DK1546151T3 - Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner - Google Patents

Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner

Info

Publication number: DK1546151T3
Authority: DK; Denmark
Prior art keywords: disorder; benzodioxanes; heterocycle; annealed; anxiety
Prior art date: 2002-09-12

Application number

DK03795686T

Other languages

Danish (da)

English (en)

Inventor

Gary Paul Stack

Deborah Ann Evrard

Uresh Shantilal Shah

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-12

Filing date

2003-09-11

Publication date

2006-07-31

2003-09-11 Application filed by Wyeth Corp filed Critical Wyeth Corp

2006-07-31 Application granted granted Critical

2006-07-31 Publication of DK1546151T3 publication Critical patent/DK1546151T3/da

Links

230000001430 anti-depressive effect Effects 0.000 title 1
239000000935 antidepressant agent Substances 0.000 title 1
229940005513 antidepressants Drugs 0.000 title 1
BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical class C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 title 1
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
206010068631 Childhood depression Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
208000027030 Premenstrual dysphoric disease Diseases 0.000 abstract 1
206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
229960003920 cocaine Drugs 0.000 abstract 1
201000006145 cocaine dependence Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
208000024732 dysthymic disease Diseases 0.000 abstract 1
238000011010 flushing procedure Methods 0.000 abstract 1
208000029364 generalized anxiety disease Diseases 0.000 abstract 1
208000013403 hyperactivity Diseases 0.000 abstract 1
208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
208000024714 major depressive disease Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1
230000001457 vasomotor Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Addiction (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK03795686T 2002-09-12 2003-09-11 Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner DK1546151T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41007202P	2002-09-12	2002-09-12
US10/659,174 US6911445B2 (en)	2002-09-12	2003-09-10	Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans

Publications (1)

Publication Number	Publication Date
DK1546151T3 true DK1546151T3 (da)	2006-07-31

Family

ID=31997897

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03795686T DK1546151T3 (da)	2002-09-12	2003-09-11	Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner

Country Status (20)

Country	Link
US (1)	US6911445B2 (pt)
EP (1)	EP1546151B1 (pt)
JP (1)	JP2006503040A (pt)
KR (1)	KR20050042187A (pt)
CN (1)	CN1309722C (pt)
AT (1)	ATE323094T1 (pt)
AU (1)	AU2003266029A1 (pt)
BR (1)	BR0314430A (pt)
CA (1)	CA2498131A1 (pt)
DE (1)	DE60304590T2 (pt)
DK (1)	DK1546151T3 (pt)
EC (1)	ECSP055659A (pt)
ES (1)	ES2259776T3 (pt)
MX (1)	MXPA05002838A (pt)
NO (1)	NO20051770L (pt)
NZ (1)	NZ539253A (pt)
PT (1)	PT1546151E (pt)
RU (1)	RU2005107591A (pt)
SI (1)	SI1546151T1 (pt)
WO (1)	WO2004024732A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200616967A (en)	2004-06-24	2006-06-01	Smithkline Beecham Corp	Novel indazole carboxamides and their use
TW200626142A (en)	2004-09-21	2006-08-01	Glaxo Group Ltd	Chemical compounds
JP2008530229A (ja)	2005-02-17	2008-08-07	ワイス	シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
US8063071B2 (en)	2007-10-31	2011-11-22	GlaxoSmithKline, LLC	Chemical compounds
WO2008042735A1 (en) *	2006-09-29	2008-04-10	Wyeth	Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines
AR065804A1 (es)	2007-03-23	2009-07-01	Smithkline Beecham Corp	Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US20090042874A1 (en) *	2007-05-30	2009-02-12	Wyeth	Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans
US8354539B2 (en)	2009-03-10	2013-01-15	Glaxo Group Limited	Indole derivatives as IKK2 inhibitors
WO2026078446A2 (en) *	2024-10-08	2026-04-16	Brandaris Therapeutics B.V.	5,6-bicyclic 5-ht2ar agonists and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9318431D0 (en) *	1993-09-06	1993-10-20	Boots Co Plc	Therapeutic agents
US5468767A (en) *	1994-01-06	1995-11-21	Bristol-Myers Squibb Company	Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
AR004229A1 (es)	1995-11-06	1998-11-04	Wyeth Corp	Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
GB9627005D0 (en)	1996-12-27	1997-02-12	Knoll Ag	Therapeutic agents
GB9704948D0 (en) *	1997-03-11	1997-04-30	Knoll Ag	Therapeutic agents
US6162803A (en) *	1998-04-08	2000-12-19	American Home Products Corp.	Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression
CN1304409A (zh) *	1998-04-08	2001-07-18	美国家用产品公司	用于治疗抑郁症的吲哚－3－基－环己胺衍生物(5－ht1受体拮抗剂)
DE60201829T2 (de)	2001-03-14	2005-10-27	Wyeth	Azaheterocyclylmethylderivative des 2,3-dihydro-1,4-dioxino(2,3-f)chinolin als antidepressivum
CN1503798A (zh)	2001-04-26	2004-06-09		抗抑郁的氧杂环稠合的－[1,4]苯并二噁烷的氮杂环基甲基衍生物

2003
- 2003-09-10 US US10/659,174 patent/US6911445B2/en not_active Expired - Fee Related
- 2003-09-11 DE DE60304590T patent/DE60304590T2/de not_active Expired - Fee Related
- 2003-09-11 WO PCT/US2003/028459 patent/WO2004024732A1/en not_active Ceased
- 2003-09-11 BR BR0314430-5A patent/BR0314430A/pt not_active IP Right Cessation
- 2003-09-11 CA CA002498131A patent/CA2498131A1/en not_active Abandoned
- 2003-09-11 AU AU2003266029A patent/AU2003266029A1/en not_active Abandoned
- 2003-09-11 MX MXPA05002838A patent/MXPA05002838A/es active IP Right Grant
- 2003-09-11 SI SI200330260T patent/SI1546151T1/sl unknown
- 2003-09-11 AT AT03795686T patent/ATE323094T1/de not_active IP Right Cessation
- 2003-09-11 DK DK03795686T patent/DK1546151T3/da active
- 2003-09-11 NZ NZ539253A patent/NZ539253A/en unknown
- 2003-09-11 ES ES03795686T patent/ES2259776T3/es not_active Expired - Lifetime
- 2003-09-11 EP EP03795686A patent/EP1546151B1/en not_active Expired - Lifetime
- 2003-09-11 KR KR1020057004091A patent/KR20050042187A/ko not_active Withdrawn
- 2003-09-11 JP JP2004536479A patent/JP2006503040A/ja active Pending
- 2003-09-11 PT PT03795686T patent/PT1546151E/pt unknown
- 2003-09-11 RU RU2005107591/04A patent/RU2005107591A/ru not_active Application Discontinuation
- 2003-09-11 CN CNB038214695A patent/CN1309722C/zh not_active Expired - Fee Related
2005
- 2005-03-10 EC EC2005005659A patent/ECSP055659A/es unknown
- 2005-04-11 NO NO20051770A patent/NO20051770L/no unknown

Also Published As

Publication number	Publication date
AU2003266029A1 (en)	2004-04-30
ES2259776T3 (es)	2006-10-16
DE60304590T2 (de)	2007-05-10
KR20050042187A (ko)	2005-05-04
BR0314430A (pt)	2005-09-27
CN1681821A (zh)	2005-10-12
NO20051770L (no)	2005-06-07
JP2006503040A (ja)	2006-01-26
US20040171667A1 (en)	2004-09-02
HK1073849A1 (en)	2005-10-21
CN1309722C (zh)	2007-04-11
ATE323094T1 (de)	2006-04-15
NZ539253A (en)	2006-09-29
ECSP055659A (es)	2005-07-06
RU2005107591A (ru)	2006-01-20
MXPA05002838A (es)	2005-08-16
PT1546151E (pt)	2006-07-31
CA2498131A1 (en)	2004-03-25
WO2004024732A1 (en)	2004-03-25
EP1546151B1 (en)	2006-04-12
EP1546151A1 (en)	2005-06-29
SI1546151T1 (sl)	2006-08-31
US6911445B2 (en)	2005-06-28
DE60304590D1 (de)	2006-05-24

Publication	Publication Date	Title
BR0314429A (pt)	2005-08-23	Derivados de aza-heterociclil-metil antidepressivo e benzodioxanos fundidos por heterociclo
TW200505942A (en)	2005-02-16	Antibody molecules having specificity for human IL-1β
PL368442A1 (pl)	2005-03-21	Pochodne fenylopiperazyny jako inhibitory wychwytu zwrotnego serotoniny
DE60201829D1 (de)	2004-12-09	Azaheterocyclylmethyl derivative des 2,3-dihydro-1,4-dioxino(2,3-f)quinolins als antidepressiva
DE602004030334D1 (de)	2011-01-13	Synthese von 5-substituierten 7-azaindolen und 7-azaindolinen
MY147217A (en)	2012-11-14	Antibody molecules having specificity for human il-06
DE502004011239D1 (de)	2010-07-15	Verfahren zur dehydratisierung substituierter 4-dimethylamino-2-aryl-butan-2-ol-verbindungen und verfahren zur herstellung substituierter dimethyl-(3-katalyse
ECSP055659A (es)	2005-07-06	Derivados de cicloalquilamina antidepresiva de benzodioxanos fusionados con heterociclos
DE60315843D1 (de)	2007-10-04	Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen
AR066760A1 (es)	2009-09-09	Derivados heteroarilo de benzodioxanos heterociclo-fusionados antidepresivos, composiciones farmaceuticas, procesos de obtencion
AR035083A1 (es)	2004-04-14	Derivados azaheterociclilmetilicos de 7,8-dihidro-6h-5-oxa-1-aza-fenantreno, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de un medicamento antidepresivo e intermediarios
NO20055208L (no)	2005-11-04	4-(2-fenylsulfanyl-fenyl)-piperidinderivater som serotonin-reopptaksinhibitorer
WO2002088136A3 (en)	2003-03-20	Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
BR0209343A (pt)	2004-06-15	Antidepressivos de azaheterociclilmetila derivados de [1,4]-benzodioxanos oxaheterociclo-fundidos; métodos de tratamento usando tais compostos; processo para prepará-los
BRPI0607224A2 (pt)	2009-08-25	processo para preparação de ciclohexanona e ciclohexanol
DK1761478T3 (da)	2008-12-15	En isoleret Atomoxetin urenhed, fremgangsmåde til fremstilling af Atomoxetin urenheder og deres anvendelse som referencestandarder
BR0314431A (pt)	2005-09-27	Derivados de piperidina antidepressiva dos benzodioxanos fundidos por heterocilo
EA200801081A1 (ru)	2008-10-30	Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона
ATE402136T1 (de)	2008-08-15	Verfahren zur herstellung von aminoalkoxybenzylaminen und aminoalkoxybenzonitrilen als zwischenprodukte
CY1107139T1 (el)	2012-10-24	Μεθοδος παρασκευης πυρρολιδινοξιμων
AR048134A1 (es)	2006-04-05	La combinacion de un inhibidor de la recaptacion de serotonina y un antagonista del receptor de la histamina 3, el agonista inverso o el agonista parcial
CR7726A (es)	2005-08-12	Antidepresivos derivados de indoalquilo de benzodioxan metilaminas de heterociclo fusionado
EA200801239A1 (ru)	2008-08-29	Новые способы получения пиперазинильных и диазепанильных производных бензамина
ATE417055T1 (de)	2008-12-15	Steroid modifizierte solatriosen
HRP20070123A2 (en)	2008-10-31	Phenyl-piperazine derivatives as serotonin reuptake inhibitors