DK159308C - 4-aminoquinolinderivater, farmaceutisk middel der indeholder disse samt anvendelse af disse til fremstilling af et laegemiddel - Google Patents

4-aminoquinolinderivater, farmaceutisk middel der indeholder disse samt anvendelse af disse til fremstilling af et laegemiddel

Info

Publication number: DK159308C
Authority: DK; Denmark
Prior art keywords: 6alkyl; phenyl; preparation; medicine; pharmaceutical composition
Prior art date: 1986-09-05

Application number

DK245888A

Other languages

Danish (da)

English (en)

Other versions

DK245888D0 (da

DK245888A (da

DK159308B (da

Inventor

Thomas Henry Brown

Robert John Ife

Colin Andrew Leach

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-05

Filing date

1988-05-05

Publication date

1991-03-11

1988-05-05 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1988-05-05 Publication of DK245888D0 publication Critical patent/DK245888D0/da

1988-05-05 Publication of DK245888A publication Critical patent/DK245888A/da

1990-10-01 Publication of DK159308B publication Critical patent/DK159308B/da

1991-03-11 Application granted granted Critical

1991-03-11 Publication of DK159308C publication Critical patent/DK159308C/da

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000005011 4-aminoquinolines Chemical class 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
-1 cyano, hydroxy, carbamoyl Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
230000027119 gastric acid secretion Effects 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK245888A 1986-09-05 1988-05-05 4-aminoquinolinderivater, farmaceutisk middel der indeholder disse samt anvendelse af disse til fremstilling af et laegemiddel DK159308C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB868621425A GB8621425D0 (en)	1986-09-05	1986-09-05	Compounds
GB8621425		1986-09-05
PCT/GB1987/000624 WO1988001621A1 (en)	1986-09-05	1987-09-04	4-aminoquinoline derivatives and their use as medicaments
GB8700624		1987-09-04

Publications (4)

Publication Number	Publication Date
DK245888D0 DK245888D0 (da)	1988-05-05
DK245888A DK245888A (da)	1988-05-05
DK159308B DK159308B (da)	1990-10-01
DK159308C true DK159308C (da)	1991-03-11

Family

ID=10603729

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK245888A DK159308C (da)	1986-09-05	1988-05-05	4-aminoquinolinderivater, farmaceutisk middel der indeholder disse samt anvendelse af disse til fremstilling af et laegemiddel

Country Status (28)

Country	Link
US (2)	US4806549A (de)
EP (1)	EP0259174B1 (de)
JP (1)	JPH07602B2 (de)
KR (1)	KR950013850B1 (de)
CN (1)	CN1019802B (de)
AT (1)	ATE73776T1 (de)
AU (1)	AU598299B2 (de)
CA (1)	CA1308106C (de)
CZ (1)	CZ398291A3 (de)
DE (1)	DE3777505D1 (de)
DK (1)	DK159308C (de)
EG (1)	EG18408A (de)
ES (1)	ES2033316T3 (de)
FI (1)	FI88919C (de)
GB (1)	GB8621425D0 (de)
GR (1)	GR3004692T3 (de)
HU (1)	HU199804B (de)
IE (1)	IE61104B1 (de)
IL (1)	IL83691A (de)
MX (1)	MX9203550A (de)
MY (1)	MY102689A (de)
NO (1)	NO172388C (de)
NZ (1)	NZ221663A (de)
PH (1)	PH23695A (de)
PT (1)	PT85651B (de)
WO (1)	WO1988001621A1 (de)
ZA (1)	ZA876581B (de)
ZW (1)	ZW16787A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8610981D0 (en) *	1986-05-06	1986-06-11	Ici America Inc	Quinoline amides
US4789678A (en) *	1986-08-25	1988-12-06	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
US5049567A (en) *	1988-02-25	1991-09-17	Smithkline Beckman Intercredit B.V.	Substituted 4-aminoquinazoline derivatives and method of use
GB8804448D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
GB8804446D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
GB8804447D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
GB8804445D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
GB8804443D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
GB8804444D0 (en) *	1988-02-25	1988-03-23	Smithkline Beckman Intercredit	Compounds
DK273689A (da) *	1988-06-06	1989-12-07	Sanofi Sa	4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
FR2632305B1 (fr) *	1988-06-06	1992-05-15	Sanofi Sa	Amino-4 aroyl-3 quinoleines et naphtyridines, leur procede de preparation et leur application en therapeutique
CA2011086A1 (en) *	1989-03-17	1990-09-17	Karl-Heinz Geiss	2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
GB8918265D0 (en) *	1989-08-10	1989-09-20	Smithkline Beckman Intercredit	Compounds
KR920701162A (ko) *	1990-03-28	1992-08-11	오츠카 아끼히코	퀴놀린 유도체, 당해 유도체를 함유하는 항궤양제 및 당해 유도체의 제조방법
GB9126438D0 (en) *	1991-12-12	1992-02-12	Smithkline Beecham Intercredit	New quinoline derivatives
US5493027A (en) *	1993-01-22	1996-02-20	Board Of Regents, The University Of Texas System	Anticonvulsive agents and uses thereof
US5362743A (en) *	1993-03-09	1994-11-08	Pfizer Inc.	Aminoquinoline derivatives
US5556863A (en) *	1993-06-11	1996-09-17	Astra Aktiebolag	Compound for gastric acid secretion inhibition
IS4164A (is) *	1993-06-11	1994-12-12	Ab Astra	Efnasambönd sem hindra flæði magasýru
SE9302005D0 (sv)	1993-06-11	1993-06-11	Ab Astra	New active compounds
US5650415A (en) *	1995-06-07	1997-07-22	Sugen, Inc.	Quinoline compounds
IN188411B (de) *	1997-03-27	2002-09-21	Yuhan Corp
US6852739B1 (en)	1999-02-26	2005-02-08	Nitromed Inc.	Methods using proton pump inhibitors and nitric oxide donors
GB2396815B (en) *	1999-10-27	2004-09-08	Phytopharm Plc	A composition comprising a pregnenone derivative and an NSAID
UA80393C2 (uk)	2000-12-07	2007-09-25	Алтана Фарма Аг	Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
EP1453493A2 (de) *	2001-11-19	2004-09-08	ALTANA Pharma AG	Reversibele protonpumpen-hemmer zur behandlung von atemwegserkrankungen
MY140561A (en)	2002-02-20	2009-12-31	Nycomed Gmbh	Dosage form containing pde 4 inhibitor as active ingredient
EP1506016A2 (de) *	2002-05-07	2005-02-16	ALTANA Pharma AG	Neue kombination von reversiblen protonenpumpenhemmern und atemwegstherapeutika zur behandlung von atemwegserkrankungen
WO2004012659A2 (en) *	2002-08-01	2004-02-12	Nitromed, Inc.	Nitrosated proton pump inhibitors, compositions and methods of use
PT1606261E (pt)	2003-03-10	2010-01-11	Nycomed Gmbh	Novo processo para a preparação de roflumilast
EP1682133A1 (de)	2003-11-03	2006-07-26	AstraZeneca AB	Imidazo-1,2-a-pyridin-derivate zur behandlung von beschwerdefreiem gastroösophagealem reflux
SE0400284D0 (sv) *	2004-02-10	2004-02-10	Astrazeneca Ab	Novel compounds
US8663694B2 (en) *	2005-03-16	2014-03-04	Takeda Gmbh	Taste masked dosage form containing roflumilast
US7981908B2 (en)	2005-05-11	2011-07-19	Vecta, Ltd.	Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en)	2005-05-11	2010-09-28	Vecta, Ltd.	Composition and methods for inhibiting gastric acid secretion
PL2046334T3 (pl)	2006-07-25	2015-02-27	Vecta Ltd	Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI
EP2086543A2 (de)	2006-10-27	2009-08-12	The Curators of the University of Missouri	Zusammensetzungen mit mindestens einem säurelabilen protonenpumpen-hemmenden mittel, wahlweise anderen pharmazeutisch wirksamen mitteln und anwendungsverfahren dafür
TW200829555A (en) *	2006-11-10	2008-07-16	Astrazeneca Ab	Chemical compounds
CL2008000191A1 (es) *	2007-01-25	2008-08-22	Astrazeneca Ab	Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer.
JP2011512416A (ja)	2008-02-20	2011-04-21	ザ・キュレイターズ・オブ・ザ・ユニバーシティー・オブ・ミズーリ	オメプラゾール及びランソプラゾールの組合せと緩衝剤を含んでなる組成物とそれを使用する方法
JP2011520804A (ja) *	2008-05-07	2011-07-21	アストラゼネカアクチボラグ	化合物
US8247280B2 (en)	2009-10-20	2012-08-21	Taiwan Semiconductor Manufacturing Company, Ltd.	Integration of low and high voltage CMOS devices
US12171755B2 (en) *	2017-10-25	2024-12-24	Children's Medical Center Corporation	PAPD5 inhibitors and methods of use thereof
US12486234B2 (en)	2019-04-24	2025-12-02	Children's Medical Center Corporation	PAPD5 inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4343804A (en) *	1979-03-26	1982-08-10	A. H. Robins Company, Inc.	4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
JO1406B1 (en) *	1984-11-02	1986-11-30	سميث كلاين اند فرينش لابوراتوريز ليمتد	Chemical compounds
PH22302A (en) *	1985-02-11	1988-07-22	Fujisawa Pharmaceutical Co	Piperidine compounds
EP0193329A3 (de) *	1985-02-22	1987-08-19	Beecham Group Plc	Pyrazolopyridine, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4789678A (en) *	1986-08-25	1988-12-06	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds

1986
- 1986-09-05 GB GB868621425A patent/GB8621425D0/en active Pending
1987
- 1987-08-27 MY MYPI87001459A patent/MY102689A/en unknown
- 1987-08-31 IL IL83691A patent/IL83691A/xx not_active IP Right Cessation
- 1987-08-31 ZW ZW167/87A patent/ZW16787A1/xx unknown
- 1987-09-01 PH PH35755A patent/PH23695A/en unknown
- 1987-09-02 CA CA000545915A patent/CA1308106C/en not_active Expired - Lifetime
- 1987-09-03 ZA ZA876581A patent/ZA876581B/xx unknown
- 1987-09-03 US US07/092,749 patent/US4806549A/en not_active Expired - Fee Related
- 1987-09-03 EG EG520/87A patent/EG18408A/xx active
- 1987-09-03 NZ NZ221663A patent/NZ221663A/xx unknown
- 1987-09-03 PT PT85651A patent/PT85651B/pt not_active IP Right Cessation
- 1987-09-04 EP EP87307824A patent/EP0259174B1/de not_active Expired - Lifetime
- 1987-09-04 KR KR1019880700495A patent/KR950013850B1/ko not_active Expired - Lifetime
- 1987-09-04 AT AT87307824T patent/ATE73776T1/de active
- 1987-09-04 CN CN87106163A patent/CN1019802B/zh not_active Expired
- 1987-09-04 JP JP62505181A patent/JPH07602B2/ja not_active Expired - Lifetime
- 1987-09-04 HU HU874336A patent/HU199804B/hu not_active IP Right Cessation
- 1987-09-04 AU AU78741/87A patent/AU598299B2/en not_active Ceased
- 1987-09-04 IE IE237087A patent/IE61104B1/en not_active IP Right Cessation
- 1987-09-04 ES ES198787307824T patent/ES2033316T3/es not_active Expired - Lifetime
- 1987-09-04 WO PCT/GB1987/000624 patent/WO1988001621A1/en not_active Ceased
- 1987-09-04 DE DE8787307824T patent/DE3777505D1/de not_active Expired - Lifetime
1988
- 1988-05-04 FI FI882089A patent/FI88919C/fi not_active IP Right Cessation
- 1988-05-04 NO NO881940A patent/NO172388C/no unknown
- 1988-05-05 DK DK245888A patent/DK159308C/da not_active IP Right Cessation
- 1988-05-12 US US07/192,996 patent/US4806550A/en not_active Expired - Fee Related
1991
- 1991-12-20 CZ CS913982A patent/CZ398291A3/cs unknown
1992
- 1992-05-26 GR GR920401026T patent/GR3004692T3/el unknown
- 1992-06-26 MX MX9203550A patent/MX9203550A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0259174B1 (de)	1992-03-18
MX9203550A (es)	1992-09-01
AU7874187A (en)	1988-03-24
EP0259174A1 (de)	1988-03-09
CN1019802B (zh)	1992-12-30
IL83691A (en)	1993-08-18
HU199804B (en)	1990-03-28
FI882089A7 (fi)	1988-05-04
FI88919C (fi)	1993-07-26
AU598299B2 (en)	1990-06-21
IE872370L (en)	1988-03-05
CA1308106C (en)	1992-09-29
IE61104B1 (en)	1994-10-05
ZW16787A1 (en)	1988-05-25
GR3004692T3 (de)	1993-04-28
NO172388B (no)	1993-04-05
CZ398291A3 (en)	1994-02-16
FI88919B (fi)	1993-04-15
DE3777505D1 (de)	1992-04-23
ZA876581B (en)	1989-04-26
ES2033316T3 (es)	1993-03-16
DK245888D0 (da)	1988-05-05
KR880701711A (ko)	1988-11-04
NO881940D0 (no)	1988-05-04
JPH01500664A (ja)	1989-03-09
ATE73776T1 (de)	1992-04-15
NO881940L (no)	1988-05-04
US4806550A (en)	1989-02-21
DK245888A (da)	1988-05-05
DK159308B (da)	1990-10-01
NZ221663A (en)	1989-08-29
FI882089A0 (fi)	1988-05-04
KR950013850B1 (ko)	1995-11-17
MY102689A (en)	1992-09-30
JPH07602B2 (ja)	1995-01-11
US4806549A (en)	1989-02-21
GB8621425D0 (en)	1986-10-15
EG18408A (en)	1993-02-28
PT85651A (en)	1987-10-01
NO172388C (no)	1993-07-14
PH23695A (en)	1989-09-27
HUT47913A (en)	1989-04-28
CN87106163A (zh)	1988-03-16
WO1988001621A1 (en)	1988-03-10
PT85651B (pt)	1990-05-31

Legal Events

Date	Code	Title	Description
1997-05-20	PBP	Patent lapsed

Publication	Publication Date	Title
DK159308C (da)	1991-03-11	4-aminoquinolinderivater, farmaceutisk middel der indeholder disse samt anvendelse af disse til fremstilling af et laegemiddel
DE3862928D1 (de)	1991-06-27	Chinazolinon-derivate.
ZA895613B (en)	1990-05-30	Chemical compounds
IS1564B (is)	1994-12-13	Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
FI895046A0 (fi)	1989-10-24	4-amino-3-acylkinolinderivat samt deras anvaendning saosom inhibitorer av sekretion av matsmaeltningsvaetskor.
MY105158A (en)	1994-08-30	Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibutors.
DK414488D0 (da)	1988-07-22	Substituerede quinolinderivater, fremgangsmaade til deres fremstilling samt farmaceutiske midler indeholdende disse forbindelser
DK164057C (da)	1992-09-28	Oe5,6aa-cis-1,3-oxathianderivater og fremgangsmaade til deres fremstilling og farmaceutisk middel indeholdende et saadant derivat
ATE54665T1 (de)	1990-08-15	Hydantoin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.