DK158781A - Fremgangsmaade til fremstilling af forbindelser med inhiberende virkning paa niosyntesen af cholesterol - Google Patents

Fremgangsmaade til fremstilling af forbindelser med inhiberende virkning paa niosyntesen af cholesterol

Info

Publication number
DK158781A
DK158781A DK158781A DK158781A DK158781A DK 158781 A DK158781 A DK 158781A DK 158781 A DK158781 A DK 158781A DK 158781 A DK158781 A DK 158781A DK 158781 A DK158781 A DK 158781A
Authority
DK
Denmark
Prior art keywords
niosynthesis
cholesterol
relationships
preparing
procedure
Prior art date
Application number
DK158781A
Other languages
English (en)
Inventor
A Sato
A Terahara
Y Tsujita
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK158781A publication Critical patent/DK158781A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium
    • C12R2001/82—Penicillium chrysogenum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium
    • C12R2001/825—Penicillium notatum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Botany (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK158781A 1980-04-08 1981-04-08 Fremgangsmaade til fremstilling af forbindelser med inhiberende virkning paa niosyntesen af cholesterol DK158781A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4600480A JPS56142236A (en) 1980-04-08 1980-04-08 Ml-236a and mb-530a derivative

Publications (1)

Publication Number Publication Date
DK158781A true DK158781A (da) 1981-10-09

Family

ID=12734918

Family Applications (1)

Application Number Title Priority Date Filing Date
DK158781A DK158781A (da) 1980-04-08 1981-04-08 Fremgangsmaade til fremstilling af forbindelser med inhiberende virkning paa niosyntesen af cholesterol

Country Status (10)

Country Link
JP (1) JPS56142236A (da)
BE (1) BE888332A (da)
DE (1) DE3114242A1 (da)
DK (1) DK158781A (da)
FI (1) FI811080A7 (da)
FR (1) FR2479809A1 (da)
GB (1) GB2073199A (da)
IT (1) IT1144327B (da)
NL (1) NL8101749A (da)
SE (1) SE8102254L (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS5855443A (ja) * 1981-09-25 1983-04-01 Sankyo Co Ltd オクタヒドロナフタリン誘導体およびその製造法
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
EP0164049B1 (en) * 1984-06-04 1990-12-12 Merck & Co. Inc. Process for preparing hmg-coa reductase inhibtors with a 3,5-dihydroxypentanoate subunit
EP0204287A3 (en) * 1985-06-04 1987-07-01 Merck & Co. Inc. Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
HUP0302929A3 (en) * 2000-09-07 2004-10-28 Kaneka Corp Methods for crystallization of hydroxycarboxylic acids
CN1535145A (zh) 2001-06-13 2004-10-06 ʵ 作为新型HMG-CoA还原酶抑制剂的辛伐他汀的甲基类似物
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (da) 1974-06-07 1981-03-18
JPS5840476B2 (ja) * 1975-05-12 1983-09-06 三共株式会社 新生理活性物質ml−236cおよびその製造法
JPS5817443B2 (ja) * 1976-11-02 1983-04-07 三共株式会社 Ml−236b金属塩を主成分とする高脂血症治療剤
JPS5925599B2 (ja) 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンkおよびその製造法
JPS55150898A (en) 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b

Also Published As

Publication number Publication date
IT8167490A0 (it) 1981-04-08
FI811080L (fi) 1981-10-09
DE3114242A1 (de) 1982-06-16
BE888332A (fr) 1981-10-08
NL8101749A (nl) 1981-11-02
JPS56142236A (en) 1981-11-06
FI811080A7 (fi) 1981-10-09
SE8102254L (sv) 1981-10-09
FR2479809A1 (fr) 1981-10-09
IT1144327B (it) 1986-10-29
GB2073199A (en) 1981-10-14

Similar Documents

Publication Publication Date Title
DK534481A (da) Fremgangsmaade til fremstilling af 1-sulfo-2-oxoazetidinderivater
DK99781A (da) Fremgangsmaade til fremstilling af carboxtyrilderivater
DK2281A (da) Fremgangsmaade til fremstilling af tiazolinderivater
DK300981A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK190281A (da) Fremgangsmaade til fremstilling af aminothiadiazoler
DK161581A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK157920C (da) Analogifremgangsmaade til fremstilling af indolderivater
DK57480A (da) Fremgangsmaade til fremstilling af insulinderivater
DK100281A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK157995C (da) Analogifremgangsmaade til fremstilling af indolderivater
DK136881A (da) Fremgangsmaade til fremstilling af imidazopyridiner
DK465581A (da) Fremgangsmaade til fremstilling af tetrasubstituerede benzenderivater
DK564781A (da) Fremgangsmaade til fremstilling af pyrazoloindazolderivater
DK34781A (da) Fremgangsmaade til fremstilling af phenylalkansyrederivater
DK172181A (da) Fremgangsmaade til fremstilling af 9-carbamoyl-9-aminoalkylfluoren-derivater
DK554581A (da) Fremgangsmaade til fremstilling af alkylendioxybenzenderivater
DK565281A (da) Fremgangsmaade til fremstilling af quinolon-derivater
DK364481A (da) Fremgangsmaade til fremstilling af caprylolactamer
DK500081A (da) Fremgangsmaade til fremstilling af glutaminderivater
DK424781A (da) Fremgangsmaade til fremstilling af quinolonderivater
DK448981A (da) Fremgangsmaade til fremstilling af 4-chinolinmethanderivater
DK85281A (da) Fremgangsmaade til fremstilling af phenoxyderivater
DK296281A (da) Fremgangsmaade til fremstilling af aminocyklopentanonamider
DK551481A (da) Fremgangsmaade til fremstilling af triazolderivater
DK579181A (da) Fremgangsmaade til fremstilling af diarylthiophener

Legal Events

Date Code Title Description
PBP Patent lapsed