid mixture |
| EP1716900A1 (en) * | 2005-04-29 | 2006-11-02 | Eidgenössische Technische Hochschule Zürich | Method and device for chromatographic purification |
| CN100434135C (zh) * | 2005-09-23 | 2008-11-19 | 中国科学院过程工程研究所 | 一种使用三相逆流色谱分离纯化天然产物的方法 |
| US7544293B2 (en) | 2005-09-26 | 2009-06-09 | Semba Inc. | Valve and process for interrupted continuous flow chromatography |
| US7413660B2 (en) | 2005-09-30 | 2008-08-19 | 3M Innovative Properties Company | Single pass method and apparatus for separating a target molecule from a liquid mixture |
| EP2056948B1 (en) | 2006-08-30 | 2019-08-07 | Semba Biosciences, Inc. | Valve module and methods for simulated moving bed chromatography |
| US8807164B2 (en) * | 2006-08-30 | 2014-08-19 | Semba Biosciences, Inc. | Valve module and methods for simulated moving bed chromatography |
| US7790040B2 (en) | 2006-08-30 | 2010-09-07 | Semba Biosciences, Inc. | Continuous isocratic affinity chromatography |
| JP5140721B2 (ja) * | 2007-04-17 | 2013-02-13 | イクスエンド、ホールディング、ベスローテン、フェンノートシャップ | 連続メンブレン吸着方法および装置 |
| US7901581B2 (en) | 2007-06-15 | 2011-03-08 | Ge Healthcare Bio-Sciences Ab | Chromatography method |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US8188242B2 (en) | 2008-04-08 | 2012-05-29 | Bio-Rad Laboratories, Inc. | Chromatography purification of antibodies |
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| JP5816170B2 (ja) | 2009-06-26 | 2015-11-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体 |
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| CN101798587B (zh) * | 2010-03-22 | 2012-07-25 | 黑龙江八一农垦大学 | 玉米降血压肽的分离纯化方法 |
| KR101152036B1 (ko) * | 2010-04-27 | 2012-06-08 | (주)셀트리온 | 컬럼 순환 및 시료 연속주입법을 이용한 단백질 ａ 크로마토그래피 정제 방법 |
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| CA2810909A1 (en) * | 2010-09-20 | 2012-03-29 | Abbvie Inc. | Purification of antibodies using simulated moving bed chromatography |
| KR102027596B1 (ko) | 2010-12-06 | 2019-10-01 | 타폰 바이오시스템즈, 인코포레이티드 | 생물학적 산물을 위한 연속 처리 방법 |
| EP2578286A1 (en) | 2011-10-04 | 2013-04-10 | Merck Patent GmbH | Method and apparatus for chromatographic purification |
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| SG10201709131UA (en) | 2013-03-08 | 2017-12-28 | Genzyme Corp | Continuous purification of therapeutic proteins |
| TWI671312B (zh) * | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| CN104263787B (zh) * | 2014-09-10 | 2015-05-20 | 中国海洋大学 | 一种脱除南极磷虾多肽中氟化物和灰分的方法 |
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| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| CN109071613A (zh) | 2016-05-11 | 2018-12-21 | 通用电气医疗集团生物工艺研发股份公司 | 分离基质 |
| KR102369014B1 (ko) | 2016-08-16 | 2022-03-02 | 리제너론 파아마슈티컬스, 인크. | 혼합물로부터 개별 항체들을 정량하는 방법 |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| EA201990986A1 (ru) | 2016-10-25 | 2019-09-30 | Ридженерон Фармасьютикалз, Инк. | Способы и системы анализа хроматографических данных |
| GB201622343D0 (en) * | 2016-12-29 | 2017-02-15 | Ge Healthcare Bio Sciences Ab | Method in bioprocess purification system |
| GB201703116D0 (en) | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
| GB201703258D0 (en) * | 2017-02-28 | 2017-04-12 | Ge Healthcare Bio Sciences Ab | Parallel separation and washing |
| GB201710130D0 (en) | 2017-06-26 | 2017-08-09 | Ge Healthcare Bioprocess R & D Ab | A Method of seperation |
| WO2019060062A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals Inc. | METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM |
| CN109836479B (zh) * | 2017-11-27 | 2021-01-12 | 申联生物医药（上海）股份有限公司 | 应用模拟流动床分离纯化fmd灭活病毒抗原的方法 |
| CN111902720B (zh) | 2018-03-21 | 2025-02-07 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| JP7264913B2 (ja) * | 2018-04-20 | 2023-04-25 | プロファーマ グループ ヨーロッパ ビー．ブイ． | 擬似移動床を用いた分離のための方法 |
| GB201810772D0 (en) | 2018-06-29 | 2018-08-15 | Ge Healthcare Bio Sciences Ab | Method in bioprocess purification system |
| TWI853823B (zh) | 2018-07-02 | 2024-09-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| HK40046210A (en) | 2018-08-31 | 2021-10-29 | Genzyme Corporation | Sterile chromatography resin and use thereof in manufacturing processes |
| EA202192422A1 (ru) | 2019-03-05 | 2021-12-09 | Ридженерон Фармасьютикалз, Инк. | Человеческий сывороточный альбумин в составах |
| EP3742159A1 (en) | 2019-05-24 | 2020-11-25 | Sartorius Stedim Biotech GmbH | Chromatography method, method of determining the influence of the interdependency of at least two parameters in a chromatography method and method of obtaining at least one chromatography method parameter |
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| WO2023192810A2 (en) * | 2022-03-27 | 2023-10-05 | Purdue Research Foundation | Multi-dimension, multi-mode chromatography methods for producing high purity, high yield lithium, cobalt, nickel, and manganese salts from waste lithium-ion batteries and other feedstocks |
| KR102853272B1 (ko) * | 2022-12-27 | 2025-09-01 | 삼성바이오로직스 주식회사 | 분리된 정제구획을 포함하는 생물학적 물질의 정제 시스템 |
| KR20260048268A (ko) | 2023-08-08 | 2026-04-09 | 씨티바 스웨덴 에이비 | 다중 모듈식 크로마토그래피 시스템 |
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| US5959085A (en) * | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
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| CN1036050C (zh) * | 1994-12-07 | 1997-10-08 | 中国石化扬子石油化工公司 | 改进的模拟移动床的吸附分离方法 |
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| DK1545574T3 (da) | 2002-09-13 | 2014-09-08 | Biogen Idec Inc | Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi |
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-
2003
- 2003-09-12 DK DK03754547.2T patent/DK1545574T3/da active
- 2003-09-12 NZ NZ539297A patent/NZ539297A/en not_active IP Right Cessation
- 2003-09-12 US US10/661,086 patent/US7220356B2/en not_active Expired - Lifetime
- 2003-09-12 AU AU2003272368A patent/AU2003272368C1/en not_active Expired
- 2003-09-12 JP JP2004536270A patent/JP2006507249A/ja active Pending
- 2003-09-12 WO PCT/US2003/028809 patent/WO2004024284A2/en not_active Ceased
- 2003-09-12 CN CN201010541907.0A patent/CN102050865B/zh not_active Expired - Fee Related
- 2003-09-12 CN CN03824460.8A patent/CN1777435B/zh not_active Expired - Fee Related
- 2003-09-12 CA CA2498725A patent/CA2498725C/en not_active Expired - Lifetime
- 2003-09-12 EP EP03754547.2A patent/EP1545574B8/en not_active Expired - Lifetime
- 2003-09-12 NZ NZ563078A patent/NZ563078A/en not_active IP Right Cessation
- 2003-09-12 SI SI200332386T patent/SI1545574T1/sl unknown
-
2007
- 2007-05-21 US US11/751,147 patent/US8608960B2/en active Active - Reinstated
-
2009
- 2009-03-04 AU AU2009200842A patent/AU2009200842B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US20040241878A1 (en) | 2004-12-02 |
| US20070215534A1 (en) | 2007-09-20 |
| EP1545574B1 (en) | 2014-08-20 |
| AU2003272368B2 (en) | 2008-12-04 |
| CN1777435A (zh) | 2006-05-24 |
| AU2009200842A1 (en) | 2009-03-26 |
| CN102050865B (zh) | 2014-03-12 |
| NZ539297A (en) | 2008-04-30 |
| CN1777435B (zh) | 2011-01-12 |
| EP1545574A4 (en) | 2006-07-19 |
| CA2498725A1 (en) | 2004-03-25 |
| SI1545574T1 (sl) | 2014-10-30 |
| EP1545574A2 (en) | 2005-06-29 |
| AU2003272368C1 (en) | 2009-07-23 |
| WO2004024284A3 (en) | 2004-09-23 |
| WO2004024284A2 (en) | 2004-03-25 |
| CN102050865A (zh) | 2011-05-11 |
| JP2006507249A (ja) | 2006-03-02 |
| US7220356B2 (en) | 2007-05-22 |
| EP1545574B8 (en) | 2014-09-24 |
| NZ563078A (en) | 2009-07-31 |
| HK1077228A1 (en) | 2006-02-10 |
| CA2498725C (en) | 2014-07-08 |
| US8608960B2 (en) | 2013-12-17 |
| AU2009200842B2 (en) | 2011-06-02 |
| AU2003272368A1 (en) | 2004-04-30 |
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