DK1585548T3 - Sammensætninger og fremgangsmåder til afgivelse af farmakologiske midler - Google Patents

Sammensætninger og fremgangsmåder til afgivelse af farmakologiske midler Download PDF

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Publication number
DK1585548T3
DK1585548T3 DK03799876.2T DK03799876T DK1585548T3 DK 1585548 T3 DK1585548 T3 DK 1585548T3 DK 03799876 T DK03799876 T DK 03799876T DK 1585548 T3 DK1585548 T3 DK 1585548T3
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Prior art keywords
pharmaceutical composition
albumin
paclitaxel
pharmaceutical
propofol
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DK03799876.2T
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English (en)
Inventor
Neil P Desai
Andrew Yang
Sherry Xiaopei Ci
Tapas De
Vuong Trieu
Patrick Soon-Shiong
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Abraxis Bioscience Llc
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Application filed by Abraxis Bioscience Llc filed Critical Abraxis Bioscience Llc
Priority claimed from PCT/US2003/038941 external-priority patent/WO2004052401A2/en
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Publication of DK1585548T3 publication Critical patent/DK1585548T3/da

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Claims (25)

1. Farmaceutisk sammensætning, der omfatter et farmaceutisk middel og en farmaceutisk acceptabel bærer, hvor den farmaceutisk acceptable bærer omfatter albumin, hvor forholdet (vægt/vægt) mellem albumin og det farmaceutiske middel er 1:1 til 9:1, og hvor den farmaceutiske sammensætning omfatter partikler eller smådråber med en størrelse på mindre end 200 nm, hvor det farmaceutiske middel er valgt blandt taxan, camptothecin, propofol, amiodaron, cyclosporin, amphotericin, liothyronin, epothilon, colchicin, skjoldbruskkirtelhormon, corticosteroid, melatonin, tacrolimus, mycophenolsyre og derivater deraf, eller hvor det farmaceutiske middel er docetaxel eller rapamycin.
2. Farmaceutisk sammensætning ifølge krav 1, hvor forholdet (vægt/vægt) mellem albumin og farmaceutisk middel i den farmaceutiske sammensætning er 1:1 til 5:1.
3. Farmaceutisk sammensætning ifølge krav 2, hvor forholdet (vægt/vægt) mellem albumin og farmaceutisk middel i den farmaceutiske sammensætning er 1:1 til 3:1.
4. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3, hvor den farmaceutiske sammensætning omfatter smådråber med en størrelse på mindre end 200 nm.
5. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3, hvor den farmaceutiske sammensætning omfatter partikler med en størrelse på mindre end 200 nm.
6. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 5, hvor sammensætningen er i enhedsdosis, indeholdt i en forseglet beholder.
7. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 5, hvor sammensætningen er i multidosis, indeholdt i en forseglet beholder.
8. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 7, hvor det farmaceutiske middel er en taxan.
9. Farmaceutisk sammensætning ifølge krav 8, hvor taxanen er paclitaxel.
10. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor albuminet er humant serumalbumin.
11. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1-7, hvor det farmaceutiske middel er docetaxel eller rapamycin.
12. Farmaceutisk sammensætning ifølge krav 11, hvor forholdet (vægt/vægt) mellem albumin og farmaceutisk middel i den farmaceutiske sammensætning er 1:1 til 5:1.
13. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 12, hvor sammensætningen er i flydende form og omfatter 0,1 til 25 vægt-% albumin.
14. Farmaceutisk sammensætning ifølge krav 13, hvor den farmaceutiske sammensætning omfatter 0,5 til 5 vægt-% albumin.
15. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 11 til 14, hvor den farmaceutiske sammensætning er dehydreret.
16. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 11 til 14, hvor den farmaceutiske sammensætning er lyofiliseret.
17. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 11-14, hvor den farmaceutiske sammensætning er en væske.
18. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 11 til 17, hvor sammensætningen er i enhedsdosis, indeholdt i en forseglet beholder.
19. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 11 til 17, hvor sammensætningen er i multidosis, indeholdt i en forseglet beholder.
20. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 11 til 19, hvor sammensætningen endvidere omfatter deferoxamin.
21. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 11 til 20, hvor albuminet er humant serumalbumin.
22. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 21 til anvendelse i en fremgangsmåde til behandling af en sygdom.
23. Farmaceutisk sammensætning til anvendelse ifølge krav 22, hvor fremgangsmåden er til behandling af cancer, kardiovaskulær sygdom eller artritis.
24. Farmaceutisk sammensætning til anvendelse ifølge krav 22, hvor fremgangsmåden omfatter forøgelse af transporten af det farmaceutiske middel til stedet for en funktionsnedsættelse, forøgelse af det farmaceutiske middels binding til en celle eller forhøjelse af sammensætningens stabilitet.
25. Anvendelse af den farmaceutiske sammensætning ifølge et hvilket som helst af kravene 1 til 21 til fremstilling af et medikament til behandling af cancer, kardiovaskulær sygdom eller artritis.
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