NO20053473L - Fremgangsmate for fremstilling av R,R (eller S,S) konfigurasjonen av glykopyrroniumstereoisomerer - Google Patents

Fremgangsmate for fremstilling av R,R (eller S,S) konfigurasjonen av glykopyrroniumstereoisomerer

Info

Publication number
NO20053473L
NO20053473L NO20053473A NO20053473A NO20053473L NO 20053473 L NO20053473 L NO 20053473L NO 20053473 A NO20053473 A NO 20053473A NO 20053473 A NO20053473 A NO 20053473A NO 20053473 L NO20053473 L NO 20053473L
Authority
NO
Norway
Prior art keywords
glycopyrronium
stereoisomers
preparing
configuration
glycopyrronium stereoisomers
Prior art date
Application number
NO20053473A
Other languages
English (en)
Other versions
NO330851B1 (no
NO20053473D0 (no
Inventor
Christian R Noe
Martin R Walter
Original Assignee
Pharmacon Forschung & Beratung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacon Forschung & Beratung Gmbh filed Critical Pharmacon Forschung & Beratung Gmbh
Publication of NO20053473D0 publication Critical patent/NO20053473D0/no
Publication of NO20053473L publication Critical patent/NO20053473L/no
Publication of NO330851B1 publication Critical patent/NO330851B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20053473A 2002-12-18 2005-07-15 Fremgangsmate for fremstilling av R,R- (eller S,S-) konfigurasjonen av glykopyrroniumstereoisomerer NO330851B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0189602A AT412088B (de) 2002-12-18 2002-12-18 Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere
PCT/EP2003/014432 WO2004054971A1 (de) 2002-12-18 2003-12-18 Verfaren zur herstellung des r,r (oder s,s) konfugurierten glycopyrronium-stereoisomers

Publications (3)

Publication Number Publication Date
NO20053473D0 NO20053473D0 (no) 2005-07-15
NO20053473L true NO20053473L (no) 2005-09-19
NO330851B1 NO330851B1 (no) 2011-08-01

Family

ID=31192804

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053473A NO330851B1 (no) 2002-12-18 2005-07-15 Fremgangsmate for fremstilling av R,R- (eller S,S-) konfigurasjonen av glykopyrroniumstereoisomerer

Country Status (15)

Country Link
US (1) US7569598B2 (no)
EP (1) EP1572641B1 (no)
JP (1) JP2007524565A (no)
CN (1) CN100349867C (no)
AT (2) AT412088B (no)
AU (1) AU2003290075B2 (no)
CA (1) CA2510280C (no)
DK (1) DK1572641T3 (no)
ES (1) ES2383799T3 (no)
NO (1) NO330851B1 (no)
NZ (1) NZ541098A (no)
PL (1) PL214802B1 (no)
PT (1) PT1572641E (no)
RU (1) RU2337096C2 (no)
WO (1) WO2004054971A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504463D0 (en) 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
JP5902612B2 (ja) * 2009-04-09 2016-04-13 ノバルティス アーゲー ピロリジニウム塩の調製方法
ES2528957T3 (es) * 2010-06-14 2015-02-13 Chiesi Farmaceutici S.P.A. Forma cristalina del cloruro de glicopirronio
CN103159659A (zh) * 2011-12-19 2013-06-19 沈阳药科大学 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法
LT2607351T (lt) * 2011-12-22 2017-06-12 Cerbios-Pharma S.A. Ciklinių tretinių aminų nepertraukiamo alkilinimo būdas
CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
ES2699257T3 (es) 2013-02-28 2019-02-08 Dermira Inc Sales de glicopirrolato
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
CN104586841A (zh) * 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
CN107345945B (zh) * 2016-05-05 2019-12-17 辽宁药联制药有限公司 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法
CN113234003B (zh) * 2021-04-23 2024-02-02 广东嘉博制药有限公司 一种格隆溴铵及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937041B1 (de) * 1996-11-11 2003-04-23 Christian R. Noe Verwendung eines pharmazeutisch geeigneten Salzes von (3R,2'R)-3-[(Cyclopentyl-hydroxyphenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium zur Herstellung eines Arzneimittels

Also Published As

Publication number Publication date
CN1751022A (zh) 2006-03-22
NO330851B1 (no) 2011-08-01
AT412088B (de) 2004-09-27
CA2510280A1 (en) 2004-07-01
JP2007524565A (ja) 2007-08-30
CA2510280C (en) 2011-09-27
RU2337096C2 (ru) 2008-10-27
ES2383799T3 (es) 2012-06-26
NO20053473D0 (no) 2005-07-15
DK1572641T3 (da) 2012-07-02
US7569598B2 (en) 2009-08-04
RU2005122497A (ru) 2006-01-20
AU2003290075B2 (en) 2009-01-29
NZ541098A (en) 2008-08-29
PT1572641E (pt) 2012-06-15
EP1572641B1 (de) 2012-03-07
CN100349867C (zh) 2007-11-21
WO2004054971A1 (de) 2004-07-01
US20060167275A1 (en) 2006-07-27
ATA18962002A (de) 2004-02-15
EP1572641A1 (de) 2005-09-14
ATE548348T1 (de) 2012-03-15
PL377441A1 (pl) 2006-02-06
PL214802B1 (pl) 2013-09-30
AU2003290075A1 (en) 2004-07-09

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