DK1572641T3 - Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer - Google Patents

Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer

Info

Publication number
DK1572641T3
DK1572641T3 DK03782435.6T DK03782435T DK1572641T3 DK 1572641 T3 DK1572641 T3 DK 1572641T3 DK 03782435 T DK03782435 T DK 03782435T DK 1572641 T3 DK1572641 T3 DK 1572641T3
Authority
DK
Denmark
Prior art keywords
glycopyrronium
stereoisomers
preparing
glycopyrronium stereoisomers
configured glycopyrronium
Prior art date
Application number
DK03782435.6T
Other languages
English (en)
Inventor
Martin R Walter
Christian R Noe
Original Assignee
Meda Pharma Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meda Pharma Gmbh & Co Kg filed Critical Meda Pharma Gmbh & Co Kg
Application granted granted Critical
Publication of DK1572641T3 publication Critical patent/DK1572641T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/06Anti-spasmodics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK03782435.6T 2002-12-18 2003-12-18 Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer DK1572641T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0189602A AT412088B (de) 2002-12-18 2002-12-18 Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere
PCT/EP2003/014432 WO2004054971A1 (de) 2002-12-18 2003-12-18 Verfaren zur herstellung des r,r (oder s,s) konfugurierten glycopyrronium-stereoisomers

Publications (1)

Publication Number Publication Date
DK1572641T3 true DK1572641T3 (da) 2012-07-02

Family

ID=31192804

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03782435.6T DK1572641T3 (da) 2002-12-18 2003-12-18 Fremgangsmåde til fremstilling af R,R- (eller S,S-) konfigurerede glycopyrronium-stereoisomerer

Country Status (15)

Country Link
US (1) US7569598B2 (da)
EP (1) EP1572641B1 (da)
JP (1) JP2007524565A (da)
CN (1) CN100349867C (da)
AT (2) AT412088B (da)
AU (1) AU2003290075B2 (da)
CA (1) CA2510280C (da)
DK (1) DK1572641T3 (da)
ES (1) ES2383799T3 (da)
NO (1) NO330851B1 (da)
NZ (1) NZ541098A (da)
PL (1) PL214802B1 (da)
PT (1) PT1572641E (da)
RU (1) RU2337096C2 (da)
WO (1) WO2004054971A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504463D0 (en) 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
JP5902612B2 (ja) * 2009-04-09 2016-04-13 ノバルティス アーゲー ピロリジニウム塩の調製方法
ES2528957T3 (es) * 2010-06-14 2015-02-13 Chiesi Farmaceutici S.P.A. Forma cristalina del cloruro de glicopirronio
CN103159659A (zh) * 2011-12-19 2013-06-19 沈阳药科大学 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法
LT2607351T (lt) * 2011-12-22 2017-06-12 Cerbios-Pharma S.A. Ciklinių tretinių aminų nepertraukiamo alkilinimo būdas
CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
ES2699257T3 (es) 2013-02-28 2019-02-08 Dermira Inc Sales de glicopirrolato
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
CN104586841A (zh) * 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
CN107345945B (zh) * 2016-05-05 2019-12-17 辽宁药联制药有限公司 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法
CN113234003B (zh) * 2021-04-23 2024-02-02 广东嘉博制药有限公司 一种格隆溴铵及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937041B1 (de) * 1996-11-11 2003-04-23 Christian R. Noe Verwendung eines pharmazeutisch geeigneten Salzes von (3R,2'R)-3-[(Cyclopentyl-hydroxyphenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium zur Herstellung eines Arzneimittels

Also Published As

Publication number Publication date
CN1751022A (zh) 2006-03-22
NO330851B1 (no) 2011-08-01
AT412088B (de) 2004-09-27
CA2510280A1 (en) 2004-07-01
JP2007524565A (ja) 2007-08-30
CA2510280C (en) 2011-09-27
RU2337096C2 (ru) 2008-10-27
ES2383799T3 (es) 2012-06-26
NO20053473D0 (no) 2005-07-15
US7569598B2 (en) 2009-08-04
RU2005122497A (ru) 2006-01-20
AU2003290075B2 (en) 2009-01-29
NZ541098A (en) 2008-08-29
PT1572641E (pt) 2012-06-15
NO20053473L (no) 2005-09-19
EP1572641B1 (de) 2012-03-07
CN100349867C (zh) 2007-11-21
WO2004054971A1 (de) 2004-07-01
US20060167275A1 (en) 2006-07-27
ATA18962002A (de) 2004-02-15
EP1572641A1 (de) 2005-09-14
ATE548348T1 (de) 2012-03-15
PL377441A1 (pl) 2006-02-06
PL214802B1 (pl) 2013-09-30
AU2003290075A1 (en) 2004-07-09

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