DK1556414T3 - Blandinger af heparinafledte oligosaccharider, fremstilling deraf og farmaceutisk præparater, der indeholder dem - Google Patents

Blandinger af heparinafledte oligosaccharider, fremstilling deraf og farmaceutisk præparater, der indeholder dem

Info

Publication number: DK1556414T3
Authority: DK; Denmark
Prior art keywords: heparin; activity; hexasaccharide; preparation; mixtures
Prior art date: 2002-10-10

Application number

DK03807882.0T

Other languages

English (en)

Inventor

Vesna Biberovic

Luc Grondard

Pierre Mourier

Christian Viskov

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-10

Filing date

2003-10-08

Publication date

2012-06-25

2003-10-08 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2012-06-25 Application granted granted Critical

2012-06-25 Publication of DK1556414T3 publication Critical patent/DK1556414T3/da

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 3
229920000669 heparin Polymers 0.000 title abstract 3
229960002897 heparin Drugs 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 3
229920001542 oligosaccharide Polymers 0.000 title abstract 2
150000002482 oligosaccharides Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
230000000694 effects Effects 0.000 abstract 6
230000001858 anti-Xa Effects 0.000 abstract 4
150000004676 glycans Chemical class 0.000 abstract 3
229920001282 polysaccharide Polymers 0.000 abstract 3
239000005017 polysaccharide Substances 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
239000003513 alkali Substances 0.000 abstract 2
150000001720 carbohydrates Chemical group 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
150000003839 salts Chemical group 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

DK03807882.0T 2002-10-10 2003-10-08 Blandinger af heparinafledte oligosaccharider, fremstilling deraf og farmaceutisk præparater, der indeholder dem DK1556414T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0212584A FR2845686B1 (fr)	2002-10-10	2002-10-10	Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
PCT/FR2003/002960 WO2004033503A1 (fr)	2002-10-10	2003-10-08	Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number	Publication Date
DK1556414T3 true DK1556414T3 (da)	2012-06-25

Family

ID=32039597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03807882.0T DK1556414T3 (da)	2002-10-10	2003-10-08	Blandinger af heparinafledte oligosaccharider, fremstilling deraf og farmaceutisk præparater, der indeholder dem

Country Status (35)

Country	Link
EP (1)	EP1556414B1 (da)
JP (2)	JP5021898B2 (da)
CN (6)	CN101810637A (da)
AT (1)	ATE548393T1 (da)
AU (1)	AU2003300161B2 (da)
BR (1)	BR0315149A (da)
CA (1)	CA2501546C (da)
CY (1)	CY1112808T1 (da)
DK (1)	DK1556414T3 (da)
EC (1)	ECSP055722A (da)
ES (1)	ES2383597T3 (da)
FR (1)	FR2845686B1 (da)
GT (1)	GT200300181A (da)
HN (1)	HN2003000312A (da)
IL (1)	IL167868A (da)
MA (1)	MA27398A1 (da)
MX (1)	MXPA05003321A (da)
MY (1)	MY142376A (da)
NI (1)	NI200300087A (da)
NO (1)	NO20052170L (da)
NZ (1)	NZ539229A (da)
OA (1)	OA12940A (da)
PA (1)	PA8584201A1 (da)
PE (1)	PE20040507A1 (da)
PT (1)	PT1556414E (da)
RS (1)	RS20050274A (da)
RU (1)	RU2332424C2 (da)
SI (1)	SI1556414T1 (da)
SV (1)	SV2004001626A (da)
TN (1)	TNSN05101A1 (da)
TW (1)	TWI332010B (da)
UA (1)	UA81925C2 (da)
UY (1)	UY28016A1 (da)
WO (1)	WO2004033503A1 (da)
ZA (1)	ZA200502787B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2845686B1 (fr) *	2002-10-10	2013-08-30	Aventis Pharma Sa	Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
FR2857971B1 (fr) *	2003-07-24	2005-08-26	Aventis Pharma Sa	Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
EP2447285A3 (en) *	2006-05-25	2013-01-16	Momenta Pharmaceuticals, Inc.	Low molecular weight heparin composition and uses thereof
CN101389342B (zh)	2006-12-05	2012-08-08	株式会社糖质科学研究所	用于变性关节炎的治疗剂
KR101678429B1 (ko)	2009-02-02	2016-11-22	오츠카 세이야쿠 가부시키가이샤	저분자량 다황산화 히알루론산 유도체 및 이를 함유하는 의약
EP2233145A1 (en)	2009-03-19	2010-09-29	Sanofi-Aventis	A dose of AVE5026 for the treatment of venous thromboembolism in patients with severe renal impairment
EP2399591A1 (en)	2010-06-25	2011-12-28	Aventis Pharma S.A.	Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery
EP2399592A1 (en)	2010-06-25	2011-12-28	Aventis Pharma S.A.	Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399590A1 (en)	2010-06-25	2011-12-28	Aventis Pharma S.A.	Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2399593A1 (en)	2010-06-28	2011-12-28	Aventis Pharma S.A.	Semuloparin for use as an antithrombotic treatment in orthopaedic surgery with improved benefit-risk profile
JP2012046511A (ja) *	2010-07-30	2012-03-08	Otsuka Chem Co Ltd	低分子量多硫酸化ヒアルロン酸誘導体を含有する医薬
CA2974062C (en) *	2010-09-14	2018-07-17	Fuso Pharmaceutical Industries, Ltd.	High purity heparin and production method therefor
WO2012055843A1 (en)	2010-10-28	2012-05-03	Aventis Pharma S.A.	Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery
EP2446891A1 (en)	2010-10-28	2012-05-02	Aventis Pharma S.A.	Semuloparin for use as an antithrombotic treatment in major abdominal surgery with improved safety in terms of clinically relevant bleedings and major bleedings
WO2012072799A1 (en)	2010-12-02	2012-06-07	Aventis Pharma S.A.	New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample
AR085961A1 (es)	2011-04-11	2013-11-06	Sanofi Sa	Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen
EP2548561A1 (en)	2011-07-22	2013-01-23	Aventis Pharma S.A.	Semuloparin for improving the survival of patients with locally advanced cancer
WO2013044793A1 (zh) *	2011-09-26	2013-04-04	Xu Meiying	一种高纯度肝素苄酯盐及其制法和应用
CN102633908A (zh) *	2012-05-02	2012-08-15	雷晓刚	一种高品质超低分子量肝素的制备方法
ES2445494B1 (es) *	2012-08-02	2015-03-06	Rovi Lab Farmaceut Sa	Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
US9873712B2 (en) *	2014-10-03	2018-01-23	Amphastar Pharmaceuticals, Inc.	Method of purifying idraparinux sodium
US20190002596A1 (en) *	2015-12-30	2019-01-03	Shenzhen Hepalink Pharmaceutical Group Co., Ltd.	Sulfated heparin oligosaccharide and preparation method and application thereof
CZ308106B6 (cs) *	2016-06-27	2020-01-08	Contipro A.S.	Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
CN110917208B (zh) *	2019-12-27	2021-02-12	浙江医院	硫酸化甘露葡萄糖醛酸六糖在防治动脉粥样硬化中的应用
CN117534776B (zh) *	2023-09-26	2026-03-03	南京健友生化制药股份有限公司	一种依诺酯化反应液的除杂方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL61201A (en) *	1979-10-05	1984-09-30	Choay Sa	Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
FR2482611B1 (fr)	1980-05-14	1986-03-07	Pharmindustrie	Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
FR2504928A1 (fr) *	1981-04-29	1982-11-05	Choay Sa	Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments
FR2584606A1 (fr) *	1985-07-12	1987-01-16	Dropic	Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
FR2584728B1 (fr) *	1985-07-12	1987-11-20	Choay Sa	Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2669932B1 (fr) *	1990-12-03	1994-07-01	Sanofi Sa	Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
ES2161615B1 (es) *	1999-07-23	2003-03-16	Rovi Lab Farmaceut Sa	Composiciones de heparinas de muy bajo peso molecular.
JP4897991B2 (ja) *	1999-07-23	2012-03-14	ラボラトリオスファルマセウティコスロビソシエダッドアノニマ	超低分子量ヘパリン組成物
FR2807043B1 (fr) *	2000-03-28	2002-11-22	Aventis Pharma Sa	Composition pharmaceutique contenant des oligosaccharides, les nouveaux oligosaccharides et leur preparation
FR2811992B1 (fr) *	2000-07-21	2003-07-04	Aventis Pharma Sa	Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
FR2845686B1 (fr) *	2002-10-10	2013-08-30	Aventis Pharma Sa	Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

2002
- 2002-10-10 FR FR0212584A patent/FR2845686B1/fr not_active Expired - Fee Related
2003
- 2003-08-10 UA UAA200504331A patent/UA81925C2/uk unknown
- 2003-08-26 GT GT200300181A patent/GT200300181A/es unknown
- 2003-09-18 NI NI200300087A patent/NI200300087A/es unknown
- 2003-09-24 SV SV2003001626A patent/SV2004001626A/es not_active Application Discontinuation
- 2003-10-01 PA PA20038584201A patent/PA8584201A1/es unknown
- 2003-10-06 PE PE2003001005A patent/PE20040507A1/es not_active Application Discontinuation
- 2003-10-08 JP JP2004542566A patent/JP5021898B2/ja not_active Expired - Fee Related
- 2003-10-08 CN CN201010147509A patent/CN101810637A/zh active Pending
- 2003-10-08 WO PCT/FR2003/002960 patent/WO2004033503A1/fr not_active Ceased
- 2003-10-08 OA OA1200500102A patent/OA12940A/fr unknown
- 2003-10-08 RU RU2005113987/04A patent/RU2332424C2/ru not_active IP Right Cessation
- 2003-10-08 HN HN2003000312A patent/HN2003000312A/es unknown
- 2003-10-08 CN CN201010147549A patent/CN101812190A/zh active Pending
- 2003-10-08 ES ES03807882T patent/ES2383597T3/es not_active Expired - Lifetime
- 2003-10-08 MX MXPA05003321A patent/MXPA05003321A/es active IP Right Grant
- 2003-10-08 PT PT03807882T patent/PT1556414E/pt unknown
- 2003-10-08 CA CA2501546A patent/CA2501546C/fr not_active Expired - Fee Related
- 2003-10-08 AU AU2003300161A patent/AU2003300161B2/en not_active Ceased
- 2003-10-08 AT AT03807882T patent/ATE548393T1/de active
- 2003-10-08 CN CN201010147539A patent/CN101812139A/zh active Pending
- 2003-10-08 DK DK03807882.0T patent/DK1556414T3/da active
- 2003-10-08 NZ NZ539229A patent/NZ539229A/en not_active IP Right Cessation
- 2003-10-08 BR BR0315149-2A patent/BR0315149A/pt not_active IP Right Cessation
- 2003-10-08 CN CNA2003801009925A patent/CN1798771A/zh active Pending
- 2003-10-08 EP EP03807882A patent/EP1556414B1/fr not_active Expired - Lifetime
- 2003-10-08 CN CN201010120370A patent/CN101817940A/zh active Pending
- 2003-10-08 CN CN201010147528A patent/CN101812189A/zh active Pending
- 2003-10-08 SI SI200332145T patent/SI1556414T1/sl unknown
- 2003-10-08 RS YUP-2005/0274A patent/RS20050274A/sr unknown
- 2003-10-09 MY MYPI20033852A patent/MY142376A/en unknown
- 2003-10-09 TW TW092128028A patent/TWI332010B/zh not_active IP Right Cessation
- 2003-10-10 UY UY28016A patent/UY28016A1/es unknown
2005
- 2005-04-01 MA MA28192A patent/MA27398A1/fr unknown
- 2005-04-05 IL IL167868A patent/IL167868A/en not_active IP Right Cessation
- 2005-04-06 ZA ZA200502787A patent/ZA200502787B/en unknown
- 2005-04-07 TN TNP2005000101A patent/TNSN05101A1/fr unknown
- 2005-04-08 EC EC2005005722A patent/ECSP055722A/es unknown
- 2005-05-03 NO NO20052170A patent/NO20052170L/no not_active Application Discontinuation
2011
- 2011-10-21 JP JP2011231218A patent/JP5389140B2/ja not_active Expired - Fee Related
2012
- 2012-05-30 CY CY20121100489T patent/CY1112808T1/el unknown

Also Published As

Publication number	Publication date
NI200300087A (es)	2012-02-02
CN101812139A (zh)	2010-08-25
TW200418882A (en)	2004-10-01
OA12940A (fr)	2006-10-13
MY142376A (en)	2010-11-30
IL167868A (en)	2010-05-31
ES2383597T3 (es)	2012-06-22
EP1556414A1 (fr)	2005-07-27
CY1112808T1 (el)	2016-02-10
SI1556414T1 (sl)	2012-06-29
TWI332010B (en)	2010-10-21
FR2845686A1 (fr)	2004-04-16
MXPA05003321A (es)	2005-07-05
ECSP055722A (es)	2005-07-06
MA27398A1 (fr)	2005-06-01
SV2004001626A (es)	2004-03-08
AU2003300161A1 (en)	2004-05-04
EP1556414B1 (fr)	2012-03-07
CN101812189A (zh)	2010-08-25
AU2003300161B2 (en)	2009-08-27
ATE548393T1 (de)	2012-03-15
CN101812190A (zh)	2010-08-25
JP2006517185A (ja)	2006-07-20
NO20052170L (no)	2005-07-07
CN101817940A (zh)	2010-09-01
RU2332424C2 (ru)	2008-08-27
GT200300181A (es)	2004-03-24
UY28016A1 (es)	2004-04-30
PT1556414E (pt)	2012-05-21
CA2501546A1 (fr)	2004-04-22
TNSN05101A1 (fr)	2007-05-14
NZ539229A (en)	2008-03-28
HN2003000312A (es)	2005-10-20
RU2005113987A (ru)	2006-01-27
ZA200502787B (en)	2005-10-18
JP2012051926A (ja)	2012-03-15
FR2845686B1 (fr)	2013-08-30
PE20040507A1 (es)	2004-10-13
RS20050274A (sr)	2007-06-04
PA8584201A1 (es)	2004-08-31
NO20052170D0 (no)	2005-05-03
CN1798771A (zh)	2006-07-05
UA81925C2 (uk)	2008-02-25
JP5021898B2 (ja)	2012-09-12
JP5389140B2 (ja)	2014-01-15
CA2501546C (fr)	2012-04-03
WO2004033503A1 (fr)	2004-04-22
BR0315149A (pt)	2005-08-16
CN101810637A (zh)	2010-08-25

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CY1112808T1 (el)	2016-02-10	Μειγματα ολιγοσακχαριτων προερχομενων απο την ηπαρινη, η παρασκευη τους και φαρμακευτικες συνθεσεις που τα περιεχουν
Wang et al.	2013	Chemical composition and moisture-absorption/retention ability of polysaccharides extracted from five algae
US4791195A (en)	1988-12-13	Novel oligosaccharides having pharmacological properties by depolymerization of heparin
Ciancia et al.	2007	Polysaccharides from the green seaweeds Codium fragile and C. vermilara with controversial effects on hemostasis
Casu et al.	2004	Structural and conformational aspects of the anticoagulant and antithrombotic activity of heparin and dermatan sulfate
ES8206555A1 (es)	1982-08-16	Procedimiento de preparacion de mezclas de polisacaridos sulfatados.
HRP20180124T1 (hr)	2018-02-23	Glikozaminoglikani koji nisu antikoagulanti koji sadrže ponavljajuću jedinicu disaharida i njihova medicinska upotreba
FR2840612B1 (fr)	2005-05-06	Polymeres solubles de glucose hautement branches et leur procede d'obtention
NZ333721A (en)	2000-08-25	Pharmaceutically acceptable synthetic polysaccharides
SI2794667T1 (en)	2018-06-29	Low anticoagulant heparins
AR029865A1 (es)	2003-07-16	Mezclas de polisacaridos sulfatados derivados de la heparina, su preparacion y las composiciones farmaceuticas que las contienen
PT983304E (pt)	2005-09-30	Dissulfato de dermatano, um inibidor da producao de trombina e activacao do complemento
IT1282994B1 (it)	1998-04-03	Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
RU2006106790A (ru)	2007-09-20	Производные полисахаридов с высокой антитромботической активностью в плазме
ES2687900T3 (es)	2018-10-29	Derivados de glicosaminoglicanos N-desulfatados y su uso como fármacos
US5849721A (en)	1998-12-15	Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
Tako et al.	1998	Synergistic interaction between κ-carrageenan isolated from Hypnea charoides Lamouroux and galactomannan on its gelation
DK0986580T3 (da)	2003-08-04	Oligosaccharidblandinger med antitrombotisk aktivitet
AR045917A1 (es)	2005-11-16	Mezclas de oligosacaridos derivados de la heparina, su preparacion y las composiciones farmaceuticas que las contienen
NO985831L (no)	1999-02-11	Syntetiske polysakkarider, fremgangsmÕter for Õ fremstille dem og farmas°ytiske blandinger inneholdende nevnte polysakkarider
NO934044L (no)	1993-11-08	Genetisk kontroll av acetylering og pyruvylering av xantanbaserte poly-sakkaridpolymerer
ATE388169T1 (de)	2008-03-15	Niedermolekulare polysaccharide mit antithrombotischer wirkung
Franz et al.	1995	Novel pharmaceutical applications of polysaccharides
Lindahl	1990	Approaches to the synthesis of heparin
AR041555A1 (es)	2005-05-18	Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen