DK1572641T3 - Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer - Google Patents

Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer

Info

Publication number
DK1572641T3
DK1572641T3 DK03782435.6T DK03782435T DK1572641T3 DK 1572641 T3 DK1572641 T3 DK 1572641T3 DK 03782435 T DK03782435 T DK 03782435T DK 1572641 T3 DK1572641 T3 DK 1572641T3
Authority
DK
Denmark
Prior art keywords
glycopyrronium
stereoisomers
preparing
glycopyrronium stereoisomers
configured glycopyrronium
Prior art date
Application number
DK03782435.6T
Other languages
English (en)
Inventor
Martin R Walter
Christian R Noe
Original Assignee
Meda Pharma Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meda Pharma Gmbh & Co Kg filed Critical Meda Pharma Gmbh & Co Kg
Application granted granted Critical
Publication of DK1572641T3 publication Critical patent/DK1572641T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK03782435.6T 2002-12-18 2003-12-18 Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer DK1572641T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0189602A AT412088B (de) 2002-12-18 2002-12-18 Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere
PCT/EP2003/014432 WO2004054971A1 (de) 2002-12-18 2003-12-18 Verfaren zur herstellung des r,r (oder s,s) konfugurierten glycopyrronium-stereoisomers

Publications (1)

Publication Number Publication Date
DK1572641T3 true DK1572641T3 (da) 2012-07-02

Family

ID=31192804

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03782435.6T DK1572641T3 (da) 2002-12-18 2003-12-18 Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer

Country Status (15)

Country Link
US (1) US7569598B2 (da)
EP (1) EP1572641B1 (da)
JP (1) JP2007524565A (da)
CN (1) CN100349867C (da)
AT (2) AT412088B (da)
AU (1) AU2003290075B2 (da)
CA (1) CA2510280C (da)
DK (1) DK1572641T3 (da)
ES (1) ES2383799T3 (da)
NO (1) NO330851B1 (da)
NZ (1) NZ541098A (da)
PL (1) PL214802B1 (da)
PT (1) PT1572641E (da)
RU (1) RU2337096C2 (da)
WO (1) WO2004054971A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504463D0 (en) 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
KR101290893B1 (ko) * 2009-04-09 2013-07-29 노파르티스 아게 피롤리디늄 염의 제조 방법
CN102939280B (zh) * 2010-06-14 2014-11-19 奇斯药制品公司 格隆氯铵的晶型
CN103159659A (zh) * 2011-12-19 2013-06-19 沈阳药科大学 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法
ES2625498T3 (es) * 2011-12-22 2017-07-19 Cerbios-Pharma S.A. Proceso continuo para la alquilación de aminas terciarias cíclicas
CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
NZ710740A (en) 2013-02-28 2020-06-26 Dermira Inc Glycopyrrolate salts
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
CN104586841A (zh) * 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
CN107345945B (zh) * 2016-05-05 2019-12-17 辽宁药联制药有限公司 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法
CN113234003B (zh) * 2021-04-23 2024-02-02 广东嘉博制药有限公司 一种格隆溴铵及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0937041T1 (en) * 1996-11-11 2003-10-31 Christian R. Noe Use of a pharmaceutically acceptable salt of (3R,2'R)-3-((Cyclopently-hydroxyphenylacetyl)oxy)-1,1-dimethyl-pyrrolidinium for the preparation of a medicament

Also Published As

Publication number Publication date
PL214802B1 (pl) 2013-09-30
EP1572641A1 (de) 2005-09-14
US20060167275A1 (en) 2006-07-27
NO20053473D0 (no) 2005-07-15
CA2510280C (en) 2011-09-27
ATA18962002A (de) 2004-02-15
RU2005122497A (ru) 2006-01-20
RU2337096C2 (ru) 2008-10-27
ATE548348T1 (de) 2012-03-15
PL377441A1 (pl) 2006-02-06
JP2007524565A (ja) 2007-08-30
NZ541098A (en) 2008-08-29
AU2003290075B2 (en) 2009-01-29
CN100349867C (zh) 2007-11-21
WO2004054971A1 (de) 2004-07-01
PT1572641E (pt) 2012-06-15
EP1572641B1 (de) 2012-03-07
AT412088B (de) 2004-09-27
NO20053473L (no) 2005-09-19
CN1751022A (zh) 2006-03-22
NO330851B1 (no) 2011-08-01
CA2510280A1 (en) 2004-07-01
US7569598B2 (en) 2009-08-04
ES2383799T3 (es) 2012-06-26
AU2003290075A1 (en) 2004-07-09

Similar Documents

Publication Publication Date Title
DK1226188T3 (da) Fremgangsmåde til fremstilling af mannichaddukter, som indeholder polyisobutenphenol
DE60304422D1 (de) Druckqualitätsverbesserungsverfahren
DK1638750T3 (da) Fremgangsmåder til fremstilling af gelplader
DK2322511T3 (da) Fremgangsmåde til fremstilling af Telmisartan
DE602005015397D1 (de) Leuchtstoff, Verfahren zu seiner Herstellung und diesen Leuchtstoff verwendende Lichtquelle
DE60234952D1 (de) VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL
DE60322453D1 (de) System zum Bereitstellen von Diensten
DE60328522D1 (de) Verfahren zur herstellung von bisphenol
DK2135957T3 (da) Fremgangsmåde til fremstilling af glucaner
IS7755A (is) Aðferð við framleiðslu á (S,S)-cis-2-benshýdríl-3-bensýlamínókínuklídín
DK1536685T4 (da) Fremgangsmåde til fremstilling af pasta-ekstruderede sulfonamidsammensætninger
NO20053473D0 (no) Fremgangsmate for fremstilling av R,R (eller S,S) konfigurasjonen av glykopyrroniumstereoisomerer
DK1713801T3 (da) Fremgangsmåde til fremstilling af 1-(2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amin
DE502005001841D1 (de) Verfahren zur herstellung von 1,4-diphenylazetidinon-derivaten
ITMI20020902A0 (it) Processo per preparare membrane ionomeriche
DE602005021110D1 (de) Verfahren zur herstellung von n-piperidino-1,5-diphenylpyrazol-3-carboxamid-derivaten
DE502005007702D1 (de) Verfahren zur herstellung von terrylen-3,4:11,12-t
DK1395587T3 (da) Fremgangsmåde til fremstilling af imipenem
GB0423498D0 (en) Blade clamping apparatus
DK1578720T3 (da) Fremgangsmåde til fremstilling af gamma-cyhalothrin
FI20020163L (fi) Menetelmä selluloosakarbamaatin valmistamiseksi
DE602005026841D1 (de) Verfahren zur herstellung von 1,2,2,2-tetrafluor-ethyl-difluor-methylether
ITMI20041920A1 (it) Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina
DE602006008329D1 (de) Verfahren zur herstellung von anilinen
DK1632567T3 (da) Fremgangsmåde til fremstilling af phosphorylase